Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mei-Lan Tsai, Ming-Kai Tsai, Yi-Giien Tsai, Yu-Chih Lin, Ya-Ling Hsu, Yi-Ting Chen, Yi-Ching Lin, Chih-Hsing Hung
Summary: This study investigated the effects of LTRAs on the expression of epithelium-derived cytokines in human airway epithelial cells and explored the underlying intracellular processes, including epigenetic regulation. It was found that LTRAs might induce the production of IL-25, IL-33, and TSLP by activating the MAPK and NF-kappa B pathways and regulating histone H3 acetylation and H3K36 and H3K79 trimethylation, exacerbating inflammation and asthma symptoms. Therefore, LTRA monotherapy may not be an appropriate therapeutic option for asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
J. Zhang, L. Sun, M. H. H. Withanage, S. M. Ganesan, M. A. Williamson, J. T. Marchesan, Y. Jiao, F. R. Teles, N. Yu, Y. Liu, D. Wu, K. L. Moss, A. K. Mangalam, E. Zeng, Y. L. Lei, S. Zhang
Summary: This study identified a risk locus TRAF3IP2 associated with periodontitis and investigated its underlying mechanism in the development of periodontitis. The results showed that TRAF3IP2 plays a significant role in the production of chemokines mediated by IL-17 and in host defense against periodontal pathogens.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Food Science & Technology
Wannaporn Chayalak, Chatsri Deachapunya, Sunit Suksamran, Sutthasinee Poonyachoti
Summary: The study showed that Hydroxyxanthones have a protective effect on preventing inflammation-induced TJ barrier disruption, making them a potential candidate for treating diseases related to leaky gut.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Sara C. Credendino, Marta De Menna, Irene Cantone, Carmen Moccia, Matteo Esposito, Luigi Di Guida, Mario De Felice, Gabriella De Vita
Summary: FOXE1, a lineage-restricted transcription factor, is involved in thyroid cancer susceptibility by regulating gene expression, affecting cancer development processes such as cell migration and immune cell recruitment. The expression of FOXE1 induces changes in specific chemokines, thus influencing macrophage infiltration in the thyroid cancer microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Timothy S. Kountz, Amit Jairaman, Candace D. Kountz, Kenneth A. Stauderman, Robert P. Schleimer, Murali Prakriya
Summary: The study found that human AECs require CRAC channels for the production of both PGE(2) and IL-6 in response to extracellular ATP stimulation. The synthesis of PGE(2) involves activation of P2Y2 receptors and cytosolic phospholipase A(2) signaling mediated by CRAC channels, while the synthesis of IL-6 occurs through activation of P2X receptors and calcineurin/NFAT signaling mediated by CRAC channels. It highlights P2Y2 receptors, CRAC channels, and P2X receptors as potential targets for intervention in airway diseases.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jonathan Yde, Stephen J. Keely, Hanne B. Moeller
Summary: AQP3 is a water, glycerol and H2O2 transporting channel expressed in colonic epithelia. Although altered in several intestinal disorders, the regulation and specific roles of AQP3 remain to be fully defined. This mini-review summarizes the current understanding of AQP3 protein in colonic epithelia concerning intestinal absorption, secretion and barrier function.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Article
Multidisciplinary Sciences
Dongke Xu, Ruijun Ma, Yi Ju, Xiaowei Song, Baolin Niu, Wenting Hong, Rong Wang, Qin Yang, Zhi Zhao, Yuchen Zhang, Yufan Zheng, Qianming Bai, Mingfang Lv, Ning Sun, Xiaobo Li
Summary: Cholesterol sulfate exhibits therapeutic efficacy against ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells, thereby contributing to the healing of the mucosal barrier.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Mohd Fazil, Tokeer Ahmad
Summary: Pristine and Sr-doped TiO2 nanoparticles were synthesized through an eco-friendly hydrothermal route for water-splitting applications. The crystallinity, purity, structure, size, morphology, surface area, and optoelectronic properties of the synthesized materials were analyzed. The 1% Sr-doped TiO2 nanoparticles showed activity as photocatalysts, with higher hydrogen production. Furthermore, electrocatalysis studies revealed that 1% and 5% Sr-doped TiO2 exhibited the highest current density for both HER and OER.
Article
Multidisciplinary Sciences
Andrew Thorne, Akanksha Bansal, Amandah Necker-Brown, Mahmoud Mostafa, Alex Gao, Andrei Georgescu, Cora Kooi, Richard Leigh, Robert Newton
Summary: BIRC2 and BIRC3 genes play important roles in the inflammatory signaling pathway and cell death protection, with BIRC3 exhibiting a more prominent role in cell death. BIRC2 is involved in rapid signal transduction events, while BIRC3 is more important for later effects. Glucocorticoids have a modest effect on BIRC3 expression, but little effect on BIRC2 expression.
Article
Multidisciplinary Sciences
Anissa Fries, Fanny Saidoune, Francois Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Summary: This study establishes the role of interleukin 26 (IL-26) in the generation of IL-17A producing Th17 CD4(+) T cells, indicating its involvement in the pathogenic response of psoriasis. IL-26-producing cells infiltrate psoriatic skin and promote their own differentiation into IL17A-producing T(H)17 cells through epithelial crosstalk involving paracrine production of TGF-& beta;1.
