Article
Fisheries
Lan Hao Liu, P. Nie, Su Wang, Jun Zou, Yong-an Zhang, Shan Nan Chen
Summary: In this study, seven type I interferons and two type II interferons were identified in the snakehead Channa argus. These interferons share amino acid sequence similarities with those in other fish species, are located at conserved loci, and are induced by polyI:C in examined organs/tissues. Additionally, a new hypothesis about the evolution of type I interferons in teleost fish was proposed based on known evidence.
AQUACULTURE REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Xuanhui Wu, Yong Wang, Bingyi Chen, Yongbo Liu, Fang Li, Yangjing Ou, Haiwei Zhang, Xiaoxia Wu, Xiaoming Li, Lingxia Wang, Wuwei Rong, Jianling Liu, Mingyan Xing, Xiaoming Zhao, Han Liu, Lingling Ge, Ankang Lv, Lan Wang, Zhichao Wang, Ming Li, Haibing Zhang
Summary: ABIN1 (Q478) prevents the development of hematopoietic deficiencies by regulating type I interferon expression.
Article
Cell Biology
Laura L. Dickey, Laura J. Martins, Vicente Planelles, Timothy M. Hanley
Summary: Macrophages chronically infected with HIV-1 can enter a latent state resembling latency, characterized by decreased viral transcription and maintenance of a non-permissive state. This transition to viral latency is mediated by type I interferon signaling and requires the viral accessory protein Vpr. Understanding the mechanisms of HIV-1 latency in macrophages can lead to potential therapeutic targets for eliminating this important HIV-1 reservoir.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Immunology
Shohei Eto, Yoko Nukui, Miyuki Tsumura, Yu Nakagama, Kenichi Kashimada, Yoko Mizoguchi, Takanori Utsumi, Maki Taniguchi, Fumiaki Sakura, Kosuke Noma, Yusuke Yoshida, Shinichiro Ohshimo, Shintaro Nagashima, Keisuke Okamoto, Akifumi Endo, Kohsuke Imai, Hirokazu Kanegane, Hidenori Ohnishi, Shintaro Hirata, Eiji Sugiyama, Nobuaki Shime, Masanori Ito, Hiroki Ohge, Yasutoshi Kido, Paul Bastard, Jean-Laurent Casanova, Osamu Ohara, Junko Tanaka, Tomohiro Morio, Satoshi Okada
Summary: The study revealed that patients with pre-existing autoantibodies to type I interferons have a higher risk of life-threatening COVID-19 pneumonia in the Japanese population.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Pengfei Chen, Junrui Zhu, Jiarong Yu, Ruilin Liu, Mengqin Lao, Lingxue Yu, Fei Gao, Yifeng Jiang, Changlong Liu, Wu Tong, Huili Liu, Guangzhi Tong, Yanjun Zhou
Summary: This study found that PEDV infection activates the host innate immune response, leading to the production of abundant type I/III interferons and interferon-stimulated genes. In the late stage of infection, the JAK-STAT signaling pathway is activated and promotes interferon expression. Silencing of the RLRs and TLRs signaling pathways resulted in a significant decrease in type I/III interferons and interferon-stimulated genes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Shuai Wang, Shan Nan Chen, Zheng Sun, An Ning Pang, Su Wang, Lan Hao Liu, Yang Liu, P. Nie
Summary: This study identified four type I IFNs and four cytokine receptor family B members in Asian arowana, an ancient species with commercial and conservation values. The IFNs and their receptor genes are widely expressed in examined organs/tissues and induced following polyI:C stimulation, indicating evolutionary diversification in this ancient fish species. The interaction between type I IFNs and their receptors display diversity in Asian arowana.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Shan Nan Chen, Lin Huang, Jian Ping Fu, An Ning Pang, Kai Lun Wang, Pin Nie
Summary: In this study, seven type I interferon genes were identified from the Chinese soft-shelled turtle. These interferons play a critical role in the antiviral response of the turtle. The type I interferon genes in the turtle are located on two different loci, shedding light on the evolution of type I interferon genes in vertebrates.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Immunology
