Article
Chemistry, Multidisciplinary
Jiahao Liu, Lina Guo, Ze Mi, Zhenguo Liu, Pengfei Rong, Wenhu Zhou
Summary: A two-step low-dose radiotherapy strategy combined with spherical nucleic acids-based nanomedicine was used to enhance the accumulation and penetration of nanoparticles in tumors. The strategy successfully recruited macrophages into the tumor, which not only served as drug depots but also enhanced extravasation to improve nanoparticle accumulation. Through optimized timing and administration, the delivered nanoparticles promoted a phenotype switch in macrophages, resulting in increased phagocytosis and further enhancing accumulation and penetration. This approach showed significant enhancement of nanoparticles accumulation compared to passive targeting, with efficient deep penetration throughout the tumor tissue.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Immunology
Ricardo Wesley Alberca, Eliane Gomes, Momtchilo Russo
Summary: This study explored the immunomodulatory effect of CpG-ODN on allergic sensitization to OVA with alum, focusing on dendritic cells expressing the MyD88 molecule and the suppressive IL-10 cytokine. CpG-ODN inhibited allergic sensitization and consequent lung allergic inflammation signaling through MyD88 pathway on dendritic cells. IL-10 was found to be dispensable for the inhibition of allergic lung Th2 responses by CpG-ODN.
Article
Immunology
Dongwen Wu, Catherine H. Poholek, Saikat Majumder, Qixing Liu, Shankar K. Revu, Kanishka Mohib, David M. Rothstein, Mandy J. McGeachy
Summary: Prior exposure to pathogen-associated stimuli can reduce morbidity and mortality to new infections through innate immune training, which can be further improved by childhood vaccination. This study demonstrates that inflammatory training of fibroblastic reticular cells (FRC) in the gut enhances immune responses to bacterial pathogens and reduces colon inflammation through IL-10 production by B cells, ultimately improving clearance of infection. These findings suggest a new mode of immune training through FRC that can impact future adaptive responses and better preserve host health.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Belinda S. Hall, Louise Tzung-Harn Hsieh, Sandra Sacre, Rachel E. Simmonds
Summary: Buruli ulcer is a devastating skin disease caused by Mycobacterium ulcerans, with its pathogenesis involving the exotoxin mycolactone that suppresses the immune system and is cytotoxic. Despite immune blockade, evidence suggests that IL-1 beta production is possible, shedding light on potential treatments for the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Avi Maimon, Victor Levi-Yahid, Kerem Ben-Meir, Amit Halpern, Ziv Talmi, Shivam Priya, Gabriel Mizraji, Shani Mistriel-Zerbib, Michael Berger, Michal Baniyash, Sonja Loges, Tal Burstyn-Cohen
Summary: The activation of TAM receptor tyrosine kinases promotes tumor progression through various cellular mechanisms. The study reveals an unexpected antimetastatic role of myeloid-derived PROS1 in suppressing metastatic potential in lung and breast tumor models. The PROS1/MERTK axis within BMDMs is identified as a potent regulator of adaptive immune responses with the potential to suppress metastatic seeding.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Stephen T. Yeung, Luis J. Ovando, Ashley J. Russo, Vijay A. Rathinam, Kamal M. Khanna
Summary: Macrophages play important roles in regulating pathogen clearance and immune homeosta-sis in tissues. The functional diversity of macrophage subsets depends on tissue environment and the nature of the pathological insult. CD169+ macrophage subsets are crucial for protection under excessive inflammatory conditions. They control inflammatory responses via interleukin-10 (IL-10) and may serve as a potential therapeutic target under damaging inflammatory conditions.
Article
Immunology
Izabel Patik, Naresh S. Redhu, Alal Eran, Bin Bao, Anubhab Nandy, Ying Tang, Shorouk El Sayed, Zeli Shen, Jonathan Glickman, James G. Fox, Scott B. Snapper, Bruce H. Horwitz
Summary: Loss of IL-10R function leads to severe early onset colitis and the accumulation of immature inflammatory colonic macrophages. IL-10R inhibits STAT1 signaling in newly recruited colonic macrophages, thereby interfering with the development of an inflammatory phenotype. Additionally, IL-10R inhibits the generation of cell extrinsic signals that promote the accumulation of immature macrophages.
MUCOSAL IMMUNOLOGY
(2022)
Article
Oncology
Nicoletta Nastasi, Amada Pasha, Gennaro Bruno, Angela Subbiani, Laura Pietrovito, Angela Leo, Lucia Scala, Lorena de Simone, Gabriella Casazza, Federica Lunardi, Maria Letizia Taddei, Angela Tamburini, Annalisa Tondo, Claudio Favre, Maura Calvani
Summary: Osteosarcoma is a common malignant bone tumor that mainly affects children and adolescents. Standard treatment includes surgery and chemotherapy, but the effectiveness is limited for metastatic or recurrent cases. This study investigates the efficacy of mifamurtide and identifies interleukin-10 as a possible target to improve its effectiveness. The synergistic use of mifamurtide and an anti-IL-10 antibody significantly increases cell death and reduces metastasis in a mouse model. The findings suggest that combining mifamurtide with an anti-IL-10 antibody may improve outcomes for osteosarcoma patients.