NATURE COMMUNICATIONS
(2023)
Article
Agriculture, Multidisciplinary
Jinfan Liu, Lu Fu, Fei Yin, Li Yin, Xiaomei Song, Hong Guo, Jianhui Liu
Summary: Crohn's disease (CD) is a chronic inflammatory bowel disease caused by dysfunction in the barrier function formed by polarized monolayer of epithelial cells. Diosmetin has been found to increase cell viability, maintain barrier integrity, and decrease the protein content of ABCG2 in Caco-2 cells and CD mice. Mechanistically, diosmetin attenuates the phosphorylation of AMPK, PI3K/AKT, and CREB, while AMPK inhibitor prevents the effect of diosmetin on tight junction proteins. These findings suggest that diosmetin improves barrier dysfunction in CD through the AMPK/AKT/CREB-mediated expression of ABCG2.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Surgery
Ravi Dhital, Shashi Anand, Brianna Graber, Qiang Zeng, Victoria M. Velazquez, Srinivasa R. Boddeda, James R. Fitch, Ranjana W. Minz, Mukut Minz, Ashish Sharma, Rachel Cianciolo, Masako Shimamura
Summary: Human cytomegalovirus (HCMV) infection is associated with renal allograft failure. CMV promotes allograft damage via cytokine-mediated Th1/17 cell recruitment. Pharmacologic inhibition of the Th17 cell signature cytokine, IL-17A, ameliorates CMV-associated allograft damage.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Cell Biology
Barbara Polese, Bavanitha Thurairajah, Hualin Zhang, Cindy Leung Soo, Clara A. McMahon, Ghislaine Fontes, Sabah N. A. Hussain, Valerie Abadie, Irah L. King
Summary: The study investigated the effects of PGE2 on γδ T cells and found that PGE2 can enhance cytokine production by γδ T cells, with varying effects in different tissues. While it is dispensable for cutaneous γδ T cell activation, it plays a crucial role in intestinal γδ T cell responses and disease severity in experimental colitis.
Article
Oncology
Ru Li, Mousumi Beto Mukherjee, Jun Lin
Summary: In this review, the effects of cytokines and chemokines on myeloid-derived suppressor cells in cancer metastasis are summarized. Cytokines and chemokines in the tumor microenvironment alter the functional properties of MDSCs and are involved in their production, infiltration, and immunosuppressive functions. The manipulation of MDSCs by tumors through cytokine and chemokine signaling is discussed, as well as potential treatment strategies targeting these signaling pathways to combat the immunosuppressive activities of MDSCs and improve disease outcomes.
Article
Immunology
Bao Ying Chen, Jessica R. Salas, Alyssa O. Trias, Arely Perez Rodriguez, Jonathan E. Tsang, Miriam Guemes, Thuc M. Le, Zoran Galic, H. Michael Shepard, Lawrence Steinman, David A. Nathanson, Johannes Czernin, Owen N. Witte, Caius G. Radu, Kenneth A. Schultz, Peter M. Clark
Summary: Research on multiple sclerosis and autoimmune diseases has found that targeting deoxycytidine kinase (dCK) can limit the progression of symptoms, and dCK activity is essential for activation-induced proliferation in specific lymphocytes.
Article
Medicine, General & Internal
Lawrence Steinman, Edward Fox, Hans-Peter Hartung, Enrique Alvarez, Peiqing Qian, Sibyl Wray, Derrick Robertson, DeRen Huang, Krzysztof Selmaj, Daniel Wynn, Gary Cutter, Koby Mok, Yanzhi Hsu, Yihuan Xu, Michael S. Weiss, Jenna A. Bosco, Sean A. Power, Lily Lee, Hari P. Miskin, Bruce A. C. Cree
Summary: Ublituximab shows promise as a treatment for relapsing multiple sclerosis, reducing relapse rates and brain lesions compared to teriflunomide over a 96-week period. However, it does not significantly decrease the risk of disability worsening.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Clinical Neurology
Carolyn Goldschmidt, Steven L. Galetta, Robert P. Lisak, Laura J. Balcer, Andrew Hellman, Michael K. Racke, Amy E. Lovett-Racke, Roberto Cruz, Matthew S. Parsons, Neda Sattarnezhad, Lawrence Steinman, Scott S. Zamvil, Elliot M. Frohman, Teresa C. Frohman
Summary: A woman was diagnosed with relapsing-remitting multiple sclerosis (MS) as a teenager and later developed neuromyelitis optica spectrum disorder in her sixties. This case highlights the importance of reconsidering the working diagnosis when faced with evidence of a distinctly different disorder.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Review
Immunology
Lawrence Steinman, Roberto Patarca, William Haseltine
