Review
Immunology
Ashleigh R. Murphy-Schafer, Silke Paust
Summary: Mast cells are initially implicated as a source of immunopathology in severe influenza, but emerging evidence suggests they also play a crucial role in suppressing inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Christoph Thurm, Burkhart Schraven, Sascha Kahlfuss
Summary: ABC transporters represent a diverse group of ATP-dependent transport proteins that regulate the import and export of various substances. Recent studies have shown that these transporters play a role in the development and function of different T cell populations, impacting immunity to viruses, tumors, and autoimmune diseases. Understanding the function of ABC transporters in T cells may lead to novel therapies for autoimmune disorders and improve immune responses to infections and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Sara P. H. van den Berg, Josien Lanfermeijer, Ronald H. J. Jacobi, Marion Hendriks, Martijn Vos, Roos van Schuijlenburg, Nening M. Nanlohy, Jose A. M. Borghans, Josine van Beek, Debbie van Baarle, Jelle de Wit
Summary: CMV infection is associated with lower frequencies of memory IAV-specific T cells in healthy individuals, but does not seem to hamper T-cell response during acute IAV infection. In addition, CMV infection is not associated with increased severity of influenza-related symptoms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yan Yan, Wei Zhao, Wei Liu, Yan Li, Xu Wang, Jingna Xun, Chantsalmaa Davgadorj
Summary: CCL19 enhances Ag-responsive IFN-γ(+) CD8(+) T cells in patients with HBV infection and promotes rapid clearance of intrahepatic HBV in mice.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Immunology
Roberto Tinoco, Emily N. Neubert, Christopher J. Stairiker, Monique L. Henriquez, Linda M. Bradley
Summary: PSGL-1 acts as a key regulator of effector and memory T cell differentiation during acute viral infection, by limiting survival, sustaining PD-1 expression, and reducing effector responses. This suggests that PSGL-1 may limit excessive stimulation of memory T cells during acute viral infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Andrew Baessler, Bryce Fuchs, Bryant Perkins, Andrew W. Richens, Camille L. Novis, Malia Harrison-Chau, Linda M. Sircy, Kendall A. Thiede, J. Scott Hale
Summary: This study reveals the important role of Tet2 in CD4+ T cell differentiation and memory formation, which in turn affects the enhancement of immune response. The absence of Tet2 leads to preferential recall of Tfh phenotype in memory cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Medicine, Research & Experimental
Daniel Kvistad, Suresh Pallikkuth, Tirupataiah Sirupangi, Rajendra Pahwa, Alexander Kizhner, Constantinos Petrovas, Francois Villinger, Savita Pahwa
Summary: Natural aging and HIV infection are associated with impaired antibody responses to vaccines like the flu vaccine and chronic low-grade systemic inflammation. IL-21 has been shown to enhance flu vaccine-induced antibody responses in aged SIV+ rhesus macaques, acting as an adjuvant modulating LN germinal center activity. Supplementing IL-21 in aging populations could be a valuable strategy for improving vaccine responses in individuals living with HIV.
Article
Toxicology
Nicholas L. Drury, Toriq Mustapha, Ross A. Shore, Jiayun Zhao, Gus A. Wright, Aline Rodrigues Hoffmann, Susanne U. Talcott, Annette Regan, Robert M. Tighe, Renyi Zhang, Natalie M. Johnson
Summary: Research suggests that pregnant women exposed to ultrafine particles during pregnancy may experience abnormal immune responses to influenza, increasing the severity of infection.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Koen van de Ven, Josien Lanfermeijer, Harry van Dijken, Hiromi Muramatsu, Caroline Vilas Boas de Melo, Stefanie Lenz, Florence Peters, Mitchell B. Beattie, Paulo J. C. Lin, Jose A. Ferreira, Judith van den Brand, Debbie van Baarle, Norbert Pardi, Jorgen de Jonge
Summary: This study evaluated a novel T cell-inducing nucleoside-modified messenger RNA (mRNA) vaccine that encoded conserved proteins of an H1N1 influenza virus, and found that it induced broadly reactive T cells and enhanced protection against potential influenza viruses.
