Review
Immunology
Joshua M. Moreau, Maria Velegraki, Chelsea Bolyard, Michael D. Rosenblum, Zihai Li
Summary: TGF-beta 1 plays a crucial role in the development and function of T-reg, although its pleiotropic and context-dependent activity makes it complicated.
SCIENCE IMMUNOLOGY
(2022)
Article
Microbiology
Haijun Gao, Lele Huo, Xiaojin Mo, Bin Jiang, Yanping Luo, Bin Xu, Jingzhong Li, Xingming Ma, Tao Jing, Zheng Feng, Ting Zhang, Wei Hu
Summary: This study found that Pseudolaric acid B (PAB) has a potent anti-echinococcal effect with lower toxicity compared to albendazole, making it a potential chemotherapeutic agent for alveolar echinococcosis. The suppressive effect of PAB on the parasite may involve down-regulation of the TGF-β1 signaling pathway.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Mi-Gyeong Gwon, Hyun-Jin An, Hyemin Gu, Young-Ah Kim, Sang Mi Han, Kwan-Kyu Park
Summary: Renal fibrosis is a progressive and chronic process that affects patients with chronic kidney disease, leading to irreversible failure of renal function. TGF-beta 1 signaling plays a key role in inducing myofibroblast activation and extracellular matrix production in renal fibrosis. Apamin has been shown to have a beneficial effect in inhibiting renal fibrosis through the modulation of TGF-beta 1 signaling pathways.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Environmental Sciences
Hua Wei, Dong Li, Yueling Luo, Yingchuan Wang, Erbing Lin, Xi Wei
Summary: This study reveals that aluminum accumulation in kidney tissues can lead to kidney function impairment, apoptosis of renal tubular cells, and kidney fibrosis. The activation of the TGF-beta 1/Smads pathway may play a crucial role in these processes. This study provides a new theoretical basis for studying nephrotoxicity induced by excessive aluminum exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, Research & Experimental
Xiaoping Chen, Linzi Long, Ying Cheng, Jianfeng Chu, Zhiqing Shen, Liya Liu, Jiapeng Li, Qiurong Xie, Huixin Liu, Meizhu Wu, Youqin Chen, Jun Peng, Aling Shen
Summary: Our studies suggest that QDG reduces blood pressure and cardiac fibrosis, protects cardiac function, and suppresses TGF-β1/Smad2/3 signaling in vivo and in vitro.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Hongjuan He, Lihua Cao, Zheng Wang, Zhenzhen Wang, Jinxin Miao, Xiu-Min Li, Mingsan Miao
Summary: Sin suppresses epithelial-mesenchymal transition (EMT) by inhibiting IL-4 and downregulating TGF-beta 1 and Smad3 expression, thereby alleviating airway remodeling and inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Sharada Swaminathan, Tatiana Scorza, Alexis Yero, Omar Farnos, Stephanie C. Burke C. Schinkel, Jonathan B. Angel, Mohammad-Ali Jenabian
Summary: During HIV infection, the frequencies of regulatory T cells (Tregs) increase in the peripheral blood and lymphoid tissues, contributing to immune dysfunction and disease progression. However, thymic Tregs (tTregs) show reduced susceptibility to HIV infection compared to other thymocytes. In addition, although TGF-beta 1 treatment can increase Treg differentiation, it does not affect HIV infection rates.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tianxiao Sun, Haihua Li, Yan Zhang, Guixin Xiong, Yuerun Liang, Fang Lu, Rong Zheng, Qi Zou, Jiejie Hao
Summary: In this study, it was found that DGM could inhibit TGF-beta 1-induced EMT in A549 cells and bleomycin-induced pulmonary fibrosis in rats. Furthermore, DGM treatment improved lung function, reduced lung inflammation and fibrosis, and decreased collagen deposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Rongrong Gao, Ang Li, Sen Li, Xiangrong Li, Shuye Zhang, Xiaoyan Zhang, Jianqing Xu
Summary: Induced regulatory T (iTreg) cells play a crucial role in immune tolerance and controlling chronic inflammation. A novel engineering strategy has been developed to generate stably induced regulatory T (SI T-reg) cells that maintain their regulatory properties and possess potent immunosuppressive functions even in unfavorable environments. These findings suggest that SI T-reg cells hold great promise for future clinical applications and provide a rational therapeutic approach for transplant rejection.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Pharmacology & Pharmacy
