Article
Biochemistry & Molecular Biology
Quang Luu Quoc, Youngwoo Choi, Tra Cao Thi Bich, Eun-Mi Yang, Yoo Seob Shin, Hae-Sim Park
Summary: S100A9 is a potential serum biomarker and therapeutic target for neutrophilic asthma. Patients with neutrophilic asthma had higher levels of S100A9 protein in their blood, which could be used as a potential biomarker and therapeutic target.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Immunology
Cancan Zhang, Huisha Xu, Keilah G. Netto, Leon A. Sokulsky, Yiyan Miao, Zhongyuan Mo, Yan Meng, Yingying Du, Chengyong Wu, Liyou Han, Lirong Zhang, Chi Liu, Guojun Zhang, Fuguang Li, Ming Yang
Summary: In this study, the therapeutic potential of GGsTop, a γ-glutamyl transferase inhibitor, on acute asthma exacerbations was investigated using a murine model. The results showed that GGsTop significantly attenuated hallmark features of asthma exacerbation, including airway hyperresponsiveness, mucus hypersecretion, collagen deposition, and expression of inflammatory cytokines. Furthermore, GGsTop restored the level of glutathione and inhibited the activation of the LPS/NFκB signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Anne-Charlotte Jonckheere, Sven F. Seys, Brecht Steelant, Tatjana Decaesteker, Kaat Dekoster, Jonathan Cremer, Ellen Dilissen, Dominique Schols, Yoichiro Iwakura, Greetje Vande Velde, Christine Breynaert, Rik Schrijvers, Jeroen Vanoirbeek, Jan L. Ceuppens, Lieven J. Dupont, Dominique M. A. Bullens
Summary: This study developed a murine model for non-allergic neutrophilic asthma and found that ILC play a key role in inducing airway hyperreactivity. ILC are also associated with inflammatory response and cytokine release.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Ajinkya R. Limkar, Caroline M. Percopo, Jamie L. Redes, Kirk M. Druey, Helene F. Rosenberg
Summary: Respiratory virus infections can have long-term effects on lung function, even after acute responses have resolved. This study found that mice developed airway hyperresponsiveness after PVM infection, persisting for several days, providing a model to explore post-viral AHR and lung dysfunction.
Article
Biochemistry & Molecular Biology
Shanshan Xu, Nan Wang, Dandan Yan, Yingjie Zhong
Summary: The study found that PE can alleviate asthma caused by obesity. In both mouse and cell experiments, PE can reduce airway inflammation and oxidative damage, as well as reduce body weight and inflammation levels in obese asthmatic mice.
MOLECULAR IMMUNOLOGY
(2023)
Article
Plant Sciences
Xin-rui Qiao, Tao Feng, Dong Zhang, Li-li Zhi, Jin-tao Zhang, Xiao-fei Liu, Yun Pan, Jia-wei Xu, Wen-Jing Cui, Liang Dong
Summary: This study found that luteolin, a flavonoid substance, can alleviate neutrophilic asthma by inhibiting the IL-36 gamma secretion-mediated MAPK pathway. These findings provide a theoretical basis for the application of luteolin in the treatment of neutrophilic asthma.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Chemistry, Applied
Wen-Chung Huang, Shu-Ju Wu, Li-Wen Fang, Tzu-Yung Lin, Chian-Jiun Liou
Summary: Phillyrin was found to alleviate airway hyperresponsiveness (AHR) and eosinophil infiltration in asthmatic mice, as well as reduce inflammatory responses in BEAS-2B cells. It also decreased serum OVA-IgE levels and Th2-associated cytokine production in asthmatic mice.
FOOD AND AGRICULTURAL IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Daniel R. Laucirica, Stephen M. Stick, Luke W. Garratt, Anthony Kicic
Summary: Persistent respiratory bacterial infections in chronic inflammatory airway diseases are often associated with neutrophil infiltration, leading to airway tissue damage. Bacteriophages are identified as alternative therapy for antimicrobial resistant airway infections.
