Article
Agriculture, Multidisciplinary
Zhong-yue Bian, Zong-cai Tu, Hui Wang, Yue-ming Hu, Guang-xian Liu
Summary: This study investigated the impact of Co-60 gamma-ray irradiation on the antigenicity of ovalbumin (OVA) and found that it enhances the allergenicity of OVA through oxidative modification, leading to structural changes and specific oxidation sites.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Immunology
Jin Yuan, Ping Tong, Xuanyi Meng, Yong Wu, Xin Li, Jinyan Gao, Hongbing Chen
Summary: This study investigated the effects of co-exposure to Staphylococcus aureus enterotoxin B (SEB) and Ovalbumin (OVA) on the development of food allergy. The results suggested that this co-exposure could impair the intestinal barrier, disrupt the intestinal Th immune balance, and decrease the diversity of intestinal flora in OVA-sensitized mice. Additionally, it enhanced the transport of OVA in the Caco-2 cell monolayer, promoted the uptake and presentation of OVA in bone marrow dendritic cells (BMDCs), and enhanced Th cell differentiation. These findings suggest that SEB in allergens should be considered a risk factor for food allergy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yan Li, Silin Jiang, Jiawei Li, Mengzhuo Yin, Fuxin Yan, Yuyuan Chen, Yan Chen, Tongwei Wu, Mengliang Cheng, Yihua He, Hongbin Liang, Hang Yu, Qingqing Qiao, Zhigang Guo, Yan Xu, Yanan Zhang, Zheng Xiang, Zhinan Yin
Summary: The study found a significant decrease in the number of γδ T cells in patients with coronary atherosclerotic heart disease, with V delta 2(+) T cells showing a significant decrease and V delta 1(+) T cells also at a lower proportion in CAD patients compared to healthy individuals.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Anna Maria Corsale, Marta Di Simone, Elena Lo Presti, Carmela Picone, Francesco Dieli, Serena Meraviglia
Summary: This article reviews recent studies on altered tumor metabolism and gamma delta T cells, emphasizing the potential of gamma delta T cells in overcoming limitations associated with conventional T cells and their anti-tumor effects. A deeper understanding of tumor metabolism and the polarization of gamma delta T cells could lead to the development of new immunotherapeutic approaches targeting tumor metabolisms.
Article
Immunology
J. C. Andreu-Ballester, M. A. Arribas, M. Rico, C. Garcia-Ballesteros, L. Galindo-Regal, R. Sorando-Serra, L. Albert, A. Navarro, F. Lopez-Chulia, F. Peydro, C. Cuellar
Summary: This study aimed to investigate the relationship between changes in γδT cell count and the progression of sepsis. The results showed that the number of γδT cells decreased with the severity of sepsis, particularly in non-surviving patients, while cell apoptosis increased.
CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
James W. Krempski, Jyoti K. Lama, Koji Iijima, Takao Kobayashi, Mayumi Matsunaga, Hirohito Kita
Summary: This study developed a mouse model to simulate the effects of early introduction of peanut products on peanut allergies. The results showed that ingestion of a peanut product protected mice from peanut allergy induced by environmental exposure. The CTLA-4 pathway, which regulates Tfh cell responses, played a pivotal role in this protection.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Cell Biology
Nicola Beucke, Svenja Wingerter, Karin Haehnel, Lisbeth Aagaard Larsen, Kaare Christensen, Graham Pawelec, Kilian Wistuba-Hamprecht
Summary: The study found that latent cytomegalovirus infection affects the differentiation status of alpha beta and gamma delta T cells in humans. Additionally, genetic factors also influence the differentiation of gamma delta and alpha beta T cell subsets.
Article
Gastroenterology & Hepatology
Emily Becker, Mark Dedden, Christine Gall, Maximilian Wiendl, Arif Bulent Ekici, Anja Schulz-Kuhnt, Anna Schweda, Caroline Voskens, Ahmed Hegazy, Francesco Vitali, Raja Atreya, Tanja Martina Mueller, Imke Atreya, Markus F. Neurath, Sebastian Zundler
Summary: This study investigated the non-linear exposure-efficacy characteristics of vedolizumab in IBD patients. The research found that blocking T-Eff cell trafficking with vedolizumab while allowing residual homing of T-Reg cells could be a strategy to optimize treatment outcomes. These findings were supported by data from Gemini II and III trials.
