期刊
JOURNAL OF IMMUNOLOGY
卷 184, 期 12, 页码 6782-6789出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1000155
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资金
- National Institutes of Health [AI050260]
Intestinal bacteria drive the formation of lymphoid tissues, and in rabbit, bacteria also promote development of the preimmune Ab repertoire and positive selection of B cells in GALT. Previous studies indicated that Bacillus subtilis promotes B cell follicle formation in GALT, and we investigated the mechanism by which B. subtilis stimulates B cells. We found that spores of B. subtilis and other Bacillus species, including Bacillus anthracis, bound rabbit IgM through an unconventional, superantigen-like binding site, and in vivo, surface molecules of B. anthracis spores promoted GALT development. Our study provides direct evidence that B cell development in GALT may be driven by superantigen-like molecules, and furthermore, that bacterial spores modulate host immunity. The Journal of Immunology, 2010, 184: 6782-6789.
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