Jing Sun, Jiaxin Zhu, Lei Chen, Bingjing Duan, Ruyi Wang, Mengyuan Zhang, Jian Xu, Wenyuan Liu, Yunhui Xu, Feng Feng, Wei Qu
Summary: Forsythiaside B has been shown to protect myocardium from ischemia-reperfusion injury and inhibit myocardial fibrosis by suppressing the TGF-beta 1/Smad signaling pathway. It may be a rational therapeutic approach for the treatment of myocardial fibrosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pathology
J. Humberto Trevino-Villarreal, Justin S. Reynolds, P. Kent Langston, Andrew Thompson, James R. Mitchell, Ramon A. Franco
Summary: Idiopathic subglottic stenosis (iSGS) is a progressive fibrotic disease that can be improved by subglottic serial intralesional steroid injections (SILSIs). The study found that SILSI can reduce fibroblast infiltration and promote matrix remodeling, thereby counteracting the fibrotic process involving the TGF-beta1/CCN2/MMP9 axis in iSGS development.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Review
Immunology
Payal Grover, Peeyush N. Goel, Mark I. Greene
Summary: T regulatory cells employ various immunosuppressive mechanisms to limit immune responses, including secretion of cytokines, cell cytolysis, metabolic perturbation, guiding antigen-presenting cell function, etc.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Delun Li, Jian Zhang, Siyu Yuan, Chao Wang, Jiakai Chang, Yan Tong, Ran Liu, Tian Sang, Lili Li, Jijun Li, Qing Ouyang, Xiangmei Chen
Summary: In this study, the therapeutic potential of peptide-based TGF-beta 1 inhibitor P144 in IRI-induced renal fibrosis and the underlying mechanism were analyzed. The results showed that P144 decreased renal fibrosis through the blockade of the TGF-beta 1-Smad3 signaling pathway and the modulation of macrophage polarization, suggesting its potential therapeutic use in IRI-induced renal fibrosis.
CELL PROLIFERATION
(2022)
Article
Gastroenterology & Hepatology
Shiwei Wang, Lingling He, Fan Xiao, Meixin Gao, Herui Wei, Junru Yang, Yang Shu, Fuyang Zhang, Xiaohui Ye, Ping Li, Xiaohua Hao, Xingang Zhou, Hongshan Wei
Summary: GLT25D1 is upregulated in hepatic stellate cells (HSCs) during liver fibrosis and promotes the progression of fibrosis by affecting HSC activation and collagen stability.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Oncology
Daniel F. Cruz, Nilay Mitash, Fangping Mu, Carlos M. Farinha, Agnieszka Swiatecka-Urban
Summary: This study reveals the regulatory network of LMTK2 and its intersection with the TGF-beta 1 signaling pathway, demonstrating the important role of LMTK2 in cellular functions and disease pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Francisca Salas-Perez, Amanda Cuevas-Sierra, Marta Cuervo, Leticia Goni, Fermin I. Milagro, J. Alfredo Martinez, Jose Ignacio Riezu-Boj
Summary: This study aimed to identify DMRs in subjects with obesity that predict the response to a weight-loss dietary intervention and its association with metabolic variables. The study found a DMR within the PON3 gene that is related to PON3 protein levels in serum, and could be used as a potential biomarker to predict the response to weight-loss dietary interventions.
Article
Oncology
Teresa Lozano, Enrique Conde, Celia Martin-Otal, Flor Navarro, Aritz Lasarte-Cia, Rabab Nasrallah, Diego Alignani, Marta Gorraiz, Pablo Sarobe, Juan P. Romero, Amaia Vilas, Rahul Roychoudhuri, Sandra Hervas-Stubbs, Noelia Casares, Juan Jose Lasarte
Summary: Our study reveals that the expression of FOXP3 can be upregulated in CD8(+) T cells through TCR stimulation. The transfer of CD8 T cells into tumor-bearing mice also results in an upregulation of FOXP3 in vivo. Moreover, loss of FOXP3 enhances the functionality of CD8(+) T cells and improves their antitumor responses.
