期刊
JOURNAL OF IMMUNOLOGY
卷 181, 期 6, 页码 4347-4353出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.181.6.4347
关键词
-
类别
资金
- Wiener Wissenschafts-, Forschungs-, und Technologiefond (WWTF)
- Austrian Science Fund [SFB005.2]
The activation of neutrophil granulocytes has to he carefully controlled to balance desired activity against invading pathogens while avoiding overwhelming activation leading to host tissue damage. We now show that phospholipids are potential key players in this process by either enhancing or dampening the production of reactive oxygen species (ROS) during the oxidative burst. Unoxidized phospholipids induce the production of ROS, and they also work synergistically with FMLP in potentiating the oxidative burst in neutrophil granulocytes. Oxidation of these phospholipids, however, turns them into potent inhibitors of the oxidative burst. OxPIs specifically inhibit ROS production by inhibiting the assembly of the phagocyte oxidase complex but do not alter neutrophil viability, nor do they interfere with MAPK activation. Furthermore, up-regulation of the activation marker Mac-1 and phagocytosis of bacteria is not affected. Therefore, phospholipids may act as sensors of oxidative stress in tissues and either positively or negatively regulate neutrophil ROS production according to their oxidation state.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据