期刊
ORGANIC LETTERS
卷 17, 期 15, 页码 3864-3867出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01840
关键词
-
资金
- Institute for Basic Science [IBS-R010-G1]
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2010-0022179, 2011-0020322]
The catalyst-controlled C4/C8 site-selective C-H arylation of isoquinolones using aryliodonium salts as the coupling partners was developed. The C4-selective arylation was successfully achieved via an electrophilic palladation pathway. A completely different selectivity pattern was observed using an Ir(III) catalytic system, which resulted in C-C bond formation exclusively at the C8 position. The isoquinolone scaffold can be conveniently equipped with various aryl substituents at either the C4 or C8 position.
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