Article
Neurosciences
Kuniko Kohyama, Hiroya Nishida, Kimihiko Kaneko, Tatsuro Misu, Ichiro Nakashima, Hiroshi Sakuma
Summary: This study investigated the role of anti-myelin oligodendrocyte glycoprotein (MOG) autoantibodies in demyelinating disorders. The results showed that MOG-positive sera caused cell death in MOG-expressing cells, and the cytotoxic effect required the presence of anti-MOG IgG and externally added complement.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Keiko Tanaka, Takeshi Kezuka, Hitoshi Ishikawa, Masami Tanaka, Kenji Sakimura, Manabu Abe, Meiko Kawamura
Summary: Despite extensive data on MOGAD, there is still uncertainty regarding the function of MOG protein and the pathogenicity of anti-MOG autoantibodies. MOGAD differs from NMOSDs and MS in terms of disease characteristics and treatment response. Optic neuritis is a common feature of MOGAD, suggesting that the optic nerve is the most vulnerable lesion. Animal models are needed to understand the pathogenesis of MOGAD, but current models do not efficiently recognize anti-MOG autoantibodies from patients. The identification of MOG protein epitopes is also necessary for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Kathryn Pellerin, Stephen J. Rubino, Jeremy C. Burns, Benjamin A. Smith, Christie-Ann Mccarl, Jing Zhu, Luke Jandreski, Patrick Cullen, Thomas M. Carlile, Angela Li, Jorge Vera Rebollar, Jennifer Sybulski, Taylor L. Reynolds, Baohong Zhang, Rebecca Basile, Hao Tang, Chelsea Parker Harp, Alex Pellerin, John Silbereis, Nathalie Franchimont, Ellen Cahir-McFarland, Richard M. Ransohoff, Thomas O. Cameron, Michael Mingueneau
Summary: The study reveals the pathophysiological significance of autoantibody-induced Fc receptor signaling in the central nervous system, depending on central Fc receptor engagement in microglia proliferation. The activation of Fc receptors and BTK signaling in microglia provides a novel in vivo tool to further explore the roles of microglia-specific Fc receptor and BTK-driven responses in CNS homeostasis and disease.
Review
Clinical Neurology
Scott Otallah
Summary: ADEM, a disease with a long history, is still evolving in terms of diagnostic criteria and understanding. Recent advancements in diagnostic testing for MOG autoantibodies have enhanced the understanding of treatment and disease progression in ADEM patients in recent years. Recent developments in the literature aim to guide providers treating both adults and children.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Article
Clinical Neurology
Noriyuki Miyaue, Yuko Hosokawa, Yuki Yamanishi, Satoshi Tada, Rina Ando, Masahiro Nagai
Summary: CSF neopterin levels can distinguish between different CNS demyelinating diseases and may be useful for differential diagnosis and assessment of disease activity. Further studies are needed to validate its utility and compare with other biomarkers.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Immunology
Amanda Marchionatti, Gisele Hansel, Gabriela Urbanski Avila, Douglas Kazutoshi Sato
Summary: Human antibodies against MOG-IgG are crucial for diagnosing and prognosticating neurological autoimmune diseases. The use of CBA-FC as an automated technique with objective quantification is effective in diagnosing MOG-IgG. Combining CBA-IF and CBA-FC can help overcome limitations of single assays in specific cases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Meihui Xu, Chi Ma, Ming Dong, Chunjie Guo, Simin Yang, Yue Liu, Xu Wang
Summary: This study aims to characterize the clinical symptoms, MRI findings, and prognosis of adult cerebral cortical encephalitis (CCE) with anti-MOG antibody. Two adult cases of CCE with anti-MOG antibody were presented and a systematic review of the literature was conducted. The majority of patients had a favorable prognosis after treatment, highlighting the importance of early detection and immunotherapy in improving outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
