Review
Immunology
Shicheng Sun, Kevin Wijanarko, Oniko Liani, Kathleen Strumila, Elizabeth S. Ng, Andrew G. Elefanty, Edouard G. Stanley
Summary: Lymphoid cells, including T cells, B cells, NKT cells, and ILCs, play important roles in both adaptive and innate immune systems. While it is believed that these cells derive from HSCs in adult bone marrow, their ontogeny during embryogenesis is complex and involves progenitor cells predating the emergence of HSCs. Recent advancements in single cell RNA-sequencing and pluripotent stem cell-based developmental models provide new insights into lymphoid development and offer potential for clinical translation.
IMMUNOLOGICAL REVIEWS
(2023)
Editorial Material
Cell Biology
Tomoyuki Fukuda, Kazuhiro Shiozaki
Summary: The GATOR2 component Sea3 in fission yeast unexpectedly acts as part of GATOR1 to suppress TORC1. In fission yeast, GATOR1 is not required for amino acid starvation-induced TORC1 attenuation, which is mediated by the Gcn2 pathway. Absence of a nitrogen source suppresses TORC1 through GATOR1 and the Tsc1-Tsc2 complex.
Article
Cell Biology
Marc Bayer, Soren Boller, Senthilkumar Ramamoothy, Nikolay Zolotarev, Pierre Cauchy, Norimasa Iwanami, Gerhard Mittler, Thomas Boehm, Rudolf Grosschedl
Summary: The study identified the nuclear import receptor Transportin-3 (Tnpo3) as an important regulator of the transcription factor EBF1, which plays a key role in B cell development. Tnpo3 ensures proper programming of B cells in nonpermissive conditions.
GENES & DEVELOPMENT
(2022)
Article
Multidisciplinary Sciences
Geunhyo Jang, Stephania Contreras Castillo, Eduardo Esteva, Samik Upadhaya, Jue Feng, Nicholas M. Adams, Elodie Richard, Rajeshwar Awatramani, Catherine M. Sawai, Boris Reizis
Summary: Mammalian aging is associated with defects in hematopoiesis, particularly in the development of T and B lymphocytes. This impairment is believed to be caused by the accumulation of hematopoietic stem cells (HSCs) with myeloid bias in the bone marrow. However, research using genetic labeling and tracing techniques showed that the HSC population in old mice had reduced differentiation into all lineages, including lymphoid cells. The partial decoupling of old HSCs from hematopoiesis, rather than myeloid bias, was found to be the primary cause of the selective impairment of lymphopoiesis in older mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Thomas R. Jackson, Rebecca E. Ling, Anindita Roy
Summary: Human B-lymphopoiesis is a dynamic life-long process that starts in utero and continues to change throughout postnatal life. Understanding fetal B-lymphopoiesis is crucial for comprehending normal B-lymphoid development and its relevance to disease, particularly in childhood leukemia.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Qi Zhang, Bingyan Wu, Qitong Weng, Fangxiao Hu, Yunqing Lin, Chengxiang Xia, Huan Peng, Yao Wang, Xiaofei Liu, Lijuan Liu, Jiapin Xiong, Yang Geng, Yalan Zhao, Mengyun Zhang, Juan Du, Jinyong Wang
Summary: The expression of three essential factors in PSCs enables the commitment to B lineage fate and in vivo B lymphopoiesis. The regenerated B cells produced adaptive humoral immune responses and formed immune memory in response to antigen challenges. This study provides insights into treating B cell-related deficiencies using PSCs as an unlimited cell resource.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Encarnacion Montecino-Rodriguez, Kenneth Dorshkind
Summary: Traditional models of lymphopoiesis present B and T cell development as a linear process, but studies have shown that the types of lymphocytes generated before and after birth differ. This review synthesizes data from multiple laboratories, including our own work using mouse models, and demonstrates that innate and conventional B and T cells emerge in different ways and are regulated differently. Understanding this layering of lymphocyte development has implications for the composition of the adult immune system and the origin of lymphocytic leukemias.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Immunology
Diannita Kwang, Gavin Tjin, Louise E. Purton
Summary: B lymphopoiesis in adult mice involves interactions with non-hematopoietic cells in the bone marrow and spleen, which provide signals for migration, maturation, and survival. Conditional knockout and transgenic mouse models have revealed the roles of distinct microenvironment cell types in regulating B lymphopoiesis. Single cell RNA-seq studies have also identified clusters of stromal cell types in these organs, aiding in the identification of key regulators of B lymphopoiesis.
