Article
Oncology
Melanie Gaignage, Xuhao Zhang, Julie Stockis, Olivier Dedobbeleer, Camille Michiels, Perrine Cochez, Laure Dumoutier, Pierre G. Coulie, Sophie Lucas
Summary: The transmembrane protein GARP binds latent TGF-beta 1 to form complexes on the surface of Tregs, B-cells, and platelets, which release active TGF-beta 1 upon stimulation. Blocking TGF-beta 1 activation by Tregs with anti-GARP:TGF-beta 1 mAbs overcomes resistance to PD1/PD-L1 blockade in murine tumors. Furthermore, antibody-mediated blockade of GARP:TGF-beta 1 or genetic deletion of Garp in Tregs, B cells, or platelets does not alter immune responses in mice, suggesting potential for cancer immunotherapy without impairing other immune defenses.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Raghavendra Singh, Adam Bartok, Melanie Paillard, Ashley Tyburski, Melanie Elliott, Gyorgy Hajnoczky
Summary: Dysregulation of mitochondrial Ca2+ homeostasis has been linked to neurodegenerative diseases. MICU1, a calcium-sensing gatekeeper, plays a key role in regulating mitochondrial Ca2+ uptake. The study identified altered neuronal mitochondrial Ca2+ homeostasis as the cause of clinical symptoms in MICU1-deficient patients and highlighted potential therapeutic targets.
Article
Chemistry, Medicinal
Xiaohe Li, Yanhua Wang, Jingjing Liang, Zhun Bi, Hao Ruan, Yunyao Cui, Ling Ma, Yuli Wei, Bingchen Zhou, Liang Zhang, Honggang Zhou, Cheng Yang
Summary: Bergenin alleviates bleomycin-induced pulmonary fibrosis in mice by inhibiting myofibroblast activation and promoting autophagy and myofibroblast apoptosis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yan Yang, Jianyu Yang, Tengteng Ma, Xueke Yang, Yun Yuan, Ying Guo
Summary: This study explores the anti-inflammatory mechanism and antidepressant effects of THC by modulating the expression of various factors in astrocytes, providing new insights into the therapeutic potential of THC for depression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mika Yamada, Jinya Suzuki, Satsuki Sato, Yasuo Zenimaru, Rie Saito, Tadashi Konoshita, Fredric B. Kraemer, Tamotsu Ishizuka
Summary: This study demonstrates that overexpression of HSL can restore lipotoxicity in the hearts of ATGL-deficient mice, normalizing cardiac function and structure. These findings highlight the potential of cardiac HSL activation as an effective strategy for treating lipotoxic cardiomyopathy associated with ATGL deficiency.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Inwoo Hwang, Byeong-Seong Kim, Hyo Rim Ko, Seongbong Cho, Ho Yun Lee, Sung-Woo Cho, Dongryeol Ryu, Sungbo Shim, Jee-Yin Ahn
Summary: Inactivation of Ebp1 in the central nervous system leads to neuropathological changes in the cerebellum, including reduced cerebellar volume, Purkinje cell loss, and abnormal dendritic development. This results in motor defects and schizophrenia-like behaviors.
