Review
Biology
Jessica Bourque, Daniel Hawiger
Summary: T cell responses to antigens rely on dendritic cells (DCs) that have undergone maturation, which involves alterations in functionality driven by innate and intrinsic signals. Recent studies in mice have revealed a complex network of signals, including cytokines and immunomodulatory pathways, that facilitate communication and shape the functionality of DCs. This process involves amplification of the initial activation of DCs and selective ablation of specific functions. Understanding the interconnectedness of intracellular and intercellular mechanisms is crucial for comprehending the mechanistic components of DC maturation.
Review
Multidisciplinary Sciences
Chrysothemis C. Brown, Alexander Y. Rudensky
Summary: The incomplete removal of self-reactive T cells during differentiation in the thymus requires mechanisms of tolerance, while establishing tolerance to commensal microorganisms poses a further challenge. This review summarizes recent advances in understanding peripheral T cell tolerance, with a focus on mechanisms of tolerance to the gut microbiota and the establishment of intestinal tolerance. The article highlights the importance of overlapping and distinct pathways underlying tolerance to self-antigens versus commensal antigens within a broader framework for immune tolerance.
Article
Medicine, Research & Experimental
M. Hope Robinson, Nancy Y. Villa, David L. Jaye, Ajay K. Nooka, Alyssa Duffy, Samuel S. McCachren, Julia Manalo, Jeffrey M. Switchenko, Sierra Barnes, Sayalee Potdar, Maryam I. Azeem, Ava A. Horvat, Vaunita C. Parihar, Jingjing Gong, Yan Liang, Geoffrey H. Smith, Vikas A. Gupta, Lawrence H. Boise, Jonathan L. Kaufman, Craig C. Hofmeister, Nisha S. Joseph, Sagar Lonial, Kavita M. Dhodapkar, Madhav V. Dhodapkar
Summary: This study investigates the mechanisms underlying immune infiltration in human multiple myeloma (MM) and its precursor monoclonal gammopathy of undetermined significance (MGUS) using high-dimensional spatial analyses and in vitro and in vivo modeling. The results suggest that MM exhibits clustered tumor growth and spatial heterogeneity with the coexistence of T cell-rich and T cell-sparse regions, as well as areas of T cell exclusion. T cell entry into MM clusters is regulated by agonistic signals and CD2-CD58 interactions, and CLEC9A+ DCs play a role in marking the portals of entry for T cell infiltration.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Ranit Kedmi, Tariq A. Najar, Kailin R. Mesa, Allyssa Grayson, Lina Kroehling, Yuhan Hao, Stephanie Hao, Maria Pokrovskii, Mo Xu, Jhimmy Talbot, Jiaxi Wang, Joe Germino, Caleb A. Lareau, Ansuman T. Satpathy, Mark S. Anderson, Terri M. Laufer, Iannis Aifantis, Juliet M. Bartleson, Paul M. Allen, Helena Paidassi, James M. Gardner, Marlon Stoeckius, Dan R. Littman
Summary: The mutualistic relationship between gut-resident microbiota and the host immune system is crucial for maintaining homeostasis. Helicobacter species and other gut bacteria direct T cell differentiation through targeting specific antigen-presenting cells.
