Article
Cell Biology
Kinga Gecse, Andrea Edes, Tamas Nagy, Adrienn Demeter, David Virag, Marton Kiraly, Borbala Dalmadi Kiss, Krisztina Ludanyi, Zsuzsanna Kornyei, Adam Denes, Gyorgy Bagdy, Gabriella Juhasz
Summary: Altered tryptophan metabolism may increase susceptibility to migraines by interfering with neural and brain hypersensitivity, as well as interacting with chemokines and cytokines that control vascular and inflammatory processes.
Article
Oncology
Miguel Cosenza-Contreras, Agnes Schafer, Justin Sing, Lena Cook, Maren N. Stillger, Chia-Yi Chen, Jose Villacorta Hidalgo, Niko Pinter, Larissa Meyer, Tilman Werner, Darleen Bug, Zeno Haberl, Oliver Kuebeck, Kai Zhao, Susanne Stei, Anca Violeta Gafencu, Radu Ionita, Felix M. Brehar, Jaime Ferrer-Lozano, Gloria Ribas, Leo Cerda-Alberich, Luis Marti-Bonmati, Christopher Nimsky, Alexis Van Straaten, Martin L. Biniossek, Melanie Foll, Nina Cabezas-Wallscheid, Jorg Buscher, Hannes Rost, Armelle Arnoux, Jorg W. Bartsch, Oliver Schilling
Summary: This study utilized proteomics and lipidomics to analyze patient-matched initial and recurrent glioblastoma specimens, revealing increased immune cell infiltration and extracellular matrix reorganization in recurrent glioblastoma. ASAH1 and SYNM were identified as potential plasma markers for the progression of recurrent glioblastoma.
Article
Respiratory System
Tae-Ok Kim, Ki-Jeong Park, Young-Nan Cho, Hye-Mi Jin, Young-Goun Jo, Hyo Shin Kim, Jae Kyun Ju, Hong-Joon Shin, Bo-Gun Kho, Seung-Jung Kee, Yong-Wook Park
Summary: The study demonstrates that circulating MAIT cells are numerically deficient in patients with ARDS. These MAIT cells are activated, migrate into the lung, secrete IL-17, and stimulate macrophages, contributing to the worsening of inflammation in the lung of patients with ARDS.
Article
Cell Biology
Vilcy Reyes Nicolas, Joannie M. Allaire, Alain B. Alfonso, Dianne Pupo Gomez, Veronique Pomerleau, Veronique Giroux, Francois Boudreau, Nathalie Perreault
Summary: FoxL1(+)-Telocytes, originating from subepithelial in mice, play a crucial role in the pathogenesis of colonic neoplasia. Lack of BMP signalling in TCFoxL1+ leads to impaired mucosal structure, increased susceptibility to colitis, and delayed wound healing. These findings suggest the key roles of BMP signalling in TCFoxL1+ in the pathogenesis of IBD.
Article
Cell Biology
Hansjorg Schwertz, Jesse W. Rowley, Irina Portier, Elizabeth A. Middleton, Neal D. Tolley, Robert A. Campbell, Alicia S. Eustes, Karin Chen, Matthew T. Rondina
Summary: Platelets play a central role in host responses during sepsis, and abnormalities in autophagic functions in platelets during sepsis are partly due to reduced EPG5-LC3 interactions, regulated by TLR4 engagement, leading to the accumulation of autophagosomes.
Article
Entomology
Martin M. Perez, Fabiana A. Rossi, German A. Sabio, Pablo A. Bochicchio, Maria C. Leal, Luis A. Quesada-Allue, Alejandro Rabossi
Summary: The study found that male Drosophila melanogaster tan(1) mutants had a longer lifespan in adulthood compared to wild type and ebony(1) mutants, which may be attributed to lower levels of free dopamine and higher antioxidant activities in their nervous system.
