Article
Cell Biology
Horst Penkert, Alix Bertrand, Vini Tiwari, Stephan Breimann, Stephan A. Mueller, Paul M. Jordan, Mathias J. Gerl, Christian Klose, Ludovico Cantuti-Castelvetri, Mar Bosch-Queralt, Ilya Levental, Stefan F. Lichtenthaler, Oliver Werz, Mikael Simons
Summary: The study reveals that n-3 fatty acids can promote the balance of inflammatory reactions, reduce phagocytic infiltrate, accelerate the decline of microglia/macrophages, enhance oligodendrocyte generation, and ultimately improve lesion recovery in demyelinating injuries of the central nervous system.
Article
Biochemistry & Molecular Biology
Julian Hackler, Kamil Demircan, Thilo Samson Chillon, Qian Sun, Nino Geisler, Michael Schupp, Kostja Renko, Lutz Schomburg
Summary: Selenium is an essential trace element that affects the expression of SELENOP. A drug screening was performed to identify inhibitors of SELENOP expression, and resveratrol was found to be the most potent inhibitor. The results suggest that resveratrol may increase liver Se levels and selenoprotein expression.
Article
Oncology
Graham Thomas, Luca Micci, Wenjing Yang, Joseph Katakowski, Cecilia Oderup, Purnima Sundar, Xiao Wang, Kenneth G. Geles, Shobha Potluri, Shahram Salek-Ardakani
Summary: TLR agonists have shown potential as therapeutic targets for cancer immunotherapy by influencing the tumor immune microenvironment. Different TLR agonists have varying effects on immune cell composition, interferon signatures, and expression of immune checkpoint molecules. TLR3 stimulation appears to have unique effects on macrophages, monocytes, and T cells compared to TLR7 and TLR9 agonists, suggesting potential synergies with combination therapy strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Neurosciences
Dechuan Sun, Mojtaba Kermani, Matthew Hudson, Xin He, Ranjith Rajasekharan Unnithan, Chris French
Summary: Local field potentials (LFPs) recorded intracranially have location-specific oscillatory spectra related to cognitive processes. The study aimed to characterize the effects of antipsychotic drugs (APDs) and potassium channel modulators (KVMs) on LFPs, showing that both groups of drugs have significant impact on gamma power, coherence, and phase-amplitude coupling of theta and gamma oscillations in the hippocampus and pre-frontal cortex of mice.
Article
Multidisciplinary Sciences
Jiayue-Clara Jiang, Joseph A. Rothnagel, Kyle R. Upton
Summary: Transposons are active in epithelial cancers, contributing to the regulation of human gene expression. The L1PA2 subfamily plays a significant role in modulating breast cancer transcriptional regulation. Understanding the regulatory impact of L1PA2 provides insights into cancer genome regulation and potential biomarkers for diagnosis, prognosis, and therapy.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Zengyu Zhang, Pengpeng Jin, Zimin Guo, Zhilan Tu, Hualan Yang, Mengting Hu, Qinghua Li, Xingdang Liu, Weiwei Li, Shuangxing Hou
Summary: This study investigated the underlying molecular mechanisms of gray matter damage caused by chronic cerebral hypoperfusion (CCH) through integrated analysis of transcriptome and epigenetic approaches. The core regulatory factor PU.1 was identified as playing a key role in microglial activation induced by CCH. The findings provide potential targets for future research on chronic hypoperfusion-induced brain injury.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hetal Jebaliya, Anamik Shah, Sharad C. Karad, Shraddha Nakum, Batuk Dabhi
Summary: This study developed a UPLC method for the quantification and validation of common antipsychotic compounds in dosage form. The method offers good resolution, low solvent consumption, and saves time and money by eliminating the need to change mobile phases. This method is valuable for quality control laboratories.
RESULTS IN CHEMISTRY
(2022)
Article
Immunology
Arundhati Ghosh, Lulu Shao, Padmavathi Sampath, Baoyu Zhao, Nidhi Patel, Jianzhong Zhu, Bharat Behl, Robert A. Parise, Jan H. Beumer, Roderick J. O'Sullivan, Neal A. DeLuca, Stephen H. Thorne, Vijay A. K. Rathinam, Pingwei Li, Saumendra N. Sarkar
Article
Gastroenterology & Hepatology
Carlos Sanz-Garcia, Kyle L. Poulsen, Damien Bellos, Han Wang, Megan R. McMullen, Xiaoxia Li, Saurabh Chattopadhyay, Ganes Sen, Laura E. Nagy
JOURNAL OF HEPATOLOGY
(2019)
Article
Biology
Robert W. Gregg, Saumendra N. Sarkar, Jason E. Shoemaker
JOURNAL OF THEORETICAL BIOLOGY
(2019)
Review
Oncology
Reena Goswami, Gayatri Subramanian, Liliya Silayeva, Isabelle Newkirk, Deborah Doctor, Karan Chawla, Saurabh Chattopadhyay, Dhyan Chandra, Nageswararao Chilukuri, Venkaiah Betapudi
FRONTIERS IN ONCOLOGY
(2019)
Article
Genetics & Heredity
Tangjie Zhang, Saumendra N. Sarkar, Jianzhong Zhu
CYTOLOGY AND GENETICS
(2019)
Article
Biochemistry & Molecular Biology
Jonathan Barroso-Gonzalez, Laura Garcia-Exposito, Song My Hoang, Michelle L. Lynskey, Justin L. Roncaioli, Arundhati Ghosh, Callen T. Wallace, Mauro Modesti, Kara A. Bernstein, Saumendra N. Sarkar, Simon C. Watkins, Roderick J. O'Sullivan
Article
Biochemistry & Molecular Biology
Gayatri Subramanian, Sonam Popli, Sukanya Chakravarty, R. Travis Taylor, Ritu Chakravarti, Saurabh Chattopadhyay
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Virology
Anna Glanz, Karan Chawla, Stephanie Fabry, Gayatri Subramanian, Julie Garcia, Bryanna Jay, Jacob Ciricillo, Ritu Chakravarti, R. Travis Taylor, Saurabh Chattopadhyay
Review
Virology
Anna Glanz, Sukanya Chakravarty, Merina Varghese, Anita Kottapalli, Shumin Fan, Ritu Chakravarti, Saurabh Chattopadhyay
Summary: IRF3 plays a critical role in antiviral immunity by transcribing interferon and triggering apoptosis of virus-infected cells. Viruses can counteract IRF3 functions by manipulating posttranslational modifications.
