Article
Immunology
Aditya Arra, Holger Lingel, Mandy Pierau, Monika C. C. Brunner-Weinzierl
Summary: PD-1 plays a crucial role in suppressing the differentiation and function of Tc17 cells, and blockade of PD-1 can effectively enhance tumor immune response. PD-1 signaling inhibits the expression of IL-17 and related transcription factors in Tc17 cells, and also suppresses the expression of IL-21 and IL-23 receptors specific to Tc17 cells. Inhibition of PD-1 leads to the conversion of Tc17 cells into Tc1 cells, which possess tumor control characteristics.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Hematology
Alan H. Lazarus, John W. Semple
Summary: A study found that patients with chronic ITP have clonal expansions of a specific subset of CD8 T cells called terminally differentiated effector memory (TEMRA) T cells. These cells persist over the course of the disease, are more prominent in refractory ITP, and are more prevalent when the platelet count is low.
Article
Cardiac & Cardiovascular Systems
Janine van Duijn, Maaike J. M. de Jong, Naomi Benne, Romain J. T. Leboux, Marieke E. van Ooijen, Nicky Kruit, Amanda C. Foks, Wim Jiskoot, Ilze Bot, Johan Kuiper, Bram Slutter
Summary: In an atherosclerotic mouse model, a lesion-localized increase in Tc17 cells was found. Tc17 cells appeared to be non-atherogenic compared to their Tc0 counterparts.
CARDIOVASCULAR RESEARCH
(2021)
Article
Oncology
Takayuki Ohkuri, Akemi Kosaka, Maki Ikeura, Andres M. Salazar, Hideho Okada
Summary: While adoptive transfer of T-cells has been successful for B cell malignancies, developing effective T-cell-based immunotherapy for CNS tumors like glioblastoma remains challenging. Tc17-1 cells, which produce both IL-17 and IFN-gamma, showed promising results in combination with poly-ICLC and peptide vaccine treatment in a preclinical GBM model.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Miko Valori, Joonas Lehikoinen, Lilja Jansson, Jonna Clancy, Sofie A. Lundgren, Satu Mustjoki, Pentti Tienari
Summary: Somatic mutations in the STAT3 SH2 domain are found in CD8+ cells in multiple sclerosis (MS) patients and controls, with a prevalence of 26%. The mutations are associated with older age and lower neutrophil counts. There is no significant difference in the mutation prevalences between MS patients and controls.
Article
Allergy
Jared Liu, Hsin-Wen Chang, Zhi-Ming Huang, Mio Nakamura, Sahil Sekhon, Richard Ahn, Priscila Munoz-Sandoval, Shrishti Bhattarai, Kristen M. Beck, Isabelle M. Sanchez, Eric Yang, Mariela Pauli, Sarah T. Arron, Wai-Ping Fung-Leung, Ernesto Munoz, Xuejun Liu, Tina Bhutani, Jeffrey North, Anne M. Fourie, Michael D. Rosenblum, Wilson Liao
Summary: This study utilized single-cell RNA sequencing to compare the transcriptomic heterogeneity of CD8(+) T cells in psoriatic and healthy skin, identifying several inflammatory subsets enriched in psoriatic skin and two Tc17 cell subsets associated with disease severity. Despite high expression of coinhibitory receptors, the psoriatic Tc17 cells exhibited upregulated cytokine, cytolytic, and metabolic activity, distinguishing them from an exhaustion program observed in melanoma-infiltrating CD8(+) T cells.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Chiung-Hui Liu, Bo-Shiou Lin, Mei-Yao Wu, Ying-Chyi Song, Tao-Wei Ke, Yu-Lun Chou, Chuan-Teng Liu, Chia-Hsin Lin, Vedran Radojcic, Charles Drake, Hung-Rong Yen
Summary: The IL-4/AKT/Eomes/Trat1 axis promotes the transformation of Tc17 cells into therapeutic cytotoxic effectors. IL-4 priming can be used as a cell therapy engineering strategy to enhance anti-tumor responses.
Article
Immunology
Sara Quon, Bingfei Yu, Brendan E. Russ, Kirill Tsyganov, Hongtuyet Nguyen, Clara Toma, Maximilian Heeg, James D. Hocker, J. Justin Milner, Shane Crotty, Matthew E. Pipkin, Stephen J. Turner, Ananda W. Goldrath
Summary: Using the Hi-C technique, we investigated the relationship between genome configuration and CD8+ T cell differentiation. We found that CTCF mutations can affect the expression of terminal-effector genes, indicating that CTCF not only participates in genome organization, but also regulates the diversity of effector CD8+ T cells by altering interactions that regulate the transcription factor landscape and transcriptome.
