Article
Biochemistry & Molecular Biology
Xiang Ma, Yusuke Takahashi, Wenjing Wu, Wentao Liang, Jianglei Chen, Dibyendu Chakraborty, Yangxiong Li, Yanhong Du, Siribhinya Benyajati, Jian-Xing Ma
Summary: This study demonstrates that ADAM17 is responsible for shedding the soluble ectodomain of VLDLR in human retinal pigment epithelium cells, which plays anti-inflammatory and anti-angiogenic roles through inhibition of Wnt signaling. Inhibition of ADAM17 reduces sVLDLR levels in ocular tissues, suggesting it as a potential therapeutic target for disorders associated with dysregulation of Wnt signaling.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Clinical Neurology
Elahe Amini, Mohammad Rohani, Alfonso Fasano, Zahra Azad, Shahnaz Miri, Seyed Amir Hassan Habibi, Maziar Emamikhah, Reza Mirshahi, Mohammad Taghi Joghataei, Zeinab Gholibeigian, Khalil Ghasemi Falavarjani
Summary: Observing pathological structural and functional neurovascular changes in NBIA patients may provide an opportunity to elucidate the underlying mechanisms and differential retinal biomarkers in NBIA subtypes.
MOVEMENT DISORDERS
(2023)
Review
Immunology
Chunren Meng, Chufeng Gu, Shuai He, Tong Su, Thashi Lhamo, Deji Draga, Qinghua Qiu
Summary: Pyroptosis is an emerging type of inflammatory cell death that may play a crucial role in the development of diabetic retinopathy, potentially contributing to the destruction of retinal neurovascular unit cells in hyperglycemic conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Tian Yuan, Lijie Dong, Elizabeth A. Pearsall, Kelu Zhou, Rui Cheng, Jian-Xing Ma
Summary: PPAR alpha plays a critical role in pathological microgliosis, neurodegeneration, and vascular damage in diabetic retinopathy; the study reveals the underlying molecular mechanisms of microgliosis, and suggests microglial PPAR alpha as a potential therapeutic target.
Article
Neurosciences
Tae-Hoon Kim, Taeyoon Son, Dieter Klatt, Xincheng Yao
Summary: The study aimed to investigate retinal neurovascular abnormalities in the 5XFAD mouse model using concurrent OCT and OCTA imaging. Results showed quadrant- and layer-specific neurovascular degeneration in 5XFAD mice, with significant reductions in inner and outer retinal thickness in different quadrants. Arterial narrowing and decreasing capillary density were also observed in 5XFAD mice, suggesting potential for noninvasive monitoring of AD progression and treatment assessment using OCT and OCTA.
Article
Biochemistry & Molecular Biology
Xinyan Zhang, Jinxian Xu, Brendan Marshall, Zheng Dong, Yutao Liu, Diego G. Espinosa-Heidmann, Ming Zhang
Summary: Our study used RNA sequencing analysis to investigate the molecular genetic changes and pathways affected by ocular cytomegalovirus (MCMV) latency. We found that MCMV infection in mice led to differentially expressed genes and activated immune/inflammatory responses and cell death signaling pathways. These findings provide insights into the development of ocular complications associated with MCMV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Qionghua Wang, Lanyue Zhang, Qiang Shen, Chunqin Zeng, Yanhong Fang, Kepeng Ou
Summary: This study demonstrated that the compound 5-Bromo3,4-dihydroxybenzaldehyde (BDB) derived from marine red algae has a protective effect on diabetic retinopathy (DR). BDB promotes vascular integrity, inhibits the transcription of proinflammatory factors, alleviates hyperglycemia-induced permeability, and protects retinal ganglion cells (RGC) from hyperglycemia-induced apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Ophthalmology
Rasha A. Alshaikh, Katie B. Ryan, Christian Waeber
Summary: Neovascular ocular diseases share common pathological processes such as angiogenesis, edema, inflammation, cell death, and fibrosis. Current therapies targeting vascular endothelial growth factor (VEGF) have limitations due to high cost and adverse effects, prompting the search for alternative treatments with fewer side effects. This review explores sphingosine 1-phosphate (S1P) as a potential therapeutic target for neovascular ocular pathologies, highlighting the different effects mediated by S1P receptors in angiogenesis, inflammation, apoptosis, and fibrosis.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Endocrinology & Metabolism
Jose-Andres C. Portillo, Jin-Sang Yu, Sarah Vos, Reena Bapputty, Yalitza Lopez Corcino, Alyssa Hubal, Jad Daw, Sahil Arora, Wenyu Sun, Zheng-Rong Lu, Carlos S. Subauste
Summary: CD40 expressed in Muller cells is a central driver of diabetic retinopathy, activating the PLCγ1-ATP-P2X(7)-proinflammatory cytokine pathway and promoting the development of the disease.
