期刊
JOURNAL OF IMMUNOLOGY
卷 181, 期 6, 页码 3947-3954出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.181.6.3947
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资金
- Intramural Research Program of National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Department of Health and Human Services
- Institut de la Sante et de la Recherche Medicale (INSERM)
- Centre National de la Recherche Scientifique (CNRS)
Although a great deal is known about T cell entry into lymph nodes, much less is understood about how T lymphocytes access the splenic white pulp (WP). We show in this study that, as recently described for lymph nodes, fibroblastic reticular cells (FRCs) form a network in the T cell zone (periarteriolar lymphoid sheath, PALS) of the WP on which T lymphocytes migrate. This network connects the PALS to the marginal zone (MZ), which is the initial site of lymphocyte entry from the blood. T cells do not enter the WP at random locations but instead traffic to that site using the FRC-rich MZ bridging channels (MZBCs). These data reveal that FRCs form a substrate for T cells in the spleen, guiding these lymphocytes from their site of entry in the MZ into the PALS, within which they continue to move on the same network.
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