D. Doig, C. McNamara, L. Mewasingh, S. Beri, B. Jones, C. Kachramanoglou, W. Jan
Summary: This study described two children presenting with generalized seizures due to cortical encephalitis, both of whom were found to have anti-MOG antibodies. MRI scans showed bilateral cortical swelling and abnormal signal intensities.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Ki Hoon Kim, Su-Hyun Kim, Na Young Park, Jae-Won Hyun, Ho Jin Kim
Summary: The international MOGAD panel recently released proposed criteria for diagnosing MOGAD, and these criteria were applied to a single-center cohort for evaluation. Among 100 enrolled patients, 93 fulfilled the criteria during a 24-month follow-up period. The criteria were useful in confirming MOGAD in patients with clear-positive MOG-IgG as well as in patients without clear-positive MOG-IgG, including those initially negative for MOG-IgG.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Yi Hua, Xuke Yan, Liu Liu, Yilong Wang, Lu Xu, Peifang Jiang, Zhefeng Yuan, Feng Gao
Summary: This study retrospectively analyzed the clinical characteristics and follow-up data of 74 Chinese children with different clinical phenotypes of MOGAD. The results showed that the most common clinical phenotypes of MOGAD were ADEM and encephalitis, and recurrence may be related to age and sex, with a higher recurrence rate observed in females.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Jie Xu, Lingjuan Liu, Jie Xiong, Lu Zhang, Peng Huang, Li Tang, Yangyang Xiao, Xingfang Li, Jian Li, Yingying Luo, Huiling Li, Dingan Mao, Liqun Liu
Summary: Clinical differences between pediatric and adult patients with MOG-EM were identified in this study. Pediatric patients had a higher prevalence of bilateral optic neuritis and fever, while adult patients more commonly presented with NMOSD and unilateral optic nerve involvement. Visual impairment was the predominant symptom in both age groups, with fever being more common among pediatric patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Pediatrics
Xiaoang Sun, Meiyan Liu, Xiaona Luo, Fang Yuan, Chunmei Wang, Simei Wang, Quanmei Xu, Yuanfeng Zhang, Yucai Chen
Summary: Background research on MOG-Ab-associated disease (MOGAD) among Chinese children is limited. This study explored and analyzed the clinical characteristics and prognoses of Chinese children with acquired demyelinating syndromes (ADSs) who tested positive or negative for MOG-Ab. The findings showed differences in clinical features and imaging between MOG-Ab-positive and MOG-Ab-negative children with ADSs. Additional diagnoses and personalized treatment plans should be developed to improve the prognoses of children with MOGAD.
Article
Clinical Neurology
Tammy L. Smith, Thomas R. Haven, Lauren M. Zuromski, Kyphuong Luong, Stacey L. Clardy, Lisa K. Peterson
Summary: There is excellent agreement between fixed and live cell-based assays for Myelin Oligodendrocyte Glycoprotein (MOG) antibody testing in a real-world clinical laboratory setting. Clinicians should be aware of the method used to assess patients, as titers may vary between the assays.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Wojciech Ambrosius, Slawomir Michalak, Wojciech Kozubski, Alicja Kalinowska
Summary: MOG-associated disease (MOGAD) is a rare inflammatory disorder of the central nervous system with various phenotypes, most commonly presenting as optic neuritis and ADEM. Diagnosis relies on detecting serum antibodies and MRI imaging, while treatment includes acute immunotherapy and immunosuppressive therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Ziyan Li, Hong Sun, Xiao Fan, Ping Yuan, Yan Jiang, Peng Wu, Min Zhong, Jiannan Ma, Li Jiang, Xiujuan Li
