Article
Cell Biology
Anca Apavaloaei, Jean-Philippe Laverdure, Claude Perreault
Summary: PSMB11 proteasomal subunit expressed exclusively in cortical thymic epithelial cells (cTECs) is crucial for the development of functional CD8(+) T cells. PSMB11 regulates gene expression in cTECs through proteolysis of transcription factors, maintaining their distinctness from medullary TECs (mTECs) and promoting migration of developing thymocytes from cortex to medulla. Ohigashi and colleagues' data challenging these conclusions was reanalyzed and confirmed, supporting the original findings.
Article
Multidisciplinary Sciences
Chinaemerem U. Onyishi, Guillaume E. Desanti, Alex L. Wilkinson, Samuel Lara-Reyna, Eva-Maria Frickel, Gyorgy Fejer, Olivier D. Christophe, Clare E. Bryant, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May
Summary: Loss of TLR4 function enhances phagocytosis of non-opsonised C. neoformans by macrophages, and this is dampened by pre-treatment with oxidised-LDL. The scavenger receptor MSR1 is upregulated in Tlr4(-/-) macrophages and is shown to be a key non-opsonic receptor for C. neoformans.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Shiyun Xiao, Wen Zhang, Jie Li, Nancy R. Manley
Summary: This study found that Lin28 plays a critical regulatory role in TECs by modulating MHCII expression and TEC proliferation, thus influencing thymic development and differentiation. These findings provide new insights into the mechanisms underlying TEC differentiation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Izumi Ohigashi, Yousuke Takahama
Summary: Beta 5t has a specific impact on proteasome subunit composition in cTECs, contributing to the optimization of CD8(+) T cell development through the production of unique self-peptides associated with MHC-I. However, controversy exists regarding the role of beta 5t in regulating cTEC gene expression and inducing oxidative stress in thymocytes.
Article
Biochemistry & Molecular Biology
Zhen Wu, Tao Hu, Andres Merits, Yu He, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Yunya Liu, Ling Zhang, Yanling Yu, Anchun Cheng, Shun Chen
Summary: Unlike most arthropod-transmitted flaviviruses, the Tembusu virus (TMUV) remains active during winter and can be transmitted through the digestive tract. The study shows that intestinal bacteria play a crucial role in TMUV infection, with lipopolysaccharide (LPS) from Gram-negative bacteria enhancing TMUV proliferation via the Toll-like receptor 4 (TLR4) pathway.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Immunology
Andrea J. White, Sonia M. Parnell, Adam Stefano, Stefano Maio, Andrea Bacon, Emilie J. Cosway, Beth Lucas, Kieran D. James, Jennifer E. Cowan, William E. Jenkinson, Georg A. Hollander, Graham Anderson
Summary: The study investigated the role of cortical thymic epithelial cells (cTECs) and medullary thymic epithelial cells in abT cell development. It was found that cTECs express a specific gene signature to support T lineage commitment and generation of CD4+CD8+ thymocytes. The study also revealed developmental regulation and functional heterogeneity of cTECs, controlled by stage-specific thymocyte cross-talk. These findings contribute to a better understanding of the regulation mechanisms during thymocyte development.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Cell Biology
Matthew J. White, Kyle A. Jacobs, Tania Singh, Lakyn N. Mayo, Annie Lin, Christopher S. Chen, Young-wook Jun, Matthew L. Kutys
Summary: This study uses a 3D model to demonstrate that Notch1 influences epithelial morphogenesis through a mechanism independent of transcriptional signaling. Notch1 cortical signaling directly regulates epithelial cell architecture and proliferation by stabilizing adherens junctions and cortical actin. These findings provide new insights into Notch1 signaling and regulation and suggest a coordination between transcriptional and cell adhesive programs.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jian Lu, Zhouzhou Zhang, Xinxin Yin, Yingjun Tang, Runan Ji, Han Chen, Yu Guang, Xue Gong, Yong He, Wei Zhou, Haiyang Wang, Ke Cheng, Yue Wang, Xiaowei Chen, Peng Xie, Zengcai Guo
Summary: This study identifies a cortical circuit that connects the entorhinal cortex to the visual cortex and bidirectionally regulates depression-like behaviors in mice. The findings suggest that the entorhinal-visual cortical pathway plays a crucial role in the development of depression and may serve as a potential target for treating major depressive disorder.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Daniel A. Michelson, Christophe Benoist, Diane Mathis
