期刊
JOURNAL OF IMMUNOLOGY
卷 186, 期 3, 页码 1442-1449出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1003023
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资金
- National Institute of Child Health and Human Development, National Institutes of Health [RO1HD050484, K02AI53103]
- French Ministry of Education and Research
- Fondation pour la Recherche Medicale and Ligue contre le Cancer
- North Atlantic Treaty Organization Science Program
The mechanisms underlying tolerance to noninherited maternal Ags (NIMA) are not fully understood. In this study, we designed a double-transgenic model in which all the offspring's CD8(+) T cells corresponded to a single clone recognizing the K-b MHC class I protein. In contrast, the mother and the father of the offspring differed by the expression of a single Ag, K-b, that served as NIMA. We investigated the influence of NIMA exposure on the offspring thymic T cell selection during ontogeny and on its peripheral T cell response during adulthood. We observed that anti-K-b thymocytes were exposed to NIMA and became activated during fetal life but were not deleted. Strikingly, adult mice exposed to NIMA accepted permanently Kb+ heart allografts despite the presence of normal levels of anti-K-b TCR transgenic T cells. Transplant tolerance was associated with a lack of a proinflammatory alloreactive T cell response and an activation/expansion of T cells producing IL-4 and IL-10. In addition, we observed that tolerance to NIMA K-b was abrogated via depletion of CD4(+) but not CD8(+) T cells and could be transferred to naive nonexposed mice via adoptive transfer of CD4(+)CD25(high) T cell expressing Foxp3 isolated from NIMA mice. The Journal of Immunology, 2011, 186: 1442-1449.
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