Review
Immunology
Kilian Sottoriva, Kostandin V. Pajcini
Summary: This excerpt discusses the crucial role of the Notch signaling pathway in hematopoiesis and lymphoid cell development, particularly in T cell development, maintenance of the lymphoid system, and its influence in leukemia pathology.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Encarnacion Montecino-Rodriguez, Kenneth Dorshkind
Summary: Traditional models of lymphopoiesis present B and T cell development as a linear process, but studies have shown that the types of lymphocytes generated before and after birth differ. This review synthesizes data from multiple laboratories, including our own work using mouse models, and demonstrates that innate and conventional B and T cells emerge in different ways and are regulated differently. Understanding this layering of lymphocyte development has implications for the composition of the adult immune system and the origin of lymphocytic leukemias.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Cell Biology
Amber B. Ouweneel, Myrthe E. Reiche, Olga S. C. Snip, Robbert Wever, Ezra J. van der Wel, Frank H. Schaftenaar, Sona Kauerova, Esther Lutgens, Miranda Van Eck, Menno Hoekstra
Summary: This study found that HDL deficiency is associated with an increase in bone marrow stem cells and T cell production. However, HDL deficiency does not significantly affect the size of atherosclerotic lesions and collagen content.
JOURNAL OF CELL SCIENCE
(2022)
Article
Oncology
Nadav Ofshenko, Eyal Bercovich, Tania Mashiach, Michal Weiler-Sagie, Daniela Militianu, Eldad J. Dann
Summary: Hodgkin lymphoma (HL) is highly curable, but treatment-related bone mineral density (BMD) loss is common, especially in patients over 30 years old and with high cumulative steroid doses. The study suggests minimizing steroid use and switching to less toxic drugs to prevent persistent BMD loss. Adequate vitamin D levels should be maintained to preserve BMD.
Article
Immunology
Jakov Korzhenevich, Iga Janowska, Mirjam van der Burg, Marta Rizzi
Summary: This article reviews the similarities and differences in early B cell development between humans and mice, and provides a phenotypical classification of human and murine early progenitors and B cell stages based on protein expression. The role of key transcription factors and chemo- or cytokine signals during homeostatic and aberrant B lymphopoiesis in both species is critically compared.
IMMUNOLOGY LETTERS
(2023)
Article
Endocrinology & Metabolism
Huda M. Elsharkasi, Suet C. Chen, Lewis Steell, Shuko Joseph, Naiemh Abdalrahaman, Christie McComb, Blair Johnston, John Foster, Sze Choong Wong, S. Faisal Ahmed
Summary: This study investigates the role of 3T-MRI in assessing musculoskeletal health in children and young people. The results provide insights into the relationships between bone, muscle, and bone marrow, and highlight the importance of MRI as a non-invasive method for comprehensive evaluation of musculoskeletal health in growing individuals.
ENDOCRINE CONNECTIONS
(2022)
Article
Neurosciences
Renata C. N. Marchette, Adriana Gregory-Flores, Brendan J. Tunstall, Erika R. Carlson, Shelley N. Jackson, Agnieszka Sulima, Kenner C. Rice, George F. Koob, Leandro F. Vendruscolo
Summary: The study found a functional role for KORs in heroin withdrawal-induced hyperalgesia that is observed in rats of both sexes, with females requiring a higher dose of heroin to reach similar levels of analgesia and hyperalgesia compared to males. KOR antagonists were effective in reversing heroin withdrawal-induced hyperalgesia, with different durations of effects between males and females. The levels of KOR antagonists in the brain correlated with their behavioral effects, and different KOR antagonists had varied effects on naloxone-induced and spontaneous signs of opioid withdrawal in both male and female rats.
