Article
Oncology
Wenyong Huang, Dongmei Ye, Wenjing He, Xiaoshun He, Xiaomin Shi, Yifang Gao
Summary: The study found that MAIT cells in patients with HCC had lower levels in both peripheral blood and liver compared to healthy controls, with reduced IFN-γ production. While peripheral MAIT cells showed upregulation of HLA-DR and PD-1, intrasinusoidal MAIT cells did not exhibit significant differences. Additionally, MAIT cells were significantly enriched in the livers of HCC patients, showing high levels of activation and exhaustion markers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Endocrinology & Metabolism
Hans-Georg Sprenger, Thomas MacVicar, Amir Bahat, Kai Uwe Fiedler, Steffen Hermans, Denise Ehrentraut, Katharina Ried, Dusanka Milenkovic, Nina Bonekamp, Nils-Goeran Larsson, Hendrik Nolte, Patrick Giavalisco, Thomas Langer
Summary: The study reveals that cytosolic pyrimidine levels regulate the release of mitochondrial DNA and activation of cGAS-STING.
Article
Respiratory System
Tae-Ok Kim, Ki-Jeong Park, Young-Nan Cho, Hye-Mi Jin, Young-Goun Jo, Hyo Shin Kim, Jae Kyun Ju, Hong-Joon Shin, Bo-Gun Kho, Seung-Jung Kee, Yong-Wook Park
Summary: The study demonstrates that circulating MAIT cells are numerically deficient in patients with ARDS. These MAIT cells are activated, migrate into the lung, secrete IL-17, and stimulate macrophages, contributing to the worsening of inflammation in the lung of patients with ARDS.
Article
Allergy
Akhilesh Jha, Ryan S. Thwaites, Tanushree Tunstall, Onn Min Kon, Robin J. Shattock, Trevor T. Hansel, Peter J. M. Openshaw
Summary: Acute respiratory viral infections are a major concern, especially in patients with preexisting lung diseases like asthma. Toll-like receptors play a critical role in early virus detection and activating innate immunity, but measuring respiratory mucosal innate immune responses is challenging. This study found that allergic individuals have increased nasal mucosal IFN and chemokine response to the viral RNA analogue R848, indicating dysregulated innate immune responses in the nasal mucosa may impact viral exposure outcomes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yu Li, Shaorui Liu, Kewen Zhou, Yinsheng Wang, Yan Chen, Wen Hu, Shuyan Li, Hui Li, Yan Wang, Qiuying Wang, Danyang He, Heping Xu
Summary: Studies have shown that neuromedin U (NMU) regulates epithelial cell differentiation and barrier immunity by stimulating NMUR1-expressing eosinophils in the small intestine (SI), thus maintaining tissue homeostasis.
Article
Nutrition & Dietetics
Noah Joseph Murr, Tyler B. Olender, Margaret R. Smith, Amari S. Smith, Jennifer Pilotos, Lyndsay B. Richard, Chishimba Nathan Mowa, Michael Makokha Opata
Summary: The study revealed that moderately malnourished mice infected with malaria had lower parasite burden at the peak of infection, but showed damaged mucosal epithelial cells, increased intestinal permeability, shortened small intestine, and decreased number of innate immune cells in the large intestine. Despite lower numbers, macrophages in the moderately malnourished mice were highly activated in the small intestine, indicating exacerbation of some abnormalities in the gut induced by the moderate malnutrition.
Article
Immunology
Diana Boraschi
Summary: Interleukin-1 (IL-1) is a cytokine that plays a significant role in inflammation and immune response, primarily produced by macrophages during defensive reactions. It belongs to a superfamily of structurally similar proteins and acts through binding to specific receptors on the plasma membrane of target cells. IL-1 family cytokines not only have innate immune and inflammatory effects but also appear to be involved in the development of adaptive immunity in vertebrates.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Valeria Caputo, Martina Libera, Sofia Sisti, Benedetta Giuliani, Roberta A. Diotti, Elena Criscuolo
Summary: Human Immunodeficiency Virus (HIV) remains a major global health issue, and the mucosal innate immune response and microbiota play crucial roles in HIV infection. The mucosae act as a physical barrier that can be compromised by the virus, leading to innate immune response, and the mucosal microbiota can influence the development of opportunistic infections. However, a proper characterization of mucosal innate immune response and microbiota is still lacking, and further studies are needed to understand their potential in vaccine development.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Tania Lebratti, Ying Shiang Lim, Adjoa Cofie, Prabhakar Andhey, Xiaoping Jiang, Jason Scott, Maria Rita Fabbrizi, Ayse Naz Ozanturk, Christine Pham, Regina Clemens, Maxim Artyomov, Mary Dinauer, Haina Shin
Summary: The study reveals that sustained type I interferon signaling drives pathogenic neutrophil responses and identifies IL-18 as a novel component of disease during genital HSV-2 infection. Therapeutic interventions targeting IFN signaling and IL-18 may have potential in treating HSV-2 genital disease.
