Article
Immunology
Akira Hasegawa, Daichi Utsumi, Kaare Lund, Mitsuhiro Okano, Katsuyo Ohashi-Doi, Kimihiro Okubo
Summary: In Japanese HDM allergic rhinitis patients without asthma, there is a high prevalence of allergic sensitization to the HDM major allergens Der p 1, Der p 2, and Der p 23, with a significantly higher prevalence of Der p 23 sensitization in the younger age group. However, there was no significant correlation found between AR symptom scores and concentration of s-IgE towards Der p extract and any of the three HDM major allergens in this population.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Allergy
Saliha Ait Yahia, Camille Audousset, Daniel Alvarez-Simon, Han Vorng, Dieudonnee Togbe, Philippe Marquillies, Myriam Delacre, Stephanie Rose, Helene Bouscayrol, Aline Rifflet, Valerie Quesniaux, Ivo Gomperts Boneca, Mathias Chamaillard, Anne Tsicopoulos
Summary: The study found that NOD1-dependent sensing of gram-negative bacteria associated with HDM exacerbates the severity of experimental asthma, suggesting that inhibiting the NOD1 signaling pathway may be a therapeutic approach to treating asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Matheus Fonseca Aarestrup, Paula Fonseca Aarestrup, Mariana Senff de Andrade, Beatriz Juliao Aarestrup, Akinori Cardozo Nagato, Fernando Monteiro Aarestrup
Summary: Research has shown that allergic patients undergoing house dust mite SLIT generally have a high perception of satisfaction regarding treatment effectiveness, improvement in daily activities, cost-benefit balance, and overall satisfaction.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Food Science & Technology
Sara Benede, Leticia Perez-Rodriguez, Monica Martinez-Blanco, Elena Molina, Rosina Lopez-Fandino
Summary: Orally administered HDM can promote inflammatory and type 2 responses in the intestine, affecting the expression of genes encoding tight junction proteins and cytokines, and activating innate immune cells. However, there is no evidence of HDM promoting sensitization to coadministered proteins in our experimental setting.
Article
Allergy
Mariana Farraia, Ines Paciencia, Francisca Castro Mendes, Joao Cavaleiro Rufo, Mohamed H. Shamji, Ioana Agache, Andre Moreira
Summary: This study compared the cost-effectiveness of allergen immunotherapy (AIT) to standard treatment in children with allergic asthma. The results showed that AIT, especially when administered subcutaneously, was cost effective in reducing asthma exacerbations and medication use.
Article
Immunology
Xun Gao, Ting-Fan Leung, Gary Wing-Kin Wong, Wing-Hung Ko, Mengyun Cai, Ellie Jiayi He, Ida Miu-Ting Chu, Miranda Sin-Man Tsang, Ben Chung-Lap Chan, Jiawei Ling, Xiao Fan, Liwei Lu, Christopher Wai-Kei Lam, Chun-Kwok Wong
Summary: The study revealed that Metrn beta plays a crucial regulatory role in allergic asthma, effectively blocking airway hyperreactivity and reducing inflammatory cell infiltration, with anti-inflammatory properties. These findings suggest a new therapeutic strategy for allergic asthma targeting Metrn beta.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Clinical Neurology
Jed W. Smith, Raphae S. Barlas, Mamas A. Mamas, S. Matthijs Boekholdt, Ziad Mallat, Robert N. Luben, Nicholas J. Wareham, Kay-Tee Khaw, Phyo K. Myint
Summary: A nested case-control study found that sPLA2 activity, but not concentration, is associated with an increased risk of future ischaemic stroke. This finding may have implications for risk group stratification and the development of novel therapeutic agents.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Pediatrics
A. Brzozowska, K. Woicka-Kolejwa, J. Jerzynska, P. Majak, I Stelmach
Summary: The objective of this study was to identify the clinical and immunological parameters associated with the development or regression of persistent asthma. The results showed that allergic rhinitis and sensitization to house dust mite were closely related to the persistence of childhood asthma.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Hazel Dunbar, Ian J. Hawthorne, Courteney Tunstead, Michelle E. Armstrong, Seamas C. Donnelly, Karen English
Summary: Macrophage migration inhibitory factor (MIF) expression is affected by a functional promoter polymorphism, with the number of CATT repeats correlating to MIF expression level. In a pre-clinical model of allergic asthma, mice with increasing CATT repeats (CATT(5) and CATT(7)) showed varying degrees of airway inflammation. The potent MIF inhibitor SCD-19 was able to mitigate the pathophysiology observed in CATT(7) mice, indicating the important role of endogenous human MIF expression in airway inflammation severity.