MOLECULAR PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Annamaria Fidilio, Margherita Grasso, Giuseppe Caruso, Nicolo Musso, Veronica Begni, Anna Privitera, Sebastiano Alfio Torrisi, Patrizia Campolongo, Stefania Schiavone, Fabio Tascedda, Gian Marco Leggio, Filippo Drago, Marco Andrea Riva, Filippo Caraci
Summary: Early life stressful experiences, especially during the prenatal period, can increase the risk of developing depression during adolescence. This study focuses on the prenatal stress (PNS) model in rats and its role in the development of depression. It reveals a strong interaction between the transforming growth factor-beta 1 (TGF-beta 1) gene and PNS in the pathogenesis of depression. The study also suggests that targeting the TGF-beta 1 pathway could be a potential pharmacological approach to prevent adolescent depression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takujiro Homma, Yuji Takeda, Tomoyuki Nakano, Shinya Akatsuka, Daisuke Kinoshita, Toshihiro Kurahashi, Shinichi Saitoh, Ken-ichi Yamada, Satoshi Miyata, Hironobu Asao, Kaoru Goto, Tetsu Watanabe, Masafumi Watanabe, Shinya Toyokuni, Junichi Fujii
Summary: The study revealed that in double knockout mice lacking Sod1 and Akr1a, cessation of AsA supplementation resulted in oxidative damage in lung tissues, triggering immune responses and ultimately leading to death. These findings suggest that the pivotal role of AsA in combating ROS is primarily seen in pulmonary tissues exposed to a hyperoxygenic microenvironment.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Songtao Gu, Jingjing Liang, Jianwei Zhang, Zhichao Liu, Yang Miao, Yuli Wei, Shimeng Li, Jinying Gu, Yunyao Cui, Ting Xiao, Xiaohe Li, Cheng Yang
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with unknown cause and limited treatment options. Transforming growth factor-beta 1 (TGF-beta 1) is recognized as a central pathway in pulmonary fibrosis. This study explored the potential effect and mechanism of JAK1/2 inhibitor baricitinib on reducing TGF-beta 1-induced fibroblast activation and epithelial injury, as well as attenuating bleomycin-induced pulmonary fibrosis in mice.
Article
Medicine, Research & Experimental
Joselyn Rojas-Quintero, Maria Eugenia Laucho-Contreras, Xiaoyun Wang, Quynh-Anh Fucci, Patrick R. . Burkett, Se-Jin Kim, Duo Zhang, Yohannes Tesfaigzi, Yuhong Li, Abhiram R. . Bhashyam, Li Zhang, Haider Khamas, Bartolome Celli, Aprile L. . Pilon, Francesca Polverino, Caroline A. Owen
Summary: Low Club Cell 16 kDa protein (CC16) plasma levels are associated with accelerated lung function decline in chronic obstructive pulmonary disease (COPD) patients. CS-exposed Cc16-/- mice exhibit exaggerated COPD-like disease with increased NF-KB activation in their lungs. RhCC16 treatment limits COPD progression in CS-exposed Cc16-/- mice by reducing pulmonary inflammation, alveolar septal cell apoptosis, and NF-KB activation, as well as rescuing reduced Foxj1 expression. It represents a potentially novel therapeutic approach for COPD.
Article
Plant Sciences
Yuanyuan Li, Wenguang Qin, Qiuling Liang, Jiamin Zeng, Qiong Yang, Yuqin Chen, Jian Wang, Wenju Lu
Summary: This study aimed to investigate the therapeutic efficacy of the Traditional Chinese Medicine formulation "Bufei huoxue" on IPF and its mechanisms. The results showed that "Bufei huoxue" can alleviate pulmonary fibrosis, improve lung function, reduce inflammation, and inhibit EMT and ECM production by inhibiting the TGF-beta 1/Smad2/3 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Peng Lin, Xu Tong, Fan Xue, Chi Qianru, Tang Xinyu, Li Zhe, Bai Zhikun, Li Shu
Summary: Polystyrene nanoplastics (PS NPs) contamination has been identified as a serious health issue for humans and animals. This study found that combined exposure to PS NPs and lipopolysaccharide (LPS) exacerbated myocardial fibrosis and autophagy. The exposure disrupted myocardial structure, increased reactive oxygen species (ROS), triggered oxidative stress, and promoted the production of fibrotic proteins and collagen.