Review
Immunology
Lindsay M. Snyder, Eric Y. Denkers
Summary: The gastrointestinal tract serves as a major entry point for pathogens, including Toxoplasma gondii. Host defense against Toxoplasma is primarily located in the intestinal mucosa, involving a coordinated response from epithelial cells, intraepithelial lymphocytes, and lamina propria cells. Infections may lead to bacterial dysbiosis and immune-mediated tissue damage in the intestine, highlighting the complex interactions between microbiota, epithelium, and immune cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Entomology
Bin Yu, Qiuhua Yang, Junhong Wei, Guoqing Pan, Chunfeng Li, Zeyang Zhou
Summary: Nosema bombycis, as a virulent pathogen of silkworm, induces the activation of two specific genes (BmUGT10295 and BmUGT8453) in infected silkworms, providing resistance against microsporidia. This discovery sheds light on host response to pathogens and suggests potential targets for enhancing pathogen resistance.
Article
Critical Care Medicine
Daniel P. Cook, Christopher M. Thomas, Ashley Y. Wu, Mark Rusznak, Jian Zhang, Weisong Zhou, Jacqueline-Yvonne Cephus, Katherine N. Gibson-Corley, Vasiliy V. Polosukhin, Allison E. Norlander, Dawn C. Newcomb, David A. Stoltz, R. Stokes Peebles
Summary: Type 2 inflammation is observed in cystic fibrosis patients. This study reveals that CFTR deficiency leads to increased expression and release of IL-33, and deletion of IL-33 reduces allergen-induced inflammation in the CF lung.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biology
Mimmi L. E. Lundahl, Morgane Mitermite, Dylan Gerard Ryan, Sarah Case, Niamh C. Williams, Ming Yang, Roisin Lynch, Eimear Lagan, Filipa M. Lebre, Aoife L. Gorman, Bojan Stojkovic, Adrian P. Bracken, Christian Frezza, Frederick J. Sheedy, Eoin M. Scanlan, Luke A. J. O'Neill, Stephen Gordon, Ed C. Lavelle, Simon Yona
Summary: This study provides new and unexpected insights into alternative macrophage activation states in the context of mycobacterial infection. Activation with IL-4 and IL-13 induces protective innate memory against mycobacterial challenge and enhances the killing capacity of macrophages. IL-4/13 trained macrophages retain heightened oxidative phosphorylation metabolism and impede heightened pro-inflammatory cytokine responses by inhibiting oxidative phosphorylation.
Article
Oncology
Clement Anfray, Francesco Mainini, Elisabeth Digifico, Akihiro Maeda, Marina Sironi, Marco Erreni, Achille Anselmo, Aldo Ummarino, Sara Gandoy, Francisco Exposito, Miriam Redrado, Diego Serrano, Alfonso Calvo, Marvin Martens, Susana Bravo, Alberto Mantovani, Paola Allavena, Fernando Torres Andon
Summary: This study demonstrated the superior efficacy of poly(I:C) combined with R848 compared to single treatments or combined with R837 in reprogramming macrophages towards M1-like antitumor effectors in vitro, leading to significant prevention of tumor growth and metastasis in lung cancer and fibrosarcoma mouse models. The therapy also induced systemic antitumoral response and resistance to tumor rechallenge through boosted macrophage cytotoxic activity and T-cell proliferation. Proteomic experiments validated the activation of innate immunity by poly(I:C)+R848 combination, with the key activation of the STAT1 pathway.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Domenico Supino, Luna Minute, Andrea Mariancini, Federica Riva, Elena Magrini, Cecilia Garlanda
