Article
Biotechnology & Applied Microbiology
Connor G. G. Bamford, John McLauchlan
Summary: The host IFNL4 haplotype status influences the development of chronic HCV infection. Specific amino acid variants at multiple sites on the HCV polyprotein correlate with functional SNPs in the IFNL4 locus, which may affect virus replication and infection outcome. Each individual IFNL4-associated variant has a nuanced effect on viral replication, potentially mediating resistance to IFN lambda 4 effects.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Immunology
Liyuan Wang, Yang Sun, Xiaojia Song, Zehua Wang, Yankun Zhang, Ying Zhao, Xueqi Peng, Xiaodong Zhang, Chunyang Li, Chengjiang Gao, Nailin Li, Lifen Gao, Xiaohong Liang, Zhuanchang Wu, Chunhong Ma
Summary: ADAR1 interacts with HBV RNA to disrupt host immune recognition through deamination, promoting HBV replication. HBV X protein transcriptionally increases ADAR1 expression to raise the threshold for immune activation, enhancing HBV escape from immune recognition.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhongyao Qian, Chenchen Yang, Liangheng Xu, Houfack K. Mickael, Shuangfeng Chen, Yike Zhang, Yueping Xia, Tengyuan Li, Wenhai Yu, Fen Huang
Summary: Hepatitis E virus-encoded miRNA (HEV-miR-A6) activates SIRP-alpha to promote viral replication by inhibiting the expression of type I interferon beta (IFN-beta).
Article
Immunology
Gbolahan Ajibola, Pilar Garcia-Broncano, Kenneth Maswabi, Kara Bennett, Michael D. Hughes, Sikhulile Moyo, Terrence Mohammed, Patrick Jean-Philippe, Maureen Sakoi, Oganne Batlang, Shahin Lockman, Joseph Makhema, Daniel R. Kuritzkes, Mathias Lichterfeld, Roger L. Shapiro
Summary: Starting antiretroviral treatment in infancy can reduce the HIV reservoir, with negative serostatus and qualitative DNA at 84 weeks being useful markers for sustained viral suppression.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Armando B. D. Djiyou, Calixte Ida Penda, Yoann Madec, Grace Dalle Ngondi, Astrid Moukoko, Marie Varloteaux, Laure-Amelie de Monteynard, Cecile Moins, Carole Else Eboumbou Moukoko, Avelin F. Aghokeng
Summary: This study assessed the rate of sustained viral suppression (VS) and factors associated with virological failure (VF) in a cohort of adolescents receiving antiretroviral therapy (ART) in Cameroon. The study found a high rate of VS, indicating that achieving the UNAIDS 95% VS rate is feasible in this population.
Article
Multidisciplinary Sciences
Ram Kumar, Yogesh Chander, Nitin Khandelwal, Assim Verma, Krishan Dutt Rawat, Brij N. Shringi, Yash Pal, Bhupendra N. Tripathi, Sanjay Barua, Naveen Kumar
Summary: The ROCK1/MLC2 signaling pathway promotes buffalo pox virus replication by preventing viral mRNA decay. Inhibitors targeting this pathway may have therapeutic effects against buffalopox.
SCIENTIFIC REPORTS
(2022)
Article
Health Care Sciences & Services
Mathias Jachs, Lukas Hartl, David Bauer, Benedikt Simbrunner, Albert Friedrich Staettermayer, Robert Strassl, Michael Trauner, Mattias Mandorfer, Thomas Reiberger
Summary: This study retrospectively analyzed patients with long-term HBV suppression and CSPH, and found that LSM and HVPG had some predictive value for prognosis, with LSM <25 kPa significantly reducing the risk of hepatic decompensation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Virology
Xianhui Liu, Hanqin Shen, Xinming Zhang, Tairun Liang, Yanfang Ban, Linyang Yu, Leyi Zhang, Yanling Liu, Jianguo Dong, Pengfei Zhang, Kaiqi Lian, Changxu Song
Summary: Porcine circovirus type 3 (PCV3) has been widely detected worldwide and is associated with various diseases. Research shows that the capsid protein (Cap) of PCV3 activates the NF-kappa B signaling pathway, promoting the expression of inflammatory cytokines and possibly acting through the RLR and TLR signaling pathways.
