Article
Immunology
Varvara Maiorova, Murad D. Mollaev, Polina Vikhreva, Elena Kulakovskaya, Dmitry Pershin, Dmitriy M. Chudakov, Alexey Kibardin, Michael A. Maschan, Sergey Larin
Summary: A CAR-T cell targeted at AML's full-length Flt3 ligand recognition module is shown to have specific killing effects on Flt3-positive leukemia cells without cytotoxicity towards Flt3-negative cells. The cytolytic capacity of T cells plays a crucial role in the killing, and the targeting authenticity is confirmed through competitive inhibition. The developed system, functioning as a non-immunogenic equivalent of scFv-mediated targeting, shows promising antitumor effects with low off-target cytotoxicity for AML treatment.
Article
Nanoscience & Nanotechnology
Ruyan Feng, Lijuan Zhu, Xingyu Heng, Gaojian Chen, Hong Chen
Summary: Research has shown that short-chain glycopolymers demonstrate better binding ability to immune-related proteins and enhanced promotion of dendritic cell maturation compared to long-chain glycopolymers. By combining experimental characterization and theoretical simulation, a deeper understanding of the interaction between glycopolymers with different chain lengths and immune-related proteins is achieved, providing a solid theoretical basis for the design of new glycopolymer-based immune drugs.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Lena Stich, Stephan Plattner, Gordon McDougall, Ceri Austin, Alexander Steinkasserer
Summary: The water-soluble polysaccharides derived from European black elderberry can induce potent immune-modulatory effects and enhance immune responses against viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ali Asadirad, Kaveh Baghaei, Seyed Mahmoud Hashemi, Sajad Dehnavi, Hossein Ghanbarian, Esmaeil Mortaz, Ali Anissian, Hamid Asadzadeh Aghdaei, Davar Amani
Summary: This study investigates the tumor growth suppression and antitumor effects of DCs primed with miR-155-enriched exosome on the BALB/c murine model of colorectal cancer. The findings demonstrate that the primed DCs can increase IL-12p70 and IFN-gamma in serum and enhance the effects on Th and CTL cells, leading to tumor growth control and survival improvement. DC immunotherapy with miR-155-enriched exosome can be employed as a desired approach for inducing antitumor immune responses, controlling tumor growth, and improving survival in mice with colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Elektra Kantzari Robinson, Sergio Covarrubias, Simon Zhou, Susan Carpenter
Summary: The research team developed a HEK-293T cell line expressing murine GM-CSF for culturing dendritic cells and alveolar macrophages. The high levels of GM-CSF secreted by this cell line supported cell differentiation, resulting in twice as many viable cells compared to commercially purified GM-CSF.
Review
Oncology
Francisco J. Cueto, David Sancho
Summary: Current cancer immunotherapy efforts focus on enhancing T cell effector function, but stimulating dendritic cells (DCs) may improve treatment outcomes. Specifically, utilizing the Flt3/Flt3L axis to boost DC function shows promising potential for cancer immunotherapy.
Review
Biochemistry & Molecular Biology
Fabio Forghieri, Giovanni Riva, Ivana Lagreca, Patrizia Barozzi, Francesca Bettelli, Ambra Paolini, Vincenzo Nasillo, Beatrice Lusenti, Valeria Pioli, Davide Giusti, Andrea Gilioli, Corrado Colasante, Laura Galassi, Hillary Catellani, Francesca Donatelli, Annalisa Talami, Rossana Maffei, Silvia Martinelli, Leonardo Potenza, Roberto Marasca, Enrico Tagliafico, Rossella Manfredini, Tommaso Trenti, Patrizia Comoli, Mario Luppi
Summary: The C-terminal aminoacidic sequence from NPM1-mutated protein may serve as a leukemia-specific antigen, and different in silico instruments have identified the most immunogenic epitopes. Spontaneous development of endogenous NPM1-mutated-specific cytotoxic T cells has been observed in patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Maarten K. Nijen Twilhaar, Lucas Czentner, Rianne G. Bouma, Katarzyna Olesek, Joanna Grabowska, Aru Zeling Wang, Alsya J. Affandi, Saskia C. Belt, Hakan Kalay, Cornelus F. van Nostrum, Yvette van Kooyk, Gert Storm, Joke M. M. den Haan
Summary: TLR-containing GM3 liposomes are effective vectors to induce DC maturation and T cell priming. Incorporation of PGPC or MDP does not enhance immune responses. These findings provide guidance for the optimal selection of liposomal components to stimulate anti-cancer immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Valeria Fumagalli, Valentina Venzin, Pietro Di Lucia, Federica Moalli, Xenia Ficht, Gioia Ambrosi, Leonardo Giustini, Francesco Andreata, Marta Grillo, Diletta Magini, Micol Rava, Christin Friedrich, Jason D. Fontenot, Philippe Bousso, Sarah A. Gilmore, Shahzada Khan, Manuel Baca, Eric Vivier, Georg Gasteiger, Mirela Kuka, Luca G. Guidotti, Matteo Iannacone
Summary: Group 1 innate lymphoid cells (ILCs) play a role in controlling T cell-mediated liver immunopathology by limiting local IL-2 concentration.
