Review
Immunology
Delphine C. Malherbe, Ilhem Messaoudi
Summary: Drinking alcohol, even in moderation, can have disproportionate effects on the immune system, particularly on myeloid cells. These effects depend on the pattern of alcohol exposure, with acute drinking dampening inflammatory mediators and chronic drinking enhancing their production. Alcohol's impact on myeloid cells is thought to be mediated by oxidative stress and changes in cellular epigenetic landscapes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
P. Vishnyakova, A. Poltavets, E. Karpulevich, A. Maznina, V. Vtorushina, L. Mikhaleva, E. Kananykhina, A. Lokhonina, S. Kovalchuk, A. Makarov, A. Elchaninov, G. Sukhikh, T. Fatkhudinov
Summary: Macrophages play a crucial role in innate immunity and are activated by various factors. This study found that macrophages derived from CD14+ monocytes exhibit higher sensitivity to pro-inflammatory induction, showing increased levels of pro-inflammatory and anti-inflammatory cytokines compared to CD16+-derived macrophages. This data may be valuable for macrophage-based cell therapy applications, providing insights for manipulating donor monocytes for transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Genetics & Heredity
Gilson P. Dorneles, Paula C. Teixeira, Alessandra Peres, Luiz Carlos Rodrigues Junior, Simone Goncalves da Fonseca, Marta Chagas Monteiro, Sarah Eller, Tiago F. Oliveira, Eliana M. Wendland, Pedro R. T. Romao
Summary: Higher levels of endotoxin and systemic inflammatory markers were found in severe COVID-19 patients compared to healthy controls and mild COVID-19 patients. Severe COVID-19 patients also exhibited higher levels of inflammatory cytokines and altered monocyte populations. The response to endotoxin stimulation differed between severe COVID-19 patients and controls, with lower cytokine production but higher levels of PGE-2.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Immunology
Sloan A. Lewis, Suhas Sureshchandra, Brianna Doratt, Vanessa A. Jimenez, Cara Stull, Kathleen A. Grant, Ilhem Messaoudi
Summary: Chronic heavy drinking can alter classical monocyte subset composition, leading to a hyper-inflammatory response to LPS but a compromised response to pathogens. This dysregulated inflammatory response may increase susceptibility to infections and impair wound healing.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Hematology
Ana T. A. Sachetto, Nigel Mackman
Summary: The coagulation system is activated by bacterial lipopolysaccharide (LPS) and contributes to host defense. LPS induces expression of tissue factor (TF) in monocytes, leading to activation of the coagulation cascade. However, excessive activation of coagulation can lead to thrombosis. This review examines the mechanism of TF induction by LPS and its role in thrombosis and disseminated intravascular coagulation.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Multidisciplinary Sciences
Iti Saraav, Luisa Cervantes-Barragan, Philipp Olias, Yong Fu, Qiuling Wang, Leran Wang, Yi Wang, Matthias Mack, Megan T. Baldridge, Thaddeus Stappenbeck, Marco Colonna, L. David Sibley
Summary: Oral infection with Toxoplasma gondii exacerbates damage to the colon caused by chemical irritant and impairs wound healing by suppressing stem cell regeneration. Enhanced tissue damage is due to inflammatory monocytes releasing inflammatory mediators.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Chelsea E. Bray, Kristina G. Witcher, Dunni Adekunle-Adegbite, Michelle Ouvina, Mollie Witzel, Emma Hans, Zoe M. Tapp, Jonathan Packer, Ethan Goodman, Fangli Zhao, Titikorn Chunchai, Shane ONeil, Siriporn C. Chattipakorn, John Sheridan, Olga N. Kokiko-Cochran, Candice Askwith, Jonathan P. Godbout
Summary: Traumatic brain injury (TBI) is associated with chronic inflammation and neuropathology, which can be alleviated through turnover of trauma-associated microglia. Microglia turnover improves functional recovery and reduces immune reactivity to challenges. This study highlights the importance of targeting microglia in TBI treatment.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Virology
Elena K. Kokinos, Sergey A. Tsymbal, Anastasia V. Galochkina, Svetlana A. Bezlepkina, Julia V. Nikolaeva, Sofia O. Vershinina, Anna A. Shtro, Victor V. Tatarskiy, Alexander A. Shtil, Eugenia V. Broude, Igor B. Roninson, Marina Dukhinova
Summary: Hyperactivation of the immune system is a life-threatening complication in viral and bacterial infections, especially pneumonia. This study found that a selective CDK8/19 inhibitor, Senexin B, could suppress the inflammatory response of monocytic cells to H1N1 influenza virus and bacterial lipopolysaccharides, reducing inflammation symptoms.
