Review
Biochemistry & Molecular Biology
Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Atsushi Enomoto, Kiyoshi Miyagawa, Shinichi Sato, Ayumi Yoshizaki
Summary: This review explores the pathogenesis of Palmoplantar pustulosis (PPP) by examining its genetic background and molecular mechanisms, discusses the effectiveness of biological therapy, and explores its implications in relation to pathology, the IL-23-Th17 axis, and other autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Yasuaki Ogura, Shumpei Kondo, Tsuyoshi Suzuki, Masaki Otsuka, Manabu Inuzuka, Tetsuya Honda, Yoshiki Tokura
Summary: DiGeorge syndrome is a cellular immunodeficiency disease caused by hypoplasia of the thymus and hypoparathyroidism. This case report describes a DiGeorge syndrome patient with a severe palmoplantar pustulosis (PPP)-like eruption. The elevated levels of IL-22 suggest a T cell abnormality associated with DiGeorge syndrome leading to overproduction of IL-22.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Yasunari Kageyama, Yutaka Shimokawa, Kimihiko Kawauchi, Masafumi Morimoto, Koichi Aida, Tetsu Akiyama, Tsutomu Nakamura
Summary: The study found that patients with PPP have lower levels of Proteobacteria in their oral microbiota, particularly the genus Neisseria. This suggests a possible link between PPP and oral microbiota dysbiosis, indicating potential benefits of probiotics as adjunctive therapy.
Review
Biochemistry & Molecular Biology
Zexi Jia, Mengtian Guo, Xintong Ge, Fanglian Chen, Ping Lei
Summary: IL-33 is a cytokine that is passively produced in response to tissue damage or cell necrosis. It interacts with the ST2 receptor to produce pro-inflammatory cytokines and plays a crucial role in immune regulation and neurodegenerative diseases.
Article
Dermatology
Keiju Kobayashi, Ryuta Kamekura, Junji Kato, Shiori Kamiya, Takafumi Kamiya, Kenichi Takano, Shingo Ichimiya, Hisashi Uhara
Summary: PPP is characterized by sterile pustules on the palms and soles, with a strong association with smoking. IL-36 plays a pivotal role in psoriasis, and IL-36g expression is elevated in tonsillar epithelial cells of PPP patients. Smoking index is positively correlated with PPP severity in female patients. IL-36g release is induced by IL-17A in the presence of cigarette smoke extract, suggesting a role for IL-36g in PPP pathogenesis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yinghong Wang, Xiaojie Hu, Yancai Sun, Yan Huang
Summary: This review focuses on the role of ASIC1a in several inflammatory immune diseases, providing new perspectives for clinical treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Li Fu, Zheng Liu, Yang Liu
Summary: FGL2 is a membrane-bound protein with immune-associated coagulation activity and immunosuppressive functions. It plays an immunomodulatory role in inflammatory diseases and cancer, and could serve as a disease biomarker and therapeutic target.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
S. P. Deo-Gracias Berry, Camille Dossou, Ali Kashif, Niusha Sharifinejad, Gholamreza Azizi, Haleh Hamedifar, Araz Sabzvari, Zeineb Zian
Summary: This review highlights the role of IL-17 in chronic inflammation occurring in allergy, malignancy, and autoimmune diseases, and discusses the potential therapeutic approach of targeting IL-17 and/or IL-17R using monoclonal antibodies (mAbs).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hajime Honjo, Tomohiro Watanabe, Ken Kamata, Kosuke Minaga, Masatoshi Kudo
Summary: Inflammatory bowel diseases (IBDs) are increasing worldwide, with many patients showing refractoriness to current treatments. Therefore, the search for novel therapeutic targets, such as RIPK2, is crucial. Experimental and clinical studies have implicated RIPK2 in the development of autoimmune diseases, particularly IBD, suggesting its potential as a new therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yiming Leng, Ying Zhang, Xinyu Li, Zeyu Wang, Quan Zhuang, Yao Lu
