Article
Immunology
Judith Kannenberg, Henning Trawinski, Reinhard Henschler, Raymund Buhmann, Mario Honemann, Christian Jassoy
Summary: The study found that the low concentration of SARS-CoV-2 spike antibodies indicates the need for re-exposure to the virus or vaccination to fully utilize B-cell immunity, while most infected individuals had robust virus-specific memory B-cell responses 12 months after infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Cell Biology
Chenfei He, Shan Wang, Chikai Zhou, Minghui He, Jin Wang, Marcus Ladds, Danai Lianoudaki, Saikiran K. Sedimbi, David P. Lane, Lisa S. Westerberg, Shuijie Li, Mikael C. Karlsson
Summary: CD36 plays a critical role in regulating macro-autophagy in B cells, and its deficiency impairs the humoral immune response, leading to reduced plasma cell formation, mitochondrial mobilization, and oxidative phosphorylation. CD36 also regulates autophagy and is involved in T-cell-dependent immune responses.
Review
Oncology
Jia Xu, Wenjing Luo, Chenggong Li, Heng Mei
Summary: CD19-targeted CAR-T cell therapy has shown remarkable efficacy in treating B-cell malignancies, but CD19-negative relapse remains a significant challenge. CD22 serves as a potential alternative target for CD19 CAR-T cell-resistant patients, with therapies showing acceptable toxicities and promising efficacy.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Immunology
Zhenghao Wu, Junjie Zhou, Yunxiao Xiao, Jie Ming, Jing Zhou, Fang Dong, Xiaoqi Zhou, Zhuoshuo Xu, Xiangwang Zhao, Ping Lei, Tao Huang
Summary: In this study, the authors identified a subset of B cells called B-IR cells that have a memory phenotype and promote the response to immune checkpoint inhibitor (ICI) therapy. These cells were present in cancer-associated tertiary lymphoid structures and their gene signatures correlated with positive outcomes in patients treated with ICI therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Kin L. Wong, Zhengdong Li, Felix Ma, Dong Wang, Nan Song, Chi H. Chong, Ka K. Luk, Shui O. Leung
Summary: SM03, an anti-CD22 recombinant IgG1 mAb, has shown good safety and efficacy in clinical trials for systemic lupus erythematosus and rheumatoid arthritis. Its novel mechanism of action disrupts CD22 configuration and enhances the activity of immunomodulatory molecules, leading to decreased inflammation and restoration of immune tolerance.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Plant Sciences
Meizhi Xu, Xu Gu, Qiaozhi Yu, Yuting Liu, Xinxin Bian, Renyin Wang, Meina Yang, Shuang Wu
Summary: This study observed the time-course reconstruction of the stem cell niche (SCN) in intact Arabidopsis roots using an inducible system, revealing a stage-dependent anatomical reorganization and cell fate specification during SCN recovery. The local accumulation of auxin coincided with cell division patterns, and the precise re-positioning of SCN seemed to be determined by mutual antagonism between auxin and cytokinin, highlighting a conserved mechanism in damage-induced root regeneration.
Review
Immunology
Keenan J. Wiggins, Christopher D. Scharer
Summary: This study delves into the formation process of antibody-secreting cells, indicating the need for distinct transcription factors and epigenetic programs during B cell differentiation. The identification of markers can assist in facilitating the manipulation of B cell differentiation, aiding in vaccine development and treatment of antibody-related diseases.
IMMUNOLOGICAL REVIEWS
(2021)
Article
Engineering, Biomedical
Yanqun Li, Jianhui Yue, Yuan Liu, Jun Wu, Min Guan, Di Chen, Haobo Pan, Xiaoli Zhao, William W. Lu
Summary: The study revealed that strontium promotes osteogenic differentiation of mesenchymal stem cells and balances stemness maintenance and osteogenic differentiation through asymmetric cell division. Strontium activates noncanonical Wnt signaling to regulate cell division and enhance osteogenic differentiation.
