期刊
ORGANIC LETTERS
卷 17, 期 24, 页码 6190-6193出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03189
关键词
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资金
- NSFC [21172029, 21202016, 21372038]
- Ministry of Education of the People's Republic of China [NCET-13-0714]
- Jilin Provincial Research Foundation for Basic Research [20140519008JH]
- Fundamental Research Funds for the Central Universities [2412015BJ005]
- Excellent Young Scientist of NSFC [21522202]
The room-temperature nucleophilic addition of vinyl azides to propargylic alcohols under BF3 center dot Et2O catalysis provides an efficient synthesis of 4-ynamides. The procedure is operationally convenient, shows broad substrate scope, and is viable for the synthesis of multifunctional 4-ynamides. Further, a Vilsmeier intramolecular cyclization of 4-ynamides into dihydrofuran-2(3H)-ones has also been discovered, which represents the first report of alkynes being used as the nucleophiles in Vilsmeier-type reactions.
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