Summary: RIPK1/3 play key roles in cell death pathways and inflammatory signaling in cardiovascular diseases. The crosstalk between autophagy and necroptosis in cardiomyocyte death is an important research area, and understanding the mechanisms of RIPK1/3-mediated necroptosis is crucial for treating cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Zhen-yu Li, Ming-Long Cai, Yi Qin, Zhu Chen
Summary: Age/autoimmunity-associated B cells (ABCs) are a unique B cell subpopulation with distinct transcriptional and cell surface characteristics. They rely on TLR7 or TLR9 and T cell-derived cytokines for differentiation and their aberrant expansion is associated with systemic autoimmune diseases. Recent studies have shown a pathogenic role of increased ABCs in rheumatoid arthritis (RA), suggesting that targeting specific B cell subsets could be a promising treatment strategy for inflammatory arthritis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Tengfei Xiao, Mingzhong Sun, Chuanxiang Zhao, Jingjing Kang
Summary: TRPV1 is a widely expressed non-selective channel receptor in skin tissues, including keratinocytes, peripheral sensory nerve fibers, and immune cells. It is activated by various inflammatory mediators, leading to neuropeptide release and neurogenic inflammatory response. Previous studies have indicated that TRPV1 is closely associated with skin aging and chronic inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, herpes zoster, allergic contact dermatitis, and prurigo nodularis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lana Tran, Zhenling Yao, Zhenhua Xu, An Vermeulen
Summary: Population pharmacokinetic analysis showed that patients with Psoriasis, Psoriatic Arthritis, and Palmoplantar Pustulosis had similar pharmacokinetic characteristics, with slightly lower clearance rates in disease populations compared to healthy individuals after other covariate effects were taken into account.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jie Chen, Yingshu Wang, Lan Shen, Yanfeng Xiu, Bing Wang
Summary: As a member of the IL-17 cytokine family, IL-25 induces and sustains type 2 immunity. It is mainly produced by intestinal epithelial cells and its role in intestinal inflammation has been gradually investigated. This review summarizes the expression and function of IL-25 in the intestine, particularly its regulatory role on type 2 immunity-related cells. Lastly, the dual role of IL-25 in inflammatory bowel disease is discussed, providing insights for targeting IL-25 as a treatment for intestinal inflammatory diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Immunology
Shixin Duan, Jun Wang, Xinyi Lou, Dongxin Chen, Peiyunfeng Shi, Hongchao Jiang, Zhiming Wang, Wen Li, Feng Qian
Summary: IL-33 is an important member of the IL-1 family and plays a crucial role in modulating inflammatory responses. The researchers developed an effective anti-human IL-33 monoclonal antibody named 5H8, which binds to the FVLHN epitope of IL-33 and inhibits its biological activity. In vitro and in vivo experiments showed that 5H8 suppressed IL-33-induced IL-6 expression and relieved HDM-induced asthma and PR8-induced acute lung injury. The study also demonstrated that 5H8 has good thermal stability and high affinity. These findings suggest that 5H8 has potential as a therapeutic antibody for inflammatory diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Allergy
Malin Glindvad Ahlstrom, Lone Skov, Steffen Heegaard, Claus Zachariae, Lene Heise Garvey, Jeanne Duus Johansen
Summary: A retrospective study in a Danish tertiary dermatology department found that allergic contact dermatitis (ACD) in the eye region caused by topical eye medications is difficult to diagnose and may be overlooked. The study identified phenylephrine, timolol, and ketotifen as the main culprits of contact allergy to topical eye allergens/medications. Patients often had previous diagnoses of cataract or glaucoma and reported multiple previous reactions, with symptoms including edema, erythema, and dermatitis in the eye region.