Summary: This study from Southwest China analyzed the positivity and recurrence rates of autoantibody-associated demyelination disorders in children, revealing that MOG antibody is more common than AQP4 antibody in pediatric ADS. MOG-ab-positive children exhibit distinct clinical and radiological features, and generally have a better prognosis compared to AQP4-ab-positive children.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Maren Lindner, Katja Thuemmler, Ariel Arthur, Sarah Brunner, Christina Elliott, Daniel McElroy, Hema Mohan, Anna Williams, Julia M. Edgar, Cornelia Schuh, Christine Stadelmann, Susan C. Barnett, Hans Lassmann, Steve Muecklisch, Manikhandan Mudaliar, Nicole Schaeren-Wiemers, Edgar Meinl, Christopher Linington
Article
Immunology
Chelsea R. Parker Harp, Angela S. Archambault, Julia Sim, Stephen T. Ferris, Robert J. Mikesell, Pandelakis A. Koni, Michiko Shimoda, Christopher Linington, John H. Russell, Gregory F. Wu
JOURNAL OF IMMUNOLOGY
(2015)
Article
Immunology
Sevasti Flytzani, Andre Ortlieb Guerreiro-Cacais, Marie N'diaye, Maren Lindner, Christopher Linington, Edgar Meinl, Pernilla Stridh, Maja Jagodic, Tomas Olsson
JOURNAL OF NEUROINFLAMMATION
(2015)
Article
Neurosciences
Debbie Allan, Karen J. Fairlie-Clarke, Christina Elliott, Cornelia Schuh, Susan C. Barnett, Hans Lassmann, Christopher Linnington, Hui-Rong Jiang
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2016)
Article
Clinical Neurology
Andrew L. Davies, Roshni A. Desai, Peter S. Bloomfield, Peter R. McIntosh, Katie J. Chapple, Christopher Linington, Richard Fairless, Ricarda Diem, Marianne Kasti, Michael P. Murphy, Kenneth J. Smith
ANNALS OF NEUROLOGY
(2013)
Article
Neurosciences
Maren Lindner, Judy King Man Ng, Sonja Hochmeister, Edgar Meinl, Christopher Linington
EXPERIMENTAL NEUROLOGY
(2013)
Article
Cell Biology
Chris A. H. Hansell, Lindsay M. MacLellan, Rachel S. Oldham, James Doonan, Katie J. Chapple, Elinor J. R. Anderson, Christopher Linington, Iain B. McInnes, Robert J. B. Nibbs, Carl S. Goodyear
IMMUNOLOGY AND CELL BIOLOGY
(2015)
Article
Immunology
Nicolas Molnarfi, Ulf Schulze-Topphoff, Martin S. Weber, Juan C. Patarroyo, Thomas Prod'homme, Michel Varrin-Doyer, Aparna Shetty, Christopher Linington, Anthony J. Slavin, Juan Hidalgo, Dieter E. Jenne, Hartmut Wekerle, Raymond A. Sobel, Claude C. A. Bernard, Mark J. Shlomchik, Scott S. Zamvil
JOURNAL OF EXPERIMENTAL MEDICINE
(2013)
Article
Clinical Neurology
Marija Sajic, Norman Gregson, Christopher Linington, Richard A. C. Hughes, Kenneth J. Smith
MULTIPLE SCLEROSIS JOURNAL
(2012)
Editorial Material
Clinical Neurology
Hugh J. Willison, Christopher Linington
Article
Clinical Neurology
Judy King Man Ng, Joachim Malotka, Naoto Kawakami, Tobias Derfuss, Mohsen Khademi, Tomas Olsson, Christopher Linington, Masaaki Odaka, Bjoern Tackenberg, Harald Pruess, Jan M. Schwab, Lutz Harms, Hendrik Harms, Claudia Sommer, Matthew N. Rasband, Yael Eshed-Eisenbach, Elior Peles, Reinhard Hohlfeld, Nobuhiro Yuki, Klaus Dornmair, Edgar Meinl
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Clinical Neurology
Susan C. Barnett, Christopher Linington
Article
Multidisciplinary Sciences
Sonja Hochmeister, Thomas Pekar, Maren Lindner, Maja Kitic, Michaela Haindl, Maria Storch, Franz Fazekas, Christopher Linington
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Neurosciences
Hema Mohan, Anita Friese, Stefanie Albrecht, Markus Krumbholz, Christina L. Elliott, Ariel Arthur, Ramesh Menon, Cinthia Farina, Andreas Junker, Christine Stadelmann, Susan C. Barnett, Inge Huitinga, Hartmut Wekerle, Reinhard Hohlfeld, Hans Lassmann, Tanja Kuhlmann, Chris Linington, Edgar Meinl
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2014)
Article
Clinical Neurology
Faiez Al Nimer, Christina Elliott, Joakim Bergman, Mohsen Khademi, Ann M. Dring, Shahin Aeinehband, Tommy Bergenheim, Jeppe Romme Christensen, Finn Sellebjerg, Anders Svenningsson, Christopher Linington, Tomas Olsson, Fredrik Piehl
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2016)