Editorial Material
Gastroenterology & Hepatology
Amaia Lujambio, Pablo Sarobe
JOURNAL OF HEPATOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Enrique Conde, Noelia Casares, Uxua Mancheno, Edurne Elizalde, Enric Vercher, Roberto Capozzi, Eva Santamaria, Juan R. Rodriguez-Madoz, Felipe Prosper, Juan J. Lasarte, Teresa Lozano, Sandra Hervas-Stubbs
Summary: Regulatory T cells with FOXP3 overexpression in the tumor microenvironment (TME) have a metabolic advantage, leading to improved antitumor efficacy of CD8 T cells. These FOXP3overexpressing CD8 T cells exhibit tissue-resident memory-like and effector T cell features, with enriched metabolic pathways such as glycolysis, fatty acid metabolism, and oxidative phosphorylation. They compensate for ATP production loss through aerobic glycolysis and engage in fatty acid oxidation for energy demands. This ability to couple glycolysis and oxidative phosphorylation allows them to sustain proliferation under glucose restriction, enhancing their effectiveness in adoptive T cell therapy (ACT).
Article
Biochemical Research Methods
Elena Erausquin, Fabian Glaser, Juan Fernandez-Recio, Jacinto Lopez-Sagaseta
Summary: This study investigates the impact of a relevant mutation, Q498Y, present in currently circulating SARS-CoV-2 variants on the binding affinity between the spike receptor-binding domain (RBD) and ACE2. The results suggest that the Q498Y substitution increases the binding affinity and leads to stronger host-pathogen interactions.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2022)
Article
Oncology
Celia Martin-Otal, Aritz Lasarte-Cia, Diego Serrano, Noelia Casares, Enrique Conde, Flor Navarro, Ines Sanchez-Moreno, Marta Gorraiz, Patricia Sarrion, Alfonso Calvo, Carlos E. De Andrea, Jose Echeveste, Amaia Vilas, Juan Roberto Rodriguez-Madoz, Jesus San Miguel, Felipe Prosper, Sandra Hervas-Stubbs, Juan Jose Lasarte, Teresa Lozano
Summary: This study demonstrates the feasibility and efficacy of targeting the tumor-specific fibronectin splice variant EDA with CAR-T cells, providing a potential therapeutic option for different types of cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Nutrition & Dietetics
Jose Riezu-Boj, Miguel Barajas, Tania Perez-Sanchez, Maria J. Pajares, Miriam Arana, Fermin Milagro, Raquel Urtasun
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, and modulating the gut microbiota may be a promising therapeutic approach. This study found that the Lactiplantibacillus plantarum strain DSM20174 (L.p. DSM20174) can prevent NAFLD progression, improve metabolic balance, and reduce inflammation.
Article
Immunology
Belen Aparicio, Marta Ruiz, Noelia Casares, Leyre Silva, Josune Egea, Patricia Perez, Guillermo Albericio, Mariano Esteban, Juan Garcia-Arriaza, Juan J. Lasarte, Pablo Sarobe
Summary: Current vaccines based on the original Wuhan sequence induce antibodies that can cross-recognize new variants to different extents. However, breakthrough infections caused by the Omicron variant highlight the need for better immunity. A study compared the immune response induced by a Wuhan-based peptide vaccine with one based on the Omicron sequence, and found that the Wuhan-based peptide vaccine showed strong cross-recognition of Omicron, suggesting its potential for inclusion in future vaccines targeting the Omicron variant.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Noelia Silva-Pilipich, Ester Blanco, Teresa Lozano, Eva Martisova, Ana Igea, Guillermo Herrador-Canete, Maria Cristina Ballesteros-Briones, Marta Gorraiz, Patricia Sarrion, Gualberto Gonzalez-Sapienza, Juan Jose Lasarte, Lucia Vanrell, Cristian Smerdou
Summary: We aimed to improve immune checkpoint blockade therapy for cancer by using nanobodies delivered with a self-amplifying RNA vector. Our study showed that nanobodies against PD-1 and PD-L1 inhibited tumor growth and increased immune response in both human and mouse models. Dimerization of the nanobodies improved their effectiveness, and the delivery route of the SFV vector showed potent antitumor effects.
Article
Biochemistry & Molecular Biology
Laura Perucho, Laura Icardi, Elisabetta Di Simone, Veronica Basso, Alessandra Agresti, Amaia Vilas Zornoza, Teresa Lozano, Felipe Prosper, Juan Jose Lasarte, Anna Mondino
Summary: Sin3A plays a crucial role in regulating the differentiation of Th17 cells and the development of lymphocytes.
