Article
Chemistry, Medicinal
Maryam Zangi, Katherine A. Donald, Andreu Gazquez Casals, Abaigeal D. Franson, Alice J. Yu, Elise M. Marker, Molly E. Woodson, Scott D. Campbell, M. Abdul Mottaleb, Tanguturi Venkata Narayana Hajay Kumar, Makala Shakar Reddy, Lingala Vijaya Raghava Reddy, Subir Kumar Sadhukhan, David W. Griggs, Lynda A. Morrison, Marvin J. Meyers
Summary: The derivative compounds of ciclopirox olamine effectively inhibit replication of HSV-2 with low cytotoxicity, indicating their strong therapeutic potential. Structural comparison confirms the importance of hydrophobic groups in the efficacy of ciclopirox and its derivatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Catielen Paula Pavi, Isabella Dai Pra, Rafael Dorighello Cadamuro, Isamu Kanzaki, Jhuly Wellen Ferreira Lacerda, Louis Pergaud Sandjo, Roberto Messias Bezerra, Jorge Federico Orellana Segovia, Gislaine Fongaro, Izabella Thais Silva
Summary: This study evaluated the activity of seventeen extracts derived from eight Amazonian medicinal plants against herpes simplex virus and chikungunya virus. Four extracts exhibited significant activity against both viruses, including the drug-resistant strains. Virucidal tests showed a higher level of virucidal activity compared to antiviral activity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Ji Xiao, Miaomiao Cai, Yifei Wang, Ping Ding
Summary: The iridoid compounds in traditional Chinese medicine have significant antiviral effects. This study identified seven new iridoid compounds from the aerial parts of Morinda officinalis, with officinaloside C showing significant anti-HSV-1 activity.
Article
Immunology
Marzena Lenart, Edyta Dzialo, Anna Kluczewska, Kazimierz Weglarczyk, Anna Szaflarska, Magdalena Rutkowska-Zapala, Marcin Surmiak, Marek Sanak, Anna Pituch-Noworolska, Maciej Siedlar
Summary: The study identified upregulated expression of four miRNAs in patients with severe and/or recurrent HSV infection, which, when inhibited, affected NK cell antiviral response. Furthermore, these miRNAs were found to regulate genes involved in antiviral response pathways and impact NK cell intracellular protein expression.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Divya Sharma, Supriya Sharma, Natasha Akojwar, Ayusha Dondulkar, Nikhil Yenorkar, Deepti Pandita, Satyendra K. K. Prasad, Mahaveer Dhobi
Summary: This review summarizes the history, life cycle, current treatment methods, and limitations of two herpes viruses. It also discusses vaccine strategies and nanotechnological approaches for oral and genital herpes infections. The article provides insight for researchers and the healthcare sector on challenges and upcoming solutions in the treatment and vaccine development against HSV infections.
Article
Plant Sciences
Guadalupe Cantero-Gonzalez, Nelson Alvarenga, Marcos M. Florentin-Pavia, Pamela Gonzalez-Maldonado, Pablo H. Sotelo
Summary: This study analyzed the chemical composition and antiviral activity of Acanthospermum australe and Acanthospermum hispidum, and found that they have inhibitory effects against herpes simplex virus 1 (HSV-1). Certain components of these plants can interfere with different steps of viral propagation, demonstrating good antiviral activity against HSV-1.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Letter
Medicine, General & Internal
Charles-Edouard Luyt, David Hajage, Sonia Burrel, Sami Hraiech, Mamadou Hassimiou Diallo, Laurent Papazian, David Boutolleau
Summary: This analysis investigated the efficacy of acyclovir in preventing oropharyngeal HSV reactivation among mechanically ventilated patients.
