Review
Cell Biology
Christina E. Zielinski
Summary: Sodium chloride has been proposed to have potent effects on T cell responses in the context of autoimmune, allergic, and infectious tissue inflammation in both mouse models and humans. It is stringently regulated in the blood by the kidneys but displays differential deposition patterns in peripheral tissues, which may be influenced by dietary intake and intentional behavior. Its downstream cellular activities represent a potential therapeutic target given its effects on T cell cytokine production.
Article
Biochemistry & Molecular Biology
Oscar J. Cordero, Carlos Rafael-Vidal, Ruben Varela-Calvino, Cristina Calvino-Sampedro, Beatriz Malvar-Fernandez, Samuel Garcia, Juan E. Vinuela, Jose M. Pego-Reigosa
Summary: Immune system CD4 T-cells with high cell-surface CD26 expression demonstrate anti-tumoral properties, especially when engineered with a chimeric antigen receptor. Different T helper cell subsets show variations in CD26 expression levels, which could impact research on CAR-T cells. The relationship between glycoprotein sCD26 and its enzymatic activity, as well as its correlation with specific T cell subsets, still requires further understanding.
Review
Immunology
Hongbo Ni, Yinghan Chen
Summary: Regulatory T cells (Tregs) play a significant role in suppressing excessive immune response and maintaining tissue homeostasis. This review focuses on the migration of Tregs to non-lymphoid tissues and their adaptation to tissue microenvironments through the development of tissue-specific chemokine receptors, transcription factors, and phenotypes. Tumor-infiltrating Tregs (Ti-Tregs) are crucial for tumor generation and immunotherapy resistance, and their phenotypes overlap with tissue-specific Tregs. Understanding the molecular mechanisms behind tissue-specific Tregs can provide insights into potential therapeutic targets and biomarkers for inflammatory diseases and cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Yao Chen, Ziyang Xu, Hongxiang Sun, Xinxing Ouyang, Yuhen Han, Haihui Yu, Ningbo Wu, Yiting Xie, Bing Su
Summary: CD8(+) T cells play a crucial role in adaptive immune response against tumors and viruses. This review focuses on the molecular signaling mediated by mTOR complex 2 in memory and exhausted CD8(+) T cells.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Cell Biology
Anne Aalto, Adan Olguin-Olguin, Erez Raz
Summary: This article discusses the migration mechanism of zebrafish primordial germ cells during embryonic development, which involves a bleb-driven amoeboid migration mode controlled by chemical and physical cues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Mengdi Zhang, Xiaoxi Lin, Zhou Yang, Xia Li, Zhiguang Zhou, Paul E. Love, Jiaqi Huang, Bin Zhao
Summary: Cell metabolism plays a critical role in regulating T cell development, directing different metabolic pathways and signaling networks to match the specific functional requirements of different stages. Understanding this interplay may offer new therapeutic approaches to selectively regulate T cell subset functions and modulate autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mauro Di Pilato, Raphael Kfuri-Rubens, Jasper N. Pruessmann, Aleksandra J. Ozga, Marius Messemaker, Bruno L. Cadilha, Ramya Sivakumar, Chiara Cianciaruso, Ross D. Warner, Francesco Marangoni, Esteban Carrizosa, Stefanie Lesch, James Billingsley, Daniel Perez-Ramos, Fidel Zavala, Esther Rheinbay, Andrew D. Luster, Michael Y. Gerner, Sebastian Kobold, Mikael J. Pittet, Thorsten R. Mempel
Summary: The conversion of stem-like CTLs into effector-like CTLs involves chemotactic reprogramming with upregulation of chemokine receptor CXCR6. CXCR6 expression and IL-15 trans-presentation are crucial for the survival and local expansion of effector-like CTLs in the tumor microenvironment.
