期刊
ORGANIC LETTERS
卷 17, 期 10, 页码 2370-2373出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00866
关键词
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资金
- Ministerio de Educacion y Ciencia, Spain [CTQ2007-67492/BQU]
- Gobierno de Canarias [ProID20100088]
- Program JAE-C.S.I.C.
Mechanistic evidence observed in Hofmann-Loffler-Freytag-type reactions has been crucial to achieve the chemoselective functionalization of methyl groups under mild conditions. Radical-mediated methyl iodination and subsequent oxidative deiodination are the key steps in this functionalization, where iodine chemistry has a pivotal role on the formation of the C-N bond. The concepts of single hydrogen atom transfer (SHAT) and multiple hydrogen atom transfer (MHAT) are introduced to describe the observed chemoselectivity.
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