Article
Multidisciplinary Sciences
David S. Fischer, Meshal Ansari, Karolin Wagner, Sebastian Jarosch, Yiqi Huang, Christoph H. Mayr, Maximilian Strunz, Niklas J. Lang, Elvira D'Ippolito, Monika Hammel, Laura Mateyka, Simone Weber, Lisa S. Wolff, Klaus Witter, Isis E. Fernandez, Gabriela Leuschner, Katrin Milger, Marion Frankenberger, Lorenz Nowak, Katharina Heinig-Menhard, Ina Koch, Mircea G. Stoleriu, Anne Hilgendorff, Juergen Behr, Andreas Pichlmair, Benjamin Schubert, Fabian J. Theis, Dirk H. Busch, Herbert B. Schiller, Kilian Schober
Summary: This study used single-cell RNA sequencing to identify the phenotypic profile of SARS-CoV-2-reactive T cells, inducing transcriptional shifts by in vitro antigenic stimulation and revealing phenotypic effects introduced by antigen-specific stimulation. The results show that reverse phenotyping can provide an integrated insight into the cellular states of SARS-CoV-2-reactive T cells across tissues and activation states.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Dornatien Chuo Anang, Tamara H. Ramwadhdoebe, Janine S. Hahnlein, Bo van Kuijk, Noortje Smits, Krijn P. van Lienden, Mario Maas, Danielle M. Gerlag, Paul P. Tak, Niek de Vries, Lisa G. M. van Baarsen
Summary: In early RA patients and individuals at risk for RA, there is an increase in Tfh cells in lymphoid tissues with decreased IL-21 production.
Article
Oncology
Jeong A. Park, Madelyn Espinosa-Cotton, Hong-fen Guo, Sebastien Monette, Nai-Kong Cheung
Summary: This study demonstrates that using anti-VEGF antibodies can significantly improve the therapeutic efficacy of T cell immunotherapies by increasing HEVs and promoting the infiltration of cytotoxic CD8(+) TILs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Chemistry, Medicinal
Chao Zhu, Shuang Wen, Junyong Li, Hongyu Meng, Junzhe Zhang, Kuo Zhao, Ling Wang, Yingze Zhang
Summary: The study demonstrated that Fingolimod exerts beneficial effects in collagen-induced arthritis (CIA) mice by inhibiting the recruitment of CD4(+) T lymphocytes to the affected joints. Additionally, Fingolimod inhibits TNF-alpha-induced inflammation by suppressing the AKT/PI3K/NF-kappa B signaling pathway in MH7A cells.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Health Care Sciences & Services
Beatriz Rioseras, Marco Antonio Moro-Garcia, Alejandra Garcia-Torre, Eva Bueno-Garcia, Rocio Lopez-Martinez, Maria Iglesias-Escudero, Roberto Diaz-Pena, Patricia Castro-Santos, Miguel Arias-Guillen, Rebeca Alonso-Arias
Summary: Expanded CD4+CD28(null) T lymphocytes in patients with autoimmune diseases, such as rheumatoid arthritis (RA), exhibit potent inflammatory activity and favor migration to inflammatory sites, potentially contributing to disease progression. Interleukin 15 (IL-15) plays a critical role in the functional activity of these cells and may act as a selective attractor to damaged tissues. Understanding the migratory properties and transcriptional motility profile of these cells, along with the role of IL-15, may lead to the development of targeted therapeutic strategies in autoimmune disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Immunology
Lanlan Yang, Siqi Liu, Qian Zhang, Shengnan Jia, Chen Qiu, Zhenjing Jin
Summary: IL-35 regulates CD8(+) T cells in liver cirrhosis patients, suppressing their cytotoxicity and cytokine secretion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Morgane Crausaz, Guillaume Monneret, Filippo Conti, Anne-Claire Lukaszewicz, Jean-Baptiste Marchand, Perrine Martin, Genevieve Inchauspe, Fabienne Venet
Summary: This study assessed the impact of a virotherapy based on MVA-hIL-7-Fc on T cell functions in ICU patients with sepsis. The results showed that the MVA-hIL-7-Fc treatment improved T cell immune functions in patients, indicating its potential for clinical development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Julio Cesar Fernandez-Ruiz, Fatima de Lourdes Ochoa-Gonzalez, Martin Zapata-Zuniga, Eduardo Mondragon-Marin, Edgar E. Lara-Ramirez, Jose Luis Ruiz-Carrillo, Paola Amayrani DelaCruz-Flores, Esther Layseca-Espinosa, Jose Antonio Enciso-Moreno, Julio Enrique Castaneda-Delgado
