Article
Cell Biology
Rico Lepzien, Mu Nie, Paulo Czarnewski, Sang Liu, Meng Yu, Avinash Ravindran, Susanna Kullberg, Anders Eklund, Johan Grunewald, Anna Smed-Sorensen
Summary: This study found that DCs from sarcoidosis patients have a stronger ability to activate and polarize T cells, especially towards Th1 and Th17.1 cells, compared to monocytes. DCs induced higher T cell proliferation compared to monocytes, which is important for understanding the contribution of monocytes and DCs to T cell activation and immunopathology in sarcoidosis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Immunology
Zahra Alizadeh, Pooya Omidnia, Farag M. A. Altalbawy, Gamal A. Gabr, Rasha Fadhel Obaid, Narges Rostami, Saeed Aslani, Aliehsan Heidari, Hamed Mohammadi
Summary: NK cells, frontline responders, can efficiently combat various diseases and leishmaniasis. Despite lacking antigen-specific receptors, NK cells can selectively recognize pathogens through the activation of receptors and their effector functions. This review summarizes the evidence supporting NK cells' role in controlling leishmaniasis and discusses Leishmania parasites' strategies in inhibiting NK cell functions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Luis Antonio Cervantes-Candelas, Jesus Aguilar-Castro, Fidel Orlando Buendia-Gonzalez, Omar Fernandez-Rivera, Teresita De Jesus Nolasco-Perez, Monserrat Sofia Lopez-Padilla, David Roberto Chavira-Ramirez, Martha Legorreta-Herrera
Summary: Malaria is the leading cause of parasitic infection-related death globally, with higher mortality rates in men than in women, reflecting differences in immune responses influenced by sex hormones. Females typically exhibit stronger immune responses against parasites. The study indicates that 17 beta-estradiol plays a crucial role in the immune response to malaria.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Katia Jarquin-Yanez, Miguel Angel Herrera-Enriquez, Cristina Lemini, Edith Melendez-Moreno, Paulina Villena-Lopez, Maria Estela Avila, Beatriz Hernandez-Tellez, Gabriela Pinon-Zarate, Enrique Agustin Sampedro-Carrillo, Andres Eliu Castell-Rodriguez
Summary: Topical administration of E-2 reduces the number of CD207+ LC in a dose-dependent manner in mouse skin, while promoting an increase in CD207+/MHCII+ DC numbers in regional lymph nodes. Additionally, E-2 decreases expression of CD40 and CD86, while increasing expression of CD273, CD274, MHCII, and CCR7 in cultured DC.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Pharmacology & Pharmacy
Yusheng Guo, Xiangsheng Cai, Hanwei Lu, Qiqi Li, Ying Zheng, Zefang Lin, Zexiong Cheng, Maoxiang Yang, Li Zhang, Lei Xiang, Xiaorong Yang
Summary: 17 beta-estradiol can induce oxidative stress and apoptosis in HepG2 cells, potentially serving as a new treatment for hepatocellular carcinoma.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Tereza Bosakova, Antonin Tockstein, Zuzana Bosakova, Katerina Komrskova
Summary: The study aimed to investigate the interactions between 17 alpha-estradiol and sperm ER during sperm capacitation, developing a kinetic model. New autocatalytic formation of an unstable adduct between alpha E2 and ER was discovered, contributing to the understanding of tissue rejuvenation and cancer physiology related to alpha E2 signaling.
Article
Engineering, Environmental
Junzhuo Cai, Yingjie Zhu, Shanshan Xie, Baoling Niu, Ya-nan Zhang, Lina Li, Dan Li, Guohua Zhao
Summary: A circulating-flow selective photoelectrocatalysis (CF-SPEC) system is established to efficiently remove the low-concentration organic compound 17 beta-estradiol (E2) and eliminate estrogenic activity, reducing energy consumption.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Microbiology
Andrew J. R. Cooper, Jonah Clegg, Fearon C. Cassidy, Andrew E. Hogan, Rachel M. McLoughlin
Summary: This study investigates the direct response of human mucosal-associated invariant T (MAIT) cells to Staphylococcus aureus (S. aureus) infection. The results show that MAIT cells rapidly upregulate CD69, express IFN gamma and Granzyme B, and degranulate when co-cultured with dendritic cells (DCs) infected with S. aureus. The immune response is mediated by DC secretion of IL-12 and requires TCR binding of MR1. Furthermore, MAIT cell cytotoxicity leads to apoptosis of S. aureus-infected cells and reduces intracellular persistence of S. aureus.