Article
Immunology
Imke Lingel, Adrienne N. Wilburn, Julie Hargis, Jaclyn W. McAlees, Yves Laumonnier, Claire A. Chougnet, Hitesh Deshmukh, Peter Koenig, Ian P. Lewkowich, Inken Schmudde
Summary: Changes in microbiome contribute to severity of allergic asthma. Prenatal antibiotic-induced dysbiosis leads to long-term immunological effects in offspring and increases asthma severity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Haixia Lu, Ping Liu, Xiaoxia Zhang, Ting Bao, Ting Wang, Li Guo, Yiwei Li, Xiaoying Dong, Xiaorong Li, Youping Dong, Liping Sha, Lanjie He, Hao Wang
Summary: Treatment with dietary inulin and Lycium barbarum polysaccharides led to decreased blood glucose, improved gut microbiota and short-chain fatty acids, as well as enhanced gut mucosal immune cells and tight-junction proteins in diabetic rats, ultimately improving gut barrier function.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Applied
Mehdi Cherkaoui, Dominique Tessier, Virginie Lollier, Colette Larre, Chantal Brossard, Wieneke Dijk, Helene Rogniaux
Summary: This study aimed to explore the effect of heat treatment on the IgE binding capacity of ovalbumin (OVA). The results showed that both aggregation and glycation strongly impacted the IgE binding capacity. High-resolution mass spectrometry analysis revealed extensive cross-linking through disulfide and dehydroprotein bridges, as well as moderate but significant glycation. Furthermore, key amino acid residues implicated in the changes in IgE binding were identified.
Article
Allergy
James W. Krempski, Jyoti K. Lama, Koji Iijima, Takao Kobayashi, Mayumi Matsunaga, Hirohito Kita
Summary: A mouse model was developed to simulate the LEAP study, showing that ingestion of a peanut product can protect mice from peanut allergy induced by environmental exposure, possibly through the CTLA-4 pathway regulating Tfh cell responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Cell Biology
Chenduo Li, Xiaonan Du, Qiong Huang, Yiran Yang, Jingjing Wang, Xiaofeng Qin, Wenjun Wang, Zihan Liu, Huihui Yuan, Jie Liu, Zhe Lv, Yan Li, Yan Chen, Ye Cui, Chris J. Corrigan, Kewu Huang, Wei Wang, Sun Ying
Summary: Research suggests that repeated exposure to inactivated S. pneumoniae in the presence of IL-33 can induce asthma-like pathological changes and systemic adaptive immune responses. Furthermore, asthma patients showed significantly elevated concentrations of S. pneumoniae lysates-specific IgE, indicating a potential role of antigens derived from infectious microorganisms in asthma-related mucosal inflammation.
CELLULAR IMMUNOLOGY
(2021)
Article
Immunology
Katarzyna Skulska, Anna Ewa Kedzierska, Malgorzata Krzyzowska, Grzegorz Chodaczek
Summary: Many studies have shown that immune functions decline and become dysregulated with age. This study aimed to investigate the effect of aging on the immune surveillance of the female reproductive tract by gamma delta T cells. The results showed that there was an increase in gamma delta T cell number in aged mice, and these cells played a fine-tuning role in immunoregulation.