Summary: GPR15 may be associated with modulation of the chronic inflammatory response in rheumatoid arthritis (RA). Higher expression of GPR15 mRNA was found in early RA patients. The frequency of CD4+/CD8+ GPR15+ T lymphocytes is higher in RA patients compared to healthy subjects, especially in the synovial fluid. GPR15 and GPR15L are present in the synovial tissue and promote migration of PBMCs in RA patients and healthy subjects. Antagonizing GPR15/GPR15L could be a therapeutic approach in RA.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Immunology
Petra Dadova, Antonia Mikulova, Radim Jarous, Michaela Chorvatova, Stjepan Uldrijan, Lukas Kubala
Summary: The adenylyl cyclase (AC) signaling pathway is suggested to play a key role in regulating immune system functions. This study demonstrates that cyclic adenosine mono-phosphate (cAMP) affects the differentiation of T helper (Th) cells, enhancing Th1 cell phenotype, supporting Th2 differentiation but negatively affecting cell metabolism, and suppressing Th17 immunophenotype while upregulating CXCL13.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Ling Wu, Joanna Brzostek, Previtha Dawn Sakthi Vale, Qianru Wei, Clara K. T. Koh, June Xu Hui Ong, Liang-zhe Wu, Jia Chi Tan, Yen Leong Chua, Jiawei Yap, Yuan Song, Vivian Jia Yi Tan, Triscilla Y. Y. Tan, Junyun Lai, Paul A. MacAry, Nicholas R. J. Gascoigne
Summary: This study reveals that chimeric antigen receptor (CAR) signaling can occur independently of the SRC family kinase (SFK) LCK and instead relies on FYN and a CD28 intracellular domain within the CAR. LCK-deficient CAR-T cells exhibit stronger signaling through CAR and show improved in vivo efficacy with reduced exhaustion phenotype and enhanced induction of memory and proliferation. These findings provide insights into the initiation of both T cell receptor (TCR) and CAR signaling and have important clinical implications for improving CAR function.
CELL REPORTS MEDICINE
(2023)
Article
Immunology
Diana M. Matthe, Martin Dinkel, Benjamin Schmid, Tina Vogler, Markus F. Neurath, Hendrik Poeck, Clemens Neufert, Maike Buettner-Herold, Kai Hildner
Summary: Acute graft-versus-host disease (GvHD) is the most significant clinical challenge and prognosis-determining complication after allo-HSCT. Donor T cells are considered key mediators of alloreactivity, particularly against the gut. This study investigated the contribution of intestinal intra-epithelial lymphocytes (IELs) in IEC dysregulation and found that allogeneic IELs were superior in inducing IEC death compared to syngeneic IEL and allogeneic non-IEL T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Daniil Shevyrev, Valeriy Tereshchenko, Vladimir Kozlov, Alexey Sizikov, Oksana Chumasova, Veronica Koksharova
Summary: In rheumatoid arthritis (RA), Treg cells are activated and possess immunosuppressive activity. Transitional FoxP3(+)RORyt(+) cells and increased CD4(+)RORyt(+) percentages are associated with the pathological conversion of some Treg cells into Th-17, which may be key in the pathogenesis of RA.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Jianghui Tang, Jianpeng Sheng, Qi Zhang, Yongtao Ji, Xun Wang, Junlei Zhang, Jiangchao Wu, Jinyuan Song, Xueli Bai, Tingbo Liang
Summary: The study demonstrates a strategy of generating CAR-T cells with both central memory and tissue-resident memory characteristics by combining Runx3 overexpression with ex vivo AKT inhibition. This strategy enhances the persistence, cytotoxic potential, and tumor-residency ability of CAR-T cells, overcoming the limitations in solid tumor treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Critical Care Medicine
Frank Bidar, Sarah Hamada, Morgane Gossez, Remy Coudereau, Jonathan Lopez, Marie-Angelique Cazalis, Claire Tardiveau, Karen Brengel-Pesce, Marine Mommert, Marielle Buisson, Filippo Conti, Thomas Rimmele, Anne-Claire Lukaszewicz, Laurent Argaud, Martin Cour, Guillaume Monneret, Fabienne Venet
Summary: Severe COVID-19 patients exhibit profound T cell exhaustion upon ICU admission, which can be reversed ex vivo by rhIL-7.