Article
Immunology
Jie Lu, Kun Sun, Huiping Yang, Dan Fan, He Huang, Yi Hong, Shuiyan Wu, HuiTing Zhou, Fang Fang, YanHong Li, Lijun Meng, Jie Huang, Zhenjiang Bai
Summary: Sepsis-induced systemic inflammation impairs hematopoietic stem and progenitor cells (HSPCs) in producing dendritic cells (DCs), leading to decreased numbers and functions of DCs. The study found significantly lower levels of pDCs and cDCs in sepsis patients' peripheral blood samples compared to healthy donors, along with increased DC apoptosis and reduced HSPC progenitors. Additionally, sepsis-associated cytokines like G-CSF and IFN-gamma were shown to inhibit DC development from cultured HSPCs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Dan-dan Feng, Bin Zheng, Jing Yu, Man-li Zhang, Ying Ma, Xiao Hao, Jin-kun Wen, Xin-hua Zhang
Summary: The study demonstrates that 17 beta-Estradiol inhibits proliferation and oxidative stress in vivo and in vitro by promoting BHLHE40 expression, thereby suppressing MAPK signaling pathways.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Oncology
Hemavathi Dhandapani, Hascitha Jayakumar, Abirami Seetharaman, Shirley Sunder Singh, Selvaluxmy Ganeshrajah, Nirmala Jagadish, Anil Suri, Rajkumar Thangarajan, Priya Ramanathan
Summary: Dendritic cell-based immunotherapy utilizing recombinant human SPAG9 shows promise in stimulating CD4(+) and CD8(+) T cell responses for cervical cancer patients. The study suggests rhSPAG9 as a strong immunogen for DC-based immunotherapy and highlights the potential of a combinatorial regimen with cisplatin for therapeutic intervention.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Liane Babes, Raymond Shim, Paul Kubes
Summary: Patients with colorectal cancer often develop liver metastases after surgery, which can be inhibited by prior intravenous injection of α-GalCer, although some tumor cells may survive. Multiple dosing of α-GalCer reduces tumor burden and prolongs survival, with increased number and activity of iNKT cells, suggesting a potential therapeutic benefit for patients with metastatic liver disease.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Pediatrics
Sebastian Wirsching, Marina Machtakova, Frauke Borgans, Leah Pretsch, Michael Fichter, Maximiliano L. Cacicedo, Heloise Therien-Aubin, Katharina Landfester, Stephan Gehring
Summary: Childhood mortality is a significant issue, with a large number of deaths attributed to preventable infectious diseases. The study demonstrates the superior ability of the TLR7/8 agonist R848 in activating the immune system of both adults and neonates. Furthermore, R848 can be efficiently delivered along with antigens using nanocapsules, offering new possibilities for vaccine development.
FRONTIERS IN PEDIATRICS
(2022)
Review
Immunology
Izumi Sasaki, Takashi Kato, Hiroaki Hemmi, Yuri Fukuda-Ohta, Naoko Wakaki-Nishiyama, Asumi Yamamoto, Tsuneyasu Kaisho
Summary: Dendritic cells (DC) are essential in connecting innate and adaptive immunity. Among the subsets, cDC1 plays a critical role in maintaining intestinal immune homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ildefonso Sanchez-Cerrillo, Diego Calzada-Fraile, Ana Triguero-Martinez, Marta Calvet-Mirabent, Olga Popova, Cristina Delgado-Arevalo, Mariel Valdivia-Mazeyra, Marta Ramirez-Huesca, Enrique Vazquez de Luis, Alberto Benguria, Teresa Acena-Gonzalo, Roberto Moreno-Vellisca, Magdalena Adrados de Llano, Hortensia de la Fuente, Ilya Tsukalov, Pablo Delgado-Wicke, Elena Fernandez-Ruiz, Emilia Roy-Vallejo, Reyes Tejedor-Lazaro, Almudena Ramiro, Salvador Iborra, Francisco Sanchez-Madrid, Ana Dopazo, Isidoro Gonzalez Alvaro, Santos Castaneda, Enrique Martin-Gayo
Summary: This study reveals the increased proportion of CD16(+) CD56hi NK cell subset and CD64(+) conventional dendritic cells (cDC2) in pSS patients, suggesting their involvement in the progression of the disease. The cDC2 can activate NK cells ex vivo and are found in proximity to NK cells in the salivary glands. The expression of NKG2D ligands on cDC2 from pSS patients is regulated by the IFN signatures associated with the RIG-I/DDX60 pathway. Injection of poly I:C leads to increased proportions of CD64hi RAE-1(+) cDC2 and NKG2D(+) CD11b(+) CD27(+) NK cells in the salivary glands.
