Article
Immunology
Gesine Behrens, Stephanie L. Edelmann, Timsse Raj, Nina Kronbeck, Thomas Monecke, Elena Davydova, Elaine H. Wong, Lisa Kifinger, Florian Giesert, Martin E. Kirmaier, Christine Hohn, Laura S. de Jonge, Mariano Gonzalez Pisfil, Mingui Fu, Sebastian Theurich, Stefan Feske, Naoto Kawakami, Wolfgang Wurst, Dierk Niessing, Vigo Heissmeyer
Summary: The proteins Roquin-1 and Regnase-1 play crucial roles in maintaining immune homeostasis, with mutations leading to systemic lupus erythematosus-like phenotypes and autoimmunity. Additionally, these mutations affect T cell activation, metabolic reprogramming, and autoimmunity processes.
Article
Immunology
Gemma Arderiu, Esther Pena, Anna Civit-Urgell, Lina Badimon
Summary: Hypoxic endothelial cells release extracellular microvesicles that induce monocyte homing and angiogenesis. The microvesicles contain noncoding RNAs, including miR-126, which can modulate cellular signaling pathways. Activated endothelial cells secrete microvesicles carrying miR-126, which regulate monocyte reprogramming of angiogenic genes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Miguel Reyes, Michael R. Filbin, Roby P. Bhattacharyya, Abraham Sonny, Arnav Mehta, Kianna Billman, Kyle R. Kays, Mayra Pinilla-Vera, Maura E. Benson, Lisa A. Cosimi, Deborah T. Hung, Bruce D. Levy, Alexandra-Chloe Villani, Moshe Sade-Feldman, Rebecca M. Baron, Marcia B. Goldberg, Paul C. Blainey, Nir Hacohen
Summary: The study found an expanded CD14(+) monocyte state, MS1, in patients with bacterial sepsis and severe COVID-19, with the gene expression program of MS1 correlating with sepsis severity and being up-regulated in monocytes from severe COVID-19 patients. In vitro induction of MS1 cells from healthy bone marrow HSPCs showed that plasma from sepsis or COVID-19 patients could induce myelopoiesis and expression of the MS1 gene program. The study also demonstrated that systemic cytokines such as IL-6 and IL-10 played a role in inducing myelopoiesis during severe bacterial or SARS-CoV-2 infection.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sheng-yuan Zhang, Qiu-ping Xu, Li-na Shi, Shih-wen Li, Wei-hong Wang, Qing-qing Wang, Liao-xun Lu, Hui Xiao, Jun-hong Wang, Feng-ying Li, Yin-ming Liang, Si-tang Gong, Hao-ran Peng, Zheng Zhang, Hong Tang
Summary: T lymphopenia, commonly seen in the early phase of sepsis, is associated with increased morbidity and mortality. We have discovered that CD4(+) T cells interact with macrophages through MHC II to inhibit TLR pro-inflammatory signaling, thereby regulating excessive inflammation. This finding may contribute to the development of preventive treatments for sepsis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Oncology
Jessica K. Mandula, Shiun Chang, Eslam Mohamed, Rachel Jimenez, Rosa A. Sierra-Mondragon, Darwin C. Chang, Alyssa N. Obermayer, Carlos M. Moran-Segura, Satyajit Das, Julio A. Vazquez-Martinez, Karol Prieto, Ann Chen, Keiran S. M. Smalley, Brian Czerniecki, Peter Forsyth, Richard C. Koya, Brian Ruffell, Juan R. Cubillos- Ruiz, David H. Munn, Timothy I. Shaw, Jose R. Conejo-Garcia, Paulo C. Rodriguez
Summary: The deletion or inhibition of PERK in cancer cells triggers activation of anti-tumor T cell immunity, attenuates tumor growth, and promotes immunogenic cell death. This mechanism provides a potential new target for cancer immunotherapy.