Article
Immunology
Andrea Nortey, Kimberly Garces, Tal Carmy-Bennun, Abigail S. Hackam
Summary: IL-27 has been found to reduce photoreceptor death, improve retinal function, and alleviate inflammation in a genetic model of retinal degeneration, highlighting its potential as an anti-inflammatory and neuroprotective therapy for retinal degenerative diseases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Pharmacology & Pharmacy
Chaiara Bianca Maria Platania, Filippo Drago, Claudio Bucolo
Summary: The activation of P2X7 receptor is implicated in the pathophysiology of various retinal age-related diseases, making it a potential pharmacological target for preventing these devastating conditions.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cell Biology
Yayi Wang, Shida Chen, Jiawei Wang, Yaoming Liu, Yang Chen, Tao Wen, Xiuli Fang, Manuel Vidal-Sanz, Jost B. Jonas, Xiulan Zhang
Summary: The study identified the key role of miR-93 in retinal microglial cells' reaction, showing that its overexpression can significantly reduce microglial functions, cytokine release, and subsequent RGCs death, while inhibiting the STAT3 pathway for neuroprotection.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Ming Zou, Lili Gong, Qin Ke, Ruili Qi, Xingfei Zhu, Wei Liu, Qian Sun, Xiangcheng Tang, Zhongwen Luo, Xiaodong Gong, Yizhi Liu, David Wan-Cheng Li
Summary: The study found that cGAS and STING were upregulated in mouse RPE and retina during oxidative injury, correlated with decreased chromatin compaction in their gene loci. Disruption of heterochromatin led to elevated cGAS and STING expression and enhanced inflammatory response in oxidative stress-induced RPE and retina degeneration. Application of methotrexate (MTX), a heterochromatin-promoting drug, inhibited cGAS and STING expression, attenuating RPE/retina degeneration and inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Matija Zelic, Fabrizio Pontarelli, Lisa Woodworth, Cheng Zhu, Amy Mahan, Yi Ren, Michael LaMorte, Ross Gruber, Aislinn Keane, Pequita Loring, Lilu Guo, Tai-He Xia, Boyao Zhang, Pontus Orning, Egil Lien, Alexei Degterev, Timothy Hammond, Dimitry Ofengeim
Summary: The study highlights the crucial role of RIPK1 in the progression of multiple sclerosis (MS), particularly its impact on microglia. It elucidates the mechanisms by which RIPK1 contributes to MS pathogenesis and confirms its regulatory role in the neuroinflammatory environment. Additionally, the research demonstrates that RIPK1 inhibition in a murine MS model can attenuate disease progression and suppress deleterious signaling in astrocytes and microglia.
Article
Physiology
Joshua A. Chu-Tan, Adrian V. Cioanca, Yvette Wooff, Max Kirkby, Marissa Ellis, Pranay Gulati, Tim Karl, Jeffrey H. Boatright, Katie Bales, John Nickerson, Riccardo Natoli
Summary: This study investigates the cellular changes underlying exercise-induced retinal protection and suggests that exercise may slow the progression of retinal degenerations by modulating inflammatory pathways and shifting the transcriptomic profile to a healthy phenotype.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Yuchen Chen, Dong Yang, Biao Cheng, Jian Chen, Anlin Peng, Chen Yang, Chong Liu, Mingrui Xiong, Aiping Deng, Yu Zhang, Ling Zheng, Kun Huang
Article
Gastroenterology & Hepatology
Yu Sun, Qing Wang, Yu Zhang, Mengyuan Geng, Yujuan Wei, Yanrui Liu, Shanshan Liu, Robert B. Petersen, Junqiu Yue, Kun Huang, Ling Zheng
JOURNAL OF HEPATOLOGY
(2020)
Article
Endocrinology & Metabolism
Wenquan Zhang, Dong Yang, Yangmian Yuan, Chong Liu, Hong Chen, Yu Zhang, Qing Wang, Robert B. Petersen, Kun Huang, Ling Zheng
Letter
Endocrinology & Metabolism
Yuchen Chen, Dong Yang, Chen Yang, Ling Zheng, Kun Huang
Article
Gastroenterology & Hepatology
Xue-Jing Li, Qing-Lan Li, Lin-Gao Ju, Chen Zhao, Lan-Shen Zhao, Jia-Wen Du, Yan Wang, Ling Zheng, Bao-Liang Song, Lian-Yun Li, Li Li, Min Wu
Summary: The study demonstrates that Setd2 deficiency can trigger spontaneous HCC by modulating DNA damage response and lipid metabolism in the liver. High-fat diet enhances lipid accumulation and promotes the development of HCC in Setd2-deficient mice.