Review
Chemistry, Multidisciplinary
Ying Kong, Jiazhi Duan, Feng Liu, Lin Han, Gang Li, Chunhui Sun, Yuanhua Sang, Shuhua Wang, Fan Yi, Hong Liu
Summary: The application of physical signals in tissue engineering has the potential to regulate stem cell fate through nanostructure mediation. This method provides a new perspective for research and is expected to aid in the development of remote-controlled and wireless platforms to guide stem cell differentiation.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Multidisciplinary Sciences
Narges Aghaallaei, Advaita M. Dick, Erika Tsingos, Daigo Inoue, Eva Hasel, Thomas Thumberger, Atsushi Toyoda, Maria Leptin, Joachim Wittbrodt, Baubak Bajoghli
Summary: The study in medaka fish reveals that progenitors first enter a thymic niche favoring the development of gamma delta T cells, and the gradients of interleukin-7 and Ccl25a in the niche influence the lineage outcome. This previously unknown mechanism determines the proportion of alpha beta/gamma delta lineages within species.
Article
Biochemistry & Molecular Biology
Kazuo Katoh
Summary: The study revealed that Src protein tyrosine kinases play crucial roles in cell polarity formation and elongation, with the expression and regulation of Src being essential for polarity formation during cell elongation.
Article
Multidisciplinary Sciences
Tom M. J. Evers, Vahid Sheikhhassani, Marielle C. Haks, Cornelis Storm, Tom H. M. Ottenhoff, Alireza Mashaghi
Summary: The mechanical behavior of monocytes is strain rate dependent and can be altered by chemokines. Understanding the mechanical properties of monocytes can provide physical biomarkers for disease progression and response to therapy.
Article
Biochemistry & Molecular Biology
Ruben Varela-Calvino, Marta Rodriguez-Quiroga, Patricia Dias Carvalho, Flavia Martins, Andre Serra-Roma, Lorena Vazquez-Iglesias, Maria Paez de la Cadena, Sergia Velho, Oscar J. Cordero
Summary: The glycoprotein CD26 with peptidase activity and its soluble counterpart DPP4 are altered in several cancers, indicating a potential role in metastasis development and overall survival outcomes in cancer patients. The inhibition of DPP4 enzyme activity by sitagliptin showed reductions in invasion and motility in colorectal cancer cell lines, shedding light on the molecular mechanisms underlying its antimetastatic effects. However, the specific mechanism of action and potential areas for therapeutic applications of DPP4 inhibitors in cancer treatment remain to be fully elucidated.
Article
Multidisciplinary Sciences
Calvin K. Lee, William C. Schmidt, Shanice S. Webster, Jonathan W. Chen, George A. O'Toole, Gerard C. L. Wong
Summary: This study reveals that changes in c-di-GMP levels in bacterial biofilms are not the sole factor determining surface commitment, as oscillations in c-di-GMP levels can propagate across generations. Additionally, the study demonstrates that modulation of c-di-GMP signals and cooperative surface commitment can be influenced by varying the interaction strength between PilO and SadC.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Shuna Liu, Ziqi Tao, Jianfang Lou, Rong Li, Xin Fu, Juan Xu, Ting Wang, Lei Zhang, Wenwen Shang, Yepeng Mao, Fang Wang
Summary: This study reveals the important role of CD4(+)CCR8(+) Tregs in the immune microenvironment of ovarian cancer, and CCR8 and its ligands CCL1 and CCL18 play a key regulatory role in the migration and infiltration of CD4(+) T cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Tianzhuo Zhang, Qianwen Shi, Huining Gu, Biaoyi Yu, Sha Yin, Qing Ge, Xiaoning Mo, Xiaofeng Liu, Jing Huang