Article
Medicine, Research & Experimental
Zhen-Zhen Li, Wen-Juan Han, Zhi-Chuan Sun, Yun Chen, Jun-Yi Sun, Guo-Hong Cai, Wan-Neng Liu, Tao-Zhi Wang, Yang-Dan Xie, Hong-Hui Mao, Fei Wang, Sui-Bin Ma, Fu-Dong Wang, Rou-Gang Xie, Sheng-Xi Wu, Ceng Luo
Summary: Patients with neuropathic pain often have comorbid psychiatric disorders. The study revealed that LAMB1 in the ECM plays a crucial role in modulating pain plasticity through signal transduction pathways, highlighting a potential therapeutic target for neuropathic pain treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Kaveri R. Washimkar, Manendra Singh Tomar, Chirag Kulkarni, Shobhit Verma, Ashutosh Shrivastava, Naibedya Chattopadhyay, Madhav Nilakanth Mugale
Summary: This study elucidates the association of TGF-β1/Smad and Nrf2 signaling in the EMT and metabolic alterations associated with the etiology and progression of PF.
Article
Chemistry, Medicinal
Lin Cheng, Pu Yao, Hongping Wang, Qian Yuan, Xiaowen Wang, Wei Feng, Fengjun Sun, Qian Wang
Summary: LP-HFY15 can reduce the inflammation levels and related indicators of lupus nephritis in mice by regulating the TGF-β1 signaling pathway, playing a significant role in experimental intervention for lupus nephritis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Oncology
Caroline Laheurte, Evan Seffar, Eleonore Gravelin, Julie Lecuelle, Adeline Renaudin, Laura Boullerot, Marine Malfroy, Amelie Marguier, Benoit Lecoester, Beatrice Gaugler, Philippe Saas, Caroline Truntzer, Francois Ghiringhelli, Olivier Adotevi
Summary: Plasmacytoid dendritic cells (pDCs) in non-small cell lung cancer patients have been shown to have an ambivalent role in cancer immunity. Higher levels of circulating pDCs are associated with improved overall survival (OS) in NSCLC, especially in early-stage patients, and a high pDC signature in the tumor microenvironment predicts better efficacy of immune checkpoint inhibitors in these patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Takashi MaruYama, Hirofumi Miyazaki, Yun-Ji Lim, Jian Gu, Masaki Ishikawa, Taichi Yoshida, WanJun Chen, Yuji Owada, Hiroyuki Shibata
Summary: Pyrolyzed deketene curcumin GO-Y022 prevents carcinogenesis in a gastric cancer mouse model, but its effect on tumor-induced immune suppression is still unclear. In this study, it was found that GO-Y022 inhibited Treg generation in the presence of transforming growth factor beta 1 (TGF-beta). However, GO-Y022 had limited impact on Foxp3(+) Tregs in the gastric tumor microenvironment. Gastric tumor cells produced a large amount of L-lactate in the presence of GO-Y022, which undermined the inhibitory effect of GO-Y022 on Treg generation in response to TGF-beta. Combination treatment with GO-Y022 and 2-deoxy-d-glucose (2DG) reduced L-lactate production and Treg generation in gastric tumor cells, leading to inhibition of gastric tumor cell survival and promotion of anti-tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Yasmin El Mahi, Alexis Varin, Mathieu Vetter, Ludivine Dal Zuffo, Loic Mazzeo, Jean-Paul Pais De Barros, Francois Aubin, Philippe Saas, Irene Gallais Serezal
Summary: The relapses of psoriasis are related to T cells that reside in the skin, with the fatty acid intake capacity of tissue-resident memory T cells playing a crucial role in their function. The composition of fatty acids in the skin is linked to the functions of epidermal T cells and may affect the severity of psoriasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Etienne Daguindau, Cecile Chague, Philippe Saas
M S-MEDECINE SCIENCES
(2023)
Editorial Material
Immunology
Philippe Saas, Guo-Chang Fan
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Maxime Samson, Coraline Genet, Marc Corbera-Bellalta, Helene Greigert, Georgina Espigol-Frigole, Claire Gerard, Claudie Cladiere, Roser Alba-Rovira, Marion Ciudad, Pierre-Henry Gabrielle, Catherine Creuzot-Garcher, Georges Tarris, Laurent Martin, Philippe Saas, Sylvain Audia, Bernard Bonnotte, Maria C. Cid
Summary: This study evaluated the effect of Human Monocyte-derived Suppressor Cells (HuMoSC) on inflammation and vascular remodeling in Giant Cell Arteritis (GCA) treatment. The results showed that HuMoSCs or their supernatant could decrease vascular inflammation and remodeling, which may address the unmet need in GCA treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Eleonora Sosa Cuevas, Philippe Saas, Caroline Aspord
Summary: Immunotherapies using immune checkpoint blockers have shown clinical success in melanoma, but some patients still relapse or do not respond. Dendritic cells (DCs) play a key role in immune responses and their understanding is important for developing effective immunotherapies. This review provides an overview of DC diversity, their role in melanoma pathophysiology and clinical outcomes, tumor-induced DC subversion mechanisms, and DC-based therapeutic developments.
