Article
Biochemistry & Molecular Biology
Puja Upadhaya, Felipe F. Lamenza, Suvekshya Shrestha, Peyton Roth, Sushmitha Jagadeesha, Hasan Pracha, Natalie A. Horn, Steve Oghumu
Summary: Berries and their active constituents have potential therapeutic effects in mitigating contact hypersensitivity (CHS). This study demonstrated that black raspberry extract (BRB-E) and certain natural compounds found in berries can inhibit the activation of dendritic cells (DCs) and reduce the production of proinflammatory cytokines, suggesting potential novel approaches for alleviating CHS.
Article
Immunology
Anna Strzepa, Cody J. Gurski, Landon J. Dittel, Marian Szczepanik, Kirkwood A. Pritchard, Bonnie N. Dittel
Summary: The study found that MPO plays a dual role in the pathogenesis of CHS. During the induction phase, MPO promotes IL-1 beta production in the skin, affecting migratory DC and effector T cells. In the elicitation phase, inhibiting MPO significantly reduces ear swelling and vascular permeability, indicating that MPO could potentially be a therapeutic target for ACD treatment in humans.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Chen-Yun Yeh, Sheng-Han Su, Yeh Fong Tan, Tsen-Fang Tsai, Pi -Hui Liang, Musin Kelel, Hao-Jui Weng, Yu -Ping Hsiao, Chun-Hao Lu, Ching -Hui Tsai, Chih-Hung Lee, Bjoern E. Clausen, Fu -Tong Liu, Yungling Leo Lee
Summary: Psoriasis is an inflammatory autoimmune dermatosis mediated by IL-23/IL-17, and UVB may suppress immunity and improve symptoms. One mechanism of UVB therapy involves the production of cis-urocanic acid (cis-UCA) by keratinocytes. This study found that FLG expression and serum cis-UCA levels were lower in psoriasis patients compared to healthy controls. It was also observed that cis-UCA inhibited psoriasiform inflammation by reducing Vg4+ gdT17 cells in mouse skin and lymph nodes. Additionally, cis-UCA induced PD-L1 expression on Langerhans cells, leading to suppressed proliferation and migration of gdT-cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Allergy
Shuhei Kobayashi, Hai The Phung, Yoshiteru Kagawa, Hirofumi Miyazaki, Yu Takahashi, Atsuko Asao, Takashi Maruyama, Akihiko Yoshimura, Naoto Ishii, Yuji Owada
Summary: The study reveals that FABP3 functions as a negative regulator of skin inflammation by limiting the generation of pathogenic V gamma 4(+) gamma/delta T cells in the thymus.
Article
Immunology
Dorcas O. Owusu, Ernest Adankwah, Wilfred Aniagyei, Isaac Acheampong, Difery Minadzi, Augustine Yeboah, Joseph F. Arthur, Millicent Lamptey, Monika M. Vivekanandan, Mohammed K. Abass, Francis Kumbel, Francis Osei-Yeboah, Amidu Gawusu, Linda Batsa Debrah, Alexander Debrah, Ertan Mayatepek, Julia Seyfarth, Richard O. Phillips, Marc Jacobsen
Summary: In Nigeria, BCG vaccination leads to immune conversion and changes in the phenotype of tuberculosis-specific T cells. A study comparing BCG-vaccinated and non-vaccinated infants showed that BCG vaccination causes delayed immune conversion and differences in cell phenotype among tuberculosis patients.
Article
Biochemistry & Molecular Biology
Ruirui Wang, Chen Ni, Xiaohan Lou, Lijing Zhang, Linlin Wang, Xiaohan Yao, Xixi Duan, Jiajia Wan, Pan Li, Zhihai Qin
Summary: This study found that treatment with cisplatin often caused IFN gamma-dependent tumor vascular damage. The researchers developed nanoparticles that targeted the leakage site of damaged tumor blood vessels and blocked IFN gamma activity, promoting blood vessel integrity and drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Food Science & Technology
Eui Jeong Han, Hyun-Soo Kim, Kyungsook Jung, Kalu Kapuge Asanka Sanjeewa, Kalahe Hewage Iresha Nadeeka Madushani Herath, WonWoo Lee, Youngheun Jee, You-Jin Jeon, Jeongjun Lee, Taehee Kim, Ilekuttige Priyan Shanura Fernando, Ginnae Ahn
Summary: The study demonstrated that Sargassum horneri 70% ethanol extracts (SHE) has significant anti-inflammatory effects in both TNF-alpha/IFN-gamma-induced inflammation in HaCaT keratinocytes and TPA-induced ear edema in mice. Further research could potentially develop SHE as a food supplement/nutricosmetic to enhance protective effects against inflammatory skin diseases.