ARCHIVES OF VIROLOGY
(2021)
Article
Gastroenterology & Hepatology
Mauricio Lisker-Melman, Abdus S. Wahed, Marc G. Ghany, Raymond T. Chung, Wendy C. King, David E. Kleiner, Atul K. Bhan, Mandana Khalili, Mamta K. Jain, Mark Sulkowski, David K. Wong, Gavin Cloherty, Richard K. Sterling
Summary: In patients coinfected with HBV and HIV, HBV RNA and HBcrAg can still be detected despite viral suppression, and their levels are associated with the extent of HBsAg and HBcAg staining in liver cells. This suggests that residual transcription and translation may contribute to liver pathology even when viral replication is suppressed.
Article
Microbiology
Yizi He, Chunxiu Wu, Zijian Liu, Yudi Zhang, Fengling Feng, Zihan Lin, Congcong Wang, Qing Yang, Ziyu Wen, Yichu Liu, Fan Zhang, Yanqin Lin, Hao Zhang, Linbing Qu, Linghua Li, Weiping Cai, Caijun Sun, Ling Chen, Pingchao Li
Summary: This study demonstrates the potential of arsenic trioxide (As2O3) as a component of the shock-and-kill strategy for achieving a functional cure for HIV. As2O3 not only impacts viral latency and reactivates the viral reservoir, but also induces apoptosis of HIV-infected cells, preventing secondary infection. Additionally, the combination of As2O3 and antiretroviral therapy (ART) effectively restores CD4(+) T cell count, delays disease progression, and improves survival in acutely SIV-infected macaques.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Yizi He, Chunxiu Wu, Zijian Liu, Yudi Zhang, Fengling Feng, Zihan Lin, Congcong Wang, Qing Yang, Ziyu Wen, Yichu Liu, Fan Zhang, Yanqin Lin, Hao Zhang, Linbing Qu, Linghua Li, Weiping Cai, Caijun Sun, Ling Chen, Pingchao Li
Summary: Arsenic trioxide (As2O3) can reactivate the viral reservoir, delay viral rebound after antiretroviral therapy (ART) interruption, and induce apoptosis of SIV-infected CD4(+) T cells, thus blocking the secondary infection of bystanders.
MICROBIOLOGY SPECTRUM
(2023)
Article
Virology
Tareq Abualfaraj, Nafiseh Chalabi Hagkarim, Robert Hollingworth, Laura Grange, Satpal Jhujh, Grant S. Stewart, Roger J. Grand
Summary: The Ad12E1B55K protein affects cellular DNA damage response pathways and DNA replication by interacting with multiple proteins, leading to genomic instability.
Article
Immunology
Yosuke Suehiro, Masataka Tsuge, Mio Kurihara, Takuro Uchida, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Grace Naswa Makokha, Takashi Nakahara, Eisuke Murakami, Hiromi Abe-Chayama, Tomokazu Kawaoka, Daiki Miki, Michio Imamura, Hiroshi Aikata, C. Nelson Hayes, Takashi Fujita, Kazuaki Chayama
Summary: HBV infection upregulates TRAIL-R3, which inhibits both TRAIL-dependent apoptosis and suppression of HBV replication. The upregulation of TRAIL-R3 is regulated by the TRAIL-R3 promoter and HBV signal pathway. The results suggest a mechanism by which HBV persists by escaping host immunity through upregulation of TRAIL-R3.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Bingfeng Liu, Wanying Zhang, Baijin Xia, Shuliang Jing, Yingying Du, Fan Zou, Rong Li, Lijuan Lu, Shaozhen Chen, Yonghong Li, Qifei Hu, Yingtong Lin, Yiwen Zhang, Zhangping He, Xu Zhang, Xiejie Chen, Tao Peng, Xiaoping Tang, Weiping Cai, Ting Pan, Linghua Li, Hui Zhang
Summary: This study investigated the safety and antiviral activity of bNAb-derived CAR T cell therapy in individuals infected with HIV-1 undergoing analytical interruption of antiretroviral therapy. The therapy was found to be safe and effective, reducing viral reservoir, but rebound was due to viral escape mutations.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Infectious Diseases
Yue Zhang, Hu Yan, Xian Li, Dihan Zhou, Maohua Zhong, Jingyi Yang, Bali Zhao, Xuxu Fan, Jun Fan, Jiayi Shu, Mengji Lu, Xia Jin, Ejuan Zhang, Huimin Yan