Qian Zhang, Andres Pizzorno, Lisa Miorin, Paul Bastard, Adrian Gervais, Tom Le Voyer, Lucy Bizien, Jeremy Manry, Jeremie Rosain, Quentin Philippot, Kelian Goavec, Blandine Padey, Anastasija Cupic, Emilie Laurent, Kahina Saker, Martti Vanker, Karita Saerekannu, Tamara Garcia-Salum, Marcela Ferres, Nicole Le Corre, Javier Sanchez-Cespedes, Maria Balsera-Manzanero, Jordi Carratala, Pilar Retamar-Gentil, Gabriela Abelenda-Alonso, Adoracion Valiente, Pierre Tiberghien, Marie Zins, Stephanie Debette, Isabelle Meyts, Filomeen Haerynck, Riccardo Castagnoli, Luigi D. Notarangelo, Luis I. Gonzalez-Granado, Nerea Dominguez-Pinilla, Evangelos Andreakos, Vasiliki Triantafyllia, Carlos Rodriguez-Gallego, Jordi Sole-Violan, Jose Juan Ruiz-Hernandez, Felipe Rodriguez de Castro, Jose Ferreres, Marisa Briones, Joost Wauters, Lore Vanderbeke, Simon Feys, Chen-Yen Kuo, Wei-Te Lei, Cheng-Lung Ku, Galit Tal, Amos Etzioni, Suhair Hanna, Thomas Fournet, Jean-Sebastien Casalegno, Gregory Queromes, Laurent Argaud, Etienne Javouhey, Manuel Rosa-Calatrava, Elisa Cordero, Teresa Aydillo, Rafael A. Medina, Kai Kisand, Anne Puel, Emmanuelle Jouanguy, Laurent Abel, Aurelie Cobat, Sophie Trouillet-Assant, Adolfo Garcia-Sastre, Jean-Laurent Casanova
Summary: In a study of 279 international patients with hypoxemic influenza pneumonia, 4.6% of patients were found to have autoantibodies neutralizing IFN-alpha and/or -omega, which may contribute to life-threatening COVID-19 pneumonia and severe adverse reactions to yellow fever vaccine. These antibodies increased influenza virus replication and were more prevalent in patients under 70 years old compared to the general population. Patients with high concentrations of both IFN-alpha 2 and IFN-omega antibodies had the highest risk of critical influenza.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Jesus Troya, Paul Bastard, Laura Planas-Serra, Pablo Ryan, Montse Ruiz, Maria de Carranza, Juan Torres, Amalia Martinez, Laurent Abel, Jean-Laurent Casanova, Aurora Pujol
Summary: In severe cases of COVID-19 pneumonia, approximately 10.6% of patients were found to have autoantibodies neutralizing type I IFN, which correlated with increased C-reactive protein levels and decreased lymphocyte counts, possibly increasing the risk of death. Subcutaneous IFN-beta treatment did not seem to improve clinical outcomes.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Christian Meisel, Bengisu Akbil, Tim Meyer, Erwin Lankes, Victor M. Corman, Olga Staudacher, Nadine Unterwalder, Uwe Kolsch, Christian Drosten, Marcus A. Mall, Tilmann Kallinich, Dirk Schnabel, Christine Goffinet, Horst von Bernuth
Summary: This study found that patients with APS-1 and preexisting neutralizing autoantibodies against IFN-alpha and IFN-omega developed only mild symptoms of COVID-19 after contracting SARS-CoV-2, without progressing to severe cases. These patients were mostly female and under the age of 26.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Jonathan Lopez, Marine Mommert, William Mouton, Andres Pizzorno, Karen Brengel-Pesce, Mehdi Mezidi, Marine Villard, Bruno Lina, Jean-Christophe Richard, Jean-Baptiste Fassier, Valerie Cheynet, Blandine Padey, Victoria Duliere, Thomas Julien, Stephane Paul, Paul Bastard, Alexandre Belot, Antonin Bal, Jean-Laurent Casanova, Manuel Rosa-Calatrava, Florence Morfin, Thierry Walzer, Sophie Trouillet-Assant
Summary: The nasal IFN-I/III signature in mildly symptomatic COVID-19 patients correlates with serum IFN-a(2) levels, while critically ill patients with autoantibodies against IFN-I showed low nasal IFN-I/III scores despite high viral loads. Functional assays confirmed the role of autoantibodies in compromising the antiviral effects of IFN-I at the early stages of SARS-CoV-2 infection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Biology
Enrico Palermo, Daniele Di Carlo, Marco Sgarbanti, John Hiscott
Summary: The innate antiviral immune response plays a crucial role in limiting virus replication, while viruses have evolved multiple evasion strategies. Understanding host-virus interactions is essential for comprehending SARS-CoV-2 pathogenesis.