Summary: Medullary thymic epithelial cells (mTECs) are crucial for T cell central tolerance. In addition to the transcription factor Aire, we found that mTECs express the inhibitory receptor CTLA-4. CTLA-4(+) mTECs have a distinct gene signature associated with antigen presentation and interferon-gamma signaling, complementing the role of Aire.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Sandeep M. Nalluri, Chinmay S. Sankhe, Joseph W. O'Connor, Paul L. Blanchard, Joelle N. Khouri, Steven H. Phan, Gage Virgi, Esther W. Gomez
Summary: Epithelial-mesenchymal transition (EMT) is a physiological process essential for embryogenesis and wound healing, but also implicated in pathologies like fibrosis and cancer. Regulation of phosphorylation status can impact cell physiology and gene expression changes during TGFβ1-induced EMT, highlighting the crucial role of intricate crosstalk between signaling cascades in regulating EMT processes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Soo Hyun Ahn, Sean L. Nguyen, Tae Hoon Kim, Jae-Wook Jeong, Ripla Arora, John P. Lydon, Margaret G. Petroff
Summary: Progesterone is a crucial hormone for the success of pregnancy, specifically in the female reproductive organs. It prepares the endometrium for embryo implantation and plays a role in thymic involution during pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Tsukasa Nabekura, Elfira Amalia Deborah, Saeko Tahara, Yuya Arai, Paul E. Love, Koichiro Kako, Akiyoshi Fukamizu, Masafumi Muratani, Akira Shibuya
Summary: The protein scaffold Themis2 is identified as a critical regulator of memory NK cell differentiation and function. It suppresses NK cell effector function and promotes Zfp740-mediated repression to regulate the persistence of memory NK cells.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Julia L. M. Dunn, Julie M. Caldwell, Adina Ballaban, Netali Ben-Baruch Morgenstern, Mark Rochman, Marc E. Rothenberg
Summary: The study reveals a complex network of crosstalk between eosinophils and esophageal epithelial cells in patients with eosinophilic esophagitis (EoE), where the epithelial cells mediate eosinophil survival and induce reciprocal changes in cellular transcripts.
MUCOSAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhanfeng Liang, Zhaoqi Zhang, Qian Zhang, Xue Dong, Xiaofeng Yang, Jiayu Zhang, Tong Lei, John W. M. Creemers, Baojun Zhang, Yong Zhao
Summary: The study revealed that Furin is highly expressed in thymic epithelial cells (TECs) and its deletion leads to reduced TECs, thymic atrophy, impaired thymopoiesis, and autoimmune disorders. Furin promotes TEC development through the cleavage of proproteins and activation of signaling pathways. This study highlights the importance of post-translational modification of immature proproteins in TEC biology.
Article
Pharmacology & Pharmacy
Elena Isaeva, Ruslan Bohovyk, Mykhailo Fedoriuk, Alexey Shalygin, Christine A. Klemens, Adrian Zietara, Vladislav Levchenko, Jerod S. Denton, Alexander Staruschenko, Oleg Palygin
Summary: The inhibition of K(ir)4.1/K(ir)5.1 channels affects ENaC activity, leading to the regulation of electrolyte balance and blood pressure. Amitriptyline is a potential K(ir)4.1/K(ir)5.1 inhibitor.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Imran Siddiqui, Karin Schaeuble, Vijaykumar Chennupati, Silvia A. Fuertes Marraco, Sandra Calderon-Copete, Daniela Pais Ferreira, Santiago J. Carmona, Leonardo Scarpellino, David Gfeller, Sylvain Pradervand, Sanjiv A. Luther, Daniel E. Speiser, Werner Held
Article
Dermatology
Catherine Ronet, Katiuska Passelli, Melanie Charmoy, Leo Scarpellino, Elmarie Myburgh, Yazmin Hauyon La Torre, Salvatore Turco, Jeremy C. Mottram, Nicolas Fasel, Sanjiv A. Luther, Stephen M. Beverley, Pascal Launois, Fabienne Tacchini-Cottier
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Immunology
Patricia Aparicio-Domingo, Helene Cannelle, Matthew B. Buechler, Sylvain Nguyen, Sandra M. Kallert, Stephanie Favre, Nagham Alouche, Natalie Papazian, Burkhard Ludewig, Tom Cupedo, Daniel D. Pinschewer, Shannon J. Turley, Sanjiv A. Luther
Summary: Upon viral infection, stressed or damaged cells release IL-33 as endogenous danger signals to alert immune cells, mainly sourced from FRC and LEC cells. IL-33 plays a crucial role in antiviral T-cell responses, particularly in FRC.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Biology
Juana Serrano-Lopez, Shailaja Hegde, Sachin Kumar, Josefina Serrano, Jing Fang, Ashley M. Wellendorf, Paul A. Roche, Yamileth Rangel, Leolene J. Carrington, Hartmut Geiger, H. Leighton Grimes, Sanjiv Luther, Ivan Maillard, Joaquin Sanchez-Garcia, Daniel T. Starczynowski, Jose A. Cancelas
Summary: This study reveals the rapid migration of myeloid progenitors from bone marrow to lymphatics during systemic inflammation, mediated by specific signaling pathways, which plays an anti-inflammatory role.