ENTOMOLOGIA EXPERIMENTALIS ET APPLICATA
(2021)
Article
Psychiatry
Hayley F. North, Christin Weissleder, Janice M. Fullerton, Rachel Sager, Maree J. Webster, Cynthia Shannon Weickert
Summary: Inflammation plays a role in regulating neurogenesis, with reduced expression of neurogenesis markers observed in the brains of patients with schizophrenia and bipolar disorder. The study found a significantly higher proportion of these patients in high inflammation subgroups, suggesting a potential link between inflammation and impaired neuronal differentiation in psychiatric disorders.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Hematology
Eli Sihn Samdal Steinskog, Kenneth Finne, Marianne Enger, Lars Helgeland, Per Ole Iversen, Emmet McCormack, Helge Wiig, Olav Tenstad
Summary: This study examined the response in the interstitial fluid phase of the spleen and liver during the development of acute myeloid leukemia (AML). The results showed increased STAT3 and CREB signaling in the spleen and depressed signaling in the liver in AML. Proteins related to these pathways were also differently expressed in lymph and plasma in AML compared with the control group.
Article
Biophysics
Dragana Savic, Vicky Ball, Lorenz Holzner, David Hauton, Kerstin N. Timm, M. Kate Curtis, Lisa C. Heather, Damian J. Tyler
Summary: The study investigated the effects of meldonium on cardiac metabolism in diabetic rats, revealing an increase in pyruvate dehydrogenase flux and improvement in cardiac recovery after ischemia.
NMR IN BIOMEDICINE
(2021)
Article
Neurosciences
Irene Matre Thowsen, Tine Karlsen, Elham Nikpey, Hanne Haslene-Hox, Trude Skogstrand, Gwendalyn J. Randolph, Bernd H. Zinselmeyer, Olav Tenstad, Helge Wiig
Summary: Recent studies have shown that the skin acts as a major reservoir for sodium ions by regulating the content of glycosaminoglycans and osmotic gradients. This study investigated the presence of electrolyte gradients in the skin and the storage of sodium ions from a fluid balance perspective. The results revealed a gradient of sodium ions from the epidermis to the dermis, with a higher concentration in the epidermis. This hydration-dependent concentration of sodium ions in the interstitial fluid contributes to the skin barrier and limits water loss. Additionally, intracellular storage of sodium ions in muscle and myocardium may have electromechanical consequences in salt stress.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Medicine, Research & Experimental
Aslaug Helland, Hege G. Russnes, Gro Live Fagereng, Khalid Al-Shibli, Yvonne Andersson, Thomas Berg, Line Bjorge, Egil Blix, Bodil Bjerkehagen, Sigmund Brabrand, Marte Gronlie Cameron, Astrid Dalhaug, Dalia Dietzel, Tom Donnem, Espen Enerly, Asmund Flobak, Sverre Fluge, Bjornar Gilje, Bjorn Tore Gjertsen, Bjorn Henning Gronberg, Kari Gronas, Tormod Guren, Hanne Hamre, Ase Haug, Daniel Heinrich, Geir Olav Hjortland, Eivind Hovig, Randi Hovland, Ann-Charlotte Iversen, Emiel Janssen, Jon Amund Kyte, Hedda von der Lippe Gythfeldt, Ragnhild Lothe, Jo-Asmund Lund, Leonardo Meza-Zepeda, Monica Cheng Munthe-Kaas, Olav Toai Duc Nguyen, Pitt Niehusmann, Hilde Katarina NilsenPuco, Anne Hansen Ree, Tonje Boyum Riste, Karin Semb, Eli Sihn Samdal Steinskog, Andreas Stensvold, Pal Suhrke, Oyvind Tennoe, Geir E. Tjonnfjord, Liv Jorunn Vassbotn, Eline Aas, Kristine Aasebo, Kjetil Tasken, Sigbjorn Smeland
