Article
Immunology
Davide Cossu, Kazumasa Yokoyama, Shigeto Sato, Sachiko Noda, Tamami Sakanishi, Leonardo Antonio Sechi, Nobutaka Hattori
Summary: Research shows that PINK1 protein plays a crucial role in modulating the immune response during EAE, potentially contributing to the pathogenesis of neuroinflammatory and other associated conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lawrence Steinman, Roberto Patarca, William Haseltine
Summary: Twenty years ago, a tribute was published in this journal to celebrate the 70th anniversary of an animal model known as experimental autoimmune encephalomyelitis (EAE). Recent research has helped explain how Epstein-Barr virus triggers multiple sclerosis through molecular mimicry. These observations bring us back to Rivers' first paper on EAE, published 90 years ago, and show the continued importance of this animal model in understanding disease mechanisms.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Luisa F. Duarte, Maria J. Altamirano-Lagos, Jorge H. Tabares-Guevara, Ma Cecilia Opazo, Maximo Diaz, Romina Navarrete, Catalina Muza, Omar P. Vallejos, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis, Pablo A. Gonzalez
Summary: The study evaluated the impact of HSV-1 infection on EAE and found that prior exposure to HSV-1 may accelerate and enhance EAE, suggesting a potential contribution of asymptomatic HSV-1 to the onset and severity of MS.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Angela A. Wang, Jennifer L. Gommerman, Olga L. Rojas
Summary: B cells play a critical role in the adaptive immune system by differentiating into plasmablasts and plasma cells to produce antibodies. Plasmablasts/plasma cells can survive for years in the bone marrow and intestine, producing cytokines and acting as regulatory cells.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takuma Hayashi, Motoki Ichikawa, Ikuo Konishi
Summary: NOD/ShiLtJ mice are used as an animal model for type 1 diabetes. Decreased expression of nuclear factor-kappa B1 (NF-kappa B1) may be involved in the development of type 1 diabetes. Genetically modified NOD Nf kappa b1 homozygote mice were found to develop severe myocarditis, while NOD Nf kappa b1 heterozygote mice developed early insulitis. Vaccination could induce myocarditis in genetically modified mice.
Article
Immunology
Guan Yang, Wenqiang Song, Jielin Xu, J. Luke Postoak, Feixiong Cheng, Jennifer Martinez, Jianhua Zhang, Lan Wu, Luc Van Kaer
Summary: The PIK3C3/VPS34 subunit of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex plays a critical role in macrophage functions and regulation of EAE. Deficiency in PIK3C3 results in phenotypic changes in myeloid cells and reduces severity of EAE in mice, highlighting the potential therapeutic implications of PIK3C3 inhibition for MS and other autoimmune diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Clinical Neurology
Anusha Yeshokumar, Eliza Gordon-Lipkin, Ana Arenivas, Mark Rosenfeld, Kristina Patterson, Raia Blum, Brenda Banwell, Arun Venkatesan, Eric Lancaster, Jessica Panzer, John Probasco
Summary: Anti-NMDA receptor encephalitis is associated with long-term adaptive behavior, and younger age at onset is correlated with poorer adaptive behavior. These findings highlight the distinct consequences that the disease may have on the early developing brain.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Multidisciplinary Sciences
Jian Li, Lisen Lu, Kyle Binder, Jian Xiong, Lilin Ye, Yan H. Cheng, Sonia Majri-Morrison, Wei Lu, Jae W. Lee, Zhihong Zhang, Yu-zhang Wu, Lixin Zheng, Michael J. Lenardo
Summary: This study found that an injectable myelin-based antigen can effectively suppress autoimmune demyelinating diseases of the central nervous system without major side effects. The mechanism of action involves the uptake of the antigen by perivascular F4/80+ cells and the induction of apoptosis in encephalitogenic T cells, leading to reduced inflammation.
Article
Multidisciplinary Sciences
Katharina Robichon, Sven Sondhauss, T. William Jordan, Robert A. Keyzers, Bronwen Connor, Anne C. La Flamme
Summary: This study investigated the tissue distribution and localization of clozapine in the brain using mass spectrometry techniques and found that clozapine was enriched in specific brain regions and significantly elevated in serum during EAE. Additionally, changes in dopamine receptor expression on brain-resident and infiltrating immune cells during EAE were observed, providing insights into how neuroinflammation alters the distribution and downstream effects of clozapine.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Soo Hyun Lee, Gakyung Lee, Ji-Eun Seo, Mahbub Hasan, Oh-Seung Kwon, Byung Hwa Jung
Summary: The study examined the influence of age on autoimmunity in EAE, revealing that changes in unsaturated fatty acid and tryptophan metabolism are risk factors for EAE development, while alterations in tyrosine and sphingolipid metabolism are more pronounced. Regardless of age, these metabolic changes impact the incidence and severity of EAE.
MOLECULAR IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Michelle Zuo, Naomi M. Fettig, Louis-Philippe Bernier, Elisabeth Possnecker, Shoshana Spring, Annie Pu, Xianjie Ma, Dennis Sw Lee, Lesley A. Ward, Anshu Sharma, Jens Kuhle, John G. Sled, Anne-Katrin Probstel, Brian A. MacVicar, Lisa C. Osborne, Jennifer L. Gommerman, Valeria Ramaglia
Summary: The progression and pathology of multiple sclerosis (MS) in patients are associated with age and other immune cells, such as neutrophils, in addition to the inflammation caused by autoreactive T cells.
Article
Immunology
Byunghyun Park, Yu Sun Jeong, Wonseok Hu, Mingyu Lee, Ji Cheol Kim, Geon Ho Bae, Yong-Soo Bae, Yoe-Sik Bae
Summary: Multiple sclerosis (MS) is a disease that damages the brain and spinal cord, leading to paralysis. Recent research has shown that B cells play a significant role in the pathogenesis of MS, as autoantibodies from B cells are closely related to central nervous system damage and prognosis. Regulating the activity of antibody secreting cells may be linked to the severity of MS symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shishi Shen, Xi Cheng, Luyao Zhou, Yipeng Zhao, Hai Wang, Jie Zhang, Xiaobo Sun, Yuge Wang, Yaqing Shu, Yanteng Xu, Yu Tao, Mingqiang Li, Zhengqi Lu, Wei Cai, Guangjun Nie, Wei Qiu
Summary: This study developed neutrophil-derived nanovesicles (NNVs) to enhance the efficiency of myelin debris clearance in microglia for multiple sclerosis (MS) therapy. The results showed that NNVs treatment ameliorated lesional neuroinflammation and improved neurological functions and white matter integrity in a mouse model of MS. Additionally, NNVs treatment upregulated the expression of NRF2 in microglia and activated the transcription of RUBCN, leading to enhanced phagocytosis of myelin debris.
Article
Immunology
Ping Li, Zengli Guo, Yisong Y. Wan
Summary: Research has shown that SKI expression plays a critical role in the differentiation of pathogenic Th17 cells, and controlling SKI expression can modulate the function of these cells and treat Th17-related diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Wenlin Hao, Qinghua Luo, Michael D. Menger, Klaus Fassbender, Yang Liu
Summary: Anti-CD52 therapy demonstrates neuroprotective effects in EAE mice by reducing T lymphocyte counts, preventing myelin loss, and protecting neurons. Neuronal BDNF regulates the neuroprotective and anti-inflammatory effects of CD52 antibody in EAE mice.
FRONTIERS IN IMMUNOLOGY
(2021)