Article
Chemistry, Medicinal
Atsushi Tsuge, Atsuki Watanabe, Yuki Kodama, Shinsuke Hisaka, Mitsuhiko Nose
Summary: The study suggests that Orengedokuto (OGT) exerts anti-allergic effects by regulating the activation of effector T cells involved in inflammatory skin diseases such as atopic dermatitis, rather than inducing or activating regulatory T cells.
JOURNAL OF NATURAL MEDICINES
(2022)
Article
Cell Biology
Harold F. Dvorak
Summary: VEGF has the dual function of promoting angiogenesis and increasing vascular permeability, which contributes to the formation of vascular connective tissue stroma in wound healing, solid tumors, and chronic inflammatory diseases. This complex pathophysiological process initiated by VEGF plays a crucial role in tissue repair and disease progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Charles K. Crawford, Veronica Lopez Cervantes, Mary L. Quilici, Anibal G. Armien, Maria Questa, Muhammad S. Matloob, Leon D. Huynh, Aeelin Beltran, Sophie J. Karchemskiy, Katti R. Crakes, Amir Kol
Summary: This study investigates the direct effects of three inflammatory cytokines (TNF alpha, IFN gamma, and IL-18) on the bovine intestinal barrier. The results show that TNF alpha and IFN gamma treatment lead to intestinal epithelial barrier dysfunction and alterations in tight junction morphology and cellular turnover.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Joseph Rabin, Yunge R. Zhao, Ezzat J. Mostafa, Manal Al-Suqi, Emily L. Fleischmann, Mark R. Conaway, Barbara J. Mann, Preeti L. Chhabra, Kenneth L. Brayman, Alexander Krupnick, Joel Linden, Christine L. Lau
Summary: Intravenous infusion of RA in COVID-19 patients is safe and reduces inflammation, improves oxygen saturation, and decreases D-dimer levels. In addition, studies in mice show that RA increases survival rate in SARS-CoV-2-infected mice.
Review
Cell Biology
Victoria Kaupp, Kinga G. Blecharz-Lang, Christina Dilling, Patrick Meybohm, Malgorzata Burek
Summary: This article discusses the defects in the endothelial cell barrier and its association with various central nervous system disorders and systemic diseases. The importance of the blood-brain barrier is highlighted, along with recent discoveries related to the regulation of cellular processes in brain microvascular endothelial cells.
NEURAL REGENERATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Joanne Ellis, Daniel J. B. Marks, Naren Srinivasan, Christine Barrett, Thomas G. Hopkins, Anna Richards, Rainard Fuhr, Muna Albayaty, Martin Coenen, Lia Liefaard, Karen Leavens, Katherine L. Nevin, Shuo Tang, Stephen A. Hughes, Lea Fortunato, Ken Edwards, Yi Cui, Rabia Anselm, Christopher J. Delves, Emilie Charles, Maria Feeney, Thomas M. Webb, Sara J. Brett, Tim S. Schmidt, John Stone, Caroline O. S. Savage, Nicolas Wisniacki, Ruth M. Tarzi
Summary: GSK2831781, a novel afucosylated humanized IgG1 monoclonal antibody that depletes LAG-3 expressing cells, showed promising pharmacological activity in a phase I/Ib clinical study for psoriasis. The treatment led to significant reduction in LAG-3(+) and CD3(+) T-cell counts in psoriasis plaques, along with modulation of proinflammatory and epithelial barrier integrity genes. Psoriasis disease activity improved with GSK2831781, supporting further investigation in T-cell-mediated inflammatory diseases.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Immunology
Takahiro Nagatake, Shigenobu Kishino, Emiko Urano, Haruka Murakami, Nahoko Kitamura, Kana Konishi, Harumi Ohno, Prabha Tiwari, Sakiko Morimoto, Eri Node, Jun Adachi, Yuichi Abe, Junko Isoyama, Kento Sawane, Tetsuya Honda, Asuka Inoue, Akiharu Uwamizu, Takashi Matsuzaka, Yoichi Miyamoto, So-ichiro Hirata, Azusa Saika, Yuki Shibata, Koji Hosomi, Ayu Matsunaga, Hitoshi Shimano, Makoto Arita, Junken Aoki, Masahiro Oka, Akira Matsutani, Takeshi Tomonaga, Kenji Kabashima, Motohiko Miyachi, Yasuhiro Yasutomi, Jun Ogawa, Jun Kunisawa
Summary: Microbiota plays an essential role in utilizing dietary lipids for controlling inflammatory diseases. A novel postbiotic, alpha KetoA, derived from alpha-linolenic acid, exerts anti-inflammatory effects and improves glucose intolerance through immune modulation.
