期刊
ORGANIC LETTERS
卷 17, 期 3, 页码 406-409出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol503683q
关键词
-
资金
- DST New Delhi [SB/S1/OC-72/2013]
- CSIR, New Delhi
- IITM
A metal-free one-pot strategy has been developed for the first time to synthesize pharmaceutically important a-amino ketones from readily available benzylic secondary alcohols and amines using N-bromosuccinimide. This new reaction proceeds via three consecutive steps involving oxidation of alcohols, a-bromination of ketones, and nucleophilic substitution of a-bromo ketones to give a-amino ketones. Importantly, this novel one-pot greener reaction avoids direct usage of toxic and corrosive bromine. This methodology has been employed efficiently to synthesize pharmaceutically important amfepramone and pyrovalerone in a single step.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据