Article
Medicine, General & Internal
Bartosz Symonides, Jacek Lewandowski, Wojciech Marcinkowski, Jacek Zawierucha, Tomasz Prystacki, Jolanta Malyszko
Summary: This study aimed to assess the prevalence, characteristics, and determinants of apparent treatment-resistant hypertension (aTRH) in a large population of end-stage kidney disease (ESKD) patients undergoing hemodialysis (HD). Prevalence rates of hypertension and aTRH were determined using pre- and post-dialysis blood pressure criteria. The results showed that aTRH in ESKD HD patients appears to be multifactorial, influenced by patient-related factors rather than dialysis-related factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Somayeh Hosseinpour-Niazi, Bahar Bakhshi, Parvin Mirmiran, Fereidoun Azizi
Summary: This study demonstrated a negative association between nut consumption and MetS risk, especially walnuts and pistachios could reduce the risk of MetS. Among adults, consuming nuts higher than the median and engaging in moderate to high physical activity levels significantly decreased the risk of MetS. Non-smokers were more likely to reduce their risk of MetS, and individuals with higher education levels also showed a tendency to lower their risk of MetS.
CLINICAL NUTRITION
(2021)
Article
Surgery
Bailey M. Humphreys, Kelvin O. Memeh, Alex Funkhouser, Tanaz M. Vaghaiwalla
Summary: This study analyzed the survival rate of Hurthle cell carcinoma using population-level data and found significant associations between age, gender, race, ethnicity, household income, tumor grade and stage, and the survival rate of Hurthle cell carcinoma. Surgical treatment had a positive impact on patients' survival, but the extent of surgery did not affect the survival rate.
Article
Clinical Neurology
Alexandre Vallee, Emmanuel Wiernik, Sofiane Kab, Cedric Lemogne, Marcel Goldberg, Marie Zins, Jacques Blacher
Summary: Gender differences in the association between depressive symptoms and blood pressure levels and hypertension were observed, with educational level having the main modifying effect in women.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, Research & Experimental
Hailang Liu, Wei Wu, Wei Xiang, Jingdong Yuan
Summary: This study used a two-sample Mendelian randomization (MR) design based on summary-level data to assess the causal effect of lifestyle factors, metabolic factors, and socioeconomic status on the risk of female pelvic organ prolapse (POP). The results showed that waist-to-hip ratio (WHR), WHR adjusted for body mass index (WHRadjBMI), and education attainment have a causal association with POP.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Hellyda de Souza Bezerra, Roberta Machado Alves, Talita Araujo de Souza, Arthur de Almeida Medeiros, Isabelle Ribeiro Barbosa
Summary: The study analyzed the associations between individual characteristics and social context with mental distress symptoms in the Brazilian population. The results showed that young and middle-aged individuals, low education, women, absence of partner, smokers or former smokers were at highest risk for depressive thoughts, while belonging to classes D-E and living in states with lower expected years of schooling were protective factors. These findings emphasize the importance of strengthening psychosocial care targeted at vulnerable groups.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Salah Gariballa, Abderrahim Nemmar, Ozaz Elzaki, Nur Elena Zaaba, Javed Yasin
Summary: This study investigated the levels of oxidative damage markers in the urine of community free-living subjects with increased prevalence of obesity. The results showed significant associations between urinary oxidative damage and metabolic risk factors, and higher levels of urinary oxidative damage markers in diabetic, hypertensive, smoker, and male subjects.
Article
Chemistry, Multidisciplinary
Ty Felmingham, Fakir M. Amirul Islam
Summary: Globally, around 5% of adults suffer from depressive disorder. This study examined the association between sociodemographic factors and depression using data from a national survey in Australia. The findings showed that depression is more prevalent among younger individuals, females, and those with lower socioeconomic status in the Australian population. Appropriate intervention programs should be implemented for this specific group.