Article
Biochemistry & Molecular Biology
Valerie Pireaux, Cedric Delporte, Alexandre Rousseau, Jean-Marc Desmet, Pierre Van Antwerpen, Martine Raes, Karim Zouaoui Boudjeltia
Summary: Hemodialyzed patients exhibit significantly higher concentrations of inflammatory biomarkers such as CRP, M-CSF, and IL-8, as well as myeloperoxidase-associated oxidative stress biomarkers like chloro-tyrosine and homocitrulline. In addition, there is a greater percentage of M2 monocytes in the plasma of hemodialysis patients compared to controls.
Article
Immunology
Ioanna Pantazi, Ahmed A. Al-Qahtani, Fatimah S. Alhamlan, Hani Alothaid, Sabine Matou-Nasri, George Sourvinos, Eleni Vergadi, Christos Tsatsanis
Summary: The major cause of death in SARS-CoV-2 infected patients is deregulation of the innate immune system and development of cytokine storm. SARS-CoV-2 S protein can induce pro-inflammatory cytokine production in macrophages, potentially exacerbating inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Alessanda S. Rieder, Angela T. S. Wyse
Summary: Despite the development of vaccines and their importance, the SARS-CoV-2 pandemic continues to have a global impact. COVID-19 severity is associated with the cytokine storm phenomenon and inflammation. The nicotinic cholinergic system, specifically the nicotinic receptor alpha 7 (nAchRα7), has been linked to COVID-19 due to its protective role in inflammation. Additionally, the spike protein subunits of SARS-CoV-2 can interact with nAchRα7 and induce toll-like receptor (TLR) activation, leading to pro- and anti-inflammatory responses. This article discusses the role of IRAK-M and microglia phenotype in the inflammatory cell response to SARS-CoV-2 infection when the cholinergic system is constantly activated via nAchRα7.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Hematology
Theodoros Kelesidis, Madhav Sharma, Eashan Sharma, Isabelle Ruedisueli, Elizabeth Tran, Holly R. Middlekauff
Summary: The use of electronic cigarettes (ECIGs) may increase vulnerability to future atherosclerotic cardiovascular disease due to changes in circulating factors. Monocyte transendothelial migration and monocyte-derived foam cell formation were higher in ECIG users and tobacco cigarette (TCIG) smokers compared to nonsmokers. However, these alterations were less severe in ECIG users compared to TCIG smokers.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Chemistry, Medicinal
Nora Kirsten, Julia Ohmes, Maria Dalgaard Mikkelsen, Thuan Thi Nguyen, Martina Bluemel, Fanlu Wang, Deniz Tasdemir, Andreas Seekamp, Anne S. Meyer, Sabine Fuchs
Summary: Fucoidans, sulfated and fucose-rich polysaccharides from brown seaweed, have multiple promising biological effects, including anti-inflammatory properties. In this study, high molecular weight (HMW) fucoidan extract with higher purity was found to reduce the inflammatory response of endothelial cells in cases of LPS-induced bacterial infection, indicating their potential use as an anti-inflammatory agent.
Article
Immunology
Kisha Pradhan, Shuo Geng, Yao Zhang, Rui-Ci Lin, Liwu Li
Summary: The study reveals a competing intracellular circuitry involving TRAM and IRAK-M that modulate the polarization of low-grade inflammatory monocytes with an immune-enhancing function. They found that subclinical superlow-dose LPS can trigger the expression of CD40 and CD11a on these monocytes, leading to an exacerbation of the inflammatory environment conducive for chronic diseases. Additionally, mice with IRAK-M deficiency have increased inflammatory monocytes population and reduced CD8 T regulatory cells, while mice with TRAM deficiency exhibit the opposite effect.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Cecilia Rosel-Pech, Sandra Pinto-Cardoso, Monserrat Chavez-Torres, Nadia Montufar, Ivan Osuna-Padilla, Santiago Avila-Rios, Gustavo Reyes-Teran, Charmina Aguirre-Alvarado, Norma Angelica Matias Juan, Hector Perez-Lorenzana, Jose Guillermo Vazquez-Rosales, Vilma Carolina Bekker-Mendez
Summary: The gut microbiota of children perinatally-infected with HIV (CLWH) appears similar to that of HIV-unexposed and -uninfected children (HUU), and most markers of HIV disease progression are normalized with long-term antiretroviral therapy (ART), suggesting a beneficial effect of ART on the gut microbial ecology. The relationship between exhausted and activated CD4+ T cells and Proteobacteria suggests a connection between the gut microbiome and premature aging in CLWH.
FRONTIERS IN IMMUNOLOGY
(2023)