Article
Medicine, Research & Experimental
Adele Mucci, Gabriele Antonarelli, Carolina Caserta, Francesco Maria Vittoria, Giacomo Desantis, Riccardo Pagani, Beatrice Greco, Monica Casucci, Giulia Escobar, Laura Passerini, Nico Lachmann, Francesca Sanvito, Matteo Barcella, Ivan Merelli, Luigi Naldini, Bernhard Gentner
Summary: Understanding the immunosuppressive microenvironment around tumor cells and reprogramming the immune system through gene transfer have shown promising results in inhibiting tumor progression and enhancing T cell recruitment and activation. The activity of interferon-gamma can be further enhanced by co-delivery of other immune factors or drugs blocking immunosuppressive escape pathways, showing potential for obtaining durable responses.
EMBO MOLECULAR MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Philipp Ralfs, Brantley Holland, Eduardo Salinas, Bill Bremer, Minghang Wang, Jingting Zhu, Charuta Ambardekar, Heather Blasczyk, Christopher M. Walker, Zongdi Feng, Arash Grakoui
Summary: This study investigates the role of ORF2s in HEV replication and antibody generation. The findings suggest that ORF2s may not be essential for viral replication in vivo but is required for the formation of long-lived antibody responses and protection against HEV re-exposure.
Article
Genetics & Heredity
Gilson P. Dorneles, Paula C. Teixeira, Alessandra Peres, Luiz Carlos Rodrigues Junior, Simone Goncalves da Fonseca, Marta Chagas Monteiro, Sarah Eller, Tiago F. Oliveira, Eliana M. Wendland, Pedro R. T. Romao
Summary: Higher levels of endotoxin and systemic inflammatory markers were found in severe COVID-19 patients compared to healthy controls and mild COVID-19 patients. Severe COVID-19 patients also exhibited higher levels of inflammatory cytokines and altered monocyte populations. The response to endotoxin stimulation differed between severe COVID-19 patients and controls, with lower cytokine production but higher levels of PGE-2.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Multidisciplinary Sciences
Carlos E. Rivera, Yulai Zhou, Daniel P. Chupp, Hui Yan, Amanda D. Fisher, Raphael Simon, Hong Zan, Zhenming Xu, Paolo Casali
Summary: Maturation of antibody responses involves B cell Toll-like receptor (TLR) coengagement with B cell receptor (BCR), leading to various processes including somatic hypermutation (SHM), class-switch DNA recombination (CSR), plasma cell differentiation, and memory B cell generation. TLR-BCR coengagement requires linkage of TLR and BCR ligands, and it can induce mature antibody responses and protective antibodies against microbial pathogens, such as Escherichia coli and Salmonella Typhi-murium, without T cell help.
Article
Multidisciplinary Sciences
Dianicha Santana Nunez, Asrar B. Malik, Quinn Lee, Sang Joon Ahn, Arnold Coctecon-Murillo, Dana Lazarko, Irena Levitan, Dolly Mehta, Yulia A. Komarova
Summary: Endothelial cells sense shear stress through Piezo1 and activate ER Ca2+ entry and release via IP3R2. The involvement of sAC and IP3R2 in this process is crucial.