ANNALS OF INTENSIVE CARE
(2022)
Article
Cardiac & Cardiovascular Systems
Hongxuan Fan, Jianqi Zhao, Shaobin Mao, Yongle Wang, Miao Wang, Xiaosu Song, Gaizhen Liu, Caihong Wang, Xin Wang, Bin Liang
Summary: This study found that an increase in the absolute and percentage of Th17 cells in the peripheral blood of patients with rheumatoid arthritis (RA) was associated with the development of atherosclerotic cardiovascular disease (ASCVD). Th17/Treg may be a promising biomarker for indicating comorbidity with ASCVD in patients with RA.
CLINICAL CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Lotte M. de Boer, Anna O. J. Oorthuys, Albert Wiegman, Miranda W. Langendam, Jeffrey Kroon, Rene Spijker, Aeilko H. Zwinderman, Barbara A. Hutten
Summary: Statin therapy does not lead to clinically important differences in Lp(a) compared to placebo in patients at risk for CVD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cell Biology
Lucy Y. Tao, Katarzyna B. Lagosz-Cwik, Jolanda M. A. Hogervorst, Ton Schoenmaker, Aleksander M. Grabiec, Tim Forouzanfar, Fridus A. van der Weijden, Teun J. de Vries
Summary: Research suggests that metformin has beneficial effects on the periodontal status of periodontitis patients by inhibiting osteoclast formation and activity, potentially benefiting the bone as a whole.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Aleksandra Wielento, Grzegorz P. Bereta, Katarzyna B. Lagosz-Cwik, Sigrun Eick, Richard J. Lamont, Aleksander M. Grabiec, Jan Potempa
Summary: PPAD and fimbriae from P. gingivalis are important for TLR2-dependent host cell responses, contributing to the generation of inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Ophthalmology
Els M. Pameijer, Pauline Heus, Johanna A. A. Damen, Rene Spijker, Lotty Hooft, Peter J. Ringens, Saskia M. Imhof, Redmer van Leeuwen
Summary: The aim of this paper is to summarize the available evidence on the association between nutrition and antioxidant, vitamin, and mineral supplements and the development or progression of age-related macular degeneration (AMD). The study found that a high consumption of specific nutrients, use of antioxidant supplements, and adherence to a Mediterranean diet can decrease the risk of progression of early to late AMD. On the other hand, high alcohol consumption is associated with an increased risk of developing AMD.
