Article
Immunology
Casimiro Luca Gigliotti, Elena Boggio, Francesco Favero, Danny Incarnato, Claudio Santoro, Salvatore Oliviero, Jose Maria Rojo, Silvia Zucchelli, Francesca Persichetti, Gianluca Baldanzi, Umberto Dianzani, Davide Cora
Summary: ICOS and CD28 costimulatory signals play distinct roles in the activation of naive T cells by modulating different sets of immunological and immunometabolic genes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Fabienne Mazerolles, Frederic Rieux-Laucat
Summary: The expression of co-signalling receptors on T cells plays a crucial role in regulating T cell responses, and an imbalance between activating and inhibitory signals may lead to autoimmunity. Research showed that activated TEFFs and TREGs express different co-signalling receptors, and the expression of PD-L1 on activated TEFFs is correlated with their proliferation.
Article
Immunology
Yasuhito Tokumoto, Yasuto Araki, Yusuke Narizuka, Yosuke Mizuno, Susumu Ohshima, Toshihide Mimura
Summary: This study presents a method to culture memory-like T cells from naive human T cells, which involves activation of T cells and subsequent culture under hypoxic conditions. The surviving cells exhibited characteristics of memory T cells and resumed proliferation upon reactivation.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Immunology
Patrick M. McTernan, Danielle E. Levitt, David A. Welsh, Liz Simon, Robert W. Siggins, Patricia E. Molina
Summary: This study found that ethanol disrupts CD4(+) T cell differentiation, increasing pro-inflammatory cells and decreasing immunosuppressive cells, as well as affecting CD4(+) T cell immunometabolism and impairing mitochondrial repair processes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Christina Seitz, Anne-Laure Joly, Fang Fang, Katie Frith, Paul Gray, John Andersson
Summary: The transcription factor FOXP3 is crucial for the development and function of CD4(+)FOXP3(+) regulatory T (Treg) cells. Alterations in the expression of FOXP3 isoforms are associated with inflammatory disease progression. This study investigates the effects of a specific FOXP3 mutation on Treg cell subsets. The findings suggest that the full-length FOXP3 isoform is important for maintaining Treg cell lineage stability but not essential for Treg cell activation.
CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Naoya Tatsumi, Yosuke Kumamoto
Summary: Conventional dendritic cells (cDCs) are a powerful type of antigen-presenting cells, consisting of different subsets with distinct developmental, phenotypic, and functional characteristics. After immunization, each subset of cDCs acquires antigens in the secondary lymphoid organs and presents them to CD4T cells in a spatiotemporal manner, resulting in multiple waves of antigen presentation. This review focuses on the kinetics of antigen presentation by each cDC subset and its impact on priming naive CD4T cells, as well as its implications in CD4T cell differentiation.
CURRENT OPINION IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Noriko Sato, Richard N. Bamford, Bonita R. Bryant, Yutaka Tagaya, Thomas A. Waldmann
Summary: When purified, naive T cells and regulatory T cells could not proliferate to the γC-cytokines IL-2, IL-7, or IL-15, despite expressing the cognate cytokine receptors. However, dendritic cells enabled their proliferation through cell-to-cell contact, independent of T cell receptor stimulation. This preconditioning effect activated specific cellular pathways and facilitated cytokine-mediated proliferation of T cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Enric Mocholi, Laura Russo, Keshav Gopal, Andrew G. Ramstead, Sophia M. Hochrein, Harmjan R. Vos, Geert Geeven, Adeolu O. Adegoke, Anna Hoekstra, Robert M. van Es, Jose Ramos Pittol, Sebastian Vastert, Jared Rutter, Timothy Radstake, Jorg van Loosdregt, Celia Berkers, Michal Mokry, Colin C. Anderson, Ryan M. O'Connell, Martin Vaeth, John Ussher, Boudewijn M. T. Burgering, Paul J. Coffer
Summary: Upon antigen-specific TCR engagement, the generation of extramitochondrial pyruvate is crucial for acetyl-CoA production and subsequent histone acetylation remodeling. PDH-deficient T cells show that PDH-dependent acetyl-CoA production is a rate-limiting step during T cell activation. This study highlights the integration of metabolic and histone-modifying enzymes in CD4+ T cell activation, suggesting a potential therapeutic approach for regulating antigen-driven T cell activation.