Article
Biochemistry & Molecular Biology
Hazel Dunbar, Ian J. Hawthorne, Courteney Tunstead, Michelle E. Armstrong, Seamas C. Donnelly, Karen English
Summary: The expression of macrophage migration inhibitory factor (MIF) is controlled by a functional promoter polymorphism, where the number of tetranucleotide repeats (CATTn) corresponds to the level of MIF expression. Using a pre-clinical model of allergic asthma, novel humanized MIF mice with increasing CATT repeats (CATT5 and CATT7) were employed to study airway inflammation. The results showed that high expression of human MIF in CATT7 mice led to a severe asthma phenotype, which could be mitigated by the MIF inhibitor SCD-19. This study provides a reproducible model for studying asthma airway remodeling and suggests a potential role of MIF in driving this process.
Article
Allergy
Lydia Lamara Mahammed, Brahim Belaid, Lylia Meriem Berkani, Fatma Merah, Sarah Yasmine Rahali, Anis Ait Kaci, Ismahane Berkane, Wafa Sayah, Ines Allam, Reda Djidjik
Summary: The study revealed a prevalence of 20.4% shrimp sensitization among HDM-allergic patients, with a tropomyosin-specific IgE positivity rate of 82.8% among shrimp-allergic patients. Shrimp allergy appears to be strictly dependent on HDM sensitization in this geographical area. Therefore, systematic screening for shrimp sensitization and inquiry about shellfish consumption should be conducted in HDM-allergic patients.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Immunology
Huijuan Yuan, Jie Chen, Sanmei Hu, Timothy B. Oriss, Sagar Laxman Kale, Sudipta Das, Seyed M. Nouraie, Prabir Ray, Anuradha Ray
Summary: This study demonstrates the establishment of stable airway tolerance to the allergen in newborn mice by repeatedly exposing them to a low dose of the allergen. The findings suggest an important role of mitochondrial H2O2 in constraining lung dendritic cell numbers towards the establishment of early-life airway tolerance to allergens.
MUCOSAL IMMUNOLOGY
(2022)
Article
Allergy
Magdalena Zemelka-Wiacek, Anna Kosowska, Ewa Winiarska, Ewa Sobanska, Marek Jutel
Summary: This study aimed to demonstrate the reproducibility of defined clinical endpoints after AEC house dust mite (HDM) challenge under optimal conditions. The results showed that in a constant environment, the concentration of HDM remained stable within the targeted values, and the severity of symptoms and other endpoints were reproducible. A concentration of 5000 particles/m³ and a challenge duration of 120 minutes were found to be optimal.
