期刊
JOURNAL OF IMMUNOLOGY
卷 182, 期 1, 页码 522-529出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.182.1.522
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资金
- Italian Ministry of Health
- Evaluation of Longterm non progressor Viro-immunological Italian Studies Concerted Action [ISS AIDS 40G.66]
V gamma 9V delta 2 T cells display a broad antimicrobial activity by directly killing infected cells and by inducing an effective adaptive immune response. The activation of V gamma 9V delta 2 T cells by aminobisphosphonate drugs such as zoledronic acid (ZOL) results in a massive release of cytokines and chemokines that may induce a bystander activation of other immune cells. The aim of this work was to evaluate the ability of soluble factors released by ZOL-activated V gamma 9V delta 2 T cells to induce granulocyte activation. We showed that soluble factors released by ZOL-stimulated V gamma 9V delta 2 T cells activate granulocytes by inducing their chemotaxis, phagocytosis, and alpha-defensins release. Proteomic analysis allowed us to identify a number of cytokines and chemokines specifically released by activated V gamma 9V delta 2 T cells. Moreover, MCP-2 depletion by neutralizing Ab revealed a critical role of this chemokine in induction of granulocyte alpha-defensins release. Altogether, these data show a V gamma 9V delta 2-mediated activation of granulocytes through a bystander mechanism, and confirm the wide ability of V gamma 9V delta 2 T-lymphocytes in orchestrating the immune response. In conclusion, an immune modulating strategy targeting V gamma 9V delta 2 T cells may represent a key switch to induce an effective and well-coordinated immune response, and can be proposed as a way to strengthen the immune competence during infectious diseases. The Journal of Immunology, 2009, 182: 522-529.
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