Article
Multidisciplinary Sciences
Alison Gaylo, Michael G. Overstreet, Deborah J. Fowell
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2016)
Article
Immunology
Michael G. Overstreet, Helen Freyberger, Ian A. Cockburn, Yun-Chi Chen, Sze-Wah Tse, Fidel Zavala
EUROPEAN JOURNAL OF IMMUNOLOGY
(2010)
Review
Immunology
Michael Glen Overstreet, Ian Andrew Cockbum, Yun-Chi Chen, Fidel Zavala
IMMUNOLOGICAL REVIEWS
(2008)
Article
Immunology
Sumana Chakravarty, G. Christian Baldeviano, Michael G. Overstreet, Fidel Zavala
INFECTION AND IMMUNITY
(2008)
Article
Immunology
Young-Min Hyun, Ronen Sumagin, Pranita P. Sarangi, Elena Lomakina, Michael G. Overstreet, Christina M. Baker, Deborah J. Fowell, Richard E. Waugh, Ingrid H. Sarelius, Minsoo Kim
JOURNAL OF EXPERIMENTAL MEDICINE
(2012)
Article
Immunology
Michael G. Overstreet, Alison Gaylo, Bastian R. Angermann, Angela Hughson, Young-Min Hyun, Kris Lambert, Mridu Acharya, Alison C. Billroth-MacLurg, Alexander F. Rosenberg, David J. Topham, Hideo Yagita, Minsoo Kim, Adam Lacy-Hulbert, Martin Meier-Schellersheim, Deborah J. Fowell
Article
Multidisciplinary Sciences
Michael G. Overstreet, Yun-Chi Chen, Ian A. Cockburn, Sze-Wah Tse, Fidel Zavala
Article
Immunology
Christopher Palma, Michael G. Overstreet, Jean-Marc Guedon, Egbert Hoiczyk, Cameron Ward, Kasey A. Karen, Fidel Zavala, Gary Ketner
Article
Microbiology
Ian A. Cockburn, Yun-Chi Chen, Michael G. Overstreet, Jason R. Lees, Nico van Rooijen, Donna L. Farber, Fidel Zavala
Article
Microbiology
David J. Mock, Joseph A. Hollenbaugh, Waaqo Daddacha, Michael G. Overstreet, Chris A. Lazarski, Deborah J. Fowell, Baek Kim
Article
Oncology
Ruoyan Chen, Saravanan Rajan, Michael G. Overstreet, Elaine M. Hurt, Suneetha B. Thomas, Vanessa Muniz-Medina, Christopher Ward, Agnieszka Sadowska, Ryan Fleming, Subramanya Karanth, Shannon Breen, Bo Zheng, Yuling Wu, William O. Iverson, Steven Novick, Terrence O'Day, Dipesha P. Shah, Nazzareno Dimasi, Arnaud C. Tiberghien, Jane Osbourn, Jill Walker
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Biochemistry & Molecular Biology
Sumana Chakravarty, Ian A. Cockburn, Salih Kuk, Michael G. Overstreet, John B. Sacci, Fidel Zavala
Article
Cell Biology
Ana Acacia de Sa Pinheiro, Alexandre Morrot, Surnana Chakravarty, Michael Overstreet, Jay H. Brearn, Pablo M. Irusta, Fidel Zavala
JOURNAL OF LEUKOCYTE BIOLOGY
(2007)
Article
Immunology
Ian A. Cockburn, Sumana Chakravarty, Michael G. Overstreet, Adolfo Garcia-Sastre, Fidel Zavala
JOURNAL OF IMMUNOLOGY
(2008)