Article
Pharmacology & Pharmacy
Shaobing Xie, Hua Zhang, Fengjun Wang, Zhihai Xie, Weihong Jiang, Kelei Gao
Summary: The study found that serum MIF levels were significantly elevated in allergic rhinitis patients, especially in those with severe disease, and MIF levels were positively correlated with clinical symptoms, serum specific IgE, and other markers. In patients with house dust mite-induced AR undergoing SLIT treatment, serum MIF levels had predictive value for clinical response, indicating that MIF could serve as an independent predictor for treatment responsiveness.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pediatrics
Yaqi Yang, Dongxia Ma, Nan Huang, Wenjing Li, Qing Jiang, Yin Wang, Xiaolong Wang, Lin Yang, Rongfei Zhu
Summary: The study found that house dust mite subcutaneous immunotherapy is safe in preschool children with respiratory allergic diseases. Higher body mass index and specific immunoglobulin E levels to house dust mite in children are risk factors for developing local reactions.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Cell Biology
Munehiro Yamaguchi, Jennifer Zacharia, Tanya M. Laidlaw, Barbara Balestrieri
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Multidisciplinary Sciences
Katia Urso, Julia F. Charles, Gary E. Shull, Antonios O. Aliprantis, Barbara Balestrieri
Meeting Abstract
Allergy
Munehiro Yamaguchi, Jannatul Firdous, Joshua A. Boyce, Barbara Balestrieri
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Sachin K. Samuchiwal, Barbara Balestrieri, Hannah Raff, Joshua A. Boyce
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Immunology
M. Yamaguchi, S. K. Samuchiwal, O. Quehenberger, J. A. Boyce, B. Balestrieri
MUCOSAL IMMUNOLOGY
(2018)
Article
Immunology
Giorgio Giannattasio, Shin Ohta, Joshua R. Boyce, Wei Xing, Barbara Balestrieri, Joshua A. Boyce
JOURNAL OF IMMUNOLOGY
(2011)
Article
Immunology
Shin Ohta, Mitsuru Imamura, Wei Xing, Joshua A. Boyce, Barbara Balestrieri
JOURNAL OF IMMUNOLOGY
(2013)
Review
Biochemistry & Molecular Biology
Sachin K. Samuchiwal, Barbara Balestrieri
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2019)
Article
Medicine, Research & Experimental
Jun Nagai, Barbara Balestrieri, Laura B. Fanning, Timothy Kyin, Haley Cirka, Junrui Lin, Marco Idzko, Andreas Zech, Edy Y. Kim, Patrick J. Brennan, Joshua A. Boyce
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Biochemistry & Molecular Biology
Masaya Koganesawa, Munehiro Yamaguchi, Sachin K. Samuchiwal, Barbara Balestrieri
Summary: Macrophages activated by IL-4 (M2) or LPS+IFN gamma (M1) have distinct lipid metabolism profiles, with Pla2g5 playing a key role in this process. Pla2g5 is involved in phospholipid metabolism and eicosanoid production in both types of activated macrophages.
Editorial Material
Allergy
Tanya M. Laidlaw, Barbara Balestrieri
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Barbara Balestrieri, Francescopaolo Granata, Stefania Loffredo, Angelica Petraroli, Giulia Scalia, Paolo Morabito, Chiara Cardamone, Gilda Varricchi, Massimo Triggiani
Summary: Two subpopulations of pulmonary macrophages were separated from human lung parenchyma based on density gradients, with high-density macrophages (HDMs) and low-density macrophages (LDMs) exhibiting differences in characteristics and responses to lipopolysaccharide (LPS). These distinct subpopulations of macrophages are likely to play different roles in lung inflammation and immune responses.
Review
Biochemistry & Molecular Biology
Barbara Balestrieri, David Di Costanzo, Daniel F. Dwyer
Summary: This article reviews the diverse functions of macrophages in inflammatory processes and introduces the fatty acids and oxylipins generated by macrophages and their role in immune responses. Moreover, the review discusses the impact of lipidomic studies on macrophage polarization.
Editorial Material
Parasitology
Qihua Ye, Barbara Balestrieri, Nora A. Barrett
Summary: In a recent study, Ahrends et al. found that helminthelicited T2I can protect excitatory neurons and enteric function by expanding Arginase-1-expressing macrophages, enhancing our understanding of the protective role T2I plays in inflamed barrier tissue.
TRENDS IN PARASITOLOGY
(2022)
Editorial Material
Allergy
Qihua Ye, Nora Barrett, Barbara Balestrieri
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)