Summary: Twenty years ago, a tribute was published in this journal to celebrate the 70th anniversary of an animal model known as experimental autoimmune encephalomyelitis (EAE). Recent research has helped explain how Epstein-Barr virus triggers multiple sclerosis through molecular mimicry. These observations bring us back to Rivers' first paper on EAE, published 90 years ago, and show the continued importance of this animal model in understanding disease mechanisms.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Sharon A. Sagan, Zahra Moinfar, Carson E. Moseley, Ravi Dandekar, Collin M. Spencer, Alan S. Verkman, Ole Petter Ottersen, Raymond A. Sobel, John Sidney, Alessandro Sette, Mark S. Anderson, Lawrence Steinman, Michael R. Wilson, Joseph J. Sabatino, Scott S. Zamvil
Summary: This study investigates the role of AQP4-specific Th17 cells in the pathogenesis of neuromyelitis optica (NMO). The research shows that AQP4-specific T cells have a high affinity for binding to MHC II, and their clonal expansion is observed in AQP4-deficient mice. Thymic negative selection alone does not account for the tolerance to AQP4 in wild-type (WT) mice. AQP4-specific Th17 cells can cause paralysis followed by recovery, associated with apoptosis of donor T cells. However, these cells can persist and cause persistent paralysis in mice deficient in both T and B cells or lacking T cells only. In contrast, MOG-specific T cells survive and cause sustained disease in WT mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Aude Chiot, Shanu F. Roemer, Lisa Ryner, Alina Bogachuk, Katie Emberley, Dillon Brownell, Gisselle A. Jimenez, Michael Leviten, Randall Woltjer, Dennis W. Dickson, Lawrence Steinman, Bahareh Ajami
Summary: This study found that alpha 5 integrin is prominently expressed in motor pathways and perivascular zones associated with the blood-brain barrier in ALS patients and mouse models. Treatment with an antibody against alpha 5 integrin improved survival and motor function in the mouse model.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Tobias Lanz, William H. Robinson, Peggy P. Ho, Lawrence Steinman
Summary: We propose studying the molecular mechanisms underlying the clonal antibody response in cerebrospinal fluid and exploring therapeutic approaches to block EBV-triggered multiple sclerosis. These include antiviral clinical trials, development of nucleic acid-based vaccines, cellular adoptive therapy, and vaccines to EBV. These topics are not exhaustive, but our medical science community has the tools to tackle EBV-triggered MS and potentially eradicate the disease, as we have done with poliomyelitis.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2023)
Meeting Abstract
Clinical Neurology
K. W. Selmaj, L. Steinman, G. Comi, A. Bar-Or, H. P. Hartung, X. Montalban, E. K. Havrdova, J. K. Sheffield, A. Thorpe, J. V. Riolo, A. Krakovich, C. Y. Cheng, L. Kappos, J. A. Cohen, B. A. C. Cree
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Meeting Abstract
Clinical Neurology
Enrique Alvarez, Lawrence Steinman, Hans-Peter Hartung, Edward Fox, Peiqing Qian, Sibyl Wray, Derrick Robertson, Koby Mok, Christopher A. Garner, Bruce Cree
Meeting Abstract
Clinical Neurology
Lawrence Steinman, Edward Fox, Hans-Peter Hartung, Enrique Alvarez, Peiqing Qian, Sibyl Wray, Derrick Robertson, Deren Huang, Krzysztof Selmaj, Daniel Wynn, Jenna Bosco, Koby Mok, Christopher A. Garner, Bruce Cree
Meeting Abstract
Clinical Neurology
K. W. Selmaj, J. A. Cohen, L. Steinman, G. Comi, A. Bar-Or, H. Hartung, X. Montalban, L. Kappos, J. K. Sheffield, A. Krakovich, C. Cheng, J. Riolo, D. Silva, B. A. Cree
MULTIPLE SCLEROSIS JOURNAL
(2023)
Meeting Abstract
Clinical Neurology
B. A. Cree, K. Selmaj, L. Steinman, G. Comi, A. Bar-Or, D. L. Arnold, H. Hartung, X. Montalban, E. K. Havrdova, J. K. Sheffield, C. Cheng, J. V. Riolo, D. Silva, L. Kappos, J. A. Cohen
MULTIPLE SCLEROSIS JOURNAL
(2023)
Meeting Abstract
Clinical Neurology
T. V. Lanz, R. C. Brewer, P. P. Ho, L. Steinman, W. H. Robinson
MULTIPLE SCLEROSIS JOURNAL
(2023)
Meeting Abstract
Clinical Neurology
D. L. Arnold, L. Freeman, H. -P. Hartung, X. Xavier Montalban, J. A. Cohen, A. Bar-Or, L. Steinman, J. DeLuca, C. -Y. Cheng, J. V. Riolo, D. Silva, C. Pachai, B. A. C. Cree
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
B. A. Cree, K. W. Selmaj, L. Steinman, G. Comi, A. Bar-Or, D. L. Arnold, H. -P. Hartung, X. Montalban, K. Havrdova, H. Desai, J. K. Sheffield, N. Minton, C. -Y. Cheng, D. Silva, L. Kappos, J. A. Cohen
MULTIPLE SCLEROSIS JOURNAL
(2022)