ACTA BIOMATERIALIA
(2021)
Article
Infectious Diseases
Anat Achiron, Michael Gurevich, Rina Falb, Sapir Dreyer-Alster, Polina Sonis, Mathilda Mandel
Summary: The majority of convalescent COVID-19 subjects maintain a long-term IgG antibody response to SARS-CoV-2, with a protective level lasting up to 9 months, regardless of age, gender, major blood types, or clinical symptomatology.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Yongguang Zhang, Dongya Cui, Miaohui Huang, Yongwei Zheng, Baijiao Zheng, Liling Chen, Qi Chen
Summary: The protein NONO is a multifunctional nuclear protein that regulates transcriptional regulation, mRNA splicing, and DNA repair. This study shows that NONO has a critical role in B-cell development and B-cell activation. Deletion of NONO impairs early B-cell development and B-cell maturation, as well as the activation of pathways involved in B-cell activation, such as ERK, AKT, and NF-kappa B.
Article
Chemistry, Multidisciplinary
Senlian Hong, Chenhua Yu, Peng Wang, Yujie Shi, Weiqian Cao, Bo Cheng, Digantkumar G. Chapla, Yuanhui Ma, Jie Li, Emily Rodrigues, Yoshiki Narimatsu, John R. Yates, Xing Chen, Henrik Clausen, Kelly W. Moremen, Matthew Scott Macauley, James C. Paulson, Peng Wu
Summary: By modifying natural killer cells with glycan ligands targeting CD22, as well as selectins to promote trafficking to bone marrow, it is possible to achieve targeted killing of B lymphoma cells and improve cell trafficking to cancer cell locations, resulting in efficient suppression of lymphoma in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Immunology
Imran J. Anwar, Isabel F. DeLaura, Qimeng Gao, Joseph Ladowski, Annette M. Jackson, Jean Kwun, Stuart J. Knechtle
Summary: Despite the significant improvement in kidney transplantation outcomes over the last decades, long-term results remain unsatisfactory due to antibody-mediated rejection. Currently, there are no FDA-approved regimens for this treatment, but several clinical trials are underway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
John H. Baird, Matthew J. Frank, Juliana Craig, Shabnum Patel, Jay Y. Spiegel, Bita Sahaf, Jean S. Oak, Sheren F. Younes, Michael G. Ozawa, Eric Yang, Yasodha Natkunam, John Tamaresis, Zachary Ehlinger, Warren D. Reynolds, Sally Arai, Laura Johnston, Robert Lowsky, Everett Meyer, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Kara L. Davis, Sneha Ramakrishna, Liora Schultz, Chelsea Mullins, Allison Jacob, Ilan Kirsch, Steven A. Feldman, Crystal L. Mackall, David B. Miklos, Lori Muffly
Summary: Despite poor prognosis in LBCL patients following CAR19 therapy failure, treatment with CAR22 in three consecutive patients showed promising results with all patients achieving complete remission and experiencing tolerable side effects, suggesting potential efficacy of CAR22 therapy in this population.
Article
Immunology
Wan-Chun Lai, Yu-Chia Hsieh, Yi-Ching Chen, Chen-Yen Kuo, Chih-Jung Chen, Yhu-Chering Huang, Cheng-Hsun Chiu, Tzou-Yien Lin, Kuan-Ying A. Huang
Summary: The cellular basis for antigen-specific antibody response to acute M. pneumoniae infection in children was investigated. A strong M. pneumoniae P1-specific antibody-secreting B cell (ASC) response was detected in the peripheral blood of M. pneumoniae-positive patients. No M. pneumoniae-specific ASCs were detected in M. pneumoniae-negative patients.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Public, Environmental & Occupational Health
P. C. S. Lian, B. Morrish
Summary: This study retrospectively examined the antibody response after an accelerated course of Hepatitis B vaccination and found that it confers a high level of immunity. Females and individuals under 40 years old had a better antibody response.