SCIENCE IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Bushra Riaz, S. M. Shamsul Islam, Hye Myung Ryu, Seonghyang Sohn
Summary: Activating the immune system is important for maintaining homeostasis and defending against infections, but abnormalities in the immune response can lead to harmful immunopathological responses and severe inflammation. Dendritic cells play a role in influencing immune responses through the differentiation of T cells. CD83, expressed on mature dendritic cells, activated B cells, and T cells, has been studied extensively and has been suggested to have functions in co-stimulation and resolving inflammatory reactions. However, its roles in autoimmune diseases and pathogen immune evasion are not fully understood. This article outlines current findings and proposed functions of CD83 in inflammatory disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Sara Michelini, Francesco Barbero, Alessandra Prinelli, Philip Steiner, Richard Weiss, Thomas Verwanger, Ancuela Andosch, Ursula Lutz-Meindl, Victor F. Puntes, Damjana Drobne, Albert Duschl, Jutta Horejs-Hoeck
Summary: The study revealed that gold nanoparticles (AuNPs) may impact dendritic cell function and alter immune responses, especially in the presence of microbial inflammatory stimulus lipopolysaccharide (LPS). The findings suggest that AuNPs are safe in homeostatic conditions but caution is needed in patients with infections or immune system disorders.
Article
Biotechnology & Applied Microbiology
Ikhwan Rinaldi, Melva Louisa, Resti Mulya Sari, Elly Arwanih
Summary: The one-year survival of AML patients in Indonesia is not affected by FLT3-ITD mutation and FLT3 ligand plasma level. However, the glomerular filtration rate (GFR) showed an association with one-year survival in this cohort study.
ONCOTARGETS AND THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Maidul Islam, Britni M. Arlian, Fabian Pfrengle, Shiteng Duan, Scott A. Smith, James C. Paulson
Summary: The study reveals that binding ligands of inhibitory Siglecs to anti-receptor antibodies can suppress immune cell activation and modulate unwanted immune responses.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Multidisciplinary Sciences
Rasheid Smith, Emad Wafa, Sean M. Geary, Kareem Ebeid, Suhaila O. Alhaj-Suliman, Aliasger K. Salem
Summary: Nanoscale formulations can enhance the efficacy of cancer vaccines by combating the immunosuppressive nature of the tumor microenvironment. A newly synthesized nanoparticulate formulation demonstrated adjuvant properties in vivo, leading to increased TAA-specific T cells, reduced tumor burden, protection against tumor rechallenge, and improved median survival in tumor-challenged mice.
Article
Gastroenterology & Hepatology
Laurence P. Diggs, Benjamin Ruf, Chi Ma, Bernd Heinrich, Linda Cui, Qianfei Zhang, John C. McVey, Simon Wabitsch, Sophia Heinrich, Umberto Rosato, Walter Lai, Varun Subramanyam, Thomas Longerich, Sven H. Loosen, Tom Luedde, Ulf Peter Neumann, Sabina Desar, David Kleiner, Gregory Gores, Xin Wei Wang, Tim F. Greten
Summary: Stimulating antigen-presenting cells such as macrophages and dendritic cells through CD40 agonist significantly enhances the response to anti-PD-1 therapy in intrahepatic cholangiocarcinoma (iCCA) models, leading to a greater reduction in tumor burden. The combination of CD40 agonist and PD-1 inhibitor, along with chemotherapy, shows promising results in improving therapeutic efficacy and overall survival.
JOURNAL OF HEPATOLOGY
(2021)