Article
Biochemistry & Molecular Biology
Hugo Martin, Marie Doumic, Maria Teresa Teixeira, Zhou Xu
Summary: This study provides a mathematical description of the generation-dependent processes underlying non-terminal arrests in telomerase-negative cells. The research highlights differences in the mechanisms and states between non-terminal and terminal senescence arrests. The findings suggest that these two processes contribute to different consequences of senescence at the population level.
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Fan Wu, Luyun Zhang, Caiyun Lai, Xinyue Peng, Susu Yu, Cheng Zhou, Bo Zhang, Wenjuan Zhang
Summary: N6-methyladenosine (m6A) methylation plays an important role in cellular senescence. ROS level differs between replicative and premature senescence, leading to changes in the expression profiles of m6A-related enzymes and binding proteins. Total m6A content and RNA methylation enzyme activity decrease in senescent cells. Specific m6A methylation levels regulate the expression of certain genes in replicative and premature senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Katarzyna Malgorzata Kwiatkowska, Eleni Mavrogonatou, Adamantia Papadopoulou, Claudia Sala, Luciano Calzari, Davide Gentilini, Maria Giulia Bacalini, Daniele Dall'Olio, Gastone Castellani, Francesco Ravaioli, Claudio Franceschi, Paolo Garagnani, Chiara Pirazzini, Dimitris Kletsas
Summary: The aim of this study was to characterize DNA methylation patterns in replicative and induced senescence in different human cell types. Three epigenetic signatures were identified: cell type- and treatment-specific signature, cell type-specific senescence-related signature, and cell type-transversal replicative senescence-related signature. Cluster analysis revealed distinct DNA methylation patterns in replicative senescent cells, and enrichment in pathways related to the nervous system was shown. Despite no statistically significant evidence of age acceleration, a trend of increased biological age in replicative senescent cultures of all three cell types was observed. This work highlights the heterogeneity of senescent cells and their impact on tissue homeostasis.
Review
Cardiac & Cardiovascular Systems
Priyanka Banerjee, Sivareddy Kotla, Loka Reddy Velatooru, Rei J. Abe, Elizabeth A. Davis, John P. Cooke, Keri Schadler, Anita Deswal, Joerg Herrmann, Steven H. Lin, Jun-ichi Abe, Nhat-Tu Le
Summary: Cellular senescence plays a crucial role in the development of cancer and cardiovascular diseases, particularly at the intersection between the two. The senescence-associated secretory phenotype (SASP) of senescent cells is a common factor in both cancer and CVD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Endocrinology & Metabolism
Christopher D. Wiley, Judith Campisi
Summary: Cellular senescence involves a permanent proliferative arrest and the release of biologically active molecules known as SASP. Studies show that senescence and SASP are sensitive to metabolic states, potentially driving phenotypes associated with metabolic dysfunction. Effective interventions may disrupt the feedback loop in which cellular senescence promotes metabolic diseases.
Article
Biochemistry & Molecular Biology
Ji-Hwan Park, Sung Jin Ryu, Byung Ju Kim, Hyun-Ji Cho, Chi Hyun Park, Hyo Jei Claudia Choi, Eun-Jin Jang, Eun Jae Yang, Jeong-A Hwang, Seung-Hwa Woo, Jun Hyung Lee, Ji Hwan Park, Kyung-Mi Choi, Young-Yon Kwon, Cheol-Koo Lee, Joon Tae Park, Sung Chun Cho, Yun-Il Lee, Sung Bae Lee, Jeong A. Han, Kyung A. Cho, Min-Sik Kim, Daehee Hwang, Young-Sam Lee, Sang Chul Park
Summary: Impairment of nuclear-cytoplasmic trafficking (NCT) has been linked to cellular senescence, where signals transmission between the nucleus and cytoplasm is reduced as cells age. This disrupted communication may play a critical role in the aging process by affecting cell growth and division. Additional studies are needed to fully understand the mechanisms behind this phenomenon and its impact on cellular senescence.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Pathology
M. Komine, A. Massa, L. Moon, T. Mullaney
JOURNAL OF COMPARATIVE PATHOLOGY
(2014)
Article
Pathology
B. H. Lee, A. T. Massa, K. R. Taylor
JOURNAL OF COMPARATIVE PATHOLOGY
(2020)
Article
Agriculture, Dairy & Animal Science
Alisha T. Massa, Michelle R. Mousel, Codie J. Durfee, Maria K. Herndon, Kaneesha M. Hemmerling, J. Bret Taylor, Holly L. Neibergs, Stephen N. White
Summary: Sheep are affected by an incurable viral infection that impacts production efficiency, with genetic factors potentially playing a role in improving herd health through gene expression regulatory elements. The underlying causes of the disease may be related to mutations in DNA that affect gene expression. Genetic marker assisted selection for disease-resilient sheep presents an attractive management solution.