Summary: This article explores the roles of interleukin-1 (IL-1) family members and their receptors in regulating immune and inflammatory processes at the molecular level. It discusses their significance in the development of diseases and their potential therapeutic applications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Reproductive Biology
Masanori Ono, Takashi Kajitani, Hiroshi Uchida, Toru Arase, Hideyuki Oda, Sayaka Uchida, Kuniaki Ota, Takashi Nagashima, Hirotaka Masuda, Kaoru Miyazaki, Hironori Asada, Naoko Hida, Yo Mabuchi, Satoru Morikawa, Mamoru Ito, Serdar E. Bulun, Hideyuki Okano, Yumi Matsuzaki, Yasunori Yoshimura, Tetsuo Maruyama
BIOLOGY OF REPRODUCTION
(2015)
Article
Endocrinology & Metabolism
Kaoru Miyazaki, Fumie Miki, Sayaka Uchida, Hirotaka Masuda, Hiroshi Uchida, Tetsuo Maruyama
Review
Immunology
Hiroshi Uchida, Tetsuo Maruyama, Hirotaka Masuda, Sayaka Uchida, Fumie Miki, Hanako Hihara, Satomi Katakura, Yushi Yoshimasa, Mamoru Tanaka
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2016)
Article
Obstetrics & Gynecology
Hirotaka Masuda, Toyohide Endo, Yushi Yoshimasa, Hiroshi Uchida, Akira Nakabayashi, Tetsuo Maruyama, Mamoru Tanaka
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2016)
Article
Obstetrics & Gynecology
Sayaka Uchida, Tetsuo Maruyama, Maki Kagami, Fumie Miki, Hanako Hihara, Satomi Katakura, Yushi Yoshimasa, Hirotaka Masuda, Hiroshi Uchida, Mamoru Tanaka
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2017)
Article
Obstetrics & Gynecology
M. Ono, T. Kajitani, H. Uchida, T. Arase, H. Oda, S. Nishikawa-Uchida, H. Masuda, T. Nagashima, Y. Yoshimura, T. Maruyama
HUMAN REPRODUCTION
(2010)
Article
Multidisciplinary Sciences
Hirotaka Masuda, Yumi Matsuzaki, Emi Hiratsu, Masanori Ono, Takashi Nagashima, Takashi Kajitani, Toru Arase, Hideyuki Oda, Hiroshi Uchida, Hironori Asada, Mamoru Ito, Yasunori Yoshimura, Tetsuo Maruyama, Hideyuki Okano
Article
Multidisciplinary Sciences
Kaoru Miyazaki, Tetsuo Maruyama, Hirotaka Masuda, Akiko Yamasaki, Sayaka Uchida, Hideyuki Oda, Hiroshi Uchida, Yasunori Yoshimura
Article
Multidisciplinary Sciences
Sayaka Uchida, Hiroshi Uchida, Tetsuo Maruyama, Takashi Kajitani, Hideyuki Oda, Kaoru Miyazaki, Maki Kagami, Yasunori Yoshimura
Article
Cell & Tissue Engineering
Tomoka Takao, Hirotaka Masuda, Takashi Kajitani, Fumie Miki, Kaoru Miyazaki, Yushi Yoshimasa, Satomi Katakura, Shoko Tomisato, Sayaka Uchida, Hiroshi Uchida, Mamoru Tanaka, Tetsuo Maruyama
Summary: This study identified the HHUA cell line as a useful tool for discovering and identifying endometrial CSC-selective drugs. The drug sorafenib showed potential as an effective anti-endometrial cancer treatment targeting endometrial CSCs.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Developmental Biology
Satomi Katakura, Tomoka Takao, Toru Arase, Yushi Yoshimasa, Shoko Tomisato, Sayaka Uchida, Hirotaka Masuda, Hiroshi Uchida, Mamoru Tanaka, Tetsuo Maruyama
Article
Obstetrics & Gynecology
Masataka Furuya, Hirotaka Masuda, Kanako Hara, Hiroshi Uchida, Kenji Sato, Suguru Sato, Hironori Asada, Tetsuo Maruyama, Yasunori Yoshimura, Hidetaka Katabuchi, Mamoru Tanaka, Hideyuki Saya
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2017)
Meeting Abstract
Obstetrics & Gynecology
Kaoru Miyazaki, Tetsuo Maruyama, Hirotaka Masuda, Akiko Yamasaki, Sayaka Uchida, Hideyuki Oda, Hiroshi Uchida, Yasunori Yoshimura
REPRODUCTIVE SCIENCES
(2013)
Meeting Abstract
Obstetrics & Gynecology
Kaoru Miyazaki, Yuki Ueno, Hirotaka Masuda, Hiroshi Uchida, Tetsuo Maruyama
REPRODUCTIVE SCIENCES
(2015)
Meeting Abstract
Obstetrics & Gynecology
Hiroshi Uchida, Tetsuo Maruyama, Sayaka Nishikawa-Uchida, Hideyuki Oda, Kaoru Miyazaki, Takashi Kajitani, Yasunori Yoshimura
REPRODUCTIVE SCIENCES
(2010)