Article
Medicine, Research & Experimental
Mohsen Keshavarz, Forough Shamsizadeh, Ahmad Tavakoli, Neda Baghban, Arezoo Khoradmehr, Ali Kameli, Poorya Rasekh, Adel Daneshi, Iraj Nabipour, Katayoun Vahdat, Maryam Farrokhnia, Amin Tamadon
Summary: The ethanolic extract of Holothuria parva demonstrates significant antiviral activities against HSV-1 by reducing virus titers and interfering with virus attachment to cell receptors. Octadecanoic acid 2-hydroxy-1-(hydroxymethyl) ethyl ester and 2',6'-acetoxylidide are major constituents in the extract. Computational docking analysis suggests that the extract compounds may inhibit virus attachment by covering both virus and host cell binding domains.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Medicinal
Alexia Damour, Magali Garcia, Hye-Sun Cho, Andy Lariviere, Nicolas Leveque, Chankyu Park, Charles Bodet
Summary: Hg-CATH and Pb-CATH4, derived from Heterocephalus glaber and Python bivittatus, were found to exhibit potent antiviral activity against herpes simplex virus, making them potential candidates for new therapies targeting HSV-1.
Article
Virology
Michiel van Gent, Jessica J. Chiang, Santoshi Muppala, Cindy Chiang, Walid Azab, Lisa Kattenhorn, David M. Knipe, Nikolaus Osterrieder, Michaela U. Gack
Summary: Recent studies show that herpes simplex virus 1 (HSV-1) can evade the immune response by phosphorylating the cytosolic pathogen sensor RIG-I, keeping it in a signaling-repressed state.
JOURNAL OF VIROLOGY
(2022)
Article
Pharmacology & Pharmacy
Hiroki Kondo, Tetsuo Koshizuka, Ryuichi Majima, Keita Takahashi, Ken Ishioka, Tatsuo Suzutani, Naoki Inoue
Summary: The compound 147B3 has shown efficacy in inhibiting HCMV and HSV-1 infection, potentially by targeting viral transactivators through their interaction with factors required for the viral gene expression system.
ANTIVIRAL RESEARCH
(2021)
Article
Microbiology
Karoline Fontana Agostinho, Daniele Zendrini Rechenchoski, Ligia Carla Faccin-Galhardi, Andre Luiz Nascimento de Sousa, Arcelina Pacheco Cunha, Nagila Maria Pontes Silva Ricardo, Rosa Elisa Carvalho Linhares, Carlos Nozawa
Summary: This study evaluated the inhibitory effect of Cucumis melo sulfated pectin on herpes simplex virus-1 infection, showing a high selectivity anti-viral action against both sensitive and resistant strains. The results suggest that SPCm is a promising alternative compound to control HSV infection.
FEMS MICROBIOLOGY LETTERS
(2021)
Article
Integrative & Complementary Medicine
Ji Xiao, Ping Liu, Yuze Hu, Tao Liu, Yuying Guo, Pinghua Sun, Junxia Zheng, Zhe Ren, Yifei Wang
Summary: This study aimed to explore the anti-herpesvirus activity and mechanism of Fr.8.3 extracted from Artemisia vulgaris L. The results showed that Fr.8.3 had anti-HSV-1 activity by acting directly on the virus itself. LC-MS analysis identified the main components as 1 and 2, which may interfere with virus adhesion to cell receptors, providing new insights for drug development.
Article
Infectious Diseases
Kanyaluck Jantakee, Panchika Prangkio, Aussara Panya, Yingmanee Tragoolpua
Summary: HSV infections are common worldwide and can cause life-threatening diseases. Silk extracts from silkworm cocoons, particularly the non-sericin extract, show potential antiviral activity against HSV-1 and HSV-2, as well as virucidal effects. Treatment with non-sericin extract in HSV-2-infected cells can reduce cell death and inflammation.
Article
Nutrition & Dietetics
Boonpa Suantai, Kanyaluck Jantakee, Thida Kaewkod, Sirikwan Sangboonruang, Thararat Chitov, Yingmanee Tragoolpua
Summary: The ethanolic and aqueous extracts of red jasmine rice from Chiang Mai, Thailand were examined for their anthocyanins and phenolic contents. The ethanolic extract exhibited higher antioxidant and antiviral activity, as well as anticancer potential. These findings suggest that red jasmine rice extract demonstrates nutritional value and biological activity on HSV, free radicals, and cancer cell inhibition.