Article
Multidisciplinary Sciences
Abdalla Sheikh, Jennie Jackson, Hanjoo Brian Shim, Clement Yau, Jung Hee Seo, Ninan Abraham
Summary: Interleukin-7 (IL-7) plays an important role in shaping CD8 T cell responses during acute viral infections. IL-7 is required for proper expansion and effector functions of influenza-specific CD8 T cells in the mediastinal lymph node. IL-7 also affects terminal differentiation, degranulation, and cytokine production of specific CD8 T cells. Understanding IL-7's role in respiratory diseases will help expand therapeutic options.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Judith Grau-Exposito, Nerea Sanchez-Gaona, Nuria Massana, Marina Suppi, Antonio Astorga-Gamaza, David Perea, Joel Rosado, Anna Falco, Cristina Kirkegaard, Ariadna Torrella, Bibiana Planas, Jordi Navarro, Paula Suanzes, Daniel Alvarez-Sierra, Alfonso Ayora, Irene Sansano, Juliana Esperalba, Cristina Andres, Andres Anton, Santiago Ramon y Cajal, Benito Almirante, Ricardo Pujol-Borrell, Vicenc Falco, Joaquin Burgos, Maria J. Buzon, Meritxell Genesca
Summary: The study suggests that lung resident memory T cells play a crucial role in limiting the spread of SARS-CoV-2 and COVID-19. Different clinical outcomes are associated with distinct virus-specific T cell responses, and the persistence of antiviral lung T-RM cells in convalescent patients may help limit reinfection.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Maireid B. Bull, Haogao Gu, Fionn N. L. Ma, Liyanage P. Perera, Leo L. M. Poon, Sophie A. Valkenburg
Summary: In this study, we investigated the influenza virus genome in infected mice to determine its potential to adapt to T cell responses. We found that vaccination with the Wyeth/IL-15/5Flu vaccine led to an increased incidence and frequency of mutations across the influenza genome. However, these mutations were not enriched within T cell epitope regions. Instead, high allele frequency mutations were observed in conserved hemagglutinin stem regions and PB2 mammalian adaptive mutations. Depletion of CD4(+) and CD8(+) T cell subsets in vaccinated mice resulted in a reduction in the frequency of mutants, indicating that vaccine-mediated T cell responses play an important role in driving virus diversification.
Article
Immunology
Shohei Harabuchi, Omar Khan, Hamid Bassiri, Taku Yoshida, Yohei Okada, Masaomi Takizawa, Osamu Ikeda, Akihiro Katada, Taku Kambayashi
Summary: This study investigates the role of TCR signaling pathways in chronic viral infection, revealing the distinct effects of DAG and ERK on CD8+ T cell activation and survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhuofan Li, Ki-Hye Kim, Noopur Bhatnagar, Bo Ryoung Park, Subbiah Jeeva, Yu-Jin Jung, Jannatul Raha, Sang-Moo Kang, Xinyuan Chen
Summary: This study presents a physical radiofrequency adjuvant (RFA) that can conveniently and effectively enhance the immunogenicity and efficacy of H5N1 vaccine. The RFA treatment on the skin induces thermal stress to enhance immune responses and does not cause significant adverse reactions. The RFA significantly increases antibody titers, reduces viral titers, body weight loss, and improves survival rates in murine models. It has no gender difference in its effects.
Review
Medicine, General & Internal
Maike Hofmann, Catrin Tauber, Nina Hensel, Robert Thimme
Summary: CD8(+) T cell responses play a crucial role in chronic HCV infection and HCC, strong virus-specific CD8(+) T cell responses contribute to virus clearance while failure leads to chronic infection development. Tumor-associated and tumor-specific CD8(+) T cells are considered potential targets for immunotherapeutic strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Ruth Forman, Larisa Logunova, Hannah Smith, Kelly Wemyss, Iris Mair, Louis Boon, Judith E. Allen, Werner Muller, Joanne L. Pennock, Kathryn J. Else
Summary: The study shows that colonic macrophages can express RELM alpha protein without responding to IL-4 and IL-13 during Trichuris muris infection. This finding is important for understanding and potentially treating inflammatory conditions.
Article
Immunology
Xiaofei Xu, Errol Prens, Edwin Florencia, Pieter Leenen, Luis Boon, Patrick Asmawidjaja, Anne-Marie Mus, Erik Lubberts
Summary: The up-regulation of IL-19 and IL-24 induced by IL-17A in skin stromal cells contributes to keratinocyte proliferation. Depletion of IL-10 leads to increased expression of IL-23/IL-17 pathway related cytokines followed by significant up-regulation of IL-19 and IL-24.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jesus Gil-Pulido, Nuria Amezaga, Ivana Jorgacevic, Helga D. Manthey, Melanie Roesch, Theresa Brand, Peter Cidlinsky, Sarah Schafer, Andreas Beilhack, Antoine-Emmanuel Saliba, Kristina Lorenz, Louis Boon, Immo Prinz, Ari Waisman, Thomas Korn, Clement Cochain, Alma Zernecke
Summary: IL-23R(+) gamma delta T cells predominantly found in the aortic root promote early atherosclerotic lesion formation, plaque necrosis, and inflammation at this site. Targeting IL-23R may be explored as a therapeutic approach to mitigate atherosclerotic lesion development.