Article
Biochemistry & Molecular Biology
Takashi MaruYama, Hirofumi Miyazaki, Taishi Komori, Shion Osana, Hiroyuki Shibata, Yuji Owada, Shuhei Kobayashi
Summary: In this study, the antitumor effects of GO-Y030, a curcumin analog, were investigated in a mouse model. The results showed that GO-Y030 treatment inhibited the expression of TGF-β and glycolysis in melanoma cells, leading to the inhibition of tumor invasion and metastasis. Furthermore, GO-Y030 administration demonstrated efficacy in inhibiting lung tumor metastasis without affecting vascular endothelial cells.
JOURNAL OF BIOCHEMISTRY
(2023)
Article
Immunology
Emilie Gaiffe, Mathilde Colladant, Maxime Desmaret, Jamal Bamoulid, Franck Leroux, Caroline Laheurte, Sophie Brouard, Magali Giral, Philippe Saas, Cecile Courivaud, Nicolas Degauque, Didier Ducloux
Summary: Unsupervised hierarchical clustering analysis was performed on pre-transplant immunological phenotype in 1113 renal transplant recipients, identifying three immune profiles correlated with clinical phenotypes. The memory immune cluster was associated with older age and diabetes, while the activated immune cluster was associated with younger age and previous exposure to CMV. Both were associated with an increased risk of acute rejection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Emilie Gaiffe, Dewi Vernerey, Laurent Bardiaux, Franck Leroux, Aurelia Meurisse, Jamal Bamoulid, Cecile Courivaud, Philippe Saas, Marc Hazzan, Pierre Tiberghien, Didier Ducloux
Summary: A longer storage duration of red blood cells (RBC) was associated with a decreased risk of transplant failure among patients who received kidney transplants and RBC transfusions. Preferential use of RBC with longer storage duration might improve kidney graft survival following transplant and transfusion.
Article
Rheumatology
Sophie Hecquet, Perle Totoson, Helene Martin, Marie-Paule Algros, Philippe Saas, Jean-Paul Pais-de-Barros, Alban Atchon, Benoit Valot, Didier Hocquet, Maude Tournier, Clement Prati, Daniel Wendling, Celine Demougeot, Frank Verhoeven
Summary: Intestinal inflammation and alterations of the intestinal barrier are not the consequence of joint damage, and intestinal changes occurred in the absence of bacterial translocation.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Immunology
Camille Niveau, Eleonora Sosa Cuevas, Benoit Roubinet, Mylene Pezet, Michel Thepaut, Stephane Mouret, Julie Charles, Franck Fieschi, Ludovic Landemarre, Laurence Chaperot, Philippe Saas, Caroline Aspord
Summary: Dendritic cell subsets play a crucial role in shaping anti-tumour immunity. The study found that melanoma tumour cells display aberrant glycan motifs which can be sensed by dendritic cells through specific receptors. This interaction may lead to abnormal immune responses. The study suggests that targeting the glycan/receptor axis could be a promising strategy for improving cancer immunotherapy.
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
Meeting Abstract
Dermatology
Y. El Mahi, A. Varin, J. Pais-De-Barros, F. Aubin, P. Saas, I. Gallais Serezal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Meeting Abstract
Pharmacology & Pharmacy
C. Peyronnel, P. Totoson, V. Petitcolin, F. Bonnefoy, X. Guillot, P. Saas, H. Martin, C. Demougeot
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)