APPLIED SCIENCES-BASEL
(2022)
Article
Medicine, General & Internal
Fatih Turker, Tolga Sahin, Alihan Oral, Erdem Kocak, Betul Cavusoglu Turker, Adil Nigdelioglu, Hayriye Esra Ataoglu
Summary: This study identified metabolic risk factors for the development of portopulmonary hypertension (PoPH) in patients with nonalcoholic steatohepatitis (NASH)-associated cirrhosis. Elevated TSH levels were independently associated with an increased risk of PoPH.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Medicine, General & Internal
Sierra N. Clark, James E. Bennett, Raphael E. Arku, Allan G. Hill, Gunther Fink, Richard M. Adanu, Richard B. Biritwum, Rudolph Darko, Ayaga Bawah, Rosemary B. Duda, Majid Ezzati
Summary: Our study found that the variation in BMI and BP among neighborhoods within Accra is almost as large as the variation across countries among women globally. Localized measures are needed to address this unequal public health challenge in Accra.
Article
Critical Care Medicine
Andreas Palm, Ludger Grote, Jenny Theorell-Haglow, Mirjam Ljunggren, Josefin Sundh, Bengt Midgren, Magnus Ekstrom
Summary: This study found that marital status, education level, household income, and country of birth significantly influence CPAP adherence. These factors predict adherence to CPAP treatment in a clinically significant manner and should be taken into consideration when treating OSA.
Article
Multidisciplinary Sciences
Sara Malo, Isabel Aguilar-Palacio, Cristina Feja, Maria Jesus Lallana, Javier Armesto, Maria Jose Rabanaque
Summary: This study analyzed patterns of antihypertensive drug use among new users in a Southern European population, identifying factors that influence persistence. The results showed that overall persistence with antihypertensive therapy was poor and influenced by sex, age, and type of therapy. Fixed combinations were found to be effective for initial therapy, especially for patients at higher risk of discontinuation.
Article
Endocrinology & Metabolism
Leila Mahmoudieh, Mina Amiri, Maryam Rahmati, Ali Siamak Habibi Moeini, Farzaneh Sarvghadi, Fereidoun Azizi, Fahimeh Ramezani Tehrani
Summary: Limited studies have investigated the impact of idiopathic hirsutism (IH) on cardiometabolic parameters. This study found that IH does not significantly affect metabolic risk factors and cardiometabolic outcomes, except for a marginal significance in type 2 diabetes mellitus (T2DM).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Environmental Sciences
Manuela Abbate, Jordi Pericas, Aina M. Yanez, Angel A. Lopez-Gonzalez, Joan De Pedro-Gomez, Antoni Aguilo, Jose M. Morales-Asencio, Miquel Bennasar-Veny
Summary: The study found that lower socio-economic status is significantly associated with the prevalence of metabolic syndrome, especially impacting women more than men. The socio-economic status gradient had a greater influence on women than men, being evident from early adulthood and reaching its highest ratio in the late stages of middle adulthood.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Cardiac & Cardiovascular Systems
Aishat Mustapha, Joseph Ssekasanvu, Ivy Chen, Mary Kathryn Grabowski, Robert Ssekubugu, Godfrey Kigozi, Steven J. Reynolds, Ronald H. Gray, Maria J. Wawer, Joseph Kagaayi, Larry W. Chang, Wendy S. Post
Summary: Individuals with higher socioeconomic status in rural Uganda have a higher prevalence of hypertension, which is mediated by BMI. Targeted interventions focusing on lifestyle modification among the highest-risk groups could optimize public health impact.