JOURNAL OF IMMUNOLOGY RESEARCH
(2023)
Article
Immunology
Khaleda Rahman Qazi, Georg B. Jensen, Marieke van Der Heiden, Sophia Bjorkander, Giovanna Marchini, Maria C. Jenmalm, Thomas Abrahamsson, Eva Sverremark-Ekstrom
Summary: Extremely low gestational age neonates with extremely low birthweight (ELGAN/ELBW) are highly susceptible to infection due to their relatively immature immune system. Prematurity strongly influences the levels of gamma delta T and NK cells, especially in cases where sepsis occurs within the first 2 weeks of life.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Review
Allergy
Yafei Huang, Zhifang Yang, Jessica McGowan, Hua Huang, Rebecca L. O'Brien, Willi K. Born
CURRENT ALLERGY AND ASTHMA REPORTS
(2015)
Article
Immunology
Yafei Huang, Andrew Getahun, Ryan A. Heiser, Thiago O. Detanico, Katja Aviszus, Greg A. Kirchenbaum, Tamara L. Casper, Chunjian Huang, M. Kemal Aydintug, Simon R. Carding, Koichi Ikuta, Hua Huang, Lawrence J. Wysocki, John C. Cambier, Rebecca L. O'Brien, Willi K. Born
JOURNAL OF IMMUNOLOGY
(2016)
Article
Immunology
Yapeng Li, Xiaopeng Qi, Bing Liu, Hua Huang
JOURNAL OF IMMUNOLOGY
(2015)
Review
Immunology
Hua Huang, Yapeng Li, Bing Liu
SEMINARS IN IMMUNOPATHOLOGY
(2016)
Article
Allergy
Yapeng Li, Bing Liu, Laura Harmacek, Zijie Long, Jinyi Liang, Kara Lukin, Sonia M. Leach, Brian O'Connor, Anthony N. Gerber, James Hagman, Axel Roers, Fred D. Finkelman, Hua Huang
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Review
Allergy
Hua Huang, Yapeng Li
CURRENT ALLERGY AND ASTHMA REPORTS
(2014)
Article
Biochemistry & Molecular Biology
Jun Nishida, Yapeng Li, Yonghua Zhuang, Zan Huang, Hua Huang
Review
Geriatrics & Gerontology
Henry Milgrom, Hua Huang
Article
Immunology
Xiaopeng Qi, Jessie Hong, Lee Chaves, Yonghua Zhuang, Yuhong Chen, Demin Wang, Jacob Chabon, Brian Graham, Keitaro Ohmori, Yapeng Li, Hua Huang
Article
Immunology
Hua Huang, Xiaopeng Qi
IMMUNOLOGIC RESEARCH
(2013)
Article
Allergy
Zhihong Chen, Shanze Wang, Nkiruka Erekosima, Yapeng Li, Jessie Hong, Xiaopeng Qi, Patricia Merkel, Vijaya Nagabhushanam, Eugene Choo, Rohit Katial, Rafeul Alam, Anita Trikha, Hong Wei Chu, Yonghua Zhuang, Meiling Jin, Chunxue Bai, Hua Huang
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2013)
Article
Immunology
Ross M. Kedl, Lawrence J. Wysocki, William J. Janssen, Willi K. Born, Matthew D. Rosenbaum, Julia Granowski, Jennifer A. Kench, Derek L. Fong, Lisa A. Switzer, Margaret Cruse, Hua Huang, Claudia V. Jakubzick, Beata Kosmider, Katsuyuki Takeda, Thomas J. Stranova, Randal C. Klumm, Christine Delgado, Saigiridhar Tummala, Stijn De Langhe, John Cambier, Katherine Haskins, Laurel L. Lenz, Douglas Curran-Everett
JOURNAL OF IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Yafei Huang, Ryan A. Heiser, Thiago O. Detanico, Andrew Getahun, Greg A. Kirchenbaum, Tamara L. Casper, M. Kemal Aydintug, Simon R. Carding, Koichi Ikuta, Hua Huang, John C. Cambier, Lawrence J. Wysocki, Rebecca L. O'Brien, Willi K. Born
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Multidisciplinary Sciences
Yapeng Li, Junfeng Gao, Mohammad Kamran, Laura Harmacek, Thomas Danhorn, Sonia M. Leach, Brian P. O'Connor, James R. Hagman, Hua Huang
Summary: The study demonstrates that GATA2 promotes chromatin accessibility at the super-enhancers of mast cell identity genes and primes both typical and super-enhancers at genes that respond to antigenic stimulation.
NATURE COMMUNICATIONS
(2021)
Article
Allergy
Yapeng Li, Junfeng Gao, Dianzheng Zhao, Xiaoyu Guan, Suzanne C. Morris, Fred D. Finkelman, Hua Huang
Summary: This study investigated how enhancers regulate Hdc gene transcription and histamine synthesis, and found that the GC box within the enhancer next to the Hdc gene is essential for Hdc gene transcription, histamine synthesis, and histamine-mediated anaphylaxis in mice and humans.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)