Article
Multidisciplinary Sciences
Alejandra Gonzalez-Loyola, Esther Bovay, Jaeryung Kim, Tania Wyss Lozano, Amelie Sabine, Francois Renevey, Silvia Arroz-Madeira, Alexis Rapin, Tomasz P. Wypych, Giorgia Rota, Stephan Durot, Dominique Velin, Benjamin Marsland, Greta Guarda, Mauro Delorenzi, Nicola Zamboni, Sanjiv A. Luther, Tatiana V. Petrova
Summary: Inactivation of Foxc2 in adult lymphatic endothelium leads to a stepwise intestine-to-lung systemic failure, compromising gut epithelial barrier and promoting dysbiosis. The loss of Foxc2 skewed the specialization of lymphatic endothelial subsets, resulting in populations with mixed identities and emergence of lymph node-like endothelial cells.
Editorial Material
Oncology
Werner Held, Sanjiv A. Luther, V. Tatiana Petrova
Summary: Tumor-infiltrated T cells with stem-cell-like properties play a crucial role in determining the response to immunotherapy. The latest research suggests that their entry into tumor tissue relies on specialized tumor-associated endothelial cells that resemble immature and inflamed lymph node vessels. Furthermore, immunotherapy has been found to enhance the recruitment capacity of these endothelial cells.
Article
Immunology
Frank P. Assen, Jun Abe, Miroslav Hons, Robert Hauschild, Shayan Shamipour, Walter A. Kaufmann, Tommaso Costanzo, Gabriel Krens, Markus Brown, Burkhard Ludewig, Simon Hippenmeyer, Carl-Philipp Heisenberg, Wolfgang Weninger, Edouard Hannezo, Sanjiv A. Luther, Jens Stein, Michael Sixt
Summary: Researchers have characterized the biomechanics of lymph node swelling and found that different fibroblast populations mechanically control its expansion in a multitier fashion.