Article
Ophthalmology
Mijie Li, Carla Lanca, Chuen-Seng Tan, Li-Lian Foo, Chen-Hsin Sun, Fabian Yap, Raymond P. Najjar, Charumathi Sabanayagam, Seang-Mei Saw
Summary: This study evaluated the association between reported time outdoors and light exposure patterns with myopia in 9-year-old Singaporean children. The findings showed that greater reported time outdoors was associated with a lower risk of myopia, while light levels and specific light measures did not have an impact.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Anna C. S. Tan, Miao Li Chee, Beau J. Fenner, Paul Mitchell, Yih Chung Tham, Tyler Rim, Kelvin Teo, Shaun S. Sim, Ching Yu Cheng, Tien Yin Wong, Usha Chakravarthy, Chui Ming Gemmy Cheung
Summary: This study aimed to report the incidence of age-related changes in drusen volume detected by optical coherence tomography (OCT) over a span of 6 years and their systemic and ocular associations. The results showed that the incidence of age-related macular degeneration (AMD) detected at 6 years was low. Drusen volume in the macular region either decreased, remained stable, or increased over the 6-year period. Older age, smoking, and chronic kidney disease were associated with decreased drusen volume, while older age and hypertension were associated with increased drusen volume.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Bingyao Tan, Nicole-Ann Lim, Rose Tan, Alfred Tau Liang Gan, Jacqueline Chua, Simon Nusinovici, Chui Ming Gemmy Cheung, Usha Chakravarthy, Tien Yin Wong, Leopold Schmetterer, Gavin Tan
Summary: Optical coherence tomography angiography (OCTA) parameters from both the retinal and choroidal microvasculature can be used to detect the presence and severity of diabetic retinopathy (DR). Choriocapillaris parameters show better discrimination between non-diabetic and diabetic without DR groups. Evaluating both retinal and choroidal microvasculature significantly improves the detection of diabetic retinopathy.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yi Xuen Chai, Alfred Tau Liang Gan, Eva K. Fenwick, Abraham Y. Sui, Benjamin Kye Jyn Tan, Debra Q. Y. Quek, Chaoxu Qian, Tien Yin Wong, Ching-Yu Cheng, Ecosse Luc Lamoureux, Ryan Eyn Kidd Man
Summary: This study aims to examine the relationship between vision impairment (VI) and employment outcomes in a multiethnic Asian population. The results suggest that even mild VI is associated with unemployment and underemployment.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Graham A. Wilson, Kirsten Cheyne, Sandhya Ramrakha, Antony Ambler, Gavin S. W. Tan, Avshalom Caspi, Ben Williams, Karen Sugden, Renate Houts, Rachael L. Niederer, Tien Yin Wong, Terrie E. Moffitt, Richie Poulton
Summary: This study investigated whether macular drusen in midlife are associated with accelerated biological ageing. The results showed no significant association between macular drusen and the pace of ageing or facial ageing.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Article
Ophthalmology
Li Lian Foo, Lingqian Xu, Charumathi Sabanayagam, Hla M. Htoon, Han Nian Marcus Ang, Jingwen Zhang, Kyoko Ohno-Matsui, Ching Yu Cheng, Quan Hoang, Chuen-Seng Tan, Seang-Mei Saw, Chee Wai Wong
Summary: The purpose of this study was to investigate the predictive factors for myopic macular degeneration (MMD) and progression in adults with myopia. The study found that in adults without MMD, tessellated fundus, age, spherical equivalent (SE), and axial length (AL) were good predictors for incident MMD. In adults with MMD, older age, more severe myopia, and longer AL were independent risk factors for progression.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Zhenzhen Liu, Shan Huang, Yingfeng Zheng, Tian Zhou, Leyi Hu, Lang Xiong, David Wan-cheng Li, Yizhi Liu
Summary: The crystalline lens is a transparent and refractive biconvex structure formed by lens epithelial cells (LECs) and lens fibers. Lens opacity, also known as cataracts, is the leading cause of blindness in the world. LECs are the principal cells of lens throughout human life, exhibiting different physiological properties and functions.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Zhuo-Xing Shi, Zhi-Chao Chen, Jia-Yong Zhong, Kun-Hua Hu, Ying-Feng Zheng, Ying Chen, Shang-Qian Xie, Xiao-Chen Bo, Feng Luo, Chong Tang, Chuan-Le Xiao, Yi-Zhi Liu
Summary: Long-read single-cell RNA isoform sequencing can reveal the complex landscape of alternative RNA splicing in individual cells, but it has a low read throughput. The authors developed circular consensus sequencing methods to achieve high-throughput and high-accuracy single-cell RNA isoform sequencing.