Summary: In this study, we investigated the correlation between viral inoculation dose and outcomes resulting from CHIKV infection by establishing acute and chronic CHIKV infections in mice. We found that a high viral inoculation dose not only resulted in persistent viral infection but also led to a typical acute-recovery-relapse model of myositis and joint injury in mice. Additionally, we observed that CHIKV RNA replication was interrupted after the acute phase, which might be related to the low antiviral T cell responses and relapse of histopathological injuries.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Multidisciplinary Sciences
Ryo Toda, Atsushi Teramoto, Masashi Kondo, Kazuyoshi Imaizumi, Kuniaki Saito, Hiroshi Fujita
Summary: This study proposes a pix2pix-based model called StylePix2pix, which allows the generation of diverse lesion images from tumor sketches. The one-to-many image generation capability of StylePix2pix suggests effectiveness in data-augmentation applications.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Hisayoshi Kubota, Kazuo Kunisawa, Moe Niijima, Mami Hirakawa, Yuko Mori, Masaya Hasegawa, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri
Summary: Phencyclidine (PCP) causes mental symptoms similar to schizophrenia by inhibiting the glutamatergic system. Deficiency of kynurenine 3-monooxygenase (KMO) may be associated with exacerbation of PCP-induced symptoms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Hitomi Yamamoto-Matsuda, Keita Miyoshi, Mai Moritoh, Hikari Yoshitane, Yoshitaka Fukada, Kuniaki Saito, Soichiro Yamanaka, Mikiko C. Siomi
Summary: Loss-of-function mutations in Drosophila lethal (3) malignant brain tumor [l(3) mbt] result in ectopic expression of germ-line genes and brain tumors. The study reveals that L(3) mbt genomic binding is not always linked to gene regulation and it controls piRNA pathway genes through multiple mechanisms. Furthermore, a novel co-regulator of L(3) mbt, Lint-O, is identified and shown to impact the levels of piRNA amplifiers.
Article
Chemistry, Multidisciplinary
Yoshitaka Isobe, Atsushi Teramoto, Fujio Morita, Kuniaki Saito, Hiroshi Fujita
Summary: In computed tomography colonography (CTC), an electronic cleansing method using CycleGAN was developed to assist diagnosis and accurately visualize the colon.
APPLIED SCIENCES-BASEL
(2022)
Article
Medicine, General & Internal
Atsushi Teramoto, Tomoyuki Shibata, Hyuga Yamada, Yoshiki Hirooka, Kuniaki Saito, Hiroshi Fujita
Summary: In this study, a cascaded deep learning model was proposed for the classification of endoscopic images and identification of the invasive region, achieving good detection results.
Article
Cardiac & Cardiovascular Systems
Eirin Sakaguchi, Akira Yamada, Hiroyuki Naruse, Hidekazu Hattori, Hideto Nishimura, Hideki Kawai, Takashi Muramatsu, Junnichi Ishii, Tadayoshi Hata, Kuniaki Saito, Hideo Izawa
Summary: Changes in GLS values are associated with the long-term prognosis of patients with a preserved LVEF and acute decompensated heart failure (HFpEF).
Article
Gastroenterology & Hepatology
Hironari Kawai, Yosuke Osawa, Tomoyuki Tsunoda, Michitaka Matsuda, Miku Okawara, Yuzuru Sakamoto, Tomonari Shimagaki, Yuriko Tsutsui, Yuichi Yoshida, Shiori Yoshikawa, Hiroyoshi Doi, Taizo Mori, Taiji Yamazoe, Sachiyo Yoshio, Tadashi Okamura, Masaya Sugiyama, Daisuke Okuzaki, Haruki Komatsu, Ayano Inui, Katsuhiko Yanaga, Toru Ikegami, Tatsuya Kanto
Summary: This study found that liver fibrosis and tumors in patients with congestive hepatopathy mainly occur in the periphery of the liver. Liver congestion increases liver stiffness, but it is unclear which factors contribute to the regional disparity of tumor development.
