Article
Immunology
Weiwei Zhu, Huifang Zhang, Qiming Dong, Hongyong Song, Lin Zhao
Summary: This study reveals the dual wave of neutrophil recruitment during C. albicans infection, emphasizing the importance of early fungal clearance for favorable disease outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Xiaoxi Sun, Bing Huang, Yuping Pan, Jinhua Fang, Hefeng Wang, Yanru Ji, Yingchen Ling, Pei Guo, Jiangguo Lin, Quhuan Li, Ying Fang, Jianhua Wu
Summary: Activation of integrins is crucial for recruitment of flowing leukocytes to inflammatory or injured vascular sites. We found that integrin activation occurs via different signaling pathways and at different timescales. Under static conditions, activation is mediated by mitogen-activated protein kinase (MAPK) or non-MAPK signaling, and is force-dependent. Under flow conditions, activation requires intracellular Ca2+ release and occurs within minutes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Danying Liao, Jesse Sundlov, Jieqing Zhu, Heng Mei, Yu Hu, Debra K. Newman, Peter J. Newman
Summary: This study investigated the impact of amino acid substitutions at interfaces between PECAM-1 molecules on homophilic binding and endothelial cell function. It was found that substitutions at key residues within the IgD1-IgD1 and IgD1-IgD2 interfaces disrupted PECAM-1 homophilic binding and downstream effector functions.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ana Bocanegra, Gonzalo Fernandez-Hinojal, Daniel Ajona, Ester Blanco, Miren Zuazo, Maider Garnica, Luisa Chocarro, Elvira Alfaro-Arnedo, Sergio Pineiro-Hermida, Pilar Morente, Leticia Fernandez, Ana Remirez, Miriam Echaide, Maite Martinez-Aguillo, Idoia Morilla, Beatriz Tavira, Alejandra Roncero, Carolina Gotera, Alfonso Ventura, Nerea Recalde, Jose G. Pichel, Juan Jose Lasarte, Luis Montuenga, Ruth Vera, Ruben Pio, David Escors, Grazyna Kochan
Summary: Recent studies show that baseline functional immunity is crucial for the success of immune checkpoint blockade therapies. In this study, high-dimensional systemic immune profiling was performed on non-small-cell lung cancer patients undergoing PD-L1/PD-1 blockade immunotherapy. Responders had a higher diversity of myeloid phenotypes in their peripheral blood. A diversity index was defined as a potential biomarker of response. Fractalkine (FKN), a chemokine linked to immune chemotaxis and adhesion, was identified as a biomarker of response and correlated with myeloid cell diversity. FKN inhibited lung adenocarcinoma growth in both human and mouse models through the involvement of systemic effector NK cells and increased tumor immune infiltration. FKN also sensitized mouse lung cancer models resistant to anti-PD-1 treatment to immunotherapy, indicating its potential therapeutic use in combination with immunotherapy.
Article
Immunology
Viktoria Szeifert, Ferenc Kolonics, Balazs Bartos, Delaram Khamari, Pal Vagi, Laszlo Barna, Erzsebet Ligeti, Akos M. Lorincz
Summary: The study demonstrates that specific stimulation of Mac-1 integrin can initiate the release of anti-bacterial and pro-inflammatory extracellular vesicles (EVs), but only when neutrophils are activated on ligand coated surfaces. This process involves clustering of Mac-1 molecules and a strong calcium signal, showing that Mac-1 stimulation and clustering are necessary and sufficient for aEV biogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ruben J. Geerdink, Maria Ines Pascoal Ramos, Luuk L. van den Hoogen, Timothy R. D. J. Radstake, Shiro Shibayama, Akira Shibuya, Louis Bont, Linde Meyaard
Summary: Neutrophils play a crucial role in antimicrobial defense, but excessive inflammation can lead to immune pathology. This study aims to investigate the regulatory role of the inhibitory receptor Allergin-1 on neutrophils.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Neurosciences
Saurav Bhowmick, Anitha Malat, Danielle Caruso, Nizmi Ponery, Veera D'Mello, Christina Finn, P. M. Abdul-Muneer
Summary: ICAM-1 plays a significant role in traumatic brain injury, mediating neuroinflammation and cell death. Deletion or blocking of ICAM-1 helps attenuate neuroinflammation and improve functional outcomes.
Article
Microbiology
Julia Lienard, Kristina Munke, Line Wulff, Clement Da Silva, Julien Vandamme, Katie Laschanzky, Thorsten Joeris, William Agace, Fredric Carlsson
Summary: The ESX-1 type VII secretion system is essential for the virulence of pathogenic mycobacteria. It interacts with infected macrophages but its role in regulating other host cells and immunopathology is not well understood.
Article
Surgery
Refukaiti Abuduhalike, Aihaidan Abudouwayiti, Sun Juan, Ailiman MaheMuti
Summary: Inflammation plays a crucial role in VTE, and the NLRP3/IL-1/NF-kB signaling pathway and cytokines regulated by macrophage polarization may be important indicators of a prethrombotic state. However, the mechanisms by which they affect VTE occurrence remain unclear.