IMMUNOLOGICAL REVIEWS
(2021)
Article
Gastroenterology & Hepatology
Yung-Tuen Chiu, Abdullah Husain, Karen Man-Fong Sze, Daniel Wai-Hung Ho, Eliana Mary Senires Suarez, Xia Wang, Eva Lee, Hoi-Tang Ma, Joyce Man-Fong Lee, Lo-Kong Chan, Irene Oi-Lin Ng
Summary: This study identified Mid-line 1 interacting protein 1 (MID1IP1) as a key gene in the metastasis of hepatocellular carcinoma (HCC). It was found that MID1IP1 promoted HCC migration and invasion by upregulating FOS like 1 (FRA1) and subsequently activating MMP9 signaling. Targeting the MID1IP1-mediated FRA1 pathway may be a potential therapeutic strategy against HCC progression.
Article
Biochemistry & Molecular Biology
Rachel Johnston, Brendan Mathias, Stephanie J. Crowley, Haley A. Schmidt, Lynn S. White, Nima Mosammaparast, Abby M. Green, Jeffrey J. Bednarski
Summary: Developing B cells generate DNA double-stranded breaks (DSBs) to assemble immunoglobulin receptor (Ig) genes necessary for the expression of a mature B cell receptor. RAG-mediated DSBs in pre-B cells activate the ATM kinase, coordinating canonical and non-canonical DDR and triggering DSB repair and B cell developmental signals. Unique properties of the RAG endonuclease regulate the distinct cellular responses to RAG DSBs in B cells.
Review
Immunology
Laurianne Scourzic, Eralda Salataj, Effie Apostolou
Summary: This review highlights the importance of high-order 3D chromatin organization in regulating gene expression, DNA recombination, and cell fate decisions in lymphocyte development and activation. The interconnections between architectural, epigenetic, and transcriptional changes are discussed, along with the major key players in genomic organization in B/T lymphocytes. Furthermore, the link between alterations in architectural factors and 3D genome organization to dysregulation of the lymphopoietic transcriptional program and hematological malignancies is presented.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tobias Riedl, Suzanne Faure-Dupuy, Maude Rolland, Svenja Schuehle, Zohier Hizir, Silvia Calderazzo, Xiaodong Zhuang, Jochen Wettengel, Martin Alexander Lopez, Romain Barnault, Valbona Mirakaj, Sandra Prokosch, Danijela Heide, Corinna Leuchtenberger, Martin Schneider, Bernd Hessling, Benjamin Stottmeier, Isabel M. Wessbecher, Peter Schirmacher, Jane A. McKeating, Ulrike Protzer, David Durantel, Julie Lucifora, Emmanuel Dejardin, Mathias Heikenwalder
Summary: The stabilization of HIF1 alpha was found to inhibit the expression of APOBEC3B and its antiviral effects against HBV. Inhibiting the expression or stabilization of HIF1 alpha could serve as an anti-HBV strategy. High levels of HIF1 alpha may provide a reservoir for HBV survival in immune-active patients, and therefore should be considered as a constraining factor in the development of immune therapies.
Review
Immunology
Yoshiki Omatsu, Takashi Nagasawa
Summary: Most blood cells, including immune cells, are generated from hematopoietic stem cells in bone marrow, which require specialized microenvironments called niches; recent studies have identified CAR cells as the major component of niches for HSCs and lymphoid progenitors, expressing high levels of critical niche factors and functioning as self-renewing mesenchymal stem cells. The findings provide insights into the interaction between hematopoietic cells and microenvironments in health and disease.
INTERNATIONAL IMMUNOLOGY
(2021)
Review
Immunology
Qing Min, Krisztian Csomos, Yaxuan Li, Lulu Dong, Ziying Hu, Xin Meng, Meiping Yu, Jolan E. Walter, Ji-Yang Wang
Summary: Mutations in RAG1 and RAG2 genes in humans are associated with various clinical phenotypes, ranging from severe combined immunodeficiency to immune dysregulation. Partial RAG deficiency often leads to hyperinflammation and autoimmunity, with intrinsic and extrinsic mechanisms causing a break in tolerance during T and B cell development. This review focuses on the recently described tolerance break, B cell abnormalities, and the molecular and cellular mechanisms of autoantibody production in patients with partial RAG deficiency.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Chelliah Anuradha, Arumugam Chandrasekar, Suthanthiram Backiyarani, Raman Thangavelu, Palaniappan Giribabu, Subbaraya Uma
Summary: This study provides valuable insights into the PR-1 gene family in banana, revealing their potential role in response to various stresses. The findings contribute to a better understanding of PR-1 gene functions and can be utilized in developing stress-tolerant banana varieties.