Article
Biochemistry & Molecular Biology
Jiao Wang, Yushuo Xiao, Chengyu Liu, Yixue Huang, Robert B. Petersen, Ling Zheng, Kun Huang
Summary: MeCP2 plays a crucial role in both neurological and non-neurological disorders, including causing Rett syndrome in the former and cardiac dysfunction, liver injury, respiratory disorders, and other conditions in the latter. Research suggests that MeCP2 can influence various physiological and pathological processes in a DNA methylation-dependent or independent manner.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Oncology
Chuntao Quan, Yuchen Chen, Xiaomu Wang, Dong Yang, Qing Wang, Yixue Huang, Robert B. Petersen, Xinran Liu, Ling Zheng, Yangkai Li, Kun Huang
Article
Chemistry, Medicinal
Chao Wang, Mingrui Xiong, Chen Yang, Dong Yang, Jiaojiao Zheng, Yu Fan, Shun Wang, Yongkang Gai, Xiaoli Lan, Hong Chen, Ling Zheng, Kun Huang
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Meng-Jie Zhao, Xiao Yao, Ping Wei, Chen Zhao, Meng Cheng, Dong Zhang, Wen Xue, Wen-Tian He, Weili Xue, Xinxin Zuo, Lei-Lei Jiang, Zhiyuan Luo, Jiaqi Song, Wen-Jie Shu, Han-Ye Yuan, Yi Liang, Hui Sun, Yan Zhou, Yu Zhou, Ling Zheng, Hong-Yu Hu, Jiwu Wang, Hai-Ning Du
Summary: Research has shown that O-GlcNAc transferase OGT-mediated O-GlcNAcylation of TDP-43 can suppress ALS-related proteinopathies and enhance TDP-43's splicing function. This study further demonstrates the importance of TDP-43 O-GlcNAcylation in maintaining neuronal health and function.
Article
Pharmacology & Pharmacy
Liang Ma, Jiaojiao Zheng, Huijing Chen, Xia Zeng, Shilin Wang, Chen Yang, Xi Li, Yushuo Xiao, Ling Zheng, Hong Chen, Kun Huang
Summary: Toxic aggregates of amyloid beta disrupt cell membranes and induce oxidative stress, but active ingredients from Traditional Chinese Medicine have shown potential in inhibiting Aβ toxicity. Further research is needed to explore the therapeutic potential of these novel chemical compounds.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Yangmian Yuan, Chengyu Liu, Xingrui Chen, Yuyan Sun, Mingrui Xiong, Yu Fan, Robert B. Petersen, Hong Chen, Kun Huang, Ling Zheng
Summary: The study suggests that Tet1 plays a crucial role in obesity by promoting lipolysis and reducing obesity. Vitamin C can treat obesity by enhancing Tet1 activity, thus decreasing hepatic steatosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Baoshen He, Shijia Kang, Zhen Chen, Xiao Liu, Jinkai Wang, Xuedan Li, Xiaomin Liu, Ling Zheng, Mengcheng Luo, Yan Wang
Summary: Hypercholesterolemia has a strong genetic component, with certain monogenic genes identified for familial hypercholesterolemia. However, in the general population, most individuals with high LDL cholesterol levels do not have known mutations associated with familial hypercholesterolemia. Whole-exome sequencing has identified numerous variants, but the functional consequences of these variants remain largely unknown.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Pharmacology & Pharmacy
Yixue Huang, Yunhao Xie, Dong Yang, Mingrui Xiong, Xingrui Chen, Di Wu, Qing Wang, Hong Chen, Ling Zheng, Kun Huang
Summary: Acetaminophen (APAP) overdose is a major cause of acute liver failure. Recent research suggests that the epigenetic enzyme Utx plays a key role in APAP-induced liver injury by promoting the clearance of toxic metabolites and alleviating ER stress. Additionally, overexpression of Sult2a1 can reduce APAP overdose-induced liver injury.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Immunology
Yunhao Xie, Jin Li, Huan Qin, Qing Wang, Zixi Chen, Chengyu Liu, Ling Zheng, Jiangxin Wang
Summary: The study found that sonicated and alkalized paramylon (SA-Pa) effectively alleviated LPS/D-Gal-induced ALI and promoted M2 macrophage activation, reducing inflammation and cell death in the liver.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Qing Wang, Yuchen Chen, Yunhao Xie, Dong Yang, Yuyan Sun, Yangmian Yuan, Hong Chen, Yu Zhang, Kun Huang, Ling Zheng
Summary: Linker histone H1.2 plays a significant role in hepatocellular carcinoma by regulating the activation of STAT3 and participating in inflammatory response. Blocking the H1.2/STAT3 loop may be a potential strategy for the treatment of hepatocellular carcinoma.