OCCUPATIONAL MEDICINE-OXFORD
(2022)
Article
Biochemistry & Molecular Biology
Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Shuang Wang, Yasuhiro Nemoto, Shigeru Oshima, Takeshi Tsubata, Takahiro Adachi, Yohei Kawano, Mamoru Watanabe, Richard S. Blumberg, Ryuichi Okamoto, Takashi Nagaishi
Summary: Research suggests that CEACAM1 can regulate mature B cell activation mediated by BCR, playing an important role in immune responses.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Amin Alborzian Deh Sheikh, Soha Gomaa, Xuexin Li, Matthew Routledge, Kazumasa Saigoh, Nobutaka Numoto, Takashi Angata, Yuki Hitomi, Hiromu Takematsu, Makoto Tsuiji, Nobutoshi Ito, Susumu Kusunoki, Takeshi Tsubata
Summary: GBS, an acute peripheral neuropathy involving autoimmune mechanisms, is associated with a rare variant of the SIGLEC10 gene that impairs ligand binding of Siglec-10, leading to the development of the disease.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Hematology
Wei Jia, Jonathan C. Poe, Hsuan Su, Sarah Anand, Glenn K. Matsushima, Jeffrey C. Rathmell, Ivan Maillard, Vedran Radojcic, Kazuhiro Imai, Nancy J. Reyes, Diana M. Cardona, Zhiguo Li, Amy N. Suthers, Itaevia M. Curry-Chisolm, Rachel A. DiCioccio, Daniel R. Saban, Benny J. Chen, Nelson J. Chao, Stefanie Sarantopoulos
Summary: Patients with chronic graft-versus-host disease (cGVHD) have elevated levels of B cell-activating factor (BAFF), which likely contributes to the development of the disease by altering the B-cell compartment and enhancing B-cell receptor (BCR) responsiveness. Targeting BAFF and BCR pathways therapeutically in patients with cGVHD may be a promising approach based on these findings.
Article
Immunology
Romain Ballet, Martin Brennan, Carolin Brandl, Ningguo Feng, Jeremy Berri, Julian Cheng, Borja Ocon, Amin Alborzian Deh Sheikh, Alex Marki, Yuhan Bi, Clare L. Abram, Clifford A. Lowell, Takeshi Tsubata, Harry B. Greenberg, Matthew S. Macauley, Klaus Ley, Lars Nitschke, Eugene C. Butcher
Summary: The study reveals the essential role of B cell expression of CD22 and the tyrosine phosphatase Shp1 in regulating the surface expression of integrin alpha(4)beta(7) and gut immunity. The findings suggest that Shp1 inhibits beta(7) endocytosis, promoting lymphocyte homing to the gut, while CD22 binds to integrin beta(7) to target Shp1 and enhance surface display of alpha(4)beta(7) on B cells. Deficiencies in Shp1 activity or CD22 expression result in reduced surface alpha(4)beta(7) levels and homing to gut-associated lymphoid tissue.
Article
Immunology
Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hajjaj H. M. Abdu-Allah, Yuki Suganuma, Akihiro Imamura, Hiromune Ando, Hiromu Takematsu, Hideharu Ishida, Takeshi Tsubata
Summary: CD22 is an inhibitory B cell coreceptor that regulates B cell development and activation by downregulating BCR signaling. CD45 plays a crucial role in CD22-mediated inhibition of BCR signaling, while disruption of ligand binding of CD22 enhances CD22 phosphorylation. SHP-1 is required for ligand-mediated regulation of CD22 and dephosphorylates CD22 as well as other substrates to enhance BCR signaling.
JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Hematology
Wei Jia, Jonathan C. Poe, Hsuan Su, Rachel A. DiCioccio, Sonali Bracken, Jonathan Visentin, Lauren S. Riley, Serach C. Patterson, Benny J. Chen, Nelson J. Chao, Stefanie Sarantopoulos
Review
Immunology
Takeshi Tsubata
Summary: Antibody production to non-protein antigens involves T cell-independent mechanisms, while inhibitory B cell co-receptors suppress B cell response to non-protein self-antigens.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Chizuru Akatsu, Amin Alborzian Deh Sheikh, Naoko Matsubara, Hiromu Takematsu, Astrid Schweizer, Hajjaj H. M. Abdu-Allah, Thomas F. Tedder, Lars Nitschke, Hideharu Ishida, Takeshi Tsubata
Summary: This study found that CD22 switches from an inhibitory to a stimulatory function in Cd45-deficient B cells, restoring BCR signaling by altering cellular phenotypes during development. CD22 is required for the increase in surface IgM-BCR on Cd45-deficient B cells, and may contribute to the partial restoration of B cell function in patients with other BCR signaling deficiencies.