FRONTIERS IN MEDICINE
(2022)
Article
Allergy
Yishu Xue, Wuping Bao, Yan Zhou, Qiang Fu, Huijuan Hao, Lei Han, Dongning Yin, Yingying Zhang, Xue Zhang, Min Zhang
Summary: This study investigated the correlation between small-airway dysfunction and large-airway function or inflammation in different endotypes of asthma using mouse models. Results showed that small-airway functional variables were positively correlated with large-airway function and had a stronger negative correlation with airway inflammation, mucus secretion, and responsiveness than large-airway function.
JOURNAL OF ASTHMA AND ALLERGY
(2021)
Article
Immunology
Ben A. A. Calvert, Erik J. J. Quiroz, Zareeb Lorenzana, Ngan Doan, Seongjae Kim, Christiana N. N. Senger, Jeffrey J. J. Anders, Wiliam D. D. Wallace, Matthew P. P. Salomon, Jill Henley, Amy L. L. Ryan
Summary: Neutrophils play a crucial role in the innate immune response against viral infection. Chronic airway neutrophilia is associated with severe COVID-19 cases. COVID-19 infection leads to epithelial pathologies and the activation of neutrophils.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Respiratory System
Cassandra Spector, Camden M. De Sanctis, Reynold A. Panettieri Jr, Cynthia J. Koziol-White
Summary: Rhinovirus infections can lead to airway remodeling, which is characterized by irreversible airway obstruction and diminished responsiveness to bronchodilators. Structural cells of the airways, including epithelial cells, smooth muscles, fibroblasts, myofibroblasts, and lung vascular endothelial cells, play a role in this process by producing various mediators and components that contribute to airway remodeling. Rhinovirus exposure can induce airway hyperresponsiveness and remodeling phenotypes such as mucus hypersecretion, epithelial-mesenchymal transition, and fibroblast-myofibroblast transdifferentiation. Different cellular responses to rhinovirus infection can lead to persistent airway remodeling in asthmatic individuals, including exaggerated type 2 inflammation, increased extracellular matrix deposition, and enhanced production of pro-angiogenic mediators.
RESPIRATORY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Brandon W. Lewis, Maria L. Ford, Aiman Q. Khan, Joshua Walum, Rodney D. Britt
Summary: Type 2-high severe asthma is a distinct subtype characterized by Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. Acute and chronic allergen models induce type 2 inflammation, but the differences in corticosteroid sensitivity remain unclear. This study found that chronic allergen exposure is associated with more persistent type 2 immune responses and corticosteroid insensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Bodie Curren, Tufael Ahmed, Daniel R. Howard, Md. Ashik Ullah, Ismail Sebina, Ridwan B. Rashid, Md. Al Amin Sikder, Patricia Namubiru, Alec Bissell, Sylvia Ngo, David J. Jackson, Marie Toussaint, Michael R. Edwards, Sebastian L. Johnston, Henry J. McSorley, Simon Phipps
Summary: Rhinvovirus-induced neutrophils and IL-33 play important roles in acute asthma exacerbations, and blocking IL-33 release can alleviate the severity of the exacerbation by attenuating neutrophil recruitment and the generation of NETs.
MUCOSAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chi-Chien Lin, Kai-Cheng Chuang, Shih-Wei Chen, Ya-Hsuan Chao, Chih-Ching Yen, Shang-Hsun Yang, Wei Chen, Kuang-Hsi Chang, Yu-Kang Chang, Chuan-Mu Chen
Summary: Lactoferrin exhibits anti-inflammation and immunoregulation activities in OVA-induced allergic asthma, ameliorating lung injury, decreasing Th2 cytokines and allergen-specific antibodies production, and influencing the functions of dendritic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wei Li, Lu Xue, Changsi Peng, Ping Zhao, Yongbo Peng, Weiwei Chen, Wenyi Wang, Jinhua Shen
Summary: PP121 exerts dual anti-contractile and anti-inflammatory effects in asthma treatment by blocking specific ion channels and downregulating inflammatory factors, mucins, and the MAPK/Akt signaling pathway in asthmatic mice, suggesting it as a promising therapeutic compound for asthma therapy.
MOLECULAR MEDICINE
(2023)
