期刊
ORGANIC LETTERS
卷 17, 期 17, 页码 4280-4283出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02068
关键词
-
资金
- National Science Foundation [NSF21272101, 21472074, 21472073]
- 111 Project [J1103307]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1138]
A novel and convenient Pd-catalyzed radical cascade iododifluoromethylation/cyclization of 1,6-enynes with ethyl difluoroiodoacetate is demonstrated. The proposed transformation presents high stereoselectivity under mild and facile reaction conditions, thereby allowing an efficient access to a variety of iodine-containing difluoromethylated pyrrolidines. A possible radical pathway for the transformation is proposed on the basis of the results of control experiments and relevant literature reviews.
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