MUCOSAL IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Takeru Amiya, Nobuhiro Nakamoto, Junichiro Irie, Nobuhito Taniki, Po-Sung Chu, Yuzo Koda, Kentaro Miyamoto, Akihiro Yamaguchi, Shunsuke Shiba, Rei Morikawa, Hiroshi Itoh, Takanori Kanai
Summary: The study revealed that CCR9 plays a key role in the inflammation of the small intestine, contributing to the pathogenesis of type 2 diabetes.
Article
Allergy
Marek Jutel, Maria J. Torres, Oscar Palomares, Cezmi A. Akdis, Thomas Eiwegger, Eva Untersmayr, Domingo Barber, Magdalena Zemelka-Wiacek, Anna Kosowska, Elizabeth Palmer, Stefan Vieths, Vera Mahler, Walter G. Canonica, Kari Nadeau, Mohamed H. Shamji, Ioana Agache
Summary: Immune modulation is a crucial treatment approach for allergic diseases, asthma, and autoimmunity. The COVID-19 vaccine has the potential to combat the global pandemic, but its administration needs to be considered in conjunction with allergen immunotherapy and biologicals.
Article
Medicine, General & Internal
Agata Sebastian, Marta Madej, Maciej Sebastian, Anna Luczak, Pawel Gajdanowicz, Magdalena Zemelka-Wiacek, Piotr Wiland
Summary: The upregulation of IFN pathways and their stimulated genes is associated with primary Sjogren's syndrome (pSS). The study found that patients with positive IFN gamma were younger and had higher levels of RF and ESSDAI compared to patients without IFN gamma.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Karolina Pieniawska-Smiech, Aleksandra Lewandowicz-Uszynska, Magdalena Zemelka-Wiacek, Marek Jutel
Summary: The study suggests that serum sIgE and total IgE may serve as diagnostic tools for patients with primary immunodeficiency (PID). However, assessing total IgE is not useful for patients receiving immunoglobulin replacement therapy.
Article
Allergy
Magdalena Zemelka-Wiacek, Anna Kosowska, Ewa Winiarska, Ewa Sobanska, Marek Jutel
Summary: This study aimed to demonstrate the reproducibility of defined clinical endpoints after AEC house dust mite (HDM) challenge under optimal conditions. The results showed that in a constant environment, the concentration of HDM remained stable within the targeted values, and the severity of symptoms and other endpoints were reproducible. A concentration of 5000 particles/m³ and a challenge duration of 120 minutes were found to be optimal.
Review
Allergy
Ioana Agache, Magdalena Zemelka-Wiacek, Mohamed H. Shamji, Marek Jutel
Summary: This article provides a summary of the significant advances in immunotherapy, including new approaches, clinical trials, and real-world evidence, further confirming the importance of immunotherapy in the treatment of allergic diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Magdalena Zemelka-Wiacek, Monika Majewska-Szczepanik, Pawel Gajdanowicz, Marian Szczepanik
Summary: Contact hypersensitivity (CHS) is an experimental model of allergic contact dermatitis (ACD) that can be studied in mice. This study presents an objective laboratory method to study the CHS reaction in mice, which can be measured and quantified by various tests. CHS is a T cell-mediated immune response that causes swelling in inflamed tissue.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Medicine, General & Internal
Agata Sebastian, Marta Madej, Pawel Gajdanowicz, Maciej Sebastian, Anna Luczak, Magdalena Zemelka-Wiacek, Marek Jutel, Piotr Wiland
Summary: Primary Sjogren syndrome (pSS) is a complex multifactorial disease, involving various cytokines including interferon. This study aimed to quantify specific cytokines involved in the pathomechanism of pSS and determine their clinical correlation. Results showed that IFN gamma was the most frequently detected cytokine, and was present along with other specific cytokines in most patients. However, no clinical correlation was observed among the three most common cytokines, IL6, IFN gamma, and TNF alpha. These preliminary research findings suggest the possibility of exploring new treatments for pSS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Magdalena Zemelka-Wiacek
Summary: Metal allergy is an environmental disorder that can cause allergic contact dermatitis. The sources of metal exposure include jewelry, everyday items, mobile phones, leather, and metal-rich food. Occupational exposure to metals is also significant in the occurrence of metal hypersensitivity. Nickel, chromium, and cobalt are the most common metal allergens, but gold, palladium, titanium, and others have also gained attention recently. This review discusses advancements in understanding metal allergy mechanisms, biomarkers, and biological treatments. It also addresses the relationship between metal hypersensitivity and implanted devices, as well as the latest diagnostic methods.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
Mohamed H. Shamji, Markus Ollert, Ian M. Adcock, Oscar Bennett, Alberto Favaro, Roudin Sarama, Carmen Riggioni, Isabella Annesi-Maesano, Adnan Custovic, Sara Fontanella, Claudia Traidl-Hoffmann, Kari Nadeau, Lorenzo Cecchi, Magdalena Zemelka-Wiacek, Cezmi A. Akdis, Marek Jutel, Ioana Agache
Summary: Allergic diseases and asthma are closely connected to our living environment and patterns of exposure. The utilization of artificial intelligence and machine-learning methods can help unlock the potential of complex environmental data sets for understanding causality models of exposure and intervention. This article discusses the progress and future prospects of applying these approaches, as well as examples of machine learning in allergic disease research and its integration with representative exposome data. The promise of artificial intelligence in personalized medicine and improving public health is also explored.