Summary: Personalized cancer care based on tumour molecular characteristics has revolutionized treatment approaches and brought hope to many patients. The implementation of emerging technologies in molecular diagnostics, publicly funded in Norway, allows for comprehensive genomic profiling of tumours, offering more cancer patients the possibility of receiving precision cancer drugs through the national infrastructure called IMPRESS-Norway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Letter
Oncology
Giulia Pianigiani, Francesca Rocchio, Sara Peruzzi, Vibeke Andresen, Barbara Bigerna, Daniele Sorcini, Michela Capurro, Bjorn Tore Gjertsen, Paolo Sportoletti, Mauro Di Ianni, Maria Paola Martelli, Lorenzo Brunetti, Brunangelo Falini
Letter
Biochemistry & Molecular Biology
Kjetil Tasken, Hege E. G. Russnes, Eline Aas, Line Bjorge, Egil S. Blix, Espen Enerly, Gro L. Fagereng, Asmund Flobak, Bjornar Gilje, Bjorn T. Gjertsen, Tormod K. Guren, Jutta Heix, Eivind Hovig, Randi Hovland, Per E. Lonning, Leonardo A. Meza-Zepeda, Per M. Maehle, Hilde L. Nilsen, Steinar O. Thoresen, Ketil Widerberg, Sigbjorn Smeland, Aslaug Helland
Correction
Medicine, Research & Experimental
Aslaug Helland, Hege G. Russnes, Gro Live Fagereng, Khalid Al-Shibli, Yvonne Andersson, Thomas Berg, Line Bjorge, Egil Blix, Bodil Bjerkehagen, Sigmund Brabrand, Marte Gronlie Cameron, Astrid Dalhaug, Dalia Dietzel, Tom Donnem, Espen Enerly, Asmund Flobak, Sverre Fluge, Bjornar Gilje, Bjorn Tore Gjertsen, Bjorn Henning Gronberg, Kari Gronas, Tormod Guren, Hanne Hamre, Ase Haug, Daniel Heinrich, Geir Olav Hjortland, Eivind Hovig, Randi Hovland, Ann-Charlotte Iversen, Emiel Janssen, Jon Amund Kyte, Hedda von der Lippe Gythfeldt, Ragnhild Lothe, Jo-Asmund Lund, Leonardo Meza-Zepeda, Monica Cheng Munthe-Kaas, Olav Toai Duc Nguyen, Pitt Niehusmann, Hilde Nilsen, Katarina Puco, Anne Hansen Ree, Tonje Boyum Riste, Karin Semb, Eli Sihn Samdal Steinskog, Andreas Stensvold, Pal Suhrke, Oyvind Tennoe, Geir E. Tjonnfjord, Liv Jorunn Vassbotn, Eline Aas, Kristine Aasebo, Kjetil Tasken, Sigbjorn Smeland
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Irene Matre Thowsen, Tore Reikvam, Trude Skogstrand, Anne-Maj Samuelsson, Dominik N. Muller, Olav Tenstad, Kari Alitalo, Tine Karlsen, Helge Wiig
Summary: Our results suggest that dermal lymphatic vessels are not involved in salt storage or blood pressure regulation in these mouse models of salt-sensitive hypertension.
Article
Oncology
Jesse M. Tettero, Waleed K. W. Al-Badri, Lok Lam Ngai, Costa Bachas, Dimitri A. Breems, Catharina H. M. J. van Elssen, Thomas Fischer, Bjorn T. Gjertsen, Gwendolyn N. Y. van Gorkom, Patrycja Gradowska, Marjolein J. E. Greuter, Laimonas Griskevicius, Gunnar Juliusson, Johan Maertens, Markus G. Manz, Thomas Pabst, Jakob Passweg, Kimmo Porkka, Bob Loewenberg, Gert J. Ossenkoppele, Jeroen J. W. M. Janssen, Jacqueline Cloos
Summary: Measurable residual disease (MRD) measured using multiparameter flow-cytometry (MFC) has significant prognostic value in acute myeloid leukemia (AML). The MRD results after cycle 1 are highly concordant with MRD status after cycle 2. Using MRD-MFC to guide consolidation treatment can safely reduce the number of allogeneic donor searches and decrease costs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Hematology
Eli Sihn Samdal Steinskog, Kenneth Finne, Marianne Enger, Lars Helgeland, Per Ole Iversen, Emmet McCormack, Helge Wiig, Olav Tenstad
Summary: This study examined the response in the interstitial fluid phase of the spleen and liver during the development of acute myeloid leukemia (AML). The results showed increased STAT3 and CREB signaling in the spleen and depressed signaling in the liver in AML. Proteins related to these pathways were also differently expressed in lymph and plasma in AML compared with the control group.