NEUROBIOLOGY OF STRESS
(2021)
Article
Endocrinology & Metabolism
Mariya Stavnichuk, Josephine T. Tauer, Zoltan Nagy, Alexandra Mazharian, Melanie Welman, Marie Lordkipanidze, Yotis A. Senis, Svetlana Komarova
Summary: Mutations in MPIG6B gene may contribute to bone marrow failure and subsequent osteosclerosis in patients with chronic myelofibrosis. Female Mpig6b(-/-) mice were more prone to developing osteosclerosis, while male mice showed a milder phenotype.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Christopher S. Wilson, Emilee M. Hoopes, Alexander C. Falk, Daniel J. Moore
Summary: The immune system of healthy individuals is capable of regulating autoimmunity. However, in Type 1 Diabetes (T1D), natural IgM is unable to perform its normal immunoregulatory function. Treating diabetic mice with IgM from healthy donors or an IgM-enriched preparation called Pentaglobin can reverse the disease and boost protective immunity.
SCIENTIFIC REPORTS
(2022)
Article
Orthopedics
S. Mancuso, Dalila Scaturro, M. Santoro, G. Di Gaetano, F. Vitagliani, V. Falco, S. Siragusa, S. Gonnelli, G. Letizia Mauro
Summary: This study aimed to investigate the skeletal complications in lymphoma patients after treatment and found that approximately 50% of patients had osteoporosis, with a high prevalence of vertebral fractures. Most patients also had hypovitaminosis D and high levels of parathyroid hormone, with a significant association between high PTH levels and previous lymphoma treatment observed. The Mini-Osteoporosis Quality of Life questionnaire showed a decrease in quality of life due to changes in bone status.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Biotechnology & Applied Microbiology
Yuxin Zhang, Tianchang Wang, Dahe Zhang, Jiayi Li, Xiaokun Yue, Weiqing Kong, Xiaoding Gu, Zixian Jiao, Chi Yang
Summary: This study investigates the effects of CGFs-loaded hydrogel on BMSCs and the reconstruction of critical-size bone defects. The results show that the hydrogel promotes the proliferation and osteogenic differentiation of BMSCs in vitro, and induces bone healing and reconstruction of medullary cavity structure in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Kerensa M. Beekman, Martine Regenboog, Aart J. Nederveen, Nathalie Bravenboer, Martin den Heijer, Peter H. Bisschop, Carla E. Hollak, Erik M. Akkerman, Mario Maas
Summary: This study aimed to determine region-specific variations and age- and gender-specific differences in bone marrow adipose tissue (BMAT) in healthy subjects. The results showed distinct distribution of BMAT throughout the human skeleton, which was associated with age and gender. Furthermore, the study found that BMAT unsaturation was highest within the axial skeleton compared to the appendicular skeleton.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Tomonori Harada, Isao Tsuboi, Hirotsugu Hino, Miyuki Yuda, Yoko Hirabayashi, Shuichi Hirai, Shin Aizawa
Summary: In aged mice, LPS treatment leads to more severe suppression of myelopoiesis and B-lymphopoiesis compared to young mice. The expression of genes encoding positive regulators of myelopoiesis and negative regulators of B cell lymphopoiesis increased in aged mice, while the expression of genes encoding positive regulators of B cell lymphopoiesis decreased.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Thiberiu Banica, Charlotte Verroken, Guy T'Sjoen, Stefan Goemaere, Hans-Georg Zmierczak, Tom Fiers, Jean-Marc Kaufman, Bruno Lapauw
Summary: Bone metabolism in men is influenced by sex steroid exposure, and declines in sex steroid levels during young and middle adulthood are associated with changes in bone mass and size.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Immunology
Sarah E. Webster, Brinda Ryali, Michael J. Clemente, Naomi L. Tsuji, Nichol E. Holodick