Article
Multidisciplinary Sciences
Jeremiah Bernier-Latmani, Cristina Mauri, Rachel Marcone, Francois Renevey, Stephan Durot, Liqun He, Michael Vanlandewijck, Catherine Maclachlan, Suzel Davanture, Nicola Zamboni, Graham W. Knott, Sanjiv A. Luther, Christer Betsholtz, Mauro Delorenzi, Cathrin Brisken, Tatiana Petrova
Summary: The specialized structure of small intestinal villus tip blood vessels is maintained by ADAMTS18(+) telocytes, which regulate the level and location of VEGFA signaling to ensure the presence of endothelial fenestrae for nutrient absorption, while avoiding excessive leakiness and destabilization of villus tip epithelial structures.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Baijayanti Jha, Marta Reverte, Catherine Ronet, Florence D. Prevel, Florence D. Morgenthaler, Chantal Desponds, Lon-Fye Lye, Katherine L. L. Owens, Leonardo Scarpellino, Lalit Kumar Dubey, Amelie Sabine, Tatiana V. V. Petrova, Sanjiv A. A. Luther, Stephen M. M. Beverley, Nicolas Fasel
Summary: The lymphatic system may serve as an efficient route for infected cells to escape from the primary site and colonize distant organs, especially when infection is associated with inflammation and exacerbated by the presence of viral endosymbiont. This study sheds light on the role of the lymphatic system in facilitating metastasis of infections caused by protozoan parasites.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Anna-Friederike Marx, Sandra M. Kallert, Tobias M. Brunner, Jose A. Villegas, Florian Geier, Jonas Fixemer, Tiago Abreu-Mota, Peter Reuther, Weldy V. Bonilla, Jelizaveta Fadejeva, Mario Kreutzfeldt, Ingrid Wagner, Patricia Aparicio-Domingo, Leo Scarpellino, Melanie Charmoy, Daniel T. Utzschneider, Claudia Hagedorn, Min Lu, Karen Cornille, Karsten Stauffer, Florian Kreppel, Doron Merkler, Dietmar Zehn, Werner Held, Sanjiv A. Luther, Max Loehning, Daniel D. Pinschewer
Summary: This study shows that T cell factor 1 (Tcf-1) expressing CD8+ T cells, known as stem-like CD8+ T cells (CD8+SL), play a crucial role in immune defense against chronic viral infection and cancer. It identifies interleukin-33 (IL-33) as a pivotal factor for the expansion and functioning of CD8+SL and virus control.
Article
Immunology
Jesus Corria-Osorio, Santiago J. J. Carmona, Evangelos Stefanidis, Massimo Andreatta, Yaquelin Ortiz-Miranda, Tania Muller, Ioanna A. A. Rota, Isaac Crespo, Bili Seijo, Wilson Castro, Cristina Jimenez-Luna, Leonardo Scarpellino, Catherine Ronet, Aodrenn Spill, Evripidis Lanitis, Pedro Romero, Sanjiv A. A. Luther, Melita Irving, George Coukos
Summary: Coukos, Corria-Osorio and colleagues have used a genetic engineering approach to improve the effectiveness of CD8(+) T cells in antitumor cell therapy. They engineered these cells to express an IL-2 variant, IL-33 and a programmed cell death protein 1 decoy. The results showed that these engineered cells had enhanced effector functions and were able to overcome exhaustion and control tumors.
Article
Medicine, Research & Experimental
Gaelen K. Dwyer, Lisa R. Mathews, Jose A. Villegas, Anna Lucas, Anne Gonzalez de Peredo, Bruce R. Blazar, Jean-Philippe Girard, Amanda C. Poholek, Sanjiv A. Luther, Warren Shlomchik, Heth R. Turnquist
Summary: In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular patterns (DAMPs) that generate proinflammatory antigen-presenting cells (APCs) secreting IL-12, which drives the response of donor Th1 cells, leading to graft-versus-host disease (GVHD). However, there are other mechanisms through which alloreactive T cell responses are initiated by directly acting on donor CD4(+) T cells. Among these mechanisms, fibroblastic reticular cell-derived DAMP IL-33 plays a critical role by enhancing T cell expansion and differentiation through the activation of T cell signaling pathways in response to alloantigen, resulting in GVHD.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Meeting Abstract
Physiology
Alejandra Gonzalez-Loyola, Esther Bovay, Jaeryung Kim, Tania Wyss Lozano, Amelie Sabine, Francois Renevey, Alexis Rapin, Tomasz P. Wypych, Giorgia Rota, Stephan Durot, Dominique Velin, Benjamin Marsland, Greta Guarda, Mauro Delorenzi, Nicola Zamboni, Sanjiv A. Luther, Tatiana V. Petrova
JOURNAL OF VASCULAR RESEARCH
(2021)
Article
Immunology
Daniela Pais Ferreira, Joana Gomes Silva, Tania Wyss, Silvia A. Fuertes Marraco, Leonardo Scarpellino, Melanie Charmoy, Roeltje Maas, Imran Siddiqui, Li Tang, Johanna A. Joyce, Mauro Delorenzi, Sanjiv A. Luther, Daniel E. Speiser, Werner Held
Meeting Abstract
Medicine, General & Internal
F. Renevey, S. Siegert, C. -Y Yang, J. Bernier-Latmani, N. Harris, T. Petrova, S. A. Luther
SWISS MEDICAL WEEKLY
(2019)