Article
Immunology
David R. Collins, Jonathan M. Urbach, Zachary J. Racenet, Umar Arshad, Karen A. Power, Ruchi M. Newman, Geetha H. Mylvaganam, Ngoc L. Ly, Xiaodong Lian, Anna Rull, Yelizaveta Rassadkina, Adrienne G. Yanez, Michael J. Peluso, Steven G. Deeks, Francesc Vidal, Mathias Lichterfeld, Xu G. Yu, Gaurav D. Gaiha, Todd M. Allen, Bruce D. Walker
Summary: Selective functional impairment of HIV-specific CD8(+) T cells may be prognostic of aborted HIV control.
Article
Immunology
Georgiana Toma, Ioana Maria Lemnian, Eliza Karapetian, Ivo Grosse, Barbara Seliger
Summary: Memory CD8(+) T cells increase with aging, leading to higher susceptibility to infections and decreased vaccine efficiency. In this study, the age-dependent expression profile of CD8(+) T cells from young and old donors was analyzed. The results showed that CD8(+)CD45RA(-) memory T cells from old donors maintained the characteristics of total CD8(+) T cells, including increased cytokine secretion and JAK-STAT pathway transcripts.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Gaia Montacchiesi, Luigia Pace
Summary: After antigen recognition, CD8(+) T lymphocytes differentiate into different subsets with distinct phenotypes, functions, and migration properties. Transcription factors and chromatin structure changes drive the functional differentiation and phenotypic diversity of these T cell subsets, which has implications for new immunotherapy protocols and vaccination strategies. Understanding the contribution of chromatin architecture and transcription factor activity in guiding CD8(+) T cell subset commitment is important for T cell plasticity, stability, and memory in infection and cancer.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
A-M Globig, A. Hipp, P. Otto-Mora, M. Heeg, L. S. Mayer, S. Ehl, H. Schwacha, M. Bewtra, V Tomov, R. Thimme, P. Hasselblatt, B. Bengsch
Summary: The T cell compartment in patients with Crohn's disease is dysregulated, and an enrichment of Tc17 cells during active disease suggests CD6 as a potential therapeutic target. The identified Tc17 signature may guide personalized treatment decisions in Crohn's disease.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Erietta Stelekati, Zhangying Cai, Sasikanth Manne, Zeyu Chen, Jean-Christophe Beltra, Lance Alec Buchness, Xuebing Leng, Svetlana Ristin, Kito Nzingha, Viktoriya Ekshyyan, Christina Niavi, Mohamed S. Abdel-Hakeem, Mohammed-Alkhatim Ali, Sydney Drury, Chi Wai Lau, Zhen Gao, Yuguang Ban, Simon K. Zhou, K. Mark Ansel, Makoto Kurachi, Martha S. Jordan, Alejandro V. Villarino, Shin Foong Ngiow, E. John Wherry
Summary: This study identifies miR-29a as a key regulator of exhausted CD8 T cells (TEX) during chronic viral infection. It shows that miR-29a improves CD8 T cell responses, inhibits exhaustion-driving transcriptional pathways, and regulates ribosomal biogenesis. As a result, miR-29a promotes a memory-like CD8 T cell differentiation state during chronic infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Marko Sustic, Maja Cokaric Brdovcak, Berislav Lisnic, Jelena Materljan, Vanda Juranic Lisnic, Carmen Rozmanic, Daniela Indenbirken, Lea Hirsl, Dirk H. Busch, Ilija Brizic, Astrid Krmpotic, Stipan Jonjic
Summary: CMV vectors have the potential to induce strong immune responses, with RAE-1 gamma MCMV showing enhanced immunoprotection against bacterial and tumor challenges. The phenotypic and functional characteristics of memory CD8 T cells induced by RAE-1 gamma MCMV were distinct compared to control vectors, with differences in cytokine production and cytotoxic potential. Adoptive transfer of cells primed with RAE-1 gamma MCMV led to efficient rejection of established tumors, highlighting the importance of latent infection and cell numbers in enhancing anti-tumor responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Vanaja Konduri, Damilola Oyewole-Said, Jonathan Vazquez-Perez, Scott A. Weldon, Matthew M. Halpert, Jonathan M. Levitt, William K. Decker
Summary: NK1.1 and its human homolog CD161 are expressed on various immune cells and play different roles in NK cells, T cells, and NKT cells. CD161-expressing CD8(+) T cells, initially studied in viral infections, have potential implications in tumor immunology, although their exact role is not well understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Applied
Chia-Lin Lee, Chien-Ming Wang, Hung-Rong Yen, Ying-Chyi Song, Chao-Jung Chen
Summary: A new indazole alkaloid, indigodole E (1), was isolated from Qing Dai, a traditional Chinese medicine. Its chemical structure was determined using various spectroscopic techniques. The compound was found to significantly inhibit the production and gene expression of IL-17A without causing cytotoxicity towards specific cells. These findings suggest that indigodole E (1) may contribute to the anti-IL-17A activity of Qing Dai.
NATURAL PRODUCT RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ying-Chyi Song, Chuan-Teng Liu, Hui-Ju Lee, Hung-Rong Yen
Summary: The study found that cordycepin treatment can prevent the occurrence of multiple sclerosis (MS) by inhibiting the activation and migration of dendritic cells, and can alleviate the progression of the disease by reducing neuroinflammation. This provides new insights for the development of treatments for MS.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Chiung-Hui Liu, Bo-Shiou Lin, Mei-Yao Wu, Ying-Chyi Song, Tao-Wei Ke, Yu-Lun Chou, Chuan-Teng Liu, Chia-Hsin Lin, Vedran Radojcic, Charles Drake, Hung-Rong Yen
Summary: The IL-4/AKT/Eomes/Trat1 axis promotes the transformation of Tc17 cells into therapeutic cytotoxic effectors. IL-4 priming can be used as a cell therapy engineering strategy to enhance anti-tumor responses.
Article
Immunology
Chuan-Teng Liu, Ying-Chyi Song, Tsai-Chen Wu, Ko-Chieh Shiung, I-Hsuan Chen, Tung-Ti Chang, Shinn-Jye Liang, Hung-Rong Yen
Summary: Studies have found that Pterostilbene (PS) can treat asthma by modulating T cell immunity and improving symptoms by inhibiting the accumulation of Th2 cells and eosinophils. PS inhibits the production of IL-4 by downregulating mTOR, GATA3, and histone acetylation. Moreover, PS attenuates HDM-induced asthma by inhibiting the Glut1/mTOR/GATA3 axis.
Article
Pediatrics
Wan-Yu Lai, David J. Kay, Chang-Ching Wei, Fen-Wei Huang, Kai-Li Liang, Hung-Rong Yen
Summary: This study translated the SN-5 questionnaire into traditional Chinese and evaluated its validity and reliability. The results showed that the traditional Chinese version of SN-5 is reliable and valid for measuring sinonasal-related quality of life in children in Chinese-speaking countries.
PEDIATRICS AND NEONATOLOGY
(2022)
Article
Endocrinology & Metabolism
Chung-Hsing Wang, Hung-Rong Yen, Wen-Li Lu, Hsieh-Hsun Ho, Wen-Yang Lin, Yi-Wei Kuo, Yen-Yu Huang, Shin-Yu Tsai, Hung-Chih Lin
Summary: This study evaluated the therapeutic efficacy of probiotics on glycated hemoglobin (HbA1c) and inflammatory cytokine levels of patients with type 1 diabetes mellitus (T1DM). The results showed that probiotics can change the gut microbiota profile of T1DM patients and significantly reduce their blood glucose levels through beneficial immune regulation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Chia-Yu Huang, Ching-Chan Lin, Ching-Yun Hsieh, Chen-Yuan Lin, Tzu-Ting Chen, Pei-Ching Wu, Dung-Huan Liu, Sio-Ian Tou, Hung-Rong Yen
Summary: This study investigated the willingness, attitudes, awareness, and knowledge of COVID-19 vaccination among elderly individuals in Taiwan. The results showed that a significant proportion of the elderly population was willing to receive COVID-19 vaccines. Older individuals who needed to visit outpatient departments and had concerns about the safety of the vaccines were less likely to accept them. Factors such as understanding the risk of infection, effectiveness of the vaccines, willingness to protect others, and perceived safety were associated with vaccine acceptance. The study highlights the importance of these factors for policymakers and medical staff in developing vaccination plans during the COVID-19 pandemic.
Review
Integrative & Complementary Medicine
Gil Ton, Chia-Hui Lin, Wen-Chao Ho, Wan-Yu Lai, Hung-Rong Yen, Yu-Chen Lee
Summary: The study shows that laser acupuncture therapy has a significant improvement in treating nocturnal enuresis. However, the quality of evidence available in the literature is relatively low, and more rigorous and higher-quality trials are needed to further investigate this treatment modality.
MEDICAL ACUPUNCTURE
(2022)
Review
Cell Biology
Chia-Yu Huang, Peter Karl Mayer, Mei-Yao Wu, Dung-Huan Liu, Pei-Ching Wu, Hung-Rong Yen
Summary: This systematic review and meta-analysis demonstrated that Tai Chi exercise can improve physical performance in elderly individuals with sarcopenia and frailty, including the 30-second chair stand test, the Timed up and go test, number of falls, and fear of falling. However, there was no significant difference in muscle mass, grip strength, gait speed, or Short Physical Performance Battery score between the Tai Chi and control groups.
AGEING RESEARCH REVIEWS
(2022)
Article
Medicine, Research & Experimental
Chuan-Teng Liu, Jui-Hung Jimmy Yen, Dennis A. Brown, Ying-Chyi Song, Mei-Yun Chu, Yu-Hsiang Hung, Yi-Huan Tang, Po-Yuan Wu, Hung-Rong Yen Abckl
Summary: Targeting Nrf2 with D3T may alleviate psoriasis symptoms by reducing hyperkeratosis and scaling, inhibiting IL-17A-secreting γδ T cells in IMQ-induced psoriatic mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Ming-Cheng Huang, Sheng-Chi Chang, Wen-Ling Liao, Tao-Wei Ke, Ai-Lin Lee, Hwei-Ming Wang, Che-Pin Chang, Hung-Rong Yen, Hen-Hong Chang, William Tzu-Liang Chen
Summary: This article reports on the efficacy of acupuncture in preventing chemotherapy-induced peripheral neuropathy in patients with colorectal cancer. The results suggest that acupuncture may have a neuroprotective effect on chemotherapy-induced peripheral neuropathy in patients with colorectal cancer.
Article
Integrative & Complementary Medicine
Chia-Yu Huang, Mei-Yao Wu, Ming-Cheng Huang, Teng-Shun Yu, Hung-Rong Yen
Summary: This study investigated the association between acupuncture therapy and the development of pressure ulcers in patients with dementia. The results showed a reduced incidence of pressure ulcers in patients who received acupuncture therapy. This finding provides important insights for further research.
INTEGRATIVE MEDICINE RESEARCH
(2023)
Article
Medicine, General & Internal
Hou-Hsun Liao, Hanoch Livneh, Miao-Chiu Lin, Ming-Chi Lu, Ning-Sheng Lai, Hung-Rong Yen, Tzung-Yi Tsai
Summary: This study aimed to compare the risk of primary Sjogren's Syndrome (SS) in patients with rheumatoid arthritis (RA) who used Chinese herbal medicine (CHM) versus those who did not. The results showed that CHM use was associated with a lower risk of SS.
MEDICINA-LITHUANIA
(2023)
Article
Oncology
Ming-Cheng Huang, Sheng-Chi Chang, Wen-Ling Liao, Tao-Wei Ke, Ai-Lin Lee, Hwei-Ming Wang, Che-Pin Chang, Hung-Rong Yen, Hen-Hong Chang, William Tzu-Liang Chen
Summary: This study investigated the efficacy of acupuncture in preventing chemotherapy-induced peripheral neuropathy (CIPN) in patients with colorectal cancer (CRC). The results showed that prophylactic acupuncture may exert neuroprotective effects on mechanical or tactile touch thresholds and this protectiveness persists at 6 months' follow-up.
Article
Integrative & Complementary Medicine
Chia-Yu Huang, Mei-Yao Wu, Ming-Cheng Huang, Greg Zimmerman, Liang-Yo Yang, Cheng-Li Lin, Sio-Ian Tou, Hung-Rong Yen
Summary: This study investigates the association between acupuncture therapy and the risk of fracture in patients with osteoarthritis (OA). The results show that patients who received acupuncture therapy have a lower incidence of fracture, and this association is independent of sex, comorbidities, drug use, and surgical experiences.
JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
(2022)