Summary: CCDC134 is a cytokine-like molecule that serves as a positive regulator of TCR-proximal signaling by interacting with CD3e and modulating its ubiquitination and degradation. T cell-specific deletion of Ccdc134 results in decreased mature CD4(+) and CD8(+) T cells, impaired T cell homeostasis, and attenuated response to TCR stimulation in vitro and in vivo. These findings highlight the importance of CCDC134 in T cell development and function, and its role in T cell-mediated inflammatory and antitumor responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Kelly A. Schats, Emily A. Van Vre, Stefanie De Schepper, Carolien Boeckx, Dorien M. Schrijvers, Wim Waelput, Erik Fransen, Isabelle Vanden Bempt, Bart Neyns, Ingrid De Meester, Mark M. Kockx
Article
Clinical Neurology
Lesley Baerts, Raf Brouns, Kaat Kehoe, Robert Verkerk, Sebastiaan Engelborghs, Peter Paul De Deyn, Dirk Hendriks, Ingrid De Meester
TRANSLATIONAL STROKE RESEARCH
(2017)
Article
Chemistry, Medicinal
Dean Rea, Roos Van Elzen, Hans De Winter, Sebastiaan Van Goethem, Bart Landuyt, Walter Luyten, Liliane Schoofs, Pieter Van Der Veken, Koen Augustyns, Ingrid De Meester, Vilmos Fulop, Anne-Marie Lambeir
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Meeting Abstract
Gastroenterology & Hepatology
Hannah Ceuleers, Joris De Man, Jurgen Joossens, Koen Augustyns, Sven M. Francque, Ingrid De Meester, Benedicte Y. De Winter
Article
Biochemistry & Molecular Biology
Mieke Metzemaekers, Anneleen Mortier, Rik Janssens, Daiane Boff, Lotte Vanbrabant, Nicole Lamoen, Jo Van Damme, Mauro M. Teixeira, Ingrid De Meester, Flavio A. Amaral, Paul Proost
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Cardiac & Cardiovascular Systems
Jae-Hwi Jang, Yoshito Yamada, Florian Janker, Ingrid De Meester, Lesley Baerts, Gwendolyn Vliegen, Ilhan Inci, Shampa Chatterjee, Walter Weder, Wolfgang Jungraithmayr
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2017)
Meeting Abstract
Gastroenterology & Hepatology
H. Ceuleers, J. G. de Man, J. Joossens, K. Augustyns, S. M. Francque, A-M. Lambeir, I. de Meester, B. Y. de Winter
NEUROGASTROENTEROLOGY AND MOTILITY
(2017)
Review
Gastroenterology & Hepatology
Hanne Van Spaendonk, Hannah Ceuleers, Leonie Witters, Eveline Patteet, Jurgen Joossens, Koen Augustyns, Anne-Marie Lambeir, Ingrid De Meester, Joris G. De Man, Benedicte Y. De Winter
WORLD JOURNAL OF GASTROENTEROLOGY
(2017)
Article
Medical Laboratory Technology
Kelly A. Schats, Emily A. Van Vre, Carolien Boeckx, Martine De Bie, Dorien M. Schrijvers, Bart Neyns, Ingrid De Meester, Mark M. Kockx
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2018)
Article
Pharmacology & Pharmacy
Hannah Ceuleers, Nikita Hanning, Jelena Heirbaut, Samuel Van Remoortel, Jurgen Joossens, Pieter Van der Veken, Sven M. Francque, Michelle De Bruyn, Anne-Marie Lambeir, Joris G. De Man, Jean-Pierre Timmermans, Koen Augustyns, Ingrid De Meester, Benedicte Y. De Winter
BRITISH JOURNAL OF PHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
Kaat Kehoe, Heidi Noels, Wendy Theelen, Emilie De Hert, Shenguan Xu, An Verrijken, Thierry Arnould, Erik Fransen, Nina Hermans, Anne-Marie Lambeir, Per Venge, Luc Van Gaal, Ingrid De Meester
Article
Immunology
Rik Janssens, Daiane Boff, Pieter Ruytinx, Anneleen Mortier, Vincent Vanheule, Olav Larsen, Viktorija Daugvilaite, Mette M. Rosenkilde, Sam Noppen, Sandra Liekens, Dominique Schols, Ingrid De Meester, Ghislain Opdenakker, Sofie Struyf, Mauro M. Teixeira, Flavio A. Amaral, Paul Proost
FRONTIERS IN IMMUNOLOGY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
Hannah Ceuleers, Qian Li, Joris De Man, Liansheng Liu, Jurgen Joossens, Koen Augustyns, Ingrid De Meester, Benedicte Y. De Winter, Pankaj J. Pasricha
Meeting Abstract
Oncology
Kelly Schats, Emily A. Van Vre, Isolde Debyser, Arno Vandenbroeck, Yanina Jansen, Teofila Seremet, Koen Marien, Erik Fransen, Dorien Schrijvers, Wim Van Criekinge, Kris Thielemans, Bart Neyns, Ingrid De Meester, Mark Kockx
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Review
Oncology
Gwendolyn Vliegen, Tom K. Raju, Dirk Adriaensen, Anne-Marie Lambeir, Ingrid De Meester
ANNALS OF TRANSLATIONAL MEDICINE
(2017)