Summary: The protective capacity of serum IgM against pneumococcal infection is maintained in aged female mice but absent in aged male mice. Aged female mice have a more diverse and active CD5+ B-1 cell pool and natural IgM repertoire, which may have implications for sex-related susceptibility to infection and disease.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Marco Barsanti, Joanna M. C. Lim, Michael L. Hun, Natalie Lister, Kahlia Wong, Maree V. Hammett, Ailin Lepletier, Richard L. Boyd, Antonietta Giudice, Ann P. Chidgey
EUROPEAN JOURNAL OF IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Emma Mitchell, Shifra L. Klein, Kimon V. Argyropoulos, Ali Sharma, Robin B. Chan, Judit Gal Toth, Luendreo Barboza, Charlotte Bavley, Analia Bortolozzi, Qiuying Chen, Bingfang Liu, Joanne Ingenito, Willie Mark, Jarrod Dudakov, Steven Gross, Gilbert Di Paolo, Francesc Artigas, Marcel van den Brink, Miklos Toth
NATURE COMMUNICATIONS
(2016)
Article
Materials Science, Biomaterials
Vinh X. Truong, Michael L. Hun, Fanyi Li, Ann P. Chidgey, John S. Forsythe
BIOMATERIALS SCIENCE
(2016)
Article
Immunology
Florian Wiede, Jarrod A. Dudakov, Kun-Hui Lu, Garron T. Dodd, Tariq Butt, Dale I. Godfrey, Andreas Strasser, Richard L. Boyd, Tony Tiganis
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Immunology
Brendan J. O'Sullivan, Suman Yekollu, Roland Ruscher, Ahmed M. Mehdi, Muralidhara Rao Maradana, Ann P. Chidgey, Ranjeny Thomas
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Mingjing Hu, David Eviston, Peter Hsu, Eliana Marino, Ann Chidgey, Brigitte Santner-Nanan, Kahlia Wong, James L. Richards, Yu Anne Yap, Fiona Collier, Ann Quinton, Steven Joung, Michael Peek, Ron Benzie, Laurence Macia, David Wilson, Ann-Louise Ponsonby, Mimi L. K. Tang, Martin O'Hely, Norelle L. Daly, Charles R. Mackay, Jane E. Dahlstrom, Peter Vuillermin, Ralph Nanan, Richard Saffery, Katrina J. Allen, Sarath Ranganathan, David Burgner, Leonard C. Harrison, Peter Sly, Terry Dwyer
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Ali Motazedian, Freya F. Bruveris, Santhosh V. Kumar, Jacqueline V. Schiesser, Tyrone Chen, Elizabeth S. Ng, Ann P. Chidgey, Christine A. Wells, Andrew G. Elefanty, Edouard G. Stanley
NATURE CELL BIOLOGY
(2020)
Article
Materials Science, Biomaterials
Anisha B. Suraiya, Michael L. Hun, Vinh X. Truong, John S. Forsythe, Ann P. Chidgey
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Immunology
Michael Ly Hun, Kahlia Wong, Josephine Rahma Gunawan, Abdulaziz Alsharif, Kylie Quinn, Ann P. Chidgey
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Immunology
David Granadier, Lorenzo Iovino, Sinead Kinsella, Jarrod A. Dudakov
Summary: The diversity of the T cell receptor repertoire in the thymus is crucial for immune responses against pathogens and malignancies, but thymic function is sensitive to negative stimuli such as acute insult or chronic damage. These insults can lead to decreased immune responses, highlighting the importance of maintaining thymic function for overall immune health.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Cell Biology
Sinead Kinsella, Cindy A. Evandy, Kirsten Cooper, Lorenzo Iovino, Paul C. DeRoos, Kayla S. Hopwo, David W. Granadier, Colton W. Smith, Shahin Rafii, Jarrod A. Dudakov
Summary: The study identifies a complex signal pathway triggered by apoptotic thymocytes during tissue damage, leading to increased production of IL-23 and BMP4 and ultimately promoting thymic regeneration. Pharmacological inhibition targeting this pathway enhances thymic function and offers a new strategy for restoring immune competence in patients with compromised thymic function.
Article
Hematology
Jarrod A. Dudakov, Anna M. Mertelsmann, Margaret H. O'Connor, Robert R. Jenq, Enrico Velardi, Lauren F. Young, Odette M. Smith, Richard L. Boyd, Marcel R. M. van den Brink, Alan M. Hanash
Article
Engineering, Biomedical
Michael Hun, Marco Barsanti, Kahlia Wong, John Ramshaw, Jerome Werkmeister, Ann P. Chidgey
Meeting Abstract
Immunology
K. Wong, M. Hun, M. Barsanti, M. Hammett, A. Lepletier, A. Alsharif, R. Boyd, A. Chidgey
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)
Meeting Abstract
Immunology
A. Lepletier, M. Hammette, K. Wong, M. Hedger, R. Boyd, K. Loveland, P. A. Chidgey
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)