Article
Biology
Frank W. Soveg, Johannes Schwerk, Nandan S. Gokhale, Karen Cerosaletti, Julian R. Smith, Erola Pairo-Castineira, Alison M. Kell, Adriana Forero, Shivam A. Zaver, Katharina Esser-Nobis, Justin A. Roby, Tien-Ying Hsiang, Snehal Ozarkar, Jonathan M. Clingan, Eileen T. McAnarney, Amy El Stone, Uma Malhotra, Cate Speake, Joseph Perez, Chiraag Balu, Eric J. Allenspach, Jennifer L. Hyde, Vineet D. Menachery, Saumendra N. Sarkar, Joshua J. Woodward, Daniel B. Stetson, John Kenneth Baillie, Jane H. Buckner, Michael Gale, Ram Savan
Summary: An isoform of oligoadenylate synthetase 1, OAS1 p46, is targeted to the endomembrane system, enhancing antiviral activity against certain RNA viruses including flaviviruses, picornaviruses, and SARS-CoV-2. The OAS1 splice-site SNP responsible for production of OAS1 p46 isoform correlates with protection from severe COVID-19, suggesting early control of SARS-CoV-2 replication through OAS1 p46 is crucial for determining COVID-19 severity.
Article
Biochemistry & Molecular Biology
Anna Glanz, Sukanya Chakravarty, Shumin Fan, Karan Chawla, Gayatri Subramanian, Tia Rahman, Dean Walters, Ritu Chakravarti, Saurabh Chattopadhyay
Summary: IRF3 is a transcription factor critical for antiviral gene induction and proapoptotic signaling. Auranofin was identified as a small-molecule inhibitor of IRF3's proapoptotic and transcriptional activities, inducing cellular autophagy to degrade IRF3 protein and suppress its functions. Auranofin effectively inhibited fatty-acid-induced apoptotic cell death in hepatocytes and may offer a potential therapeutic option in diseases where IRF3 is harmful.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Virology
Jenna McGowan, Monica Borucki, Hicham Omairi, Merina Varghese, Shahnaz Vellani, Sukanya Chakravarty, Shumin Fan, Srestha Chattopadhyay, Mashuk Siddiquee, James B. Thissen, Nisha Mulakken, Joseph Moon, Jeffrey Kimbrel, Amit K. Tiwari, Roger Travis Taylor, Dae-Wook Kang, Crystal Jaing, Ritu Chakravarti, Saurabh Chattopadhyay
Summary: Wastewater-based epidemiology (WBE) is an effective tool for predicting the community spread of infectious diseases, especially during the COVID-19 pandemic. Through analyzing the correlation between viral gene copies and clinical cases, as well as sequencing RNA from wastewater to identify viral mutants, WBE can be used to predict the spread of COVID-19 and the emergence of new variants of concern. Furthermore, significant changes in the microbial community of wastewater, particularly in bacterial genera belonging to the families of Lachnospiraceae and Actinomycetaceae, show a strong correlation with the presence of SARS-CoV-2. These microbial biomarkers could serve as prediction tools for future infectious disease surveillance and outbreak responses.
Review
Virology
Justin H. H. Franco, Saurabh Chattopadhyay, Zhixing K. K. Pan
Summary: The type-I interferon (IFN) system is the first line of defense against viral pathogens. Secreted IFNs stimulate nearby cells to produce proinflammatory cytokines and antiviral factors. IFIT proteins, known for their antiviral activity, have also been studied in nonviral pathologies.
Editorial Material
Virology
Sukanya Chakravarty, Ritu Chakravarti, Saurabh Chattopadhyay
Summary: Inflammatory responses during virus infection have different effects on the host, and managing these responses is crucial for controlling viral infection and related diseases. A recently discovered cellular anti-inflammatory mechanism called RIKA (Repression of IRF3-mediated inhibition of NF-kappa B activity) has been found to regulate viral inflammation and pathogenesis. The RIKA function of IRF3 may have potential applications in other inflammatory diseases beyond viral infection.
Article
Multidisciplinary Sciences
Brian H. Youseff, Thomas G. Brewer, Kristin L. McNally, Adaeze O. Izuogu, Kirk J. Lubick, John B. Presloid, Saad Alqahtani, Saurabh Chattopadhyay, Sonja M. Best, Xiche Hu, R. Travis Taylor