CARDIOVASCULAR RESEARCH
(2022)
Article
Immunology
Cajsa H. Classon, Muzhen Li, Ada Lerma Clavero, Junjie Ma, Xiaogang Feng, Christopher A. Tibbitt, Julian M. Stark, Rebeca Cardoso, Emma Ringqvist, Louis Boon, Eduardo J. Villablanca, Antonio Gigliotti Rothfuchs, Liv Eidsmo, Jonathan M. Coquet, Susanne Nylen
Summary: Infection by strictly intestinal helminths can increase the numbers of CD4(+) T cells in the skin of mice, leading to a skewed T(H)2 cell composition and long-term effects on skin immune responses. This indicates a novel gut-to-skin cell trafficking process and worm-mediated immunosuppression.
MUCOSAL IMMUNOLOGY
(2022)
Article
Biology
Riem Gawish, Philipp Starkl, Lisabeth Pimenov, Anastasiya Hladik, Karin Lakovits, Felicitas Oberndorfer, Shane J. F. Cronin, Anna Ohradanova-Repic, Gerald Wirnsberger, Benedikt Agerer, Lukas Endler, Tumay Capraz, Jan W. Perthold, Domagoj Cikes, Rubina Koglgruber, Astrid Hagelkruys, Nuria Montserrat, Ali Mirazimi, Louis Boon, Hannes Stockinger, Andreas Bergthaler, Chris Oostenbrink, Josef M. Penninger, Sylvia Knapp
Summary: Despite progress in understanding COVID-19, limited mechanistic insight into immunological factors and disease severity remains. Scientists generated a mouse-adapted SARS-CoV-2 strain, maVie16, and found that cytokine-driven immunopathology and ACE2 dependence determine disease severity. This study provides a new tool for discovering therapies.
Review
Biochemistry & Molecular Biology
Zuzanna Sas, Ewa Cendrowicz, Isabel Weinhauser, Tomasz P. Rygiel
Summary: The prevalence of liver cancer is increasing in Europe and the USA, with hepatocellular carcinoma being the most common subtype. Chronic liver inflammation leads to the formation of a complex tumor microenvironment in liver cancer. Therapies for liver cancer are challenged by the TME, but new immune-based treatments are being developed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Gaurang Jhala, Balasubramanian Krishnamurthy, Thomas C. Brodnicki, Tingting Ge, Satoru Akazawa, Claudia Selck, Prerak M. Trivedi, Evan G. Pappas, Leanne Mackin, Nicola Principe, Erwan Bremaud, David J. De George, Louis Boon, Ian Smyth, Jonathan Chee, Thomas W. H. Kay, Helen E. Thomas
Summary: IFN gamma regulates the expansion of antigen-specific CD8(+) T cells by controlling the expression of SOCS-1. Despite reduced inflammation in Ifngr-mutant mice, the expanded CD8(+) T cells may contribute to normal diabetes progression.
Article
Immunology
Nicola Principe, Wayne J. Aston, Danika E. Hope, Caitlin M. Tilsed, Scott A. Fisher, Louis Boon, Ian M. Dick, Wee Loong Chin, Alison M. McDonnell, Anna K. Nowak, Richard A. Lake, Jonathan Chee, Willem Joost Lesterhuis
Summary: This study investigated the combination effects of various chemotherapies with immune checkpoint blockade (ICB) and identified chemotherapy/ICB combinations that showed additive or non-additive effects. The combination of 5-fluorouracil (5-FU) or cisplatin with ICB had additive effects, while vinorelbine and etoposide did not provide additional benefit when combined with ICB. Furthermore, the study found that the combination of 5-FU with ICB increased inflammation in the tumor microenvironment, which may contribute to its effective combination therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Peter Rose, Natasja K. van den Engel, Julia R. Kovacs, Rudolf A. Hatz, Louis Boon, Hauke Winter
Summary: Depleting antibodies targeting myeloid-derived suppressor cells (MDSC) enhance the induction of tumor-specific T cells and delay the growth of melanoma.