NATURE COMMUNICATIONS
(2023)
Article
Ophthalmology
Li Lian Foo, Chuen-Seng Tan, Brennan Noel, Hla M. Htoon, Raymond P. Najjar, Biten Kathrani, Charumathi Sabanayagam, Seang-Mei Saw
Summary: The purpose of this study was to evaluate factors influencing myopia stabilisation in Singapore. The longitudinal natural history of 424 myopic participants from 1999 to 2022 was evaluated, and it was found that 82.3% of people had stabilisation of myopia within 10 years. The study also found that males and non-Chinese ethnicities were more likely to achieve myopia stabilisation.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Zitian Liu, Wenyong Huang, Zhenyu Wang, Ling Jin, Nathan Congdon, Yingfeng Zheng, Shida Chen, Yizhi Liu
Summary: This study demonstrates that the portable, self-imaging OCT is highly consistent with clinic-based SD-OCT in measuring CST and identifying most retinal lesions.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Yu Huang, Carol Y. Cheung, Dawei Li, Yih Chung Tham, Bin Sheng, Ching Yu Cheng, Ya Xing Wang, Tien Yin Wong
Summary: Cardiovascular disease (CVD) is a major cause of death globally, and the use of artificial intelligence (AI) in analyzing ocular images has the potential to enhance CVD risk prediction. This review provides an overview of AI-based ocular image analysis for predicting CVD and discusses the limitations in AI research and the challenges in clinical practice.
Article
Health Care Sciences & Services
Kang-An Wong, Bryan Chin Hou Ang, Dinesh Visva Gunasekeran, Rahat Husain, Joewee Boon, Krishna Vikneson, Zyna Pei Qi Tan, Gavin Siew Wei Tan, Tien Yin Wong, Rupesh Agrawal
Summary: This study investigates the performance of a novel remote perimetry application designed in a virtual reality metaverse environment to enable functional testing in community-based and primary care settings. The results show that the remote perimetry application has good concordance with the gold standard perimetry and could potentially be used for functional eye screening in out-of-hospital settings.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Computer Science, Information Systems
Chan Joo Lee, Tyler Hyungtaek Rim, Hyun Goo Kang, Joseph Keunhong Yi, Geunyoung Lee, Marco Yu, Soo-Hyun Park, Jin-Taek Hwang, Yih-Chung Tham, Tien Yin Wong, Ching-Yu Cheng, Dong Wook Kim, Sung Soo Kim, Sungha Park
Summary: This study validated a personalized cardiovascular disease (CVD) risk scoring system, named Reti-CVD, based on retinal images. The risk groups defined by Reti-CVD were significantly associated with increased CVD risk and remained effective in a comprehensive model with other risk factors.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2023)
Article
Biology
Charumathi Sabanayagam, Feng He, Simon Nusinovici, Jialiang Li, Cynthia Lim, Gavin Tan, Ching Yu Cheng
Summary: This study compares the accuracy of different machine learning algorithms in predicting diabetic kidney disease. The results show that machine learning models outperform logistic regression and identify novel risk factors.
Article
Ophthalmology
Kai Xiong Cheong, Hengtong Li, Yih Chung Tham, Kelvin Yi Chong Teo, Anna Cheng Sim Tan, Leopold Schmetterer, Tien Yin Wong, Chui Ming Gemmy Cheung, Ching-Yu Cheng, Qiao Fan
Summary: This study evaluated the relationship between genetic susceptibility to AMD and retinal thickness, finding that certain genetic variants were associated with thinner retinal layers, particularly the photoreceptor layers. These findings suggest that retinal thickness could serve as a potential risk marker for prodromal AMD, highlighting the importance of considering topographic variation.
OPHTHALMOLOGY SCIENCE
(2023)