Article
Biochemistry & Molecular Biology
Mayuko Noguromi, Yu Yamaguchi, Keiko Sato, Shun Oyakawa, Kuniaki Okamoto, Hiroshi Murata, Takayuki Tsukuba, Tomoko Kadowaki
Summary: Rab44 is an atypical Rab GTPase with EF-hand and coiled-coil domains at the N-terminus and a Rab-GTPase domain at the C-terminus. It is highly expressed in immune-related cells and speculated to be involved in inflammation and immune cell differentiation. However, its role in inflammation is poorly understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Adriana Dominguez-Flores, Gloria M. Rodriguez Lopez, Rodolfo Soria-Castro, Ruben Lopez-Santiago, Octavio Rodriguez-Cortes, Sonia M. Perez-Tapia, Alma D. Chavez-Blanco, Sergio Estrada-Parra, Raul Flores-Mejia, Rommel Chacon-Salinas
Summary: Brucella abortus, a Gram-negative bacteria, is a major cause of brucellosis in animals and humans. This study analyzed the role of innate immune receptors TLR2 and TLR4 in mast cell activation during B. abortus infection. The results showed that B. abortus induced the synthesis of several cytokines and activated key cell signaling molecules in mast cells. Blockade of TLR2 and TLR4 receptors decreased the release of TNF-alpha and IL-6 by mast cells in response to B. abortus. Overall, mast cells are activated by B. abortus and may contribute to the inflammatory response during the initial phase of the infection.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Mark M. Painter, Timothy S. Johnston, Kendall A. Lundgreen, Jefferson J. S. Santos, Juliana S. Qin, Rishi R. Goel, Sokratis A. Apostolidis, Divij Mathew, Bria Fulmer, Justine C. Williams, Michelle L. Mckeague, Ajinkya Pattekar, Ahmad Goode, Sean Nasta, Amy E. Baxter, Josephine R. Giles, Ashwin N. Skelly, Laura E. Felley, Maura Mclaughlin, Joellen Weaver, Oliva Kuthuru, Jeanette Dougherty, Sharon Adamski, Sherea Long, Macy Kee, Cynthia Clendenin, Ricardo da Silva Antunes, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Alexander C. Huang, Daniel J. Rader, Scott E. Hensley, Paul Bates, Allison R. Greenplate, E. John Wherry
Summary: This study examined immune responses in vaccinated individuals infected with SARS-CoV-2 during the Omicron wave. The results showed enhanced spike-specific responses, rapid activation of memory T cells, and broader immune responses in previously vaccinated individuals.
Review
Immunology
Yao Yao, Xiaoyu Cai, Fujia Ren, Yiqing Ye, Fengmei Wang, Caihong Zheng, Ying Qian, Meng Zhang
Summary: Osteoimmunity plays a crucial role in regulating the balance of bone remodeling and resorption, particularly through the macrophage-osteoclast axis. Understanding the role of this axis in osteoimmunity is significant for treating bone damage caused by inflammation and immune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ashima Bhaskar, Isha Pahuja, Kriti Negi, Akanksha Verma, Antara Ghoshal, Babu Mathew, Gaurav Tripathi, Jaswinder Singh Maras, Shivam Chaturvedi, Ved Prakash Dwivedi
Summary: Inhibition of host sirtuin 2 (SIRT2) by AGK2 enhances the efficacy of BCG vaccine against pulmonary tuberculosis (TB) by promoting stem cell memory responses. AGK2 treatment enriches IFNg-producing TSCM cells and activates β-catenin and glycolysis. SIRT2 specifically targets histone H3 and NF-kB p65 to induce proinflammatory responses. This study establishes a direct link between BCG vaccination, epigenetics, and memory immune responses and highlights the potential of SIRT2 inhibitors as immunoprophylaxis against TB.
Review
Biochemistry & Molecular Biology
Pil Soo Sung, Eui-Cheol Shin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, General & Internal
Minyoung Lee, Ho Seon Park, Min Yeong Choi, Hak Zoo Kim, Sung Jin Moon, Ji Yoon Ha, Arim Choi, Young Woo Park, Jong Suk Park, Eui-Cheol Shin, Chul Woo Ahn, Shinae Kang
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Min-Gi Shin, Jae-Woong Lee, Jun-Seok Han, Bora Lee, Jin-Hyuck Jeong, So-Hyun Park, Jong-Hwan Kim, Sumi Jang, Mooncheol Park, Seon-Young Kim, Seokho Kim, Yong Ryoul Yang, Jeong-Yoon Kim, Kwang-Lae Hoe, Chankyu Park, Kwang-Pyo Lee, Ki-Sun Kwon, Eun-Soo Kwon
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Eun Jung Park, Hae Dong Kim, Eun Kyoung Choi, Kwang-Lae Hoe, Dong-Uk Kim
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Pharmacology & Pharmacy
Jae Nam Yun, Ji-Sun Yeun, Hye-Su Kan, Minyu Lee, Namsick Kim, Tae-Young Oh, Seung-Kwan Nam, Yoon Seok Choi, In Sun Kwon, Kwang Lae Hoe, Jang Hee Hong
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2020)
Article
Biochemistry & Molecular Biology
Sol Lee, Miyoung Nam, Ah-Reum Lee, Jaewoong Lee, Jihye Woo, Nam Sook Kang, Anand Balupuri, Minho Lee, Seon-Young Kim, Hyunju Ro, Youn-Woong Choi, Dong-Uk Kim, Kwang-Lae Hoe
Summary: In this study, a gene deletion library of fission yeasts was used to screen target genes of the antifungal terbinafine, identifying several genes related to ergosterol synthesis. The ribosomal protein genes were found to participate in repressor complexes that regulate erg1 transcription. Additionally, the essential gene tif302 was shown to play a key role in susceptibility to terbinafine.