Article
Immunology
Hsuan Su, Kazuhiro Imai, Wei Jia, Zhiguo Li, Rachel A. DiCioccio, Jonathan S. Serody, Jonathan C. Poe, Benny J. Chen, Phuong L. Doan, Stefanie Sarantopoulos
Summary: De novo immune responses to myeloid and other blood-borne tumors are limited, but vaccination with RNA viral particle vectors can break B-cell tolerance and enable production of anti-tumor antibodies.
FRONTIERS IN IMMUNOLOGY
(2022)
Meeting Abstract
Hematology
Jonathan Visentin, Wei Jia, Jonathan C. Poe, Hsuan Su, Sofian Christina, Rachel A. DiCioccio, Itaevia Curry-Chisolm, Fahmin Basher, Sonali Bracken, Vincent T. Ho, Vanja Sisirak, Mitchell E. Horwitz, Nelson J. Chao, Stefanie Sarantopoulos
Article
Medicine, Research & Experimental
Jonathan C. Poe, Jiyuan Fang, Dadong Zhang, Marissa R. Lee, Rachel A. DiCioccio, Hsuan Su, Xiaodi Qin, Jennifer Y. Zhang, Jonathan Visentin, Sonali J. Bracken, Vincent T. Ho, Kathy S. Wang, Jeremy J. Rose, Steven Z. Pavletic, Frances T. Hakim, Wei Jia, Amy N. Suthers, Itaevia M. Curry-Chisolm, Mitchell E. Horwitz, David A. Rizzieri, William C. McManigle, Nelson J. Chao, Adela R. Cardones, Jichun Xie, Kouros Owzar, Stefanie Sarantopoulos
Summary: Alloreactivity can lead to autoimmune syndromes, such as chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HCT). In this study, single-cell RNA sequencing analysis was performed to study the molecular programming of B cells in allo-HCT patients. The analysis revealed different clusters of B cells with distinguishable gene expression patterns for maturation, activation, and memory. Striking transcriptional differences were observed in memory B cells, including potentially pathogenic atypical B cells that were expanded in active cGVHD.
Article
Hematology
Chenyu Lin, Rachel A. DiCioccio, Tarek Haykal, William C. McManigle, Zhiguo Li, Sarah M. Anand, Jonathan C. Poe, Sonali J. Bracken, Wei Jia, Edwin P. Alyea III, Adela R. Cardones, Taewoong Choi, Cristina Gasparetto, Michael R. Grunwald, Therese Hennig, Yubin Kang, Gwynn D. Long, Richard Lopez, Melissa Martin, Kerry K. Minor, Victor L. Perez Quinones, Anthony D. Sung, Kristi Wiggins, Nelson J. Chao, Mitchell E. Horwitz, David A. Rizzieri, Stefanie Sarantopoulos
Summary: Despite novel therapies, cGVHD remains a common cause of non-relapse mortality after allogeneic HCT. In this clinical trial, fostamatinib, an oral SYK inhibitor, was evaluated for the prevention and treatment of cGVHD. The results showed promising efficacy in reducing steroid dose, preventing relapse, and achieving high response rates.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Review
Immunology
Takeshi Tsubata
Summary: Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of membrane molecules that recognize sialic acid and inhibit immune-cell activation. In B cells, Siglecs play various roles in recognizing ligands and regulating signaling to maintain B cell homeostasis and participate in immune responses.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Immunology
Yingqian Li, Yue Tang, Jun Liu, Xin Meng, Ying Wang, Qing Min, Rongjian Hong, Takeshi Tsubata, Koji Hase, Ji-Yang Wang
Summary: The study reveals the important role of GMFG in S1P-induced MZB chemotaxis, with GMFG acting as an effector downstream of S1P receptors. Serine phosphorylation of GMFG plays a crucial role in this process. Gmfg(-/-) mice show elevated levels of IgM specific to the T-I antigen NP-Ficoll, along with dysregulated MZB localization.
INTERNATIONAL IMMUNOLOGY
(2022)
Article
Immunology
Rongjian Hong, Nannan Lai, Ermeng Xiong, Rika Ouchida, Jiping Sun, Yang Zhou, Yue Tang, Masaki Hikida, Takeshi Tsubata, Masatoshi Tagawa, Yanqing Wang, Ji-Yang Wang
INTERNATIONAL IMMUNOLOGY
(2020)