Review
Immunology
Ryosuke Nakano, Lillian M. Tran, David A. Geller, Camila Macedo, Diana M. Metes, Angus W. Thomson
Summary: Liver allograft recipients are more likely to develop transplantation tolerance, with liver interstitial dendritic cells playing pivotal roles. Interstitial liver DCs, recruited in situ or derived from circulating precursors, are involved in regulating ischemia/reperfusion injury and anti-donor immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Kayla R. Wilson, Jose A. Villadangos, Justine D. Mintern
Summary: Dendritic cells (DCs) play a crucial role in initiating immune responses. Understanding the Flt3 signaling pathway could provide new insights for vaccine development and treatment of autoimmune diseases.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Review
Cell Biology
Meng Feng, Shuping Zhou, Yong Yu, Qinghong Su, Xiaofan Li, Wei Lin
Summary: Dendritic cells (DCs) are a class of antigen-presenting cells with crucial roles in immune activation and tolerance. Understanding the migration mechanisms and regulatory factors of different DC subgroups provides new insights for disease treatment, such as infection, tumors, and vaccine preparation. Various factors, including chemokines, membrane molecules, and microenvironments, influence DC migration and immunological functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Summary: This study provides insight into epigenetic profiles and transcription factor networks associated with transcriptional signatures of tolerized and trained microglia in vivo, leading to a better understanding of innate immune memory of microglia.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Felipe Flores-Santibanez, Sofie Rennen, Dominique Fernandez, Clint De Nolf, Evelien Van de Velde, Sandra Gaete Gonzalez, Camila Fuentes, Carolina Moreno, Diego Figueroa, Alvaro Lladser, Takao Iwawaki, Maria Rosa Bono, Sophie Janssens, Fabiola Osorio
Summary: Activation of the IRE1/XBP1s axis in cancer promotes immunosuppression and tumor growth. This study investigated the role of IRE1/XBP1s in dendritic cells (DCs) in tumors, specifically in conventional type 1 DCs (cDC1s), which are important targets in immunotherapy. The results show that deletion of the RNase domain of IRE1 and/or XBP1s in DCs and cDC1s does not affect tumor growth or T cell responses. These findings argue against a pro-tumorigenic role of the IRE1/XBP1s pathway in tumor-associated DC subsets.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Laura Passeri, Fortunato Marta, Virginia Bassi, Silvia Gregori
Summary: Dendritic cells play a crucial role in autoimmune diseases by instructing T cells to respond to antigens, leading to organ damage or promoting immune tolerance. Research on different subsets of human DCs and the regulatory mechanisms associated with tolDC functions is ongoing, along with exploring tolDC-based therapies for treating autoimmune diseases. Continued expansion of research in the area of tolDCs will enhance understanding of the role of DCs in the development and treatment of autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Farhan Ullah Khan, Puregmaa Khongorzul, Ahmed Aziz Raki, Ashwini Rajasekaran, Denis Gris, Abdelaziz Amrani
Summary: Type 1 diabetes is caused by the destruction of pancreatic beta cells mediated by T cells. Dendritic cells play a crucial role in the initiation and development of this disease by presenting antigens to activate and regulate the immune response. Recent advancements in understanding dendritic cell function and regulation have led to the development of potential therapeutic strategies for treating type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yiwei Zhang, Jian Zhou, Zhiyuan Wei, Hui Dong, Di Yang, Yuanyu Deng, Jiahui Li, Saiyu Shi, Yi Sun, Huimin Lu, Jizhao Yuan, Bing Ni, Yuzhang Wu, Yi Tian, Chao Han
Summary: Dendritic cells play a crucial role in the immune system by regulating defense against pathogens and tolerance to self. This review highlights the significance of mRNA stability regulation in dendritic cells for their function and immune therapy.
Review
Immunology
Peng Liu, Liwei Zhao, Laurence Zitvogel, Oliver Kepp, Guido Kroemer
Summary: The search for immunostimulatory drugs in cancer immunotherapy can benefit from target-agnostic methods that screen agents for their functional impact on immune cells cultured in vitro without preconceived notions of their mode of action. A synthetic mini-immune system has been developed to confront stressed and dying cancer cells with dendritic cells (DCs) and CD8(+) T-cell hybridoma cells. This system can identify three types of immunostimulatory drugs: those that stimulate immunogenic cell death (ICD) of cancer cells, drugs that enhance DC response to ICD, and drugs that increase T cell effector function. Strategies to develop ICD enhancers are discussed, including ligands of pattern recognition receptors and immunometabolic modifiers, as well as methods for target deconvolution.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Mats Van Delen, Ibo Janssens, Amber Dams, Laurence Roosens, Benson Ogunjimi, Zwi N. Berneman, Judith Derdelinckx, Nathalie Cools