Article
Allergy
Marek Jutel, Giselle S. Mosnaim, Jonathan A. Bernstein, Stefano del Giacco, David A. Khan, Kari C. Nadeau, Isabella Pali-Schoell, Maria J. Torres, Magdalena Zemelka-Wiacek, Ioana Agache
Summary: The One Health approach is a collaborative and interdisciplinary strategy that focuses on the interconnections between human, animal, and environmental health. It can advance the management of allergic diseases and asthma by addressing their complex and multifactorial nature. The impacts of allergens, infectious agents, and irritants on allergic diseases and asthma are influenced by environmental health intertwined with animal health. A coordinated response across sectors such as public health, veterinary medicine, and environmental science is needed, along with activities like monitoring and surveillance, targeted interventions, and research on underlying mechanisms.
Editorial Material
Allergy
Marek Jutel, Magdalena Zemelka-Wiacek, Michal Ordak, Oliver Pfaar, Thomas Eiwegger, Maximilian Rechenmacher, Cezmi A. Akdis
Article
Immunology
Karolina Pieniawska-Smiech, Aleksandra Lewandowicz-Uszynska, Magdalena Zemelka-Wiacek, Marek Jutel
Summary: This study investigates the prevalence of autoantibodies in paediatric PID population and suggests that certain autoantibodies may be useful for screening and diagnosing autoimmune diseases in PID patients.
Article
Multidisciplinary Sciences
Magdalena Zemelka-Wiacek, Anna Kosowska, Marek Jutel
Summary: Allergen exposure chambers (AECs) are clinical facilities that allow controlled exposure to allergens for diagnostic and treatment purposes.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Allergy
Marek Jutel, Ioana Agache, Magdalena Zemelka-Wiacek, Mubeccel Akdis, Tomas Chivato, Stefano del Giacco, Pawel Gajdanowicz, Ibon Eguiluz Gracia, Ludger Klimek, Antti Lauerma, Markus Ollert, Liam O'Mahony, Jurgen Schwarze, Mohamed H. Shamji, Isabel Skypala, Oscar Palomares, Oliver Pfaar, Maria Jose Torres, Jonathan A. Bernstein, Alvaro A. Cruz, Stephen R. Durham, Stephen J. Galli, R. Maximiliano Gomez, Emma Guttman-Yassky, Tari Haahtela, Stephen T. Holgate, Kenji Izuhara, Kenji Kabashima, Desiree E. Larenas-Linnemann, Erica von Mutius, Kari C. Nadeau, Ruby Pawankar, Tomas A. E. Platts-Mills, Scott H. Sicherer, Hae-Sim Park, Stefan Vieths, Gary Wong, Luo Zhang, M. Beatrice Bilo, Cezmi A. Akdis
Summary: The exponential growth of precision diagnostic tools has led to vast amounts of data enabling in-depth disease characterization. New disease endotypes have been identified, moving from symptom-focused descriptions to identifying biomarkers and intricate pathways. The current disease taxonomy must be revised for better categorization.
Review
Allergy
Magdalena Zemelka-Wiacek, Ioana Agache, Cezmi A. Akdis, Muebeccel Akdis, Thomas B. Casale, Stephanie Dramburg, Karina Jahnz-Rozyk, Anna Kosowska, Paolo M. Matricardi, Oliver Pfaar, Mohamed H. Shamji, Marek Jutel
Summary: The importance of allergen immunotherapy (AIT) lies in its ability to improve clinical outcomes and quality of life while reducing long-term costs. AIT induces allergen tolerance through various mechanisms, including changes in immune responses, suppression of allergen-specific IgE, and modulation of cell activation. Recent advancements in biomarkers, molecular diagnostics, and mobile health applications have the potential to enhance AIT efficacy and compliance. Additionally, artificial intelligence can aid in data interpretation and prediction of patient responses. Novel AIT preparations and advancements in clinical trial models contribute to the growth and development of AIT.