HEPATOLOGY RESEARCH
(2023)
Article
Medicine, General & Internal
Yosuke Osawa, Takaaki Ohtake, Daisuke Suto, Takayuki Akita, Hidehiko Yamada, Yutaka Kohgo, Kazumoto Murata
Summary: One of the therapeutic goals for chronic hepatitis B infection is to clear HBsAg from the blood. We observed three clinical cases where HBsAg levels rapidly decreased after COVID-19 vaccination without any incentive.
Article
Oncology
Tatsuya Ando, Masato Hoshi, Hiroyuki Tezuka, Hiroyasu Ito, Kentaro Nakamoto, Yasuko Yamamoto, Kuniaki Saito
Summary: The partial loss of liver due to liver transplantation or acute liver failure induces rapid liver regeneration. Recently, we reported that the selective inhibition of indoleamine 2,3-dioxygenase (Ido) 1 promotes early liver regeneration. However, the role of Ido2 in liver regeneration remains unclear.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Chikara Takeuchi, Moe Yokoshi, Shu Kondo, Aoi Shibuya, Kuniaki Saito, Takashi Fukaya, Haruhiko Siomi, Yuka W. Iwasaki
Summary: In Drosophila, specific splice variants of the insulator protein Mod(mdg4)-N repress HeT-A expression by blocking subtelomeric enhancers and associating with the subtelomeric sequences. Furthermore, Mod(mdg4)-N recruits RNA polymerase II to the subtelomeres, reinforcing its enhancer-blocking function.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Medicine, General & Internal
Atsushi Teramoto, Tetsuya Tsukamoto, Ayano Michiba, Yuka Kiriyama, Eiko Sakurai, Kazuyoshi Imaizumi, Kuniaki Saito, Hiroshi Fujita
Summary: This study proposes an automatic classification method for idiopathic interstitial pneumonia (IIP) using deep learning, and compensates for the lack of data on rare diseases by generating pathological images using a generative adversarial network (GAN). The results show that this method is effective for the diagnosis of idiopathic pulmonary fibrosis (IPF), with high accuracy.
Article
Engineering, Biomedical
Terumasa Kondo, Atsushi Teramoto, Eiichi Watanabe, Yoshihiro Sobue, Hideo Izawa, Kuniaki Saito, Hiroshi Fujita
Summary: In this study, a two-dimensional convolutional neural network (CNN) was used to predict the short-term prognosis of CCU patients by converting their ECG data into image data. The prediction accuracy was 77.3%. The results suggest that this method could be used to predict the short-term prognosis of CCU patients using ECG waveforms, which has clinical significance in determining treatment strategies and treatment intensity.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2023)
Meeting Abstract
Oncology
Kuniaki Saito, Yuta Sasaki, Saki Shimizu, Jun Nagai, Yuki Yamagishi, Nobuyoshi Sasaki, Keiichi Kobayashi, Yoshiaki Shiokawa, Hirofumi Nakatomi, Motoo Nagane
Article
Gastroenterology & Hepatology
Masamichi Kimura, Koji Nishikawa, Yosuke Osawa, Jun Imamura, Kenzaburo Yamaji, Kenichi Harada, Hiroshi Yatsuhashi, Kazumoto Murata, Kouichi Miura, Atsushi Tanaka, Tatsuya Kanto, Michinori Kohara, Terumi Kamisawa, Kiminori Kimura
Summary: The study found that the selective CBP/beta-catenin inhibitor PRI-724 can suppress cholestatic liver fibrosis by inhibiting bile acid synthesis and exerting anti-inflammatory effects in hepatocytes. The results also suggest that the Egr-1 gene plays an important role in bile acid synthesis and fibrosis, and the CBP/beta-catenin signaling pathway regulates Egr-1 expression.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Neurosciences
Ryosuke Jozuka, Hiroki Kimura, Takashi Uematsu, Hidetsugu Fujigaki, Yasuko Yamamoto, Masato Kobayashi, Kazuya Kawabata, Haruki Koike, Toshiya Inada, Kuniaki Saito, Masahisa Katsuno, Norio Ozaki
Summary: This case highlights the importance of recognizing that even apparently mild COVID-19-related respiratory symptoms can lead to severe and persistent neuropsychiatric symptoms. It also underscores the need to elucidate the mechanisms, treatment, and long-term course of COVID-19-related neuropsychiatric symptoms in the future.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2022)