Summary: This study aimed to counter the high inflammatory state of COVID-19 by inducing T-cell hyporesponsiveness using tolerogenic dendritic cells (tolDC). The results showed that tolDC could induce SARS-CoV-2-specific T cell hyporesponsiveness, suggesting its clinical potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Shengbo Zhang, Cindy Audiger, Michael Chopin, Stephen L. Nutt
Summary: This review summarizes recent advances in understanding the transcriptional networks that regulate the development of different subsets of dendritic cells (DCs). It discusses the heterogeneity of cDC2s, the ontogeny of pDCs, and the newly described DC subset, DC3. The review also examines critical transcription factors such as IRF8, PU.1, and E2-2, and highlights their regulatory mechanisms and downstream targets. The complex interplay between these transcription factors shapes the DC transcriptome and influences their function in response to environmental stimuli. The information presented in this review provides essential insights into the regulation of DC development and function, with potential implications for developing novel therapeutic strategies for immune-related diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Huibi Cao, Jing Wu, Cathleen Duan, Kai Du, Chan Mi Lee, Herman Yeger, Jim Hu
HUMAN GENE THERAPY
(2016)
Article
Biochemistry & Molecular Biology
Chan-Mi Lee, Sahil Gupta, Jiafeng Wang, Elizabeth M. Johnson, Leslie J. Crofford, John C. Marshall, Mohit Kapoor, Jim Hu
CELL AND BIOSCIENCE
(2016)
Article
Biotechnology & Applied Microbiology
Huibi Cao, Hong Ouyang, Hartmut Grasemann, Claire Bartlett, Kai Du, Rongqi Duan, Fushan Shi, Marvin Estrada, Kyle E. Seigel, Allan L. Coates, Herman Yeger, Christine E. Bear, Tanja Gonska, Theo J. Moraes, Jim Hu
HUMAN GENE THERAPY
(2018)
Article
Cell Biology
Sahil Gupta, Chan-Mi Lee, Jia-Feng Wang, Jean Parodo, Song-Hui Jia, Jim Hu, John C. Marshall
JOURNAL OF LEUKOCYTE BIOLOGY
(2018)
Article
Genetics & Heredity
Emily Xia, Yiqian Zhang, Huibi Cao, Jun Li, Rongqi Duan, Jim Hu
Article
Medicine, Research & Experimental
Emily Xia, Rongqi Duan, Fushan Shi, Kyle E. Seigel, Hartmut Grasemann, Jim Hu
MOLECULAR THERAPY-NUCLEIC ACIDS
(2018)
Article
Biotechnology & Applied Microbiology
Zhichang Peter Zhou, Liang Leo Yang, Huibi Cao, Ziyan Rachel Chen, Yiqian Zhang, Xiao-Yan Wen, Jim Hu
HUMAN GENE THERAPY
(2019)
Article
Respiratory System
Huibi Cao, Hong Ouyang, Onofrio Laselva, Claire Bartlett, Zhichang Peter Zhou, Cathleen Duan, Tarini Gunawardena, Julie Avolio, Christine E. Bear, Tanja Gonska, Jim Hu, Theo J. Moraes
EUROPEAN RESPIRATORY JOURNAL
(2020)
Review
Chemistry, Medicinal
Mohd Farhan, Marta Silva, Shuai Li, Fengxia Yan, Jiankang Fang, Tangming Peng, Jim Hu, Ming-Sound Tsao, Peter Little, Wenhua Zheng
MEDICINAL RESEARCH REVIEWS
(2020)
Article
Genetics & Heredity
Huibi Cao, Rongqi Duan, Jim Hu
Article
Cell Biology
Ming Jiang, Yinshan Fang, Yu Li, Huachao Huang, Zichen Wei, Xia Gao, Hoon-Ki Sung, Jim Hu, Li Qiang, Jian Ruan, Qixuan Chen, Dianhua Jiang, Jeffrey A. Whitsett, Xingbin Ai, Jianwen Que
Summary: The study reveals an unexpected role of VEGFa/KDR signaling in defending against mucous metaplasia, potentially offering a therapeutic target for common airway pathologies.
DEVELOPMENTAL CELL
(2021)
Article
Endocrinology & Metabolism
Yasaman Badakhshi, Weijuan Shao, Dinghui Liu, Lili Tian, Juan Pang, Jianqiu Gu, Jim Hu, Tianru Jin
Summary: This study reveals that hepatic FGF21 is downregulated in male LTCFDN mice compared to females, implicating the involvement of estrogen-beta-cat/TCF signaling pathway. In mouse primary hepatocytes, FGF21 transcription is positively regulated by the Wnt pathway effector beta-cat/TCF. Ovariectomized female mice show reduced hepatic FGF21 production, correlated with decreased hepatic TCF expression and beta-catenin phosphorylation.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Ranmal Avinash Bandara, Ziyan Rachel Chen, Jim Hu
Summary: The use of CRISPR/Cas9 in gene therapy for CF has shown great potential, but challenges remain in delivering and achieving efficiency in vivo, especially for lung gene therapy. Utilizing HD-Ad vectors to deliver CRISPR/Cas9 for lung gene therapy presents a new avenue for overcoming these challenges and holds promise for future treatments.
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Fei Li, Jim Hu, Tong-Chuan He
Article
Cell Biology
Chan Mi Lee, Jing Wu, Yi Xia, Jim Hu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2016)