Article
Immunology
Toshio Kanno, Keisuke Miyako, Takahiro Nakajima, Satoru Yokoyama, Shigemi Sasamoto, Hikari K. Asou, Osamu Ohara, Toshinori Nakayama, Yusuke Endo
Summary: This study reveals that the decrease in monounsaturated fatty acid caused by the genetic deletion of Scd2 can activate IRF3 and induce the nuclear translocation of IRF9, leading to the production of type I interferon in CD4(+) Th1 cells. Furthermore, IRF9 selectively regulates autoimmunity-related genes in sgScd2 Th1 cells. These findings provide novel insights into the connection between fatty acid metabolism and immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zohreh Bolandi, Seyed Mahmoud Hashemi, Mozhgan Abasi, Maryam Musavi, Shahin Aghamiri, Nastaran Miyanmahaleh, Hossein Ghanbarian
Summary: This study investigates the role of miR-29b in T cell differentiation reprogramming, and demonstrates that the delivery of miR-29b through adipose mesenchymal stem cell-derived exosomes alters the differentiation of CD4(+) T cells and holds promise for treating inflammatory disorders.
MOLECULAR BIOLOGY REPORTS
(2023)
Editorial Material
Biochemical Research Methods
Andrea Olga Papadopoulos, Zaza Mtine Ndhlovu
Summary: With advancements in CRISPR technology, it is now possible to edit the naive CD4(+) T cells in the immune system, improving its overall function.
Article
Microbiology
Ryuta Uraki, Masaki Imai, Mutsumi Ito, Hiroaki Shime, Mizuyu Odanaka, Moe Okuda, Yoshihiro Kawaoka, Sayuri Yamazaki
Summary: This study showed that transient Treg-cell depletion without adjuvants in mice induced protective antigen-specific immunity to SARS-CoV-2, including the production of antibodies and cellular immune responses. The manipulation of Treg cells could activate antigen-presenting DCs, offering an innovative approach to vaccine design for SARS-CoV-2 and emerging variants.
Article
Immunology
Bilade Cherqaoui, Frederic Cremazy, Marc Lauraine, Ghazal Shammas, Roula Said-Nahal, Hendrick Mambu Mambueni, Felicie Costantino, Marine Fourmont, Audrey Hulot, Henri-Jean Garchon, Simon Glatigny, Luiza M. Araujo, Maxime Breban
Summary: The naïve CD4+ T cells of B27-rats exhibit a predisposition towards Th17 differentiation due to a STAT1 deficiency, which occurs early and is associated with an epigenetic Th17 bias. This molecular phenomenon may contribute to the persistent proinflammatory skew of CD4+ T cells in SpA patients, providing new insights for understanding and treating SpA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ming Zhao, Sujie Jia, Xiaofei Gao, Hong Qiu, Ruifang Wu, Haijing Wu, Qianjin Lu
Summary: This study revealed 802 upregulated and 598 downregulated proteins in iTfh cells compared to naive CD4(+) T cells. Intensive bioinformatics analysis provided insights into the biological processes, cellular compartments, molecular functions, KEGG pathways, and protein-protein interactions of these differentially expressed proteins. The acetylome data showed differential levels of lysine acetylation in iTfh cells, with a specific focus on core histones, suggesting a role for protein acetylation and epigenetic mechanisms in regulating Tfh cell differentiation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Anusara Daenthanasanmak, Supinya Iamsawat, Paramita Chakraborty, Hung D. Nguyen, David Bastian, Chen Liu, Shikhar Mehrotra, Xue-Zhong Yu
Article
Oncology
Shilpak Chatterjee, Paramita Chakraborty, Anusara Daenthanasanmak, Supinya Iamsawat, Gabriela Andrejeva, Libia A. Luevano, Melissa Wolf, Uday Baliga, Carsten Krieg, Craig C. Beeson, Meenal Mehrotra, Elizabeth G. Hill, Jeffery C. Rathmell, Xue-Zhong Yu, Andrew S. Kraft, Shikhar Mehrotra
CLINICAL CANCER RESEARCH
(2019)
Article
Immunology
