期刊
JOURNAL OF IMMUNOLOGICAL METHODS
卷 407, 期 -, 页码 127-134出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jim.2014.04.008
关键词
ELT humanized mice; C57BL/6 Rag2(-/-)gamma(-/-)(c)CD47(-/-); Hematopoiesis
资金
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, USA
C57BL/6 Rag2(-/-)gamma(-/-)(c)CD47(-/-) triple-knockout mice engrafted with fetal human bone marrow, liver, thymus (TKO-BLT) not only develop high levels of multi-lineage hematopoiesis but also organized lymphoid tissues including mesenteric lymph nodes, splenic follicles and gut-associated lymphoid tissues of human origin. A unique advantage of these mice is that they sustain human cell and tissue engraftment long-term without the development of graft versus host disease. Thus they can be used for long-term studies not previously feasible with other models. The production of TKO-BLT mice to obtain healthy mice with high level reconstitution of human cells and tissues requires specialized methods that are presented in detail. Published by Elsevier B.V.
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