ACTA OPHTHALMOLOGICA
(2022)
Letter
Critical Care Medicine
Chloe J. Pyle, Dhiren F. Patel, Teresa Peiro, Regis Joulia, Aleksander M. Grabiec, Tracy Hussell, Gael Tavernier, Angela Simpson, James Pease, James A. Harker, Clare M. Lloyd, Robert J. Snelgrove
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
Daniel A. Korevaar, Sara Colella, Markus Fally, Juliette Camuset, Thomas V. Colby, Lars Hagmeyer, Juergen Hetzel, Fabien Maldonado, Antonio Morais, Claudia Ravaglia, Rene Spijker, Sara Tomassetti, Lauren K. Troy, Johny A. Verschakelen, Athol U. Wells, Thomy Tonia, Jouke T. Annema, Venerino Poletti
Summary: This guideline provides evidence-based clinical practice recommendations for the role of transbronchial lung cryobiopsy (TBLC) in obtaining tissue-based diagnosis in patients with undiagnosed interstitial lung diseases (ILD). TBLC provides important diagnostic information with lower diagnostic yield compared to surgical lung biopsy (SLB), at reduced serious adverse events and length of hospitalisation.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Immunology
Katarzyna B. Lagosz-Cwik, Mariia Melnykova, Elwira Nieboga, Aureliusz Schuster, Agnieszka Bysiek, Slawomir Dudek, Weronika Lipska, Malgorzata Kantorowicz, Michal Tyrakowski, Dagmara Darczuk, Tomasz Kaczmarzyk, Marjolijn Gilijamse, Teun J. de Vries, Jan Potempa, Aleksander M. Grabiec
Summary: Interactions between gingival fibroblasts (GFs) and oral pathogens play a role in the development of chronic inflammation in periodontitis. Epigenetic changes in DNA methylation are associated with periodontitis, and DNMT inhibitors have been shown to protect against epithelial barrier disruption and bone resorption. However, the use of DNMT inhibitors may have detrimental effects on GFs, including reduced proliferation, increased inflammation, and enhanced bacterial adherence.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
A. Wielento, K. B. Lagosz-Cwik, J. Potempa, A. M. Grabiec
Summary: Gingival fibroblasts (GFs) play an essential role in maintaining the structure and integrity of the periodontium. They not only produce and remodel the extracellular matrix but also modulate the immune response to oral pathogens invading the gingival tissue. However, dysregulated activation of GFs can lead to inflammation and bone destruction, particularly in chronic periodontitis. This review discusses the biological functions of GFs in healthy and inflamed gingival tissue and explores their potential as therapeutic targets in periodontal diseases.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Aleksandra Wielento, Grzegorz P. Bereta, Katarzyna Szczesniak, Anna Jacula, Marina Terekhova, Maxim N. Artyomov, Yoshiaki Hasegawa, Aleksander M. Grabiec, Jan Potempa
Summary: Porphyromonas gingivalis, an oral pathogen, promotes dysbiosis by suppressing the bactericidal activity of the host immune system and maintaining chronic inflammation. It activates Toll-like receptor 2 (TLR2) through the secretion of virulence factors such as P. gingivalis peptidyl arginine deiminase (PPAD) and major fimbriae (FimA). PPAD-modified fimbriae trigger the host cell response, and accessory fimbrial subunits are modified by PPAD and stimulate the response to P. gingivalis infection in a TLR2-dependent manner.
MOLECULAR ORAL MICROBIOLOGY
(2023)
Review
Medicine, General & Internal
Charlie C. C. Luchen, Mwelwa Chibuye, Rene Spijker, Michelo Simuyandi, Caroline Chisenga, Samuel Bosomprah, Roma Chilengi, Constance Schultsz, Daniel R. R. Mende, Vanessa C. C. Harris
Summary: This study aimed to evaluate the risks of antibiotic use and the impact on gut bacteria in children in low- and middle-income countries (LMICs). The study found that antibiotics generally reduced the diversity of bacterial species in the gut and increased the abundance of antibiotic-resistant bacteria in children in LMICs. These findings suggest that antibiotic use may adversely affect the health of children in LMICs by placing them at higher risk of antimicrobial-resistant infections. Rating: 8/10
Review
Public, Environmental & Occupational Health
Jim J. Determeijer, Stije J. Leopold, Rene Spijker, Charles Agyemang, Michele van Vugt
Summary: This review assessed the effect and safety of family participation interventions in the care of hospitalised adults in resource-limited settings and found that family participation can be effective and safe in specific contexts, improving patient outcomes. However, more research is needed to determine the effect of family participation and justify further implementation.