CONTACT DERMATITIS
(2023)
Letter
Dermatology
Mie Siewertsen, Rownaq Al-Sofi, Hajer Dridi, Gayathri D. D. Ajenthen, Claus Zachariae, Lone Skov, Nikolai Loft
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Nita Katarina Frifelt Wienholtz, Jacob P. P. Thyssen, Casper Emil Christensen, Simon Francis Thomsen, Katrine Elisabeth Karmisholt, Gregor B. E. Jemec, Hans B. B. Lomholt, Michael Heidenheim, Anne Birgitte Simonsen, Carsten Sand, Christian Vestergaard, Diljit Kaur-Knudsen, Elisabeth Ammitzboll, Erik Lorup, Anne G. G. Danielsen, Gitte Strauss, Lone Skov, Peter H. H. Andersen, Marianne Hald, Luise W. W. Idorn, Messoud Ashina, Claus Zachariae, Alexander Egeberg
Summary: This study validates the Rosacea Area and Severity Index (RASI) as an effective tool for evaluating the severity of rosacea, with comparable agreement to the currently used Investigator's Global Assessment (IGA) method. RASI provides a more nuanced evaluation of various rosacea features and the extent of involvement in different facial areas, suggesting its widespread use in clinical and research settings.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Amanda Kvist-Hansen, Hannah Kaiser, Martin Krakauer, Peter M. M. Gortz, Xing Wang, Christine Becker, Claus Zachariae, Peter R. R. Hansen, Lone Skov
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Ida Vittrup, Niels Steen Krogh, Henrik Hedegaard Pliess Larsen, Jesper Elberling, Lone Skov, Kristina Sophie Ibler, Gregor B. E. Jemec, Charlotte G. G. Mortz, Rasmus Overgaard Bach, Carsten Bindslev-Jensen, Maiken Glud Dalager, Alexander Egeberg, Tove Agner, Mette Deleuran, Christian Vestergaard, Jacob Pontoppidan Thyssen
Summary: This study evaluated the safety, effectiveness, and drug survival of dupilumab in a Danish cohort with moderate-to-severe AD for up to 104 weeks. The results showed improvement in AD severity, but poor effectiveness in treating AD in the head-and-neck area and a high incidence of conjunctivitis.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
M. S. Liljendahl, N. Loft, A. Passey, S. Wegner, A. Egeberg, L. Skov
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Caroline Meyer Olesen, Yasemin Topal Yueksel, Claus Zachariae, Tamara Theresia Lund, Tove Agner, Tonny Studsgaard Petersen, Jacob Pontoppidan Thyssen
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Morten Bahrt Haulrig, Nikolai Loft, Christopher Willy Schwarz, Frederik Boetius Hertz, Simon Francis Thomsen, Susanne Dam Nielsen, Lone Skov
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
David Thein, Nana A. L. Roseno, Julia-Tatjana Maul, Jashin J. Wu, Lone Skov, Lars Erik Bryld, Mads K. Rasmussen, Kawa Khaled Ajgeiy, Simon Francis Thomsen, Jacob P. Thyssen, Alexander Egeberg
Summary: The real-world effectiveness of biologics in treating psoriasis was examined using a nationwide registry. The results showed that the risk of discontinuation or off-label dose escalation was lower for secukinumab compared to ustekinumab, but higher for adalimumab. However, the risk of discontinuation was higher for both secukinumab and adalimumab. For patients who were bio-naive, the risk of discontinuation was comparable between secukinumab and ustekinumab.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Anne -Sofie Halling, Blaine Gabriel Fritz, Trine Gerner, Maria Rasmussen Rinnov, Lene Bay, Mette Hjorslev Knudgaard, Nina Haarup Ravn, Simon Trautner, Iben Frier Ruge, Caroline Olesen, Isabel Diiaz-Pinees Cort, Lone Skov, Nikolaj Sorensen, Amalie Thorsti Moller Ronnstad, Simon F. Thomsen, Alexander Egeberg, Ivone Jakasa, Sanja Kezic, Thomas Bjarnsholt, Jacob P. Thyssen
Summary: This study examined the association between alterations in the skin microbiome and the risk of atopic dermatitis (AD) in a Danish birth cohort. While no overall association was found, the study showed that lower alpha diversity in the skin microbiome at 2 months of age was associated with an increased risk of AD, particularly in children with parents who have atopy.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Editorial Material
Dermatology
Charlotte Naslund-Koch, Signe Vedel-Krogh, Stig Egil Bojesen, Lone Skov
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Immunology
Charlotte Naslund-Koch, Signe Vedel-Krogh, Stig Egil Bojesen, Lone Skov
Summary: The association between smoking and psoriasis is not fully understood in terms of causality. This study used a Mendelian randomization design to investigate if smoking is an independent and causal risk factor for psoriasis. The results showed that smoking was associated with an increased risk of moderate to severe psoriasis in observational analyses, but this association was not causal when using a genetic variant as a proxy for smoking.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
A. M. Andersson, A. C. Ingham, S. M. Edslev, J. Solberg, L. Skov, A. Koch, K. Ghauharali-van der Vlugt, F. S. Stet, C. M. Brueggen, I. Jakasa, S. Kezic, J. P. Thyssen
Summary: The skin microbiota, cytokine, and lipid composition differ significantly between Greenlandic Inuit and Danish children with AD, with a stronger type 2 immune signature observed in Inuit children.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)