Article
Multidisciplinary Sciences
Jennifer K. Dowling, Remsha Afzal, Linden J. Gearing, Mariana P. Cervantes-Silva, Stephanie Annett, Gavin M. Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J. Gough, Glenn R. Bantug, Fidinny Hamid, Frances K. Nally, Conor P. Duffy, Aoife L. Gorman, Alex M. Liddicoat, Ed C. Lavelle, Christoph Hess, Peter J. Oefner, David K. Finlay, Gavin P. Davey, Tracy Robson, Annie M. Curtis, Paul J. Hertzog, Bryan R. G. Williams, Claire E. McCoy
Summary: The study reveals that Arg2 is a protein in inflammatory macrophages regulated by miR-155 and IL-10, crucial for IL-10-induced modulation of mitochondrial dynamics and oxidative respiration. Arg2 mediates this process by increasing the activity of complex II and is essential for IL-10-mediated downregulation of inflammatory mediators.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Simone Camelliti, Valentino Le Noci, Francesca Bianchi, Chiara Storti, Francesca Arnaboldi, Alessandra Cataldo, Serena Indino, Elena Jachetti, Mariangela Figini, Mario Paolo Colombo, Andrea Balsari, Nicoletta Gagliano, Elda Tagliabue, Lucia Sfondrini, Michele Sommariva
Summary: TLR9-stimulated macrophages interacting with the Fc domain of anti-PD-1 antibody acquire an immunoregulatory phenotype, leading to dampening of CpG-ODN antitumor effect. This may represent another possible mechanism of anti-PD-1 antibody therapy resistance.
Article
Biochemistry & Molecular Biology
Yanpeng Li, Zhilei Li, Kutty Selva Nandakumar, Rikard Holmdahl
Summary: A recent study found that a single nucleotide variant (NCF1(R90H)) on the NCF1 gene was associated with low production of reactive oxygen species (ROS) and causative for several autoimmune diseases. The study induced psoriasis in the skin and psoriatic arthritis using mannan and evaluated the effects. It was found that the NCF1(90H) variant promoted psoriasis and psoriatic arthritis by hyperactivating macrophages, expanding keratinocytes, and increasing numbers of γδT17 cells.
Article
Endocrinology & Metabolism
Narmadha Subramanian, Beatriz Tavira, Kaisa Hofwimmer, Beate Gutsmann, Lucas Massier, Julie Abildgaard, Anders Juul, Mikael Ryden, Peter Arner, Jurga Laurencikiene
Summary: This study found that obesity and type 2 diabetes (T2D) affect the levels of WAT IL-10 in women, but not in men. The difference is likely attributed to obesity itself and not influenced by circulating sex hormones.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Anett Mazlo, Ramona Kovacs, Noemi Miltner, Marta Toth, Zoltan Vereb, Krisztina Szabo, Ildiko Bacskai, Kitti Pazmandi, Agota Apati, Tamas Biro, Krisztian Bene, Eva Rajnavolgyi, Attila Bacsi
Summary: Findings suggest that MSCl cells promote differentiation of CTLA-4 expressing DCs through the production of all-trans retinoic acid, leading to the activation and polarization of allogeneic, naive T cells by semi-matured DCs in a CTLA-4 dependent manner. Understanding the molecular mechanisms behind MSC-mediated modulation of DC differentiation may expand the clinical application of MSCs in cell-free therapies.
Article
Oncology
Ugur cakir, Anna Hajdara, Balazs Szeky, Balazs Mayer, Sarolta Karpati, Eva Mezey, Palma Sillo, Gergely Szakacs, Andras Fueredi, Zoltan Pos, Barbara ersek, Miklos Sardy, Krisztian Nemeth
Summary: Melanoma-associated fibroblasts (MAFs) interact with macrophages, leading to the production of the anti-inflammatory agent IL-10, which promotes melanoma growth and suppresses the immune response. This finding may open up new avenues for the development of anti-melanoma treatments.
Article
Multidisciplinary Sciences
Baihao Zhang, Alexis Vogelzang, Michio Miyajima, Yuki Sugiura, Yibo Wu, Kenji Chamoto, Rei Nakano, Ryusuke Hatae, Rosemary J. Menzies, Kazuhiro Sonomura, Nozomi Hojo, Taisaku Ogawa, Wakana Kobayashi, Yumi Tsutsui, Sachiko Yamamoto, Mikako Maruya, Seiko Narushima, Keiichiro Suzuki, Hiroshi Sugiya, Kosaku Murakami, Motomu Hashimoto, Hideki Ueno, Takashi Kobayashi, Katsuhiro Ito, Tomoko Hirano, Katsuyuki Shiroguchi, Fumihiko Matsuda, Makoto Suematsu, Tasuku Honjo, Sidonia Fagarasan
Summary: This study reveals that small metabolites like GABA derived from B-lineage cells can influence immune responses by promoting anti-inflammatory macrophages and enhancing anti-tumour responses. The findings suggest that targeting these metabolites may offer a new approach to immunoregulation.