Sahar Bagherzadeh Yazdchi, Mariko Witalis, Alexandre P. Meli, Joanne Leung, Xin Li, Vincent Panneton, Jinsam Chang, Joanna Li, Stephen L. Nutt, Randy L. Johnson, Dae-Sik Lim, Hua Gu, Irah L. King, Woong-Kyung Suh
JOURNAL OF IMMUNOLOGY
(2019)
Editorial Material
Medicine, General & Internal
Yongxia Wu, Xue-Zhong Yu
Article
Biochemistry & Molecular Biology
Paramita Chakraborty, Shilpak Chatterjee, Pravin Kesarwani, Krishnamurthy Thyagarajan, Supinya Iamsawat, Annika Dalheim, Hung Nguyen, Shanmugam P. Selvam, Patrick Nasarre, Gina Scurti, Gary Hardiman, Nilanjana Maulik, Lauren Ball, Vamsi Gangaraju, Mark P. Rubinstein, Nancy Klauber-DeMore, Elizabeth G. Hill, Besim Ogretmen, Xue-Zhong Yu, Michael I. Nishimura, Shikhar Mehrotra
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Medicine, Research & Experimental
M. Hanief Sofi, Yongxia Wu, Steven D. Schutt, Min Dai, Anusara Daenthanasanmak, Jessica Heinrichs Voss, Hung Nguyen, David Bastian, Supinya Iamsawat, Shanmugam Panneer Selvam, Chen Liu, Nilanjana Maulik, Besim Ogretmen, Junfei Jin, Shikhar Mehrotra, Xue-Zhong Yu
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Review
Immunology
David Bastian, Yongxia Wu, Brian C. Betts, Xue-Zhong Yu
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Immunology
Vincent Panneton, Jinsam Chang, Mariko Witalis, Joanna Li, Woong-Kyung Suh
IMMUNOLOGICAL REVIEWS
(2019)
Article
Cell Biology
Mengqi Dong, Jinsam Chang, Marie-Eve Lebel, Noemie Gervais, Marilaine Fournier, Eve Mallet Gauthier, Woong-Kyung Suh, Heather J. Melichar
Summary: Negative selection is an important process for T-cell tolerance, and ICOS may play a role in fine-tuning T-cell receptor signals during thymic selection.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Article
Hematology
Jianming Wang, Chun-Yuan Chang, Xue Yang, Fan Zhou, Juan Liu, Sining Zhu, Xue-Zhong Yu, Chen Liu, Timothy E. Sullivan, Ping Xie, Zhaohui Feng, Wenwei Hu
Summary: Recombinant LIF protein has been found to protect against tissue damage and mortality caused by GVHD without compromising graft-versus-leukemia activity. This protection is achieved by decreasing the infiltration and activation of immune cells and protecting intestinal stem cells through the activation of STAT1 signaling and downregulation of IL-12-p40 expression.
Article
Immunology
Jinsam Chang, Antoine Bouchard, Yasser Bouklouch, Vincent Panneton, Joanna Li, Nikoletta Diamantopoulos, Saba Mohammaei, Roman Istomine, Fernando Alvarez, Ciriaco A. Piccirillo, Woong-Kyun Suh
Summary: ICOS is expressed in activated T cells and has a positive role in the differentiation and function of effector T cells. It is also expressed in a subpopulation of regulatory T cells and contributes to their homeostasis, migration, and function. However, tissue-protective Treg populations do not heavily rely on ICOS costimulation. In inflammatory conditions, ICOS has a dual positive role in both effector and Treg cells.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Immunology
Antoine Bouchard, Mariko Witalis, Jinsam Chang, Vincent Panneton, Joanna Li, Yasser Bouklouch, Woong-Kyung Suh
Article
Hematology
Mariko Witalis, Jinsam Chang, Ming-Chao Zhong, Yasser Bouklouch, Vincent Panneton, Joanna Li, Thorsten Buch, Seok Jin Kim, Won Seog Kim, Young Hyeh Ko, Andre Veillette, Woong-Kyung Suh
Article
Hematology
Supinya Iamsawat, Linlu Tian, Anusara Daenthanasanmak, Yongxia Wu, Hung D. Nguyen, David Bastian, Xue-Zhong Yu
Article
Medicine, Research & Experimental
Hung Nguyen, Sandeepkumar Kuril, David Bastian, Jisun Kim, Mengmeng Zhang, Silvia G. Vaena, Mohammed Dany, Min Dai, Jessica Lauren Heinrichs, Anusara Daenthanasanmak, Supinya Iamsawat, Steven Schutt, Jianing Fu, Yongxia Wu, David P. Fairlie, Carl Atkinson, Besim Ogretmen, Stephen Tomlinson, Xue-Zhong Yu