BIOMOLECULES & THERAPEUTICS
(2021)
Review
Medicine, General & Internal
Pil Soo Sung, Eui-Cheol Shin
Summary: The use of DAAs in treating chronic HCV infection can lead to rapid changes in the phenotypes of NK and MAIT cells, potentially reducing their cytotoxicity against cancer cells. Additionally, DAAs treatment does not normalize the increased frequencies of regulatory T cells, which may contribute to local immunosuppression and hinder cancer cell clearance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Eun Ae Kang, Hye-In Choi, Seung Wook Hong, Seokwoo Kang, Hyeon-Young Jegal, Eun Wook Choi, Byung-Soon Park, Joo Sung Kim
Article
Multidisciplinary Sciences
Anh Thu Nguyen Hoang, Kwang-Lae Hoe, Sook-Jeong Lee
Summary: CSNK1G2 plays a key role in sensitizing TAM toxicity in ER+ and ER- breast cancer cells by differently regulating PI3K/AKT/mTOR/S6K and ERK signaling pathways.
Article
Pharmacology & Pharmacy
Jae Nam Yun, Hye-Su Kan, Ji-Sun Yeun, Jae-Hoon Kim, Minyu Lee, Namsick Kim, Tae-Young Oh, Seung-Kwan Nam, Yoon Seok Choi, In Sun Kwon, Kwang Lae Hoe, Jang Hee Hong
Summary: This study demonstrated the bioequivalence between a fixed-dose combination formulation of bazedoxifene and cholecalciferol and the coadministered individual formulations through comparing the pharmacokinetic profiles and tolerability in healthy subjects.
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
(2021)
Letter
Dermatology
Byung-Soon Park, Hye-In Choi, Gyoo Huh, Won-Serk Kim
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hae Dong Kim, Eun Jung Park, Eun Kyoung Choi, Seuk Young Song, Kwang-Lae Hoe, Dong-Uk Kim
Summary: G-749, a potential TAM receptor tyrosine kinase inhibitor, effectively inhibits tumorigenesis by degrading TYRO3 and inhibiting cell proliferation signaling pathway in colon cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Virology
Yang Chan Park, Kwang-Kyu Kim, Hyun Jeong Jun, Eun-Ha Kang, Su-Rim Lee, Jun Ki Ahn, Han Kyu Seo, Su-Heon Lee, Kwang-Lae Hoe
Summary: We identified a novel virus, named cnidium polerovirus 1 (CnPV1), that infects Cnidium officinale. The complete genome sequence of CnPV1 is 6,090 nucleotides long and shows similarity to other poleroviruses. Phylogenetic analysis suggests that CnPV1 belongs to a new species within the genus Polerovirus.
ARCHIVES OF VIROLOGY
(2023)
Article
Virology
Yang Chan Park, Kwang-Kyu Kim, Hyun Jeong Jun, Eun-Ha Kang, Su-Rim Lee, Jun Ki Ahn, Han Kyu Seo, Su-Heon Lee, Kwang-Lae Hoe
Summary: A new cytorhabdovirus named cnidium virus 2 (CnV2) was identified in Cnidium officinale through high-throughput sequencing. The genome sequence of CnV2 was confirmed by Sanger sequencing. CnV2 belongs to the genus Cytorhabdovirus of the family Rhabdoviridae and shares sequence similarities with other known cytorhabdoviruses.
ARCHIVES OF VIROLOGY
(2023)
Article
Medicine, General & Internal
Galam Leem, Beom Kyung Kim, Eui-Cheol Shin, Jun Yong Park
YONSEI MEDICAL JOURNAL
(2020)