期刊
ORGANIC LETTERS
卷 17, 期 18, 页码 4596-4599出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b02323
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资金
- National Natural Science Foundation of China (NSFC) [21472213, 21202186, 21272199]
- Croucher Foundation (Hong Kong)
A new family of tartaric acid derived chiral iminophosphoranes has been developed as highly effective organocatalysts in the asymmetric chlorinations of 3-substituted oxindoles with a high level of enantioselectivity. Importantly, these catalysts are air- and moisture-stable. Recovery of the catalyst after simple chromatographic separation for reuse in the model reaction was achieved; the catalyst can be recycled six times without loss of any enantioselectivity. Several advantages of this catalytic process are high conversion after a very short reaction time at ambient temperature, low catalytic loading, and scale-up to multigram quantities with an excellent enantiomeric excess value of >99%, which meets the enantiomeric purity required for pharmaceutical purposes.
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