期刊
ORGANIC LETTERS
卷 17, 期 6, 页码 1509-1512出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b00389
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资金
- NSFC [41306146, 31290233, 81425022]
- MOST [2012AA092104]
The biosynthetic gene cluster governing production of anti-infective marformycins was identified from deep sea-derived Streptomyces drozdowiczii SCSIO 10141. The putative mfn gene cluster (45 kb, 20 orfs) was found to encode six NRPSs and related proteins for cyclodepsipeptide core construction (mfnCDEFKL), a methionyl-tRNA formyltransferase (mfnA), a SAM-dependent methyltransferase (mfnG), and a cytochrome P450 monooxygenase for piperazic acid moiety hydroxylation (mfnN); notably, only MfnN uses an intact cyclodepsipeptide intermediate as its substrate.
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