Article
Immunology
Marco Gargaro, Giulia Scalisi, Giorgia Manni, Carlos G. Briseno, Prachi Bagadia, Vivek Durai, Derek J. Theisen, Sunkyung Kim, Marilena Castelli, Chenling A. Xu, Gerd Meyer zu Horste, Giuseppe Servillo, Maria A. Della Fazia, Giulia Mencarelli, Doriana Ricciuti, Eleonora Padiglioni, Nicola Giacche, Carolina Colliva, Roberto Pellicciari, Mario Calvitti, Teresa Zelante, Dietmar Fuchs, Ciriana Orabona, Louis Boon, Alban Bessede, Marco Colonna, Paolo Puccetti, Theresa L. Murphy, Kenneth M. Murphy, Francesca Fallarino
Summary: This study identifies a previously unrecognized metabolic communication pathway, in which cDC1 cells extend their immunoregulatory capacity to cDC2 through the production of L-kynurenine. This finding has potential therapeutic implications in treating autoimmune demyelinating diseases.
Article
Multidisciplinary Sciences
Ashleigh R. Poh, Christopher G. Love, David Chisanga, James H. Steer, David Baloyan, Michael Chopin, Stephen Nutt, Jai Rautela, Nicholas D. Huntington, Nima Etemadi, Megan O'Brien, Ryan O'Keefe, Lesley G. Ellies, Christophe Macri, Justine D. Mintern, Lachlan Whitehead, Gangadhara Gangadhara, Louis Boon, Ashwini L. Chand, Clifford A. Lowell, Wei Shi, Fiona J. Pixley, Matthias Ernst
Summary: Genetic ablation or therapeutic inhibition of the myeloid-specific hematopoietic cell kinase (HCK) enhances the response to immunotherapy by modifying the tumor microenvironment and promoting immune cell activation.
Article
Immunology
Anne -Charlotte Jonckheere, Brecht Steelant, Sven F. Seys, Jonathan Cremer, Ellen Dilissen, Louis Boon, Adrian Liston, Rik Schrijvers, Christine Breynaert, Jeroen A. J. Vanoirbeek, Jan L. Ceuppens, Dominique M. A. Bullens
Summary: This study investigates the role of regulatory T cells (Tregs) in maintaining the epithelial barrier and controlling tight junction expression. The results show that Treg deficiency leads to airway inflammation and decreased tight junction expression. Treatment with CTLA4-Ig effectively prevents barrier dysfunction and suppresses inflammation and cytokine secretion. Neutralization of IL-4 partially reverses the effects of Treg depletion, while neutralization of IL-6 and IFN-g has limited effects.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Virology
Laura E. P. Huyveneers, Anke Bruns, Arjen Stam, Pauline Ellerbroek, Dorien de Jong, Noemi A. Nagy, Stephanie B. H. Gumbs, Kiki Tesselaar, Kobus Bosman, Maria Salgado, Gero Hutter, Lodewijk A. A. Brosens, Mi Kwon, Jose Diez Martin, Jan T. M. van der Meer, Theun M. de Kort, Asier Saez-Cirion, Julian Schulze zur Wiesch, Jaap Jan Boelens, Javier Martinez-Picado, Jurgen H. E. Kuball, Annemarie M. J. Wensing, Monique Nijhuis
Summary: After CCR5 Delta 32/Delta 32 allo-HSCT, HIV-1-DNA became undetectable in PBMCs, but the identical variants were still present in post-mortem tissues, indicating the importance of these tissues as viral reservoirs.
Article
Immunology
Ruben J. Geerdink, Maria Ines Pascoal Ramos, Luuk L. van den Hoogen, Timothy R. D. J. Radstake, Shiro Shibayama, Akira Shibuya, Louis Bont, Linde Meyaard
Summary: Neutrophils play a crucial role in antimicrobial defense, but excessive inflammation can lead to immune pathology. This study aims to investigate the regulatory role of the inhibitory receptor Allergin-1 on neutrophils.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Review
Immunology
Helen J. J. von Richthofen, Linde Meyaard
Summary: Similar to immune cells, non-hematopoietic cells possess mechanisms to sense environmental context and regulate their responses to microbial and endogenous threats. Inhibitory receptors on these cells can sense a wide range of signals and regulate various functions, including immune activation, proliferation, and migration. Investigating the functions of inhibitory receptors on non-hematopoietic cells systematically is important for understanding their role in immune response.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)