Article
Multidisciplinary Sciences
Benedicte Sjo Tislevoll, Monica Hellesoy, Oda Helen Eck Fagerholt, Stein-Erik Gullaksen, Aashish Srivastava, Even Birkeland, Dimitrios Kleftogiannis, Pilar Ayuda-Duran, Laure Piechaczyk, Dagim Shiferaw Tadele, Jorn Skavland, Baliakas Panagiotis, Randi Hovland, Vibeke Andresen, Ole Morten Seternes, Tor Henrik Anderson Tvedt, Nima Aghaeepour, Sonia Gavasso, Kimmo Porkka, Inge Jonassen, Yngvar Floisand, Jorrit Enserink, Nello Blaser, Bjorn Tore Gjertsen
Summary: In this study, the initial signaling response to standard induction chemotherapy in 32 acute myeloid leukemia (AML) patients was investigated using 36-dimensional mass cytometry. The reduction of extracellular-signal-regulated kinase (ERK) 1/2 and p38 mitogen-activated protein kinase (MAPK) phosphorylation in the myeloid cell compartment 24 h post-chemotherapy was found to be a significant predictor of patient 5-year overall survival in this cohort. This study demonstrates the value of mass cytometry in early response evaluation in AML and highlights the potential of functional signaling analyses in precision oncology diagnostics.
NATURE COMMUNICATIONS
(2023)
Article
Hematology
Peter Hokland, Isolda I. Fernandez, Sylvie D. Freeman, Bjorn T. Gjertsen, Jie Jin, Vidh Murthy, Masamitsu Yanada, Arnold Ganser
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Editorial Material
Hematology
Bjorn Tore Gjertsen
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Yngvar Floisand, Mats Remberger, Iris Bigalke, Dag Josefsen, Helen Valerhaugen, Else Marit Inderberg, Richard W. Olaussen, Bjorn Tore Gjertsen, Rene Goedkoop, Christiane Geiger, Petra U. Prinz, Frauke M. Schnorfeil, Kai Pinkernell, Dolores J. Schendel, Gunnar Kvalheim
Summary: For relapsing AML patients not suitable for allo-HSCT, oral azacytidine can be used as maintenance treatment in first remission, but it has substantial side effects and less toxic alternatives should be explored. In this study, autologous RNA-loaded mature dendritic cell vaccine FDC101 was used as maintenance therapy in CR1 AML patients, and the results showed good tolerability and high long-term survival.
Article
Oncology
Brunangelo Falini, Bjorn T. Gjertsen, Vibeke Andresen
Meeting Abstract
Oncology
K. Tasken, H. G. Russnes, E. Aas, L. Bjorge, E. S. Blix, E. Enerly, L. Fagereng, A. Flobak, B. Gilje, B. T. Gjertsen, T. K. K. Guren, J. Heix, E. Hovig, R. Hovland, P. E. Lonning, P. M. Maehle, H. L. Nilsen, S. Thoresen, S. Smeland, A. Helland
ANNALS OF ONCOLOGY
(2022)
Meeting Abstract
Oncology
A. Helland, K. Tasken, H. E. G. Russnes, L. Fagereng, E. S. Blix, S. Brabrand, T. Donnem, A. Flobak, B. T. Gjertsen, A. Haug, R. Hovland, G. Inpred, P. E. Lonning, P. Niehusmann, K. Puco, E. S. Samdal, S. Smeland
ANNALS OF ONCOLOGY
(2022)