Review
Medicine, Research & Experimental
Jean-Laurent Casanova, Mark S. Anderson
Summary: Since 2003, rare inborn errors of human type I IFN immunity have been discovered, each underlying severe viral illnesses. In 2006, autoantibodies neutralizing type I IFNs due to rare inborn errors of autoimmune regulator (AIRE)-driven T cell tolerance were discovered, but not initially linked to any viral disease. These two lines of clinical investigation converged in 2020, revealing that deficiencies of type I IFN immunity accounted for a significant percentage of critical COVID-19 cases in unvaccinated individuals.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biotechnology & Applied Microbiology
Jing Liao, Dan-Ni Zeng, Jin-Zhu Li, Qiao-Min Hua, Chun-Xia Huang, Jing Xu, Chong Wu, Limin Zheng, Wei-Ping Wen, Yan Wu
Summary: Reprogramming macrophages to express CD169 using a low dose of IFN enhances their phagocytic and CD8+ T cell-activating capacities, inhibits hepatoma growth, and can be further improved by blocking PD-L1 expression on macrophages.
Article
Virology
Lulu Han, Meng-Wei Zhuang, Jian Deng, Yi Zheng, Jing Zhang, Mei-Ling Nan, Xue-Jing Zhang, Chengjiang Gao, Pei-Hui Wang
Summary: The SARS-CoV-2 ORF9b protein inhibits the production of type I and type III interferons by targeting multiple molecules of innate antiviral signaling pathways, thus facilitating viral replication.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Fisheries
Bei Huang, Qin Qin Jia, Ying Liang, Wen Shu Huang, P. Nie
FISH & SHELLFISH IMMUNOLOGY
(2015)
Article
Fisheries
Peng Fei Zou, Ming Xian Chang, Ying Li, Shu Huan Zhang, Jian Ping Fu, Shan Nan Chen, Pin Nie
FISH & SHELLFISH IMMUNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Zhen Gan, Bei Wang, Wei Zhou, Yishan Lu, Yanfei Zhang, JiChang Jian, Zaohe Wu, Pin Nie
Article
Limnology
Luo Zhang, Liu Zhixin, Fu Jianping, Zhang Qiusheng, Huang Bei, Nie Pin
CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
(2016)
Article
Fisheries
Zhen Gan, Bei Wang, Jufen Tang, Yishan Lu, JiChang Jian, Zaohe Wu, Pin Nie
FISH & SHELLFISH IMMUNOLOGY
(2016)
Article
Fisheries
Zhen Gan, Shannan Chen, Jing Hou, Huijun Huo, Xiaolin Zhang, Baiye Ruan, Zubair Ahmed Laghari, Li Li, Yishan Lu, Pin Nie
FISH & SHELLFISH IMMUNOLOGY
(2016)
Article
Fisheries
Wen-Shu Huang, Li-Peng Duan, Bei Huang, Ke-Jian Wang, Cai-Liang Zhang, Qin-qin Jia, Pin Nie, Tiehui Wang
FISH & SHELLFISH IMMUNOLOGY
(2016)
Article
Fisheries
Lin Zhang, Wen Qin Chen, Yi Wei Hu, Xiao Man Wu, P. Nie, Ming Xian Chang
FISH & SHELLFISH IMMUNOLOGY
(2016)
Article
Immunology
Jia Yi, Shui Bing Xiao, Zhi Xiong Zeng, Jin Fang Lu, Lu Yi Liu, Zubair Ahmed Laghari, Pin Nie, Hong Bing Yu, Hai Xia Xie
INFECTION AND IMMUNITY
(2016)
Article
Microbiology
Ying Zhou, Lu Yi Liu, Tian Tian He, Zubair Ahmed Laghari, Pin Nie, Qian Gao, Hai Xia Xie
VETERINARY MICROBIOLOGY
(2016)
Review
Immunology
Shan Nan Chen, Peng Fei Zou, Pin Nie
Article
Immunology
Yulei Zhang, Lijuan Zhao, Wenjie Chen, Yunmao Huang, Ling Yang, V. Sarathbabu, Zaohe Wu, Jun Li, Pin Nie, Li Lin
MICROBIAL PATHOGENESIS
(2017)
Article
Fisheries
Zubair Ahmed Laghari, Li Li, Shan Nan Chen, Hui Jun Huo, Bei Huang, Ying Zhou, P. Nie
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2018)
Article
Fisheries
Gai Ling Wang, Ming Cheng Wang, Ying Li Liu, Qian Zhang, Chuan Feng Li, Pan Ting Liu, En Zhong Li, Pin Nie, Hai Xia Xie
FISH & SHELLFISH IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Qiaoqing Xu, Yousheng Jiang, Eakapol Wangkahart, Jun Zou, Mingxian Chang, Daiqin Yang, Chris J. Secombes, Pin Nie, Tiehui Wang