Article
Biochemistry & Molecular Biology
Marta Larrayoz, Maria J. Garcia-Barchino, Jon Celay, Amaia Etxebeste, Maddalen Jimenez, Cristina Perez, Raquel Ordonez, Cesar Cobaleda, Cirino Botta, Vicente Fresquet, Sergio Roa, Ibai Goicoechea, Catarina Maia, Miren Lasaga, Marta Chesi, P. Leif Bergsagel, Maria J. Larrayoz, Maria J. Calasanz, Elena Campos-Sanchez, Jorge Martinez-Cano, Carlos Panizo, Paula Rodriguez-Otero, Silvestre Vicent, Giovanna Roncador, Patricia Gonzalez, Satoru Takahashi, Samuel G. Katz, Loren D. Walensky, Shannon M. Ruppert, Elisabeth A. Lasater, Maria Amann, Teresa Lozano, Diana Llopiz, Pablo Sarobe, Juan J. Lasarte, Nuria Planell, David Gomez-Cabrero, Olga Kudryashova, Anna Kurilovich, Maria V. Revuelta, Leandro Cerchietti, Xabier Agirre, Jesus San Miguel, Bruno Paiva, Felipe Prosper, Jose A. Martinez-Climent
Summary: The lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma (MM) has hindered therapeutic discoveries. To overcome this limitation, researchers used genetically engineered mice to develop bone marrow tumors that mimic MM pathogenesis. Integrative analyses of mice and patients revealed a common genetic pathway that accelerates disease progression and immune evasion mechanisms that remodel the bone marrow microenvironment differently.
Article
Nutrition & Dietetics
Francisca Salas-Perez, Tais Silveira Assmann, Omar Ramos-Lopez, J. Alfredo Martinez, Jose Ignacio Riezu-Boj, Fermin I. Milagro
Summary: This study found a link between gut microbiota and DNA methylation patterns in individuals with obesity. Through DNA methylation and bacterial DNA sequencing analysis, they identified BMI-related differentially methylated DNA regions (DMRs) and bacterial genera. The abundance of Ruminococcus was found to be negatively correlated with BMI, and it was associated with a hypermethylated DMR located between the MACROD2/SEL1L2 genes. The mediation test showed that 19% of the effect of Ruminococcus abundance on BMI is mediated by the methylation of the MACROD2/SEL1L2 DMR. These findings suggest that crosstalk between gut microbiota and epigenetic markers may contribute to obesity development.
Article
Immunology
Noelia Casares, Maria Alfaro, Mar Cuadrado-Tejedor, Aritz Lasarte-Cia, Flor Navarro, Isabel Vivas, Maria Espelosin, Paz Cartas-Cejudo, Joaquin Fernandez-Irigoyen, Enrique Santamaria, Ana Garcia-Osta, Juan Jose Lasarte
Summary: This study explores the complex network of interactions between the olfactory, immune, and central nervous systems. It investigates the effects of an immunostimulatory odorant, menthol, on immune response and cognitive capacity in healthy and Alzheimer's Disease Mouse Models. The findings suggest that menthol enhances immune response and improves cognitive capacity, with downregulation of IL-1 beta and IL-6 mRNA in the brain. Long-term exposure to menthol prevents cognitive impairment in the Alzheimer's mouse model and depletion/inhibition of T regulatory cells also improves cognitive capacity. These results highlight the potential of odors and immune modulators as therapeutic agents for CNS-related diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Francisco Javier Cubero, Pablo Sarobe, Gisa Tiegs
Article
Virology
Alejandro J. Nicola Candia, Matias Garcia Fallit, Jorge A. Pena Agudelo, Melanie Perez Kuper, Nazareno Gonzalez, Mariela A. Moreno Ayala, Emilio De Simone, Carla Giampaoli, Noelia Casares, Adriana Seilicovich, Juan Jose Lasarte, Flavia A. Zanetti, Marianela Candolfi
Summary: This study found that Foxp3 has protumoral intrinsic effects in breast cancer cells, and gene therapy-mediated blockade of Foxp3 could be a therapeutic strategy to improve the response of these tumors to standard treatment.