ANNALS OF VASCULAR SURGERY
(2023)
Article
Multidisciplinary Sciences
Elena Boero, Ronald D. Gorham, Emmet A. Francis, Jonathan Brand, Lay Heng Teng, Dennis J. Doorduijn, Maartje Ruyken, Remy M. Muts, Christian Lehmann, Admar Verschoor, Kok P. M. van Kessel, Volkmar Heinrich, Suzan H. M. Rooijakkers
Summary: The complement system plays a crucial role in immune protection by facilitating phagocytosis of infectious agents. This study investigates the function of complement protein C3b in phagocytosis using purified C3b-coated bacterial cells and beads. The results show that C3b can effectively trigger phagocytosis and killing of bacterial cells by neutrophils. Moreover, the study reveals the requirement for multiple stimulations for efficient uptake of C3b-coated targets.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Morten Nilsen, Unni Cecilie Nygaard, Petter Brodin, Karin Cecilie Lodrup Carlsen, Cecilie Fredheim, Guttorm Haugen, Gunilla Hedlin, Christine Monceyron Jonassen, Unni Lise Albertsdottir Jonsmoen, Tadepally Lakshmikanth, Bjoern Nordlund, Axel Olin, Eva Maria Rehbinder, Havard O. Skjerven, Lars Snipen, Anne Cathrine Staff, Cilla Soederhaell, Riyas Vettukattil, Knut Rudi
Summary: Age-related changes in gut bacteria during infancy may influence immune cell composition. Specific gut bacteria species are associated with different immune cell types, particularly at 6 months of age. These findings suggest a potential role of the gut microbiota in shaping later immune cell composition.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Surgery
Refukaiti Abuduhalike, Aihaidan Abudouwayiti, Sun Juan, Ailiman MaheMuti
Summary: This study found that inflammation plays an important role in venous thromboembolism (VTE). The NLRP3/IL-1/NF-kB signaling pathway and cytokines regulated by macrophage polarization may be key indicators of a prethrombotic state. However, the mechanisms by which they affect VTE occurrence remain unclear.
ANNALS OF VASCULAR SURGERY
(2023)
Article
Biophysics
Sasa Svetina, Gasper Kokot, Tjasa Svelc Kebe, Bostjan Zeks, Richard E. Waugh
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
G. Hwang, G. Marsh, L. Gao, R. Waugh, H. Koo
JOURNAL OF DENTAL RESEARCH
(2015)
Article
Microscopy
Graham Marsh, Richard E. Waugh
JOURNAL OF MICROSCOPY
(2016)
Article
Chemistry, Multidisciplinary
Andrew D. Hughes, Graham Marsh, Richard E. Waugh, David G. Foster, Michael R. King
Article
Multidisciplinary Sciences
Eyup Cinar, Sitong Zhou, James DeCourcey, Yixuan Wang, Richard E. Waugh, Jiandi Wan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Cell & Tissue Engineering
Ah Ram Kim, Jayme L. Olsen, Samantha J. England, Yu-Shan Huang, Katherine H. Fegan, Luis F. Delgadillo, Kathleen E. McGrath, Paul D. Kingsley, Richard E. Waugh, James Palis
Article
Engineering, Biomedical
Kanika Vats, Graham Marsh, Kristen Harding, Ioannis Zampetakis, Richard E. Waugh, Danielle S. W. Benoit
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2017)
Article
Engineering, Biomedical
Tejas S. Khire, Barrett J. Nehilla, Jirachai Getpreecharsawas, Maria E. Gracheva, Richard E. Waugh, James L. McGrath
BIOMEDICAL MICRODEVICES
(2018)
Editorial Material
Biophysics
Richard E. Waugh
BIOPHYSICAL JOURNAL
(2014)
Article
Biochemical Research Methods
Henry H. Chung, Charles K. Chan, Tejas S. Khire, Graham A. Marsh, Alfred Clark, Richard E. Waugh, James L. McGrath
Article
Multidisciplinary Sciences
Mariano Sanchez-Lockhart, Ana V. Rojas, Margaret M. Fettis, Richard Bauserman, Trissha R. Higa, Hongyu Miao, Richard E. Waugh, Jim Miller
Article
Multidisciplinary Sciences
Yu-Shan Huang, Luis F. Delgadillo, Kathryn H. Cyr, Paul D. Kingsley, Xiuli An, Kathleen E. McGrath, Narla Mohandas, John G. Conboy, Richard E. Waugh, Jiandi Wan, James Palis
SCIENTIFIC REPORTS
(2017)
Article
Chemistry, Multidisciplinary
Alec T. Salminen, Jingkai Zhang, Gregory R. Madejski, Tejas S. Khire, Richard E. Waugh, James L. McGrath, Thomas R. Gaborski
Article
Cell Biology
Luis. F. Delgadillo, Elena. B. Lomakina, Julia Kuebel, Richard E. Waugh
Summary: The study explores the impact of damaging the endothelial glycocalyx layer (EGL) on leukocyte adhesion and barrier dysfunction. Results show that removing both hyaluronic acid (HA) and heparan sulfate (HS) from the EGL structure leads to increased leukocyte adhesion and decreased endothelial barrier properties. Additionally, disruption of the EGL may predispose endothelial cells to increased fluid leakage.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Engineering, Biomedical
Michael T. Beste, Elena B. Lomakina, Daniel A. Hammer, Richard E. Waugh
ANNALS OF BIOMEDICAL ENGINEERING
(2015)