期刊
JOURNAL OF IMMUNOLOGY
卷 184, 期 1, 页码 67-72出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0903118
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资金
- National Institutes of Health [R01 AI052056, R01 AI049120, R24 RR015371]
- National Center for Research Resources [P51 RR000167]
- Research Facilities Improvement Program [RR15459 01, RR020141-01]
- NATIONAL CENTER FOR RESEARCH RESOURCES [R24RR015371, C06RR020141, C06RR015459, P51RR000167] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI052056, R21AI081590, R01AI049120, R37AI052056] Funding Source: NIH RePORTER
Rational vaccines designed to engender T cell responses require intimate knowledge of how epitopes are generated and presented. Recently, we vaccinated 8 Mamu-A*02(+) rhesus macaques with every SIV protein except Envelope (Env). Surprisingly, one of the strongest T cell responses engendered was against the Env protein, the Mamu-A*02-restricted epitope, Env(788-795)RY8. In this paper, we show that translation from an alternate reading frame of both the Rev-encoding DNA plasmid and the rAd5 vector engendered Env(788-795)RY8-specific CD8(+) T cells of greater magnitude than normal SIV infection. Our data demonstrate both that the pathway from vaccination to immune response is not well understood and that products of alternate reading frames may be rich and untapped sources of T cell epitopes. The Journal of Immunology, 2010, 184: 67-72.
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