Article
Biochemical Research Methods
Sabine Tricot, Mickael Meyrand, Chiara Sammicheli, Jamila Elhmouzi-Younes, Aurelien Corneau, Sylvie Bertholet, Marie Malissen, Roger Le Grand, Sandra Nuti, Herve Luche, Antonio Cosma
Article
Immunology
Laurence Ardouin, Herve Luche, Rabie Chelbi, Sabrina Carpentier, Alaa Shawket, Frederic Montanana Sanchis, Camille Santa Maria, Pierre Grenot, Yannick Alexandre, Claude Gregoire, Anissa Fries, Thien-Phong Vu Manh, Samira Tamoutounour, Karine Crozat, Elena Tomasello, Audrey Jorquera, Even Fossum, Bjarne Bogen, Hiroaki Azukizawa, Marc Bajenoff, Sandrine Henri, Marc Dalod, Bernard Malissen
Article
Biochemical Research Methods
Andre P. Heinen, Florian Wanke, Sonja Moos, Sebastian Attig, Herve Luche, Prajna Paramita Pal, Nediljko Budisa, Hans Joerg Fehling, Ari Waisman, Florian C. Kurschus
Article
Immunology
Leila Ben Merzoug, Solenne Marie, Naoko Satoh-Takayama, Sarah Lesjean, Marcello Albanesi, Herve Luche, Hans Joerg Fehling, James P. Di Santo, Christian A. J. Vosshenrich
EUROPEAN JOURNAL OF IMMUNOLOGY
(2014)
Article
Immunology
Takahisa Miyao, Stefan Floess, Ruka Setoguchi, Herve Luche, Hans Joerg Fehling, Herman Waldmann, Jochen Huehn, Shohei Hori
Article
Immunology
Samantha L. Bailey-Bucktrout, Marc Martinez-Llordella, Xuyu Zhou, Bryan Anthony, Wendy Rosenthal, Herve Luche, Hans J. Fehling, Jeffrey A. Bluestone
Article
Immunology
Samira Tamoutounour, Martin Guilliams, Frederic Montanana Sanchis, Hong Liu, Dorothea Terhorst, Camille Malosse, Emeline Pollet, Laurence Ardouin, Herve Luche, Cindy Sanchez, Marc Dalod, Bernard Malissen, Sandrine Henri
Article
Cell Biology
Dean Franckaert, James Dooley, Evelyne Roos, Stefan Floess, Jochen Huehn, Herve Luche, Hans Joerg Fehling, Adrian Liston, Michelle A. Linterman, Susan M. Schlenner
IMMUNOLOGY AND CELL BIOLOGY
(2015)
Article
Immunology
Herve Luche, Tata Nageswara Rao, Suresh Kumar, Alpaslan Tasdogan, Franziska Beckel, Carmen Blum, Vera C. Martins, Hans-Reimer Rodewald, Hans Joerg Fehling
JOURNAL OF EXPERIMENTAL MEDICINE
(2013)
Article
Immunology
Clement Ghigo, Isabelle Mondor, Audrey Jorquera, Jonathan Nowak, Stephan Wienert, Sonja P. Zahner, Bjoern E. Clausen, Herve Luche, Bernard Malissen, Frederick Klauschen, Marc Bajenoff
JOURNAL OF EXPERIMENTAL MEDICINE
(2013)
Article
Immunology
Yumiko Nishikawa, Hitoshi Nishijima, Minoru Matsumoto, Junko Morimoto, Fumiko Hirota, Satoru Takahashi, Herve Luche, Hans Joerg Fehling, Yasuhiro Mouri, Mitsuru Matsumoto
JOURNAL OF IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Go Muto, Hitoshi Kotani, Taisuke Kondo, Rimpei Morita, Sanae Tsuruta, Takashi Kobayashi, Herve Luche, Hans Joerg Fehling, Matthew Walsh, Yongwon Choi, Akihiko Yoshimura
Article
Multidisciplinary Sciences
Robin Cloarec, Sylvian Bauer, Herve Luche, Emmanuelle Buhler, Emilie Pallesi-Pocachard, Manal Salmi, Sandra Courtens, Annick Massacrier, Pierre Grenot, Natacha Teissier, Francoise Watrin, Fabienne Schaller, Homa Adle-Biassette, Pierre Gressens, Marie Malissen, Thomas Stamminger, Daniel N. Streblow, Nadine Bruneau, Pierre Szepetowski
Article
Multidisciplinary Sciences
Clement Ricard, Aurelie Tchoghandjian, Herve Luche, Pierre Grenot, Dominique Figarella-Branger, Genevieve Rougon, Marie Malissen, Franck Debarbieux
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Cyrille Mionnet, Isabelle Mondor, Audrey Jorquera, Marie Loosveld, Julien Maurizio, Marie-Laure Arcangeli, Nancy H. Ruddle, Jonathan Nowak, Michel Aurrand-Lions, Herve Luche, Marc Bajenoff