JOURNAL OF GLOBAL HEALTH
(2023)
Review
Medicine, General & Internal
Thomas Struyf, Jonathan J. Deeks, Jacqueline Dinnes, Yemisi Takwoingi, Clare Davenport, Mariska M. G. Leeflang, Rene Spijker, Lotty Hooft, Devy Emperador, Julie Domen, Anouk Tans, Stephanie Janssens, Dakshitha Wickramasinghe, Viktor Lannoy, Sebastiaan R. A. Horn, Ann Van den Bruel
Summary: The symptoms of COVID-19 are highly variable, but anosmia and ageusia may be indicative of the disease. Combining symptoms with other information such as contact history, travel history, age, and gender can improve diagnostic accuracy.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Medicine, General & Internal
Tilly Fox, Julia Geppert, Jacqueline Dinnes, Katie Scandrett, Jacob Bigio, Giorgia Sulis, Dineshani Hettiarachchi, Yasith Mathangasinghe, Praveen Weeratunga, Dakshitha Wickramasinghe, Hanna Bergman, Brian S. Buckley, Katrin Probyn, Yanina Sguassero, Clare Davenport, Jane Cunningham, Sabine Dittrich, Devy Emperador, Lotty Hoo, Mariska M. G. Leeflang, Matthew D. F. McInnes, Rene Spijker, Thomas Struyf, Ann Van den Bruel, Jan Y. Verbakel, Yemisi Takwoingi, Sian Taylor-Phillips, Jonathan J. Deeks
Summary: The study aims to assess the accuracy of antibody testing for detecting current and past SARS-CoV-2 infection. The results show that serology tests have high sensitivity and specificity in diagnosing SARS-CoV-2 infection. However, there is some variation in test performance between different brands, and the heterogeneity in study results and smaller sample sizes in some groups make direct comparisons difficult.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Medicine, General & Internal
Jacqueline Dinnes, Pawana Sharma, Sarah Berhane, Susanna S. van Wyk, Nicholas Nyaaba, Julie Domen, Melissa Taylor, Jane Cunningham, Clare Davenport, Sabine Dittrich, Devy Emperador, Lotty Hooft, Mariska M. G. Leeflang, Matthew D. F. McInnes, Rene Spijker, Jan Y. Verbakel, Yemisi Takwoingi, Sian Taylor-Phillips, Ann Van den Bruel, Jonathan J. Deeks
Summary: Accurate rapid diagnostic tests for SARS-CoV-2 infection are crucial in managing the COVID-19 pandemic. This review assesses the diagnostic accuracy of rapid antigen tests for the diagnosis of SARS-CoV-2 infection. The study finds that sensitivity varies in different population groups and that assays meeting appropriate performance standards could replace laboratory-based RT-PCR tests in certain situations. However, the variable sensitivity of antigen tests means that false negatives are possible. Further research is needed to evaluate the effectiveness of screening programs and the use of antigen test-based repeat testing strategies.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Medicine, General & Internal
Sanam Ebrahimzadeh, Nayaar Islam, Haben Dawit, Jean-Paul Salameh, Sakib Kazi, Nicholas Fabiano, Lee Treanor, Marissa Absi, Faraz Ahmad, Paul Rooprai, Ahmed Al Khalil, Kelly Harper, Neil Kamra, Mariska M. G. Leeflang, Lotty Hooft, Christian B. van der Pol, Ross Prager, Samanjit S. Hare, Carole Dennie, Rene Spijker, Jonathan J. Deeks, Jacqueline Dinnes, Kevin Jenniskens, Daniel A. Korevaar, Jeremie F. Cohen, Ann Van den Bruel, Yemisi Takwoingi, Janneke van de Wijgert, Junfeng Wang, Elena Pena, Sandra Sabongui, Matthew D. F. McInnes
Summary: This study evaluates the diagnostic accuracy of thoracic imaging in individuals suspected of COVID-19, as well as the imaging findings in asymptomatic individuals and those who initially test negative for RT-PCR but later become positive. The results show that chest CT and lung ultrasound have high sensitivity and moderate specificity, while chest X-ray has moderate sensitivity and specificity.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)