Review
Biochemistry & Molecular Biology
Tsvetelina Batsalova, Balik Dzhambazov
Summary: Collagen type II (COL2) is significantly affected by autoimmune responses in rheumatoid arthritis (RA), and posttranslational modifications (PTMs) of COL2 have been implicated in RA autoimmunity. The discovery of anti-citrullinated protein response in RA has led to improved diagnostic assays and classification criteria for the disease. Immunological tolerance induced by modified COL2 peptides is considered as a potential strategy for RA therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Feng Gao, Ziqi Dai, Tong Zhang, Yuhao Gu, Desheng Cai, Mingjun Lu, Zijie Zhang, Qi Zeng, Bingxian Shang, Bing Xu, Haimin Lei
Summary: In this study, a series of novel sinomenine derivatives were designed and synthesized. Compound 17 exhibited excellent anti-inflammatory and analgesic activities, indicating its potential as a drug.
Article
Integrative & Complementary Medicine
Ju-Yeon Park, Young-Won Kwon, Sun-Ah Kim, Sun-Dong Park, Chang-Hyun Kim, Jin-Hee Kim, Ju-Hee Lee
Summary: The study demonstrated the anti-arthritic effects of SC-E3 in a mouse model of type-II collagen-induced arthritis, showing reduced paw swelling, bone erosion, inflammatory cell infiltration, and inflammation. SC-E3 was found to inhibit pro-inflammatory cytokines and osteoclastogenesis, indicating its potential therapeutic use for rheumatoid arthritis.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Materials Science, Biomaterials
Liang Yang, Yongjie Sha, Yuansong Wei, Hanghang Fang, Jingjing Jiang, Lichen Yin, Zhiyuan Zhong, Fenghua Meng
Summary: In this study, the researchers investigated the use of mannose-installed chimaeric polymersomes (Man-PMTX) for targeted delivery of methotrexate (MTX) in the treatment of rheumatoid arthritis (RA). Man-PMTX demonstrated high and robust loading of MTX, uniform size, minimal hemolytic activity, and glutathione-actuated drug release property. In vivo studies showed that Man-PMTX accumulated more in inflammatory joints, effectively treated RA by relieving inflammation, repolarizing macrophages, and mitigating proinflammatory cytokines, and protected synovium and bone from damage.
BIOMATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Zhengyu Fang, Yiping Hu, Jiajing Dai, Lianhua He, Juan He, Bihua Xu, Xinle Han, Fubo Zhong, Huiyao Lan, Qingwen Wang
Summary: The combination treatment with CS12192 and MTX is shown to have a better therapeutic effect on collagen-induced arthritis (CIA) in rats, with a stronger suppressive effect on T cells and macrophage-mediated joint inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Jeevithan Elango, Camilo Zamora-Ledezma, Baolin Ge, Chunyu Hou, Zhilin Pan, Bin Bao, Carlos Perez Albacete Martinez, Jose Manuel Granero Marin, Jose Eduardo Mate Sanchez de Val, Chunling Bao, Wenhui Wu
Summary: Collagen plays a significant role in regulating signaling mechanisms in bone and immune cells. Imbalance in collagen turnover can lead to complications and affect cellular homeostasis. While collagen has been widely explored for its beneficial effects, such as in the treatment of cartilage-related disorders, its potentially immunogenic properties have also been a subject of research and debate. This review aims to bridge the gap between the arthritogenic and anti-arthritogenic effects of collagen and provide insight into its mechanisms in arthritis.
BIOENGINEERING-BASEL
(2022)
Article
Immunology
Xiaolei Liu, Li Li, Qian Wang, Fengchao Jiang, Pei Zhang, Fei Guo, Hongjun Liu, Jian Huang
Summary: A new humanized anti-IL-6 mAb HZ-0408b with potent binding and neutralizing activity to human IL-6 has been developed. It showed a high species specificity and lower cross-reactivity compared to other anti-IL-6 mAbs. HZ-0408b exhibited a stronger inhibitory effect on IL-6 signaling and effectively reduced joint swelling and plasma CRP levels in a monkey CIA model.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Helena Port, Anne-Christine Bay-Jensen, Yi He, Morten A. A. Karsdal, Thorbjorn Gantzel, Christian S. S. Thudium, Signe Holm Nielsen
Summary: The development of a competitive chemiluminescence enzyme-linked immunosorbent assay, CALC2, targeting the type II collagen C-terminal pro-peptide as a marker of cartilage formation was evaluated. The CALC2 level was measured after in vitro cleavage of recombinant type II collagen and treatment of human osteoarthritis cartilage explant model with insulin-like growth factor-1. Serum CALC2 levels were found to be decreased in patients with rheumatoid arthritis and ankylosing spondylitis compared to controls. These results suggest that CALC2 may be a novel biomarker of type II collagen formation, but further studies are needed to confirm these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jing He, Yanan Chu, Jing Li, Qingren Meng, Yudong Liu, Jiayang Jin, Yifan Wang, Jian Wang, Bo Huang, Lianjie Shi, Xing Shi, Jiayi Tian, Yunzhi Zhufeng, Ruiling Feng, Wenjing Xiao, Yuzhou Gan, Jianping Guo, Changjun Shao, Yin Su, Fanlei Hu, Xiaolin Sun, Jun Yu, Yu Kang, Zhanguo Li
Summary: This study reveals the imbalance between butyrate-producing and butyrate-consuming species in rheumatoid arthritis patients. It shows that butyrate promotes the production of T-regs and reduces inflammation. Butyrate supplementation can alleviate inflammation by rebalancing immune cells and reducing antibody production.
Article
Biochemistry & Molecular Biology
Dzhemal Moten, Ivanka Teneva, Desislava Apostolova, Tsvetelina Batsalova, Balik Dzhambazov
Summary: This study investigated the pathogenesis of rheumatoid arthritis (RA) by exploring the molecular mimicry mechanism. It found that the bacterial peptide L-ASNase67-81 can mimic the immunodominant T-cell epitope CII259-273, activate specific T cells, and induce cytokine production in cells from RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Marlina O. Cordoba-Moreno, Mariana Trivilin Mendes, Regina P. Markus, Pedro Augusto Fernandes
Summary: Chronic inflammatory diseases are influenced by causal stimuli and the activation of the immune-pineal axis (IPA) may play a role in determining disease susceptibility. The murine model of collagen-induced arthritis provides insights into the different responses of resistant and susceptible animals. Imbalances in the levels of melatonin and corticosterone, as well as cytokine production, may contribute to the development of rheumatoid arthritis.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Immunology
Qiong Wang, Qinbin Ye, Xiaoyu Xi, Xiaoxue Cao, Xing Wang, Mengxiao Zhang, Yuan Xu, Tingting Deng, Xiaobing Deng, Guoqiang Zhang, Cheng Xiao
Summary: This study explored the association between RIPK1-dependent necroptosis and the pathogenesis of rheumatoid arthritis (RA), and identified a potential new treatment option. The plasma levels of RIPK1 and MLKL were found to be higher in RA patients and positively correlated with disease severity. Treatment with KW2449, a small molecule inhibitor targeting RIPK1, reduced joint inflammation and tissue damage in an animal model of RA. These findings suggest that RIPK1-dependent necroptosis could be a therapeutic target for RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jinyu Li, Qi Sun, Chenying Zheng, Chunxiao Bai, Chuyin Liu, Xueqian Zhao, Peiying Deng, Limin Chai, Yusong Jia
Summary: This study found that LXA4 could protect CIA mice by inhibiting p38 MAPK pathway, reducing synoviocyte proliferation, decreasing inflammatory cytokine levels, alleviating oxidative stress, and easing arthritis severity.
BIOCHEMICAL GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Ju-Eun Hong, Chang-Gun Lee, Soonjae Hwang, Junyoung Kim, Minjeong Jo, Da-Hye Kang, Sang-Hyeon Yoo, Woo-Seung Kim, Yongheum Lee, Ki-Jong Rhee
Summary: This study found that pulsed electromagnetic field (PEMF) can alleviate inflammation in rheumatoid arthritis (RA), particularly at a frequency of 10 Hz. The treated mice had lower levels of joint inflammation and IL-1 beta. The results suggest that PEMF treatment can preserve joint morphology and delay the occurrence of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Qixing Li, Yanpeng Li, Bibo Liang, Rui Xu, Bingze Xu, Erik Lonnblom, Hui Feng, Jing'an Bai, Roma Stawikowska, Changrong Ge, Aiping Lu, Gregg B. Fields, Lianbo Xiao, Rikard Holmdahl
Summary: The study found that anti-citrullinated protein antibodies (ACPA) from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) have the ability to specifically bind to arthritic cartilage.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Shibendra Kumar Lal Karna, Faiz Ahmad, Bilal Ahmad Lone, Yuba Raj Pokharel
Article
Chemistry, Medicinal
Rajesh Gour, Faiz Ahmad, Santosh Kumar Prajapati, Santosh Kumar Giri, Shibendra Kumar Lal Karna, K. P. Ravindranathan Kartha, Yuba Raj Pokharel
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Yong Pil Hwang, Seong Su Won, Sun Woo Jin, Gi Ho Lee, Thi Hoa Pham, Jae Ho Choi, Keon Wook Kang, Hye Gwang Jeong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Sun Woo Jin, Hoa Thi Pham, Jae Ho Choi, Gi Ho Lee, Eun Hee Han, Young Ho Cho, Young Chul Chung, Young Ho Kim, Hye Gwang Jeong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Kyeong Seok Kim, Na Yoon Kim, Ji Yeon Son, Jae Hyeon Park, Su Hyun Lee, Hae Ri Kim, Boomin Kim, Yoon Gyoon Kim, Hye Gwang Jeong, Byung Mu Lee, Hyung Sik Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Toxicology
Jung Dae Lee, Hyang Yeon Kim, Keunsoo Kang, Hye Gwang Jeong, Mi-Kyung Song, In Hwan Tae, Su Hyun Lee, Hae Ri Kim, Kyuhong Lee, Sehyun Chae, Daehee Hwang, Suhkmann Kim, Hyung Sik Kim, Kyu-Bong Kim, Byung-Mu Lee
ARCHIVES OF TOXICOLOGY
(2020)
Article
Pharmacology & Pharmacy
Jangho Lee, Ju-Yong Hyon, Jin Young Min, Yang Hoon Huh, Hyo Jung Kim, Hayoung Lee, Sung Ho Yun, Chi-Won Choi, Su Jeong Ha, Joon Park, Young-Ho Chung, Hye Gwang Jeong, Sang Keun Ha, Sung Keun Jung, YoonSook Kim, Eun Hee Han
PHARMACOLOGICAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Chung Hyo Kang, Yeongrin Kim, Heung Kyoung Lee, So Myoung Lee, Hye Gwang Jeong, Sang Un Choi, Chi Hoon Park
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Jae Ho Choi, Sun Woo Jin, Gi Ho Lee, Eun Hee Han, Yong Pil Hwang, Hye Gwang Jeong
Summary: Rutaecarpine shows protective effects against acetaminophen-induced liver toxicity by reducing liver damage indicators, inhibiting inflammatory cytokine expression, and enhancing antioxidant enzyme activity, indicating its great therapeutic potential in treating liver injury.
Article
Biochemistry & Molecular Biology
Santie Li, Myeong-Ji Kim, Sung-Ho Lee, Litai Jin, Weitao Cong, Hye-Gwang Jeong, Kwang-Youl Lee
Summary: The research revealed the crucial role of MT3 in osteoblast differentiation in C2C12 cells, where overexpression of MT3 promoted cell differentiation and reduced ROS production, while MT3 knockdown showed the opposite effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Witty Tyagi, Vivek Pandey, Yuba Raj Pokharel
Summary: RNAs play important roles in cells, and their functions can be supported by chemical modifications. Recent research has shown that glycan modifications on the surface of RNA can affect cellular responses and phenotypes, leading to a paradigm shift in RNA biology.
CANCER GENE THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Sun Woo Jin, Gi Ho Lee, Ji Yeon Kim, Chae Yeon Kim, Young Moo Choo, Whajung Cho, Jae Ho Choi, Eun Hee Han, Yong Pil Hwang, Hye Gwang Jeong
Summary: This study demonstrates the potential of porcine whole-blood protein hydrolysate (PWBPH) in enhancing exercise endurance and promoting muscle differentiation. PWBPH can be utilized as an effective resource to improve exercise function and muscle development.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Sun Woo Jin, Gi Ho Lee, Ji Yeon Kim, Chae Yeon Kim, Young Moo Choo, Whajung Cho, Eun Hee Han, Yong Pil Hwang, Yong An Kim, Hye Gwang Jeong
Summary: This study found that porcine whole-blood protein hydrolysates (PWBPH) can enhance exercise performance by promoting slow-twitch muscle fiber expression and mitochondrial function, possibly through the AMPK/SIRT1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Sun Woo Jin, Gi Ho Lee, Min Jung Jang, Gyeong Eun Hong, Jae Young Kim, Gi Deok Park, Hui Jin, Hyun Su Kim, Chul Yung Choi, Jae Ho Choi, Su Gwon Lee, Hye Gwang Jeong, Yong Pil Hwang
Article
Integrative & Complementary Medicine
Dhani Raj Chhetri, Abhijit Chhetri, Nerina Shahi, Snigdha Tiwari, Shibendra Kumar Lal